Article
Dentistry, Oral Surgery & Medicine
Sandra R. Hernandez, Alejandro R. Perez, Alessandra C. Baasch, Karen Brisson-Suarez, Debora P. Sellera, Patricia H. P. Ferrari, Jorge C. Alberdi, Claudia M. Carreira, Susana Gomes-Azevedo, Flavio R. F. Alves, Isabela N. Rocas, Jose F. Siqueira Jr
Summary: This study evaluated the treatment approaches for 6 maxillary incisors with dens invaginatus and apical periodontitis. Cone-beam computed tomography was used for diagnosis and treatment planning, and sodium hypochlorite irrigation and thermoplasticized gutta-percha obturation were the key methods used. The results showed favorable clinical and radiographic outcomes.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2022)
Article
Infectious Diseases
Zheng Wang, Ge Yang, Biao Ren, Yuan Gao, Xian Peng, Mingyun Li, Hockin H.K.Xu, Qi Han, Jiyao Li, Xuedong Zhou, Lei Cheng
Summary: This study investigated the antibacterial effect of root canal sealer containing DMADDM on persistent apical periodontitis in beagle dogs. The results showed that DMADDM-modified sealer significantly reduced the volume of periapical lesion and inflammatory grade, especially in cases of E. faecalis-induced reinfection.
Article
Biochemistry & Molecular Biology
Xiao Guo, Yan Sun, Zheng Wang, Biao Ren, Hockin H. K. Xu, Xian Peng, Mingyun Li, Suping Wang, Haohao Wang, Yao Wu, Michael D. Weir, Xuedong Zhou, Fang Lan, Lei Cheng
Summary: Persistent apical periodontitis is a critical challenge in root canal therapy. Developing root canal filling materials with continuous antibacterial effects and tight seal is important to prevent treatment failure and persistent apical periodontitis. In this study, we modified the EndoREZ root canal sealer by adding the antibacterial material DMADDM and magnetic nanoparticles (MNPs). The modified sealer showed good mechanical properties, biocompatibility, and enhanced antibacterial effects on multispecies biofilms under a magnetic field. In vivo study demonstrated its inhibitory effect on persistent apical periodontitis with minimal resorption and slight increase in periodontal ligament space.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Dentistry, Oral Surgery & Medicine
Laura C. L. Nardello, Ericka T. Pinheiro, Giulio Gavini, Lais C. Prado, Roberto X. Romero, Brenda P. F. A. Gomes, Mary C. Skelton-Macedo
Summary: This study reviewed the prevalence of bacteria in postinstrumentation samples of root canals from permanent teeth, especially focusing on as-yet uncultivated or difficult-to-culture bacterial taxa. The persisting species mainly belonged to the phylum Firmicutes, with Streptococcus as the major member.
JOURNAL OF ENDODONTICS
(2022)
Article
Medicine, General & Internal
Izabela Korona-Glowniak, Dominika Piatek, Emilia Fornal, Anna Lukowiak, Yuriy Gerasymchuk, Anna Kedziora, Gabriela Bugla-Ploskonska, Ewelina Grywalska, Teresa Bachanek, Anna Malm
Summary: This study investigated the microbial diversity of root canal microbiota related to different endodontic infections. Results showed different microbial compositions in various types of endodontic infections, with specific bacterial species correlating with the health condition of teeth.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Alaa Aldoss, Maha Alghofaily, Fahd Alsalleeh
Summary: Diabetes mellitus increases susceptibility to infection, particularly in relation to apical periodontitis. This study aimed to investigate bacterial quantities and IL-17 expression in necrotic teeth with apical periodontitis in type 2 diabetes, pre-diabetic, and non-diabetic patients. The results showed slightly higher bacterial counts and IL-17 expression in type 2 diabetes patients compared to other groups, but the differences were not statistically significant. These findings suggest that diabetes may impact the clinical outcome of endodontic diseases in diabetic patients.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Reem Alkhatri, Abdul Rahman Mohammed Saleh, Waad Kheder
Summary: This study compared the effects of zirconia, metal, and polymer-infiltrated ceramic network (PICN) materials on the restoration of teeth after root canal treatment. The results showed that the PICN group had the least extension of root fracture apically, making it suitable for post and core restoration of anterior teeth.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Review
Dentistry, Oral Surgery & Medicine
Chiara Pirani, Josette Camilleri
Summary: This systematic review aimed to investigate the impact of different obturation techniques and materials on the management of apical periodontitis (AP). The results showed that the obturation techniques and materials used did not affect the outcome of AP. Vertical compaction resulted in faster resolution of periapical lesions, while patients treated with lateral condensation had poorer oral health-related quality of life.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Marie Voit, Andrej Trampuz, Mercedes Gonzalez Moreno
Summary: This study evaluated the activity of newly isolated bacteriophages against Enterococcus faecalis and found that combination therapy of phages and antibiotics effectively reduced biofilm formation.
Article
Infectious Diseases
Felix Carrasco Calzada, John Jairo Aguilera-Correa, Juan Cuadros Gonzalez, Jaime Esteban Moreno, David Roca Biosca, Ramon Perez-Tanoira
Summary: A study conducted in Uganda isolated and tested the antimicrobial susceptibility of microorganisms causing urinary tract infections (UTI). The results showed a high prevalence of bacterial growth, with Enterococcus spp. and Escherichia coli being the most common uropathogens. The study suggests discontinuing the use of amoxicillin and ciprofloxacin as empirical treatments for UTIs in Uganda due to high resistance rates.
Review
Dentistry, Oral Surgery & Medicine
Daniel Cabanillas-Balsera, Victoria Areal-Quecuty, Cristiane Cantiga-Silva, C. B. M. de Cardoso, Luciano Tavares Angelo Cintra, Jenifer Martin-Gonzalez, Juan J. Segura-Egea
Summary: There is no association between the prevalence of AP and hypertension, but hypertensive patients have significantly increased odds of losing root-filled teeth. Given the high prevalence of hypertension, it is very common to perform root canal treatments on hypertensive patients. It is imperative to communicate this heightened risk to patients and recommend periodic monitoring of oral health and hypertension, paying special attention to this subset of patients.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Caroline Loureiro, Marilia Afonso Rabelo Buzalaf, Talita Mendes Oliveira Ventura, Vinicius Taioqui Pela, Gladiston William Lobo Rodrigues, Julia Guerra Andrade, Juliano Pelim Pessan, Rogerio Castilho Jacinto
Summary: This study quantitatively and qualitatively analyzed the proteomic profile of teeth with acute apical abscesses (AAA) and chronic apical periodontitis (CAP). The results showed significant differences in protein expression between the two groups, with AAA group mainly associated with immune inflammatory response and oxidative stress response, and CAP group mainly associated with DNA/RNA regulation and repair, and structural function.
CLINICAL ORAL INVESTIGATIONS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Stefano Corbella, Clemens Walter, Igor Tsesis
Summary: This study systematically analyzed the effectiveness of root resection techniques in managing apical periodontitis. The results showed limited data and high heterogeneity and bias among the included studies. Therefore, it is currently not possible to recommend or dismiss the use of root resection techniques for treating apical periodontitis.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Oncology
Larissa Vilas-Boas, Viviany Cozer, Peter Z. Tawil, Marcelo Santos Coelho
Summary: This study found that photodynamic therapy after root canal preparation can effectively reduce pain in posterior teeth presenting with symptomatic apical periodontitis, especially within 24 hours. There were no significant differences in pain levels between the two groups at 72 hours and 1 week, and there was no noticeable change in the number of pain relief tablets taken.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Medicine, Research & Experimental
Gustavo M. Almeida, Vitor Hugo M. Carvalho, Erika B. P. Silva, Marco Antonio F. Cancado, Leonardo S. Barroso, Erica L. Queiroz, Tien Li An, Ana Paula D. Ribeiro, Jacy R. Carvalho-Junior, Andre F. Leite
Summary: This study aims to explore whether the use of intracanal dressing during endodontic treatment promotes periradicular repair in teeth with apical periodontitis. Three different clinical approaches will be used and patients' postoperative pain levels and long-term follow-up evaluations will be recorded. The results may lead to changes in the clinical approaches of endodontic therapy for teeth with apical periodontitis and reveal the potential of complementary approaches for enhanced root canal system decontamination during preparation.