Journal
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
Volume 164, Issue 4, Pages B103-B106Publisher
ELECTROCHEMICAL SOC INC
DOI: 10.1149/2.0561704jes
Keywords
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Funding
- FCT/MCTES through national funds
- FEDER [PT2020-UID/QUI/50006/2013-POCI/01/0145/FEDER/007265]
- Portuguese Fundacao, para a Ciencia e a Tecnologia (FCT) [PD/BD/127797/2016, SFRH/BPD/76544/2011]
- Fundação para a Ciência e a Tecnologia [PD/BD/127797/2016, SFRH/BPD/76544/2011] Funding Source: FCT
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In this work T4, also known as thyroxine, a thyroid hormone with many relevant roles in human metabolism, was determined with an antibody-based biosensor, consisting on a multi thiol self-assembled monolayer (SAM) whereas a selective antibody was attached. Electroanalytical measurements were performed by impedance on a ferricyanide redox probe. A limit of detection of 1.5 ng mL(-1) and limit of quantification (LOQ) of 4.0 ngmL(-1) were obtained. This biosensor is a proof-of-concept for the creation of point-of-care electrochemical approach for the quantification of T4. (C) 2017 The Electrochemical Society. All rights reserved.
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