Review
Peripheral Vascular Disease
Zhen-Yu Zhang, Yu-Ling Yu, Kei Asayama, Tine W. Hansen, Gladys E. Maestre, Jan A. Staessen
Summary: Additional digital content is available in the text.
Review
Biochemistry & Molecular Biology
Pawel Bryniarski, Katarzyna Nazimek, Janusz Marcinkiewicz
Summary: This review article focuses on the immunomodulatory properties of angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) in hypertensive patients. ACEI and ARB can inhibit proinflammatory cytokine secretion, decrease expression of adhesion molecules, and normalize CRP concentration, thus exerting immune regulatory effects. This has significant importance in the treatment of patients with underlying chronic inflammatory responses and may also benefit those with comorbidities like metabolic syndrome, allergies, or autoimmune disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Annina S. Vischer, Gabriela M. Kuster, Raphael Twerenbold, Otmar Pfister, Qian Zhou, Andrea Villiger, Marko Poglitsch, Stephan Krahenbuhl, Michael Mayr, Stefan Osswald, Manuel Haschke, Thilo Burkard
Summary: Different antihypertensive drugs have significant effects on angiotensin II and Ang (1-7) concentrations, with perindopril and olmesartan showing distinct alterations favoring the anti-inflammatory axis.
Article
Cardiac & Cardiovascular Systems
Tlili Barhoumi, Fatmah A. Mansour, Maroua Jalouli, Hassan S. Alamri, Rizwan Ali, Abdel Halim Harrath, Maha Aljumaa, Mohamed Boudjelal
Summary: Angiotensin II (Ang II) is a key component of the renin-angiotensin-aldosterone system and is associated with cardiopathology. High levels of Ang II have been linked to inflammatory conditions such as coronary heart disease, obesity, and type 2 diabetes. This study evaluated the cellular effects of Ang II on THP-1-derived macrophages, showing that it stimulates differentiation markers and proinflammatory markers while decreasing an M2 marker. Ang II also induces calcium overload, increases reactive oxygen species, and arrests cells in the G1 phase, primarily through the angiotensin II type 1 receptor (AT1R).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Immunology
Gabriel Augusto Pires de Souza, Ikram Omar Osman, Marion Le Bideau, Jean-Pierre Baudoin, Rita Jaafar, Christian Devaux, Bernard La Scola
Summary: The study found that ARBs may increase ACE2 expression, promoting SARS-CoV-2 replication in cells and increasing viral production. As a result, the use of ARBs in hypertensive patients infected with SARS-CoV-2 should be carefully evaluated.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Anastasios Lymperopoulos, Jordana Borges, Alexandra M. Carbone, Natalie Cora, Anastasiya Sizova
Summary: The angiotensin II type 1 receptor, essential in the cardiovascular system, has been extensively studied for its physiological and pathophysiological roles. Biased AT(1) receptor ligands have been developed to selectively activate beta-arrestin transduction pathways. However, the focus on G(q) or beta-arrestins tends to neglect other non-Gq-, non beta-arrestin-dependent signaling modalities employed by the versatile AT(1) receptor in cardiovascular tissues.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jordan B. King, Ransmond O. Berchie, Catherine G. Derington, Zachary A. Marcum, Daniel O. Scharfstein, Tom H. Greene, Jennifer S. Herrick, Joshua A. Jacobs, Alexander R. Zheutlin, Adam P. Bress, Jordana B. Cohen
Summary: This study compared the effects of new users of ARBs versus ACEIs on cardiovascular disease events and death. The results showed similar rates of cardiovascular disease events between the two groups, with lower death rates associated with ARBs. There were subgroup differences in the effects of ARBs versus ACEIs.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Shiju Ye, He Huang, Xue Han, Wu Luo, Lili Wu, Yang Ye, Yingchao Gong, Xia Zhao, Weijian Huang, Yi Wang, Xiaohong Long, Guosheng Fu, Guang Liang
Summary: In this study, the researchers discovered that dectin-1, a pattern recognition receptor, plays a crucial role in cardiac remodeling. They found that Ang II can directly bind to dectin-1, activating downstream signaling pathways and inducing inflammatory responses, leading to heart damage and dysfunction. These findings suggest that dectin-1 may be a potential target for treating hypertension-related heart failure.
CIRCULATION RESEARCH
(2023)
Article
Neurosciences
Sarah B. Scheinman, Steve Zaldua, Adedoyin Dada, Kateryna Krochmaliuk, Katherine Dye, Felecia M. Marottoli, Gregory R. J. Thatcher, Leon M. Tai
Summary: Evidence suggests that angiotensin receptor blockers (ARBs) could be beneficial for Alzheimer's disease patients, particularly in terms of neuroinflammation. Studies on mice expressing the human APOE4 gene showed that female E4FAD- and E4FAD+ mice exhibited improved memory-related behavior and higher hippocampal presynaptic protein levels after treatment with the ARB prodrug candesartan.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Peripheral Vascular Disease
Laura Semenzato, Jeremie Botton, Jerome Drouin, Berangere Baricault, Clementine Vabre, Francois Cuenot, Laetitia Penso, Philippe Herlemont, Emilie Sbidian, Alain Weill, Rosemary Dray-Spira, Mahmoud Zureik
Summary: Recent evidence suggests that hypertensive patients treated with ACE inhibitors or ARBs may have a lower risk of COVID-19 hospitalization and intubation/death compared to those treated with CCBs. This contradicts initial hypotheses regarding the association between renin-angiotensin-aldosterone system inhibitors and COVID-19 risk, raising new questions for further research.
Article
Biochemistry & Molecular Biology
Moudhi Almutlaq, Fatmah A. Mansour, Jahad Alghamdi, Yassen Alhendi, Abir Abdullah Alamro, Amani Ahmed Alghamdi, Hassan S. Alamri, Fayhan Alroqi, Tlili Barhoumi
Summary: This study demonstrates that angiotensin II (Ang II) exacerbates the T-cell response to SARS-CoV-2 in recovered COVID-19 patients. The presence of Ang II increases the phosphorylation levels of proteins involved in cardiovascular diseases, inflammation, and viral infection. These findings suggest that Ang II may worsen the inflammatory response and alter the immune response to a more inflammatory profile against SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Kung-Ming Laio, Chuan-Wei Shen, Yun-Hui Huang, Chun-Hui Lu, Hsuan-Lin Lai, Chung-Yu Chen
Summary: The prescription pattern and effectiveness of antihypertensive drugs in surgical patients with aortic dissection were investigated. The study found that no specific type of antihypertensive drug was associated with a better outcome in patients with type A aortic dissection, while the use of beta-blockers and calcium channel blockers (CCBs) was related to a significantly lower risk of the composite outcome in patients with type B aortic dissection.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Laura Kate Gadanec, Kristen Renee McSweeney, Peter Kubatka, Martin Caprnda, Ludovit Gaspar, Robert Prosecky, Jozef Dragasek, Peter Kruzliak, Vasso Apostolopoulos, Anthony Zulli
Summary: Abdominal aortic aneurysms (AAA) are caused by abnormal remodeling of the vascular wall and have different vasoactive responses to Angiotensin II (AngII). This study found that mouse arteries have different responses to AngII, with iliac arteries showing significantly higher vasoconstriction responses, which may play a role in AAA development.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Medicine, General & Internal
Kiyotsugu Iede, Terumasa Yamada, Masami Ueda, Yujiro Tsuda, Shinsuke Nakashima, Katsuya Ohta, Tsukasa Tanida, Jin Matsuyama, Masakazu Ikenaga, Shusei Tominaga
Summary: This study retrospectively investigated the baseline differences between hypertensive (HT) and non-hypertensive (non-HT) patients with advanced pancreatic cancer (APC). It found significant differences in characteristics between the two groups, suggesting a major selection bias. Although no significant difference was found in treatment response, HT patients had significantly longer overall survival. The use of antihypertensive drugs was not identified as an independent prognostic factor.
Article
Food Science & Technology
Yu Pei, Shengxuan Cai, Bomi Ryu, Chunxia Zhou, Pengzhi Hong, Zhong-Ji Qian
Summary: This research evaluated the protective effects of polypeptides from microalgae on endothelial injury and found that they can block inflammation and apoptosis, thereby alleviating endothelial damage. Additionally, these polypeptides showed an antihypertensive effect and can potentially be used as a component in functional foods for preventing cardiovascular diseases.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Oncology
Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Leszek Paczek, Karl-Johan Malmberg, Sebastien Walchli, Magdalena Winiarska, Radoslaw Zagozdzon
Summary: This study provides new information on the efficacy of PD-L1-targeted CAR against PD-L1(low) targets. The results show that PD-L1-CAR cells have strong reactivity and cytotoxicity against both PD-L1(high) and PD-L1(low) target cells. Additionally, PD-L1-CAR cells also exhibit potent cytotoxic effects against non-malignant cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka Kulesza, Katarzyna Zielniok, Jakub Hawryluk, Leszek Paczek, Anna Burdzinska
Summary: This study investigated the effects of nonselective COX inhibitor ibuprofen on human bone marrow MSCs (hBM-MSCs). The results showed that ibuprofen reduced PGE(2) secretion, but did not significantly affect proliferation and migration of MSCs. However, it significantly decreased the secretion of certain pro-regenerative factors.
Article
Multidisciplinary Sciences
Barbara Lisowska-Myjak, Hanna Zborowska, Slawomir Bialek, Piotr Wroczynski, Marek Kuch, Ewa Skarzyzska
Summary: Investigating the association between serum thyroid hormone levels, triglyceride concentrations, and anthropometric parameters in young women, this study found that thyroid function is not related to body mass index (BMI) in healthy young women, but serum thyroid hormone levels are higher in overweight individuals. Moreover, the correlation between thyroid hormones and triglycerides differs in underweight and normal-weight women.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Dominika Klimczak-Tomaniak, Julia Haponiuk-Skwarlinska, Marek Kuch, Leszek Paczek
Summary: This article reviews the interaction between microRNA and oxidative stress in heart failure. Multiple microRNAs are found to be involved in the oxidative stress processes associated with heart failure development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Monika Wrzosek, Anna Hojka-Osinska, Dominika Klimczak-Tomaniak, Anna Katarzyna Zarek-Starzewska, Wioletta Dyrla, Magdalena Rostek-Bogacka, Maksym Wroblewski, Marek Kuch, Magdalena Kucia
Summary: This study observed a significant downregulation of miRNAs in diabetic patients with heart failure (HF), which has not been reported before. The downregulated miRNAs regulate angiogenesis and apoptosis.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Agnieszka Kulesza, Leszek Paczek, Anna Burdzinska
Summary: The molecular mechanisms underlying the immunomodulatory properties of MSCs and the role of PGE2 and COX-2 in these properties are not fully understood. This article summarizes previous observations regarding the role of PGE2 and COX-2 in the immunomodulatory properties and other vital functions of MSCs. The most consistent results suggest that MSC-derived PGE2 inhibits the early maturation of dendritic cells, suppresses the proliferation of activated lymphocytes, and stimulates the differentiation of macrophages into M2 phenotype. COX-2/PGE2 also plays an important role in maintaining the basic life functions of MSCs and affects the formation of niches conducive to hematopoiesis and carcinogenesis.
Review
Immunology
Krzysztof Mucha, Michal Pac, Leszek Paczek
Summary: Thanks to omics technologies, we have gained a better understanding of the pathogenesis of many diseases in the last decade. However, the risk factors for most autoimmune diseases are still unknown.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2023)
Review
Cardiac & Cardiovascular Systems
Karolina Gumiezna, Piotr Barus, Grazyna Sygitowicz, Agnieszka Wisniewska, Dorota Ochijewicz, Karolina Pasierb, Dominika Klimczak-Tomaniak, Ewa Kuca-Warnawin, Janusz Kochman, Marcin Grabowski, Grzegorz Opolski, Mariusz Tomaniak, Krzysztof J. Filipiak
Summary: Immature platelet fraction (IPF) has been found to play important roles in diagnosis, prognosis, and potential therapy in cardiovascular medicine. It serves as an independent predictor of cardiovascular death in patients with acute coronary syndromes, particularly ST-segment elevation myocardial infarction. Additionally, IPF can be used for monitoring antiplatelet therapy.
CARDIOLOGY JOURNAL
(2023)
Article
Genetics & Heredity
Krzysztof Kiryluk, Elena Sanchez-Rodriguez, Xu-Jie Zhou, Francesca Zanoni, Lili Liu, Nikol Mladkova, Atlas Khan, Maddalena Marasa, Jun Y. Zhang, Olivia Balderes, Simone Sanna-Cherchi, Andrew S. Bomback, Pietro A. Canetta, Gerald B. Appel, Jai Radhakrishnan, Hernan Trimarchi, Ben Sprangers, Daniel C. Cattran, Heather Reich, York Pei, Pietro Ravani, Kresimir Galesic, Dita Maixnerova, Vladimir Tesar, Benedicte Stengel, Marie Metzger, Guillaume Canaud, Nicolas Maillard, Francois Berthoux, Laureline Berthelot, Evangeline Pillebout, Renato Monteiro, Raoul Nelson, Robert J. Wyatt, William Smoyer, John Mahan, Al-Akash Samhar, Guillermo Hidalgo, Alejandro Quiroga, Patricia Weng, Raji Sreedharan, David Selewski, Keefe Davis, Mahmoud Kallash, Tetyana L. Vasylyeva, Michelle Rheault, Aftab Chishti, Daniel Ranch, Scott E. Wenderfer, Dmitry Samsonov, Donna J. Claes, Oleh Akchurin, Dimitrios Goumenos, Maria Stangou, Judit Nagy, Tibor Kovacs, Enrico Fiaccadori, Antonio Amoroso, Cristina Barlassina, Daniele Cusi, Lucia Del Vecchio, Giovanni Giorgio Battaglia, Monica Bodria, Emanuela Boer, Luisa Bono, Giuliano Boscutti, Gianluca Caridi, Francesca Lugani, GianMarco Ghiggeri, Rosanna Coppo, Licia Peruzzi, Vittoria Esposito, Ciro Esposito, Sandro Feriozzi, Rosaria Polci, Giovanni Frasca, Marco Galliani, Maurizio Garozzo, Adele Mitrotti, Loreto Gesualdo, Simona Granata, Gianluigi Zaza, Francesco Londrino, Riccardo Magistroni, Isabella Pisani, Andrea Magnano, Carmelita Marcantoni, Piergiorgio Messa, Renzo Mignani, Antonello Pani, Claudio Ponticelli, Dario Roccatello, Maurizio Salvadori, Erica Salvi, Domenico Santoro, Guido Gembillo, Silvana Savoldi, Donatella Spotti, Pasquale Zamboli, Claudia Izzi, Federico Alberici, Elisa Delbarba, Michal Florczak, Natalia Krata, Krzysztof Mucha, Leszek Paczek, Stanislaw Niemczyk, Barbara Moszczuk, Malgorzata Panczyk-Tomaszewska, Malgorzata Mizerska-Wasiak, Agnieszka Perkowska-Ptasinska, Teresa Baczkowska, Magdalena Durlik, Krzysztof Pawlaczyk, Przemyslaw Sikora, Marcin Zaniew, Dorota Kaminska, Magdalena Krajewska, Izabella Kuzmiuk-Glembin, Zbigniew Heleniak, Barbara Bullo-Piontecka, Tomasz Liberek, Alicja Debska-Slizien, Tomasz Hryszko, Anna Materna-Kiryluk, Monika Miklaszewska, Maria Szczepanska, Katarzyna Dyga, Edyta Machura, Katarzyna Siniewicz-Luzenczyk, Monika Pawlak-Bratkowska, Marcin Tkaczyk, Dariusz Runowski, Norbert Kwella, Dorota Drozdz, Ireneusz Habura, Florian Kronenberg, Larisa Prikhodina, David van Heel, Bertrand Fontaine, Chris Cotsapas, Cisca Wijmenga, Andre Franke, Vito Annese, Peter K. Gregersen, Sreeja Parameswaran, Matthew Weirauch, Leah Kottyan, John B. Harley, Hitoshi Suzuki, Ichiei Narita, Shin Goto, Hajeong Lee, Dong Ki Kim, Yon Su Kim, Jin-Ho Park, BeLong Cho, Murim Choi, Ans Van Wijk, Ana Huerta, Elisabet Ars, Jose Ballarin, Sigrid Lundberg, Bruno Vogt, Laila-Yasmin Mani, Yasar Caliskan, Jonathan Barratt, Thilini Abeygunaratne, Philip A. Kalra, Daniel P. Gale, Ulf Panzer, Thomas Rauen, Juergen Floege, Pascal Schlosser, Arif B. Ekici, Kai-Uwe Eckardt, Nan Chen, Jingyuan Xie, Richard P. Lifton, Ruth J. F. Loos, Eimear E. Kenny, Iuliana Ionita-Laza, Anna Koettgen, Bruce A. Julian, Jan Novak, Francesco Scolari, Hong Zhang, Ali G. Gharavi
Summary: Genome-wide association analyses have identified 30 risk loci for IgA nephropathy, a progressive form of kidney disease. Functional annotations of potential causal genes suggest inflammatory signaling pathways and cytokine ligand-receptor pairs as potential new drug targets. These findings provide valuable insights into the genetic basis of IgA nephropathy and offer potential avenues for developing therapeutic interventions.
Article
Chemistry, Analytical
Natalia Korytowska-Przybylska, Sylwia Michorowska, Aleksandra Wyczalkowska-Tomasik, Leszek Paczek, Joanna Giebultowicz
Summary: Chronic kidney disease (CKD) is diagnosed using serum creatinine or cystatin C levels, but more sensitive biomarkers are needed. This study aims to verify the correlation between saliva and serum levels of trimethylamine N-oxide (TMAO) in CKD patients. The results show a good correlation between TMAO levels in saliva and serum, suggesting that saliva can be used for non-invasive monitoring of renal failure in CKD.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Medicine, Research & Experimental
Justyna Aleksandra Skladanek, Michal Leskiewicz, Karolina Gumiezna, Piotr Barus, Adam Piasecki, Dominika Klimczak-Tomaniak, Grazyna Sygitowicz, Janusz Kochman, Marcin Grabowski, Mariusz Tomaniak
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has posed significant challenges to healthcare systems globally with high morbidity and mortality rates. Even after a full recovery, a significant proportion of patients exhibit long-term cardiovascular, pulmonary, and neurological symptoms, believed to be caused by chronic tissue damage and pathological inflammation. Microvascular dysfunction also contributes to major health issues. This review critically examines the current data on the long-term cardiovascular consequences of COVID-19, focusing on symptoms such as chest pain, fatigue, palpitations, and breathlessness, as well as important diseases like myocarditis, pericarditis, and postural tachycardia syndrome. It also includes potential risk factors and recent advancements in diagnostics and potential treatments for long COVID.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Paulina Nazaruk, Ignacy Tkaczyk, Marta Monticolo, Anna Maria Jedrzejczak, Natalia Krata, Leszek Paczek, Bartosz Foroncewicz, Krzysztof Mucha
Summary: The study evaluated the role of SARS-CoV-2 infection history in the vaccination schedules of kidney and liver transplant recipients and patients with chronic kidney disease (CKD). The results showed that patients with a COVID-19 history had higher antibody levels after two doses compared to three doses. Two doses also resulted in a longer median time to infection. The study suggests that vaccination schedules should take into account vaccine response rate and COVID-19 history.
Article
Cardiac & Cardiovascular Systems
Milena Michalska, Tadeusz Grochowiecki, Aleksandra Wyczalkowska-Tomasik, Leszek Paczek, Tomasz Jakimowicz, Andrzej Cacko, Katarzyna Jama, Albert Stec, Ewa Sikorska, Slawomir Nazarewski, Zbigniew Galazka
Summary: This study investigated the changes in NETosis markers in patients with thoracoabdominal aortic aneurysms undergoing t-Branch stent-graft implantation. The results showed that NETs play a significant role in the complex processes after the surgery, and a new marker for NETosis, ssDNA, was discovered.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Surgery
Piotr Wilkowski, Ewa Hryniewiecka, Kornelia Jasinska, Leszek Paczek, Michal Ciszek
Summary: This observational study suggests that treating patients with recurrent UTIs in an outpatient setting with high doses of oral amoxicillin with clavulanic acid can effectively reduce treatment failure and recurrence.
ANNALS OF TRANSPLANTATION
(2023)
Article
Surgery
Tomasz Pilecki, Bozena Czarkowska-Paczek, Wojciech Lisik, Slawomir Nazarewski, Leszek Paczek
Summary: Hypertension is a risk factor for graft failure and mortality among kidney transplant recipients. Monitoring blood pressure and adequate treatment contribute to longer survival of the graft and recipient.
ANNALS OF TRANSPLANTATION
(2023)