Article
Geriatrics & Gerontology
Pablo Jorge Marcos-Pardo, Noelia Gonzalez-Galvez, Ana Carbonell-Baeza, David Jimenez-Pavon, Raquel Vaquero-Cristobal
Summary: The objective of this study was to determine the diagnostic ability of GDLAM and SPPB batteries in classifying sarcopenia. The study recruited 584 participants and used the diagnostic criteria of EWGSOP19 as the standard. The GDLAM battery showed better ability in distinguishing individuals at risk for sarcopenia.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Geriatrics & Gerontology
Weiqiang Li, Zhenzhen Rao, Yanhong Fu, David C. Schwebel, Li Li, Peishan Ning, Jiaqi Huang, Guoqing Hu
Summary: The study found that the short physical performance battery (SPPB) is not an effective predictor for falls and fall-induced injuries among community-dwelling older Chinese adults. The predictive performance of SPPB alone or in combination with demographic variables and self-reported health conditions was poor.
Article
Geriatrics & Gerontology
Sarah A. Welch, Rachel E. Ward, Marla K. Beauchamp, Suzanne G. Leveille, Thomas Travison, Jonathan F. Bean
Summary: This study evaluated the use of SPPB in assessing fall risk in older adults, finding that both SPPB and its components can independently predict fall risk. Over a 4-year follow-up period, low total baseline SPPB and gait time performances predicted higher fall risk. Stratifying the sample by the STEADI model revealed that those with the lowest SPPB scores and a positive fall risk screen had the highest fall risk.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Medicine, General & Internal
Lidia Lopez-Garcia, Noel Lorenzo-Villalba, Juan Igor Molina-Puente, Aladin Kishta, Beatriz Sanchez-Sauce, Fernando Aguilar-Rodriguez, Maximo Bernanbeu-Wittel, Nuria Munoz-Rivas, Llanos Soler-Rangel, Luis Fernandez-Carmena, Emmanuel Andres, Francesco Deodati, Francisco Trapiello-Valbuena, Pilar Casasnovas-Rodriguez, Manuel Lorenzo Lopez-Reboiro, Manuel Mendez-Bailon
Summary: This study evaluated the clinical characteristics and prognosis of hospitalized patients with acute heart failure using the Short Physical Performance Battery (SPPB) scale. The results showed that patients with SPPB <= 5 had more comorbidities and greater functional limitations, and had a higher risk of mortality at 30 days, 6 months, and 1 year.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Anna Picca, Matthew Triolo, Stephanie E. E. Wohlgemuth, Matthew S. S. Martenson, Robert T. T. Mankowski, Stephen D. D. Anton, Emanuele Marzetti, Christiaan Leeuwenburgh, David A. A. Hood
Summary: Altered mitochondrial quality in muscle may contribute to age-related decline in physical function. This study investigated the relationship between autophagy, mitophagy, lysosomal markers and measures of physical performance and lower extremity tissue composition in young and older adults. The results revealed that older adults had smaller muscle volume, lower tissue composition index, and higher protein content of p62 and BNIP3. The expression levels of p62 and BNIP3 were negatively correlated with the tissue composition index and performance on the 5-time sit-to-stand test. These findings suggest that dysfunction in the autophagy/mitophagy-lysosomal system is associated with deterioration of lower extremity tissue composition and muscle dysfunction.
Article
Orthopedics
Sabine Wiegmann, Gabriele Armbrecht, Diana Borucki, Bjoern Buehring, Frank Buttgereit, Christian Detzer, Desiree Schaumburg, Kim Nikola Zeiner, Roswitha Dietzel
Summary: In patients with rheumatoid arthritis (RA), age, self-reported disability, and physical performance were significantly associated with falls, while there was no association found between sarcopenia and prospective falls. Early assessment including these factors can identify at-risk RA patients for falls in clinical practice.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Valentina Muollo, Toni Tatangelo, Laura Ghiotto, Valentina Cavedon, Chiara Milanese, Mauro Zamboni, Federico Schena, Andrea P. Rossi
Summary: This study investigated the association between handgrip strength and muscle function of the lower limbs, as well as predictors of appendicular lean mass index in older adults with obesity. Results showed that handgrip strength was weakly associated with lower limbs muscle function and physical performance, while BMI was a significant predictor for ALMI in both genders. In the group of men, markers related to strength and power of the lower limbs were found to better explain variations in ALMI compared to handgrip strength.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Geriatrics & Gerontology
Xiaoyan Chen, Lingling Xie, Xin Xia, Xiaozhen Luo, Jing Chen, Jing Zhang, Qinlan Li, Xuemei Zhang, Jiaojiao Jiang, Ming Yang
Summary: Both measurement protocols and repetitions significantly affect the maximal handgrip strength values, but have minimal impact on the identification of handgrip weakness.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Geriatrics & Gerontology
Suvi-Paivikki Sinikumpu, Maija-Helena Keranen, Jari Jokelainen, Sirkka Keinanen-Kiukaanniemi, Laura Huilaja
Summary: In subjects aged over 70 years, the prevalence of Chronic Venous Disease (CVD) was 54.3% and increased with age, with males more likely to present more severe stages of CVD. Those with CVD tended to have lower performance in functional and walking tests.
Article
Geriatrics & Gerontology
Samaneh Farsijani, Adam J. Santanasto, Iva Miljkovic, Robert M. Boudreau, Bret H. Goodpaster, Stephen B. Kritchevsky, Anne B. Newman
Summary: The study found that the association between intermuscular fat area and impaired physical function is more significant in individuals with higher muscle area. This suggests that muscle mass plays a moderating role in the relationship between muscle fat deposition and physical performance.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Roberta de Oliveira Maximo, Dayane Capra de Oliveira, Paula Camila Ramirez, Mariane Marques Luiz, Aline Fernanda de Souza, Maicon Luis Bicigo Delinocente, Andrew Steptoe, Cesar de Oliveira, Tiago da Silva Alexandre
Summary: This study found that dynapenic abdominal obesity (D/AO) is associated with a stronger decline in physical performance in older males but not in females. The identification and management of dynapenic abdominal obesity could be essential in preventing early signs of functional impairment in older males.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Geriatrics & Gerontology
Xiaoyan Chen, Gongxiang Liu, Siyuan Li, Xiufang Lin, Zhenli Han, Xiaoyi Hu, Jinhui Wu, Ming Yang
Summary: The different measurement protocols for handgrip strength recommended by the AWGS 2019 update significantly affect the measurement values and identification of handgrip strength asymmetry, but not handgrip strength weakness.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Engineering, Biomedical
Larry Duncan, Shaotong Zhu, Mackenzi Pergolotti, Smith Giri, Hoda Salsabili, Miad Faezipour, Sarah Ostadabbas, S. Abdollah Mirbozorgi
Summary: This paper presents an automatic camera-based device that can monitor and evaluate the gait speed, standing balance, and 5TSS tests of the SPPB and TUG. The device consists of a Raspberry Pi computer, cameras, and motors, and the data is processed using Python. The results of the device show high accuracy.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Geriatrics & Gerontology
Kiyoaki Matsumoto, Yasuyuki Gondo, Yukie Masui, Saori Yasumoto, Yuko Yoshida, Kazunori Ikebe, Yasumichi Arai, Mai Kabayama, Kei Kamide, Hiroshi Akasaka, Tatsuro Ishizaki
Summary: This study aimed to establish reference values for physical performance measures among 90-year-olds and compare them with those of older age groups. By analyzing hand grip strength and Short Physical Performance Battery, it was found that the physical performance measures of 90-year-olds were significantly different from those of younger age groups.
Article
Geriatrics & Gerontology
Asima Karim, Tahir Muhammad, M. Shahid Iqbal, Rizwan Qaisar
Summary: This study found that COVID-19 infection can lead to muscle decline, which persists for at least six months after infection. Plasma CAF22 may be useful in detecting muscle and functional decline in these patients. Timely evaluation and intervention of sarcopenia may be critical in COVID-19 treatment.
EXPERIMENTAL GERONTOLOGY
(2023)
Editorial Material
Cell Biology
Anna Picca, Emanuele Marzetti, Christiaan Leeuwenburgh
Article
Biochemistry & Molecular Biology
Riccardo Calvani, Jacopo Gervasoni, Anna Picca, Francesca Ciciarello, Vincenzo Galluzzo, Helio Jose Coelho-Junior, Clara Di Mario, Elisa Gremese, Sara Lomuscio, Anna Maria Paglionico, Lavinia Santucci, Barbara Tolusso, Andrea Urbani, Federico Marini, Emanuele Marzetti, Francesco Landi, Matteo Tosato
Summary: Altered L-arginine metabolism and lower nitric oxide (NO) bioavailability were observed in adults with long COVID. Supplementation of L-arginine plus vitamin C significantly increased L-arginine concentrations and L-arginine/ADMA in these individuals, suggesting its potential as a remedy to improve NO bioavailability in long COVID patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Anna Picca, Emanuele Marzetti
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Vincenzo Galluzzo, Maria Beatrice Zazzara, Francesca Ciciarello, Matteo Tosato, Alessandra Bizzarro, Annamaria Paglionico, Valentina Varriano, Elisa Gremese, Riccardo Calvani, Francesco Landi
Summary: The study found that analgesics are commonly used to manage painful symptoms during and after COVID-19, especially for persistent arthralgia and myalgia. Acetaminophen and ibuprofen were the most commonly used analgesics in the post-acute phase of COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Vincenzo Galluzzo, Maria Beatrice Zazzara, Francesca Ciciarello, Matteo Tosato, Anna Maria Martone, Cristina Pais, Giulia Savera, Riccardo Calvani, Anna Picca, Emanuele Marzetti, Francesco Landi
Summary: This study aimed to evaluate the association between physical activity levels and parameters of physical function in COVID-19 survivors with post-acute symptoms. The results showed that stopping physical activity after COVID-19 results in comparable physical performance to those who were never active. However, older adults who continue to engage in physical activity perform better in the six-minute walking test than sedentary peers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Helio Jose Coelho-Junior, Riccardo Calvani, Anna Picca, Matteo Tosato, Giulia Savera, Francesco Landi, Emanuele Marzetti
Summary: The study aimed to investigate the relationship between protein intake and blood pressure, glucose levels, and blood cholesterol in a large sample of Italian older adults. The findings showed that high protein intake was negatively associated with diastolic blood pressure and positively associated with total blood cholesterol levels in a large cohort of Italian older adults.
Review
Biochemistry & Molecular Biology
Anna Picca, Flora Guerra, Riccardo Calvani, Helio Jose Coelho, Francesco Landi, Cecilia Bucci, Emanuele Marzetti
Summary: Mitophagy plays a crucial role in maintaining mitochondrial quality, and extracellular vesicles (EVs) containing mitochondrial components are released through the endosomal-lysosomal system. This process occurs in response to mild mitochondrial damage and lysosomal dysfunction, with mitochondrial-derived vesicles (MDVs) helping to limit the release of proinflammatory mitochondrial damage-associated molecular patterns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Helio Jose Coelho-Junior, Riccardo Calvani, Anna Picca, Stefano Cacciatore, Matteo Tosato, Francesco Landi, Emanuele Marzetti
Summary: Previous studies have shown that regular aerobic training and adherence to a Mediterranean diet can lower the prevalence of sarcopenia in older adults. However, the effect of their combination on sarcopenia indices is unknown.
Article
Geriatrics & Gerontology
Matteo Tosato, Riccardo Calvani, Francesca Ciciarello, Vincenzo Galluzzo, Anna Maria Martone, Maria Beatrice Zazzara, Cristina Pais, Giulia Savera, Maria Camprubi Robles, Maria Ramirez, Francesco Landi
Summary: Malnutrition is prevalent in COVID-19 survivors and is associated with age and gender. These findings highlight the importance of implementing comprehensive nutritional assessment and therapy as part of care for COVID-19 patients.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Stefano Cacciatore, Giordana Gava, Riccardo Calvani, Emanuele Marzetti, Helio Jose Coelho-Junior, Anna Picca, Ilaria Esposito, Francesca Ciciarello, Sara Salini, Andrea Russo, Matteo Tosato, Francesco Landi
Summary: This study investigated the prevalence of high adiposity and its relationship with Mediterranean diet adherence in older adults. The results showed that low and moderate adherence to the Mediterranean diet was associated with a higher risk of high adiposity, while high adherence was associated with a lower risk. Other factors associated with high adiposity risk were age, gender, and physical inactivity.
Article
Nutrition & Dietetics
Antonella Gallo, Simona Pellegrino, Alice Lipari, Erika Pero, Francesca Ibba, Stefano Cacciatore, Emanuele Marzetti, Francesco Landi, Massimo Montalto
Summary: Lactose malabsorption is a common condition caused by intestinal lactase deficiency, but it doesn't always result in gastrointestinal symptoms. Excluding milk and dairy products from the diet may lead to nutritional disadvantages, especially for older adults. Milk and dairy products are important sources of nutrients that can impact bone and muscle health. Additionally, dairy intake has been associated with prevention of chronic diseases and overall mortality.
CLINICAL NUTRITION
(2023)
Article
Geriatrics & Gerontology
Anna Maria Martone, Francesca Ciciarello, Vincenzo Galluzzo, Riccardo Calvani, Maria Beatrice Zazzara, Matteo Tosato, Helio Jose Coelho-Junior, Emanuele Marzetti, Francesco Landi
Summary: This study aimed to establish age- and gender-specific centile reference values for calf circumference, which can be used for early detection of individuals with or at risk of sarcopenia and malnutrition.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Letter
Geriatrics & Gerontology
Riccardo Calvani, Matteo Tosato, Francesco Landi
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Helio Jose Coelho-Junior, Emanuele Marzetti, Anna Picca, Matteo Tosato, Riccardo Calvani, Francesco Landi
Summary: This study provides lower extremity muscle power estimates and centile values in a large and relatively unselected population across a wide age spectrum. The results show that absolute, relative, allometric and specific muscle power measures of the lower extremities decline significantly with age, with specific patterns observed according to sex and muscle power parameter.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)