Article
Geriatrics & Gerontology
Aaron Salinas-Rodriguez, Rosa Palazuelos-Gonzalez, Ana Rivera-Almaraz, Betty Manrique-Espinoza
Summary: The study found significant longitudinal associations between sarcopenia, mild cognitive impairment, and cognitive function among older Mexican adults, with a significant increase in the prevalence of mild cognitive impairment and sarcopenia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Geriatrics & Gerontology
Yisong Hu, Wenjia Peng, Rujing Ren, Ying Wang, Gang Wang
Summary: This study found a clear association between sarcopenia and mild cognitive impairment (MCI) among elderly adults in China, based on a large-scale survey. The longitudinal study confirmed the link between sarcopenia and cognitive decline.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Geriatrics & Gerontology
Michal S. Beeri, Sue E. Leugrans, Osvaldo Delbono, David A. Bennett, Aron S. Buchman
Summary: In this study, poor muscle function, rather than reduced lean muscle mass, was found to be associated with late-life cognitive impairment, including incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline. Further research is needed to identify muscle structure features that may enhance the specificity of sarcopenia in identifying older adults at risk for late-life cognitive impairment.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Cell Biology
Haitao Yu, Yanchao Liu, Ting He, Yao Zhang, Jiahua He, Mengzhu Li, Bijun Jiang, Yang Gao, Chongyang Chen, Dan Ke, Jianjun Liu, Benrong He, Xifei Yang, Jian-Zhi Wang
Summary: The analysis of platelet proteomics in T2DM patients with MCI revealed that the increase of optineurin and rGSK-3 beta(T/S9) can efficiently discriminate MCI patients, showing promise for predicting cognitive decline in T2DM patients.
Review
Biochemistry & Molecular Biology
Francesca Chiara Pignalosa, Antonella Desiderio, Paola Mirra, Cecilia Nigro, Giuseppe Perruolo, Luca Ulianich, Pietro Formisano, Francesco Beguinot, Claudia Miele, Raffaele Napoli, Francesca Fiory
Summary: Diabetes mellitus can lead to cognitive dysfunction, with alterations in the dopaminergic system playing a role. Research suggests that advanced glycation end products may be associated with cognitive impairment and changes in the dopaminergic system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Heaji Lee, Yunsook Lim
Summary: The study found that T2DM leads to both peripheral and central insulin resistance, resulting in abnormal energy metabolism through the reduced fibroblast growth factor 21 dependent AMP-activated kinase/surtuin1/proliferator-activated receptor gamma coactivator-1 alpha pathway in T2DM. Additionally, impaired muscle and brain function were observed in T2DM mice, along with morphological changes.
Article
Nutrition & Dietetics
Xuan Wang, Rong Xiao, Hongrui Li, Tiantian Li, Lizheng Guan, Huini Ding, Xiaoying Li, Huaguang Zheng, Kang Yu, Ai Zhao, Wannian Liang, Yuandi Xi
Summary: This study investigates the role of dietary fats, erythrocyte lipids profile, and basal metabolic rate (BMR) in the link between mild cognitive impairment (MCI) and sarcopenia (SA). It suggests that specific phospholipids, unsaturated fatty acids, and BMR might be critical factors in the development of MCI and SA and their association. The findings also indicate that inadequate dietary intake and lower concentrations of erythrocyte lipids with lower BMR may contribute to the progression of MCI and SA. These factors could potentially be used as biomarkers for the higher risk of cognitive decline and/or SA in the elderly population.
Review
Geriatrics & Gerontology
Ying Yang, Mengmeng Xiao, Lin Leng, Shixie Jiang, Lei Feng, Gaofeng Pan, Zheng Li, Yan Wang, Jiang Wang, Yanting Wen, Dan Wu, Yongxue Yang, Pan Huang
Summary: The study investigated the prevalence of mild cognitive impairment (MCI) among individuals with sarcopenia and explored the independent association between sarcopenia and MCI.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Neurosciences
Chang Li, Rongbing Jin, Kaijun Liu, Yang Li, Zhiwei Zuo, Haipeng Tong, Jingna Zhang, Junfeng Zhang, Yu Guo, Yuqi Lai, Jinju Sun, Jian Wang, Kunlin Xiong, Xiao Chen
Summary: The study revealed that T2DM-MCI patients exhibited significant reduction in white matter volume compared to T2DM-NC patients, mainly in regions such as the temporal lobe, frontal lobe, and limbic system. The white matter volume of the left posterior cingulate, precuneus, insula, and right rostral middle frontal gyrus showed high diagnostic value for detecting cognitive impairment in T2DM patients, serving as independent imaging biomarkers for early identification.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Yifan Li, Mingrui Li, Yue Feng, Xiaomeng Ma, Xin Tan, Yuna Chen, Chunhong Qin, Haoming Huang, Yi Liang, Shijun Qiu
Summary: The study aimed to explore spontaneous brain activity alterations in T2DM subjects, revealing that PerAF and ALFF may have different sensitivities in detecting abnormal brain activity. PerAF values may provide additional information and indicate potential neuronal activity in T2DM subjects without MCI, shedding new light on neuroimaging mechanisms underlying early cognitive decline associated with diabetes.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Arpita Chakraborty, Sumukha Hegde, Samir K. Praharaj, Krishnananda Prabhu, Chhaya Patole, Ashok K. Shetty, Shreemathi S. Mayya, Raviraj V. Acharya, H. Manjunath Hande, M. Mukhyaprana Prabhu, Dinesh Upadhya
Summary: The study identified the age-related prevalence of MCI in Indian T2DM patients and found a link between cognitive dysfunction in T2DM patients and serum lipid composition. Untargeted and targeted lipidomic analysis revealed decreased levels of certain lipids in the MCI group, while specific sphingolipids were increased.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Rehanguli Maimaitituerxun, Wenhang Chen, Jingsha Xiang, Yu Xie, Atipatsa C. Kaminga, Xin Yin Wu, Letao Chen, Jianzhou Yang, Aizhong Liu, Wenjie Dai
Summary: This study aimed to develop and validate a nomogram-based model for detecting mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus (T2DM). The prevalence of MCI in T2DM patients was found to be 34.1%, and factors such as age, marital status, income, duration of diabetes, diabetic retinopathy, anxiety, and depression were independently associated with MCI. The nomogram based on these factors achieved an optimal diagnosis of MCI and could serve as a clinical tool for detecting MCI in T2DM patients.
JOURNAL OF DIABETES
(2023)
Article
Endocrinology & Metabolism
Haina Zhang, Lou Yu, Gai Yun
Summary: The study aimed to investigate the levels of serum Klotho in type 2 diabetes patients with and without moderate cognitive impairment (MCI) and its prediction of MCI in older patients. The results showed that diabetic patients with MCI had significantly lower serum Klotho levels. Serum Klotho levels were negatively correlated with age, BMI, HbA1c, creatinine, and CRP, and positively correlated with education and HDL-C. Patients with reduced serum Klotho levels, along with lower HDL-C, higher HbA1c, creatinine, and CRP levels, shorter formal education, and longer duration of T2DM, had an increased risk of developing MCI.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Review
Cell Biology
Anja Baric, Marina Dobrivojevic Radmilovic
Summary: Stroke is a major cause of mortality and disability globally. Recent studies have shown evidence of diabetes involvement in producing a chronic neuroinflammatory state, affecting recovery of function and cognition after stroke.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Yue You, Zhizhen Liu, Yannan Chen, Ying Xu, Jiawei Qin, Shuai Guo, Jia Huang, Jing Tao
Summary: This study estimated the prevalence of Mild Cognitive Impairment (MCI) in Type 2 Diabetes Mellitus (T2DM) patients through systematic review and meta-analysis. The results showed a high prevalence of MCI in T2DM patients worldwide, especially in China and Asia. Female patients had a higher prevalence of MCI compared to male patients, and older patients had a lower prevalence compared to younger patients.
ACTA DIABETOLOGICA
(2021)