Article
Geriatrics & Gerontology
Vincent Guion, Ayman Sabra, Catherine Martin, Emmanuelle Blanc, Philipe De Souto Barreto, Yves Rolland
Summary: This study aimed to describe nursing home residents transferred to the emergency department (ED) with pneumonia and investigate the association of pneumonia with functional ability and mortality. The results showed that residents with pneumonia had lower ADL performance and higher mortality compared to those without pneumonia. However, there was no significant difference in functional decline between residents with and without pneumonia.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Oncology
Jaidyn Muhandiramge, Suzanne G. Orchard, Erica T. Warner, Gijsberta J. van Londen, John R. Zalcberg
Summary: Older cancer patients are more likely to experience a decline in functional status, which can be accelerated by cancer treatment. Routine assessments and interventions can slow down or partly mitigate this decline. Given the impact on quality of life and mortality, mitigating the risk of functional decline is vital.
Article
Geriatrics & Gerontology
Andrew R. R. Zullo, Melissa R. R. Riester, Kaleen N. N. Hayes, Medha N. N. Munshi, Sarah D. D. Berry
Summary: We compared the effects of three sulfonylureas (SUs) and initial SUs doses on adverse glycemic and cardiovascular events among nursing home residents. Our findings suggest that new use of glimepiride and standard SU doses may increase the risk of severe hypoglycemic events, while cardiovascular outcomes may not be affected by the choice of SU medication or dose.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Gulistan Bahat, B. Ilhan, A. Tufan, H. Dogan, M. A. Karan
Summary: The study found that a simplified modified Fried frailty scale can predict mortality among nursing home residents. Results suggest that frailty is an independent predictor of death, even after adjusting for other factors.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Medicine, General & Internal
Yizhao Wang, Xin Yang, Hao Liu, Qingling Feng, Yaqing Li, Weijia Hou, Xinlong Chen, Liping Huang, Jialing Wu
Summary: This study analyzed the distribution characteristics of frailty phenotypes in older adults of Chinese nursing homes and compared some motor function characteristics between frail and non-frail older adults. The results showed that frailty in nursing homes was associated with a decline in motor function, and both frail and non-frail older adults had poor strength. The study suggests that elderly individuals in China should focus on strength, stretch, and balance training to improve motor function, especially to prevent frailty.
Article
Geriatrics & Gerontology
Janani Thillainadesan, Alison M. Mudge, Sarah J. Aitken, Sarah N. Hilmer, John S. Cullen, Minna F. Yumol, Jacqueline C. T. Close, Christina M. Norris, Richard Kerdic, Vasi Naganathan
Summary: In older vascular surgery patients, frailty is associated with hospital-acquired geriatric syndromes such as delirium, and the Frailty Index and Clinical Frailty Scale show acceptable prognostic performance for predicting delirium. However, not all individuals identified as frail develop delirium.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Geriatrics & Gerontology
Kenneth Lam, Siqi Gan, Brian Nguyen, Bocheng Jing, Sei J. Lee
Summary: This study found that sliding scale insulin (SSI) is the most common method of administering short-acting insulin in nursing home residents. The study also identified diabetes-related factors as stronger predictors for continuing SSI or transitioning to non-SSI regimens, compared to frailty-related factors.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Nutrition & Dietetics
Caterina Trevisan, Marianna Noale, Mattia Mazzochin, Giada Ida Greco, Alessandra Imoscopi, Stefania Maggi, Paolo Spinella, Enzo Manzato, Anna-Karin Welmer, Giuseppe Sergi
Summary: This study found that falls may trigger weight loss in nursing home residents, especially in the oldest old people and those with severe cognitive impairment who receive little support. The results highlight the importance of monitoring the nutritional status of people living in institutions after falls.
Article
Geriatrics & Gerontology
Yiyang Yuan, Kate L. Lapane, Jennifer Tjia, Jonggyu Baek, Shao-Hsien Liu, Christine M. Ulbricht
Summary: The study identified three physical frailty subgroups in older nursing home residents: mild, moderate, and severe. Those with moderate or severe physical frailty were more likely to have cognitive impairment and need assistance in daily activities. The findings suggest a complex interplay between physical frailty and cognitive impairment in this population.
Article
Geriatrics & Gerontology
Giada Ida Greco, Marianna Noale, Caterina Trevisan, Giancarlo Zatti, Martino Dalla Pozza, Martina Lazzarin, Labjona Haxhiaj, Roberto Ramon, Alessandra Imoscopi, Stefano Bellon, Stefania Maggi, Giuseppe Sergi
Summary: The study indicates that COVID-19 can accelerate the aging process of institutionalized older adults in terms of physical performance and frailty by around 20%, while cognitive performance decline appears to be similar in both COVID-19 cases and controls, possibly due to the burden of social isolation and containment measures on neuropsychological health.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Geriatrics & Gerontology
Joe Hollinghurst, Helen Daniels, Richard Fry, Ashley Akbari, Sarah Rodgers, Alan Watkins, Sarah Hillcoat-Nalletamby, Neil Williams, Silviya Nikolova, David Meads, Andy Clegg
Summary: The study found that the Care&Repair Cymru home adaptation service can identify and reduce the likelihood of falls occurring at home in older people. Factors such as female gender, older age, increased frailty, and deprivation increase the risk of falls, while the odds of falling decrease post-intervention.
Article
Geriatrics & Gerontology
John P. Haran, Abigail Zeamer, Doyle Ward, Protiva Dutta, Vanni Bucci, Beth A. McCormick
Summary: The gut microbiome of older adults in nursing homes is heavily influenced by medications, age, and frailty. Dysbiosis becomes evident after 12 months of residency, but there is relative stability over time beyond that point.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Sandra M. Shi, Brianne Olivieri-Mui, Gahee Oh, Ellen McCarthy, Jonathan F. Bean, Dae H. Kim
Summary: This study examines the association between a claims-based frailty index and time at home in Medicare beneficiaries. The findings suggest a positive correlation between frailty and short time at home, indicating the need for additional resources and interventions to prevent health decline and poor quality of life.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Geriatrics & Gerontology
Xiao-Ming Zhang, Jing Jiao, Jing Cao, Xinjuan Wu
Summary: This study found an association between oral health and frailty in older nursing home residents. Having more teeth and regular toothbrushing can help lower the risk of frailty.
Article
Geriatrics & Gerontology
Mark Q. Thompson, Agathe D. Jadczak, Graeme R. Tucker, Olga Theou, Renuka Visvanathan
Summary: This study aimed to investigate changes in frailty among residential aged care services (RACS) residents and factors associated with worsening frailty. The study found that frailty was dynamic in RACS residents over 12 months, with stability, improvement, worsening, and death observed. Malnutrition, at risk of malnutrition, and diabetes were significant predictors of worsening frailty and death. Therefore, treatments such as nutritional interventions, exercise, and diabetes management are likely to benefit frailty.
Article
Virology
Robinson Ramirez-Velez, Laiene Olabarrieta-Landa, Diego Rivera, Mikel Izquierdo
Summary: This study validates the CES-D scale in patients with persistent COVID-19 and finds that the three-factor correlated model has a good fit.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Robinson Ramirez-Velez, Nora Garcia-Alonso, Gaizka Legarra-Gorgonon, Sergio Oscoz-Ochandorena, Julio Oteiza, Mikel Izquierdo
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Article
Biochemistry & Molecular Biology
Lydia Giannitrapani, Luigi Mirarchi, Simona Amodeo, Anna Licata, Maurizio Soresi, Francesco Cavaleri, Salvatore Casalicchio, Gregorio Ciulla, Maria Elena Ciuppa, Melchiorre Cervello, Mario Barbagallo, Nicola Veronese
Summary: The immune response to COVID-19 is important, but some patients experience persistent symptoms that lead to a global health and economic burden. This study investigates the potential role of IL-6 levels as a marker for long COVID. The analysis of 184 patients admitted to a hospital in Italy revealed that higher IL-6 levels were associated with a doubled risk of long COVID, mobility decline, and PTSD, indicating the significance of IL-6 in disease severity, unfavorable outcomes, and long COVID development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Sport Sciences
Robinson Ramirez-Velez, Mikel Izquierdo, Jose Francisco Lopez-Gil, David Rincon-Pabon, Edwar Nicolas Martinez-Jamioy, Rosemberg Rivera-Ruiz, Sebastian Castellanos-Montana, Miguel Alejandro Atencio-Osorio, Hugo Alejandro Carrillo-Arango, Alicia M. M. Alonso-Martinez, Antonio Garcia-Hermoso
Summary: The aim of this study was to determine whether Colombian preschool-aged children meet all three 24-hour movement guidelines and to explore the associations between socio-ecological correlates and meeting these guidelines. A cross-sectional study was conducted with data from the National Survey of Nutritional Situation (ENSIN-2015) in Colombia, 2015-2016. The sample consisted of 3002 low-income preschoolers (3-4 years old, 50.7% boys). Data on physical activity, screen time, and sleep time were collected using a questionnaire reported by parents. The prevalence of preschoolers meeting all three 24-hour movement guidelines was 4.8%, and the prevalence of not meeting any of the guidelines was 16.6%. Boys and children without a television in their bedroom were more likely to meet all three movement guidelines. Strategies to promote adherence to these guidelines in low-income preschoolers should consider the importance of sex and home environment changes.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Review
Hospitality, Leisure, Sport & Tourism
Antonio Garcia-Hermoso, Robinson Ramirez-Velez, Javier Diez, Arantxa Gonzalez, Mikel Izquierdo
Summary: This study investigates the effects of exercise training on exerkines in patients with type 2 diabetes mellitus and determines the optimal exercise prescription. The results show that exercise training can induce changes in exerkine levels, with positive effects on glycated hemoglobin, fasting glucose, waist circumference, and body mass. Therefore, exercise training is an important therapeutic approach for patients with type 2 diabetes mellitus.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2023)
Article
Physiology
Hugo Alejandro Carrillo-Arango, Miguel Alejandro Atencio-Osorio, Carlos Alejandro Lopez-Alban, Edna J. J. Nava-Gonzalez, Maria Correa-Rodriguez, Mikel Izquierdo, Robinson Ramirez-Velez
Summary: Evidence suggests that acute sprint interval training (SIT) may improve metabolic responses to postprandial glucose in individuals with overweight/obesity, but results are inconsistent. This study found that acute SIT was associated with a lower respiratory quotient (RQ) and increased fat utilization while decreasing carbohydrate utilization during the postprandial period. These findings highlight the potential benefits of acute SIT in improving metabolism in people with overweight/obesity.
PHYSIOLOGICAL REPORTS
(2023)
Article
Clinical Neurology
Ryan G. L. Koh, Tracy M. Paul, Karlo Nesovic, Daniel West, Dinesh Kumbhare, Richard D. Wilson
Summary: The aim of this study was to assess the reliability and minimal detectable difference (MDD) of pressure pain thresholds (PPTs) in pain-free participants. Two examiners measured PPTs over two consecutive days using a standardized method and hand-held algometer. The results showed high inter- and intra-rater reliability, with an MDD of 1.24 kg/cm(2) on day 1 and 0.88 kg/cm(2) on day 2.
BRITISH JOURNAL OF PAIN
(2023)
Article
Geriatrics & Gerontology
Hanna-Maria Roitto, Ulla L. L. Aalto, Hanna Ohman, Riitta K. T. Saarela, Hannu Kautiainen, Karoliina Salminen, Kaisu H. H. Pitkala
Summary: This study aimed to explore the association between medication use and the incidence of falls, related consequences, and all-cause mortality among long-term care residents. The results showed that polypharmacy, opioid and anticholinergic medication use were closely associated with increased fall rates in long-term care. Additionally, the use of more than 10 medications predicted higher all-cause mortality. It is important to pay special attention to both the type and number of medications when prescribing for long-term care.
Article
Microbiology
Nele Fogelholm, Jaakko Leskela, Muhammed Manzoor, Jacob Holmer, Susanna Paju, Kaija Hiltunen, Hanna-Maria Roitto, Riitta Kt Saarela, Kaisu Pitkala, Maria Eriksdotter, Kare Buhlin, Pirkko J. Pussinen, Paivi Mantyla
Summary: Oral health and declining cognition may have a bi-directional association. The composition of the subgingival microbiota was analyzed in subjects with normal cognition to severe cognitive decline. The study found that certain taxa of oral bacteria were associated with the MMSE score, and Lachnospiraceae [XIV] increased with decreasing MMSE. Impaired cognition is accompanied by changes in the composition of the oral microbiota, highlighting the importance of oral health-care practices among older adults.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Cell Biology
Mikel Izquierdo, Maria Fiatarone Singh
Summary: Exercise and physical activity have significant benefits for older adults with various physical and neuropsychological diseases and disabilities, including those without pharmacological treatments or with risky treatments. However, exercise is underutilized and not fully integrated into geriatric medicine practice. Frailty should not be seen as a barrier to exercise, but rather a reason to prescribe it. Exercise prescription needs to be emphasized in the training of healthcare professionals and seen as a mandatory component in geriatric medicine.
AGEING RESEARCH REVIEWS
(2023)
Article
Pediatrics
Gaizka Legarra-Gorgonon, Yesenia Garcia-Alonso, Robinson Ramirez-Velez, Blanca Erice-Echegaray, Mikel Izquierdo, Alicia M. Alonso-Martinez
Summary: This study investigates the relationship between basic motor competencies (BMC) and physical fitness in Spanish preschool children. The findings suggest that higher BMC is associated with better physical fitness, highlighting the importance of basic motor competence in promoting physical activity in preschool-aged children.
ITALIAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Antonio Garcia-Hermoso, Yasmin Ezzatvar, Alicia M. Alonso-Martinez, Robinson Ramirez-Velez, Mikel Izquierdo, Jose Francisco Lopez-Gil
Summary: This study analyzed data from a nationally representative US cohort and found that adherence to the 24-h movement guidelines during adolescence is associated with lower risk of abdominal obesity in adulthood. Adolescents who met screen time recommendation alone or combined with physical activity, as well as those who met all three recommendations, had lower waist circumference in adulthood. In addition, adhering to the 24-h movement guidelines during adolescence was also associated with lower risk of abdominal obesity in adulthood.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Sport Sciences
Cristian Cofre-Bolados, Felix Vidal, Hector Gutierrez Espinoza, Ignacio Betancourt-Peters, Pedro A. Orihuela, Mikel Izquierdo
Summary: This study shows that a periodized high-intensity aerobic training program can significantly improve cardiorespiratory fitness in previously untrained octogenarians, with or without comorbidities, suggesting potential benefits for healthy aging in the long term.
Review
Endocrinology & Metabolism
Ignacio Hormazabal-Aguayo, Yasmin Ezzatvar, Nidia Huerta-Uribe, Robinson Ramirez-Velez, Mikel Izquierdo, Antonio Garcia-Hermoso
Summary: The aim of this study was to determine the global incidence of type 1 diabetes mellitus (T1DM) in children and adolescents under 20 years of age from 2000 to 2022. The study included 126 studies from 55 countries and 18 regions. The incidence rate (IR) of T1DM from 2000 to 2022 was 14.07 per 100,000 person-years, with significant variations among different regions and an increase during the pandemic period.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Clinical Neurology
Monika Zawadka-Kunikowska, Lukasz Rzepinski, Malgorzata Tafil-Klawe, Nicola Veronese, Mario Barbagallo, Mario Habek, Nils E. Gilhus
Summary: There are differences in cardiovascular autonomic parameters between patients with myasthenia gravis (MG) and healthy controls (HCs), including altered cardiac autonomic function in MG patients.
NEUROLOGY INTERNATIONAL
(2023)
