4.7 Article

Bisphosphonate Use After Hip Fracture in Older Adults: A Nationwide Retrospective Cohort Study

Journal

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.jamda.2016.12.083

Keywords

Hip fractures; bisphosphonates; older individuals; cohort study

Funding

  1. Swedish Research Council [2016-02584]
  2. Swedish Research Council [2016-02584] Funding Source: Swedish Research Council

Ask authors/readers for more resources

Objectives: The aim of this study was to investigate the association between bisphosphonate use and the risk of new fracture in a nationwide cohort of individuals with previous hip fractures, with emphasis on individuals above 80 years of age. Design, setting, and participants: From a nationwide cohort with hip fracture (2006-2012) (n - 93, 601), each individual prescribed bisphosphonates after hip fracture (n = 5845) was matched with up to three individuals not prescribed bisphosphonates, resulting in a cohort of 21,363 individuals. Main outcome measure: A new hip fracture. Results: During a mean follow-up period of 2.98 (range, 0.02-8) years, 4581 fractures occurred in the cohort. Before the initiation of bisphosphonate therapy, individuals later prescribed bisphosphonates had an increased risk of hip fracture (multivariable adjusted odds ratio [OR], 2.63; 95% confidence interval [CI], 2.23-3.24) compared with controls. In the period after bisphosphonate therapy initiation, individuals prescribed bisphosphonates had a lower risk of hip fracture (multivariable adjusted hazard ratio [HR], 0.76; 95% CI, 0.65-0.90) compared with controls. Similar effects were seen after the initiation of bisphosphonates in individuals aged more than 80 years (HR, 0.79; 95% CI, 0.62-0.99). In contrast, the initiation of bisphosphonate therapy did not influence the risk of injurious falls not resulting in fracture (HR, 0.95; 95% CI, 0.86-1.05). Conclusion: Bisphosphonate use was associated with a decreased risk of hip fracture in this nationwide cohort of older men and women, with similar risk reductions in individuals older than 80 years. (C) 2017 AMDA The Society for Post-Acute and Long-Term Care Medicine.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Sport Sciences

Associations of Objectively Measured Physical Activity and Sedentary Time with the Risk of Stroke, Myocardial Infarction or All-Cause Mortality in 70-Year-Old Men and Women: A Prospective Cohort Study

Marcel Ballin, Peter Nordstrom, Johan Niklasson, Anna Nordstrom

Summary: The study found that every 30-min/day increment in LPA was associated with an 11% lower risk of CVD or all-cause mortality, while every 30-min/day increment in MPA was associated with a 36% lower risk. Additionally, every 1-h/day increment in ST increased the risk by 33%, but MPA could attenuate the increased risks associated with ST.

SPORTS MEDICINE (2021)

Article Public, Environmental & Occupational Health

Risk factors for COVID-19 diagnosis, hospitalization, and subsequent all-cause mortality in Sweden: a nationwide study

Jonathan Bergman, Marcel Ballin, Anna Nordstrom, Peter Nordstrom

Summary: This nationwide study in Sweden identified age, sex, and comorbidity as major risk factors for severe COVID-19. Additionally, hypertension, asthma, Down syndrome, and residence in a long-term care facility were associated with severe COVID-19.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2021)

Correction Endocrinology & Metabolism

Bisphosphonates and mortality: confounding in observational studies (vol 30, pg 1973, 2019)

J. Bergman, A. Nordstrom, A. Hommel, M. Kivipelto, P. Nordstrom

OSTEOPOROSIS INTERNATIONAL (2021)

Article Rehabilitation

Short-term balance training and acute effects on postural sway in balance-deficient older adults: a randomized controlled trial

Niklas Sorlen, Andreas Hult, Peter Nordstrom, Anna Nordstrom, Jonas Johansson

Summary: The efficacy of a 4-week balance exercise intervention on postural sway in older adults was found to be insignificant, with no significant differences detected between groups in postural sway outcomes. Hand grip strength showed significant improvement in the intervention group, while Timed Up & Go improvements were comparable between groups but only statistically significant in the control group.

BMC SPORTS SCIENCE MEDICINE AND REHABILITATION (2021)

Article Cardiac & Cardiovascular Systems

Associations of Visceral Adipose Tissue and Skeletal Muscle Density With Incident Stroke, Myocardial Infarction, and All-Cause Mortality in Community-Dwelling 70-Year-Old Individuals: A Prospective Cohort Study

Marcel Ballin, Peter Nordstrom, Johan Niklasson, Anna Nordstrom

Summary: This study found that VAT was associated with cardiovascular risk in 70-year-old men, but not with all-cause mortality. Lowering VAT may help reduce the risk of cardiovascular disease in this population.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

Article Geriatrics & Gerontology

Low or Declining Gait Speed is Associated With Risk of Developing Dementia Over 5 Years Among People Aged 85 Years and Over

Jerry Ohlin, Yngve Gustafson, Hakan Littbrand, Birgitta Olofsson, Annika Toots

Summary: Beyond simple cognitive performance assessment, improving dementia screening procedures is timely given the ongoing phenomenon of population aging. A slow or declining gait speed is a potential early indicator of cognitive decline in very old people. This study found that declining and slow gait speed were associated with higher odds of dementia development, and gait decline was linked to cognitive decline in participants who developed dementia, supporting the potential of gait speed tests to predict future cognitive decline among very old people in community and nursing home settings.

JOURNAL OF AGING AND PHYSICAL ACTIVITY (2021)

Article Geriatrics & Gerontology

Excess Mortality After COVID-19 in Swedish Long-Term Care Facilities

Marcel Ballin, Jonathan Bergman, Miia Kivipelto, Anna Nordstrom, Peter Nordstrom

Summary: This retrospective cohort study aimed to compare the 30-day mortality in LTCF residents with and without COVID-19, and investigate the impact of various risk factors on mortality in COVID-19 cases. The study found a significantly higher mortality rate in COVID-19 cases compared to controls, with factors like older age, male sex, and neuropsychological conditions contributing to higher mortality rates in COVID-19 patients.

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION (2021)

Article Chemistry, Analytical

Feasibility of Sensor Technology for Balance Assessment in Home Rehabilitation Settings

Daniel Kelly, Karla Munoz Esquivel, James Gillespie, Joan Condell, Richard Davies, Shvan Karim, Elina Nevala, Antti Alamaki, Juha Jalovaara, John Barton, Salvatore Tedesco, Anna Nordstrom

Summary: The increased use of sensor technology is crucial for remote rehabilitation, but human factors must be fully considered. The SENDoc project in Northern Europe evaluates human factors associated with sensors for remote rehabilitation. The main considerations for adopting balance assessment technology in remote rehabilitation settings are deployment constraints, usability, comfort, and accuracy.

SENSORS (2021)

Article Endocrinology & Metabolism

Trends in Hip Fracture Incidence, Length of Hospital Stay, and 30-Day Mortality in Sweden from 1998-2017: A Nationwide Cohort Study

Peter Nordstrom, Jonathan Bergman, Marcel Ballin, Anna Nordstrom

Summary: This nationwide cohort study investigated trends in hip fracture incidence, hospital length of stay, and 30-day mortality after admission in Sweden. The results showed a decrease in hip fracture incidence over the past 20 years, but an increase in short-term mortality.

CALCIFIED TISSUE INTERNATIONAL (2022)

Article Geriatrics & Gerontology

Associations of Light, Moderate to Vigorous, and Total Physical Activity With the Prevalence of Metabolic Syndrome in 4,652 Community-Dwelling 70-Year-Olds: A Population-Based Cross-Sectional Study

Marcel Ballin, Peter Nordstrom, Anna Nordstrom

Summary: This study found that greater amounts of physical activity are associated with lower odds of metabolic syndrome in older adults.

JOURNAL OF AGING AND PHYSICAL ACTIVITY (2021)

Article Environmental Sciences

Comparison of Machine Learning Techniques for Mortality Prediction in a Prospective Cohort of Older Adults

Salvatore Tedesco, Martina Andrulli, Markus akerlund Larsson, Daniel Kelly, Antti Alamaeki, Suzanne Timmons, John Barton, Joan Condell, Brendan O'Flynn, Anna Nordstroem

Summary: As global demographics shift, aging becomes a significant focus, with the application of proper prognostic indices in clinical decisions on mortality prediction becoming increasingly important. Machine learning can transform prognostic modeling, as shown in the development of machine learning models for all-cause mortality prediction in healthy older adults. Random undersampling with random forest proved to have the best results, although probability calibration slightly reduced average performance but increased model robustness.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Article Medicine, General & Internal

Association Between Risk of COVID-19 Infection in Nonimmune Individuals and COVID-19 Immunity in Their Family Members

Peter Nordstrom, Marcel Ballin, Anna Nordstrom

Summary: This cohort study found that family members without immunity had a 45% to 97% lower risk of contracting COVID-19 as the number of immune family members increased, emphasizing the importance of vaccination in reducing transmission within families.

JAMA INTERNAL MEDICINE (2021)

Article Education, Special

Web-based training intervention to increase physical activity level and improve health for adults with intellectual disability

S. Fjellstrom, E. Hansen, J. Hollta, M. Zingmark, A. Nordstrom, M. Lund Ohlsson

Summary: The study examined the effectiveness of a web-based training program on the health of individuals with intellectual disability (ID). The results showed that participants experienced a decrease in fat mass and waist circumference, as well as an increase in physical activity level. The web-based training program received high satisfaction ratings, and there were no differences in quality of life among the participants.

JOURNAL OF INTELLECTUAL DISABILITY RESEARCH (2022)

Article Medicine, General & Internal

Safety and effectiveness of monovalent COVID-19 mRNA vaccination and risk factors for hospitalisation caused by the omicron variant in 0.8 million adolescents: A nationwide cohort study in Sweden

Peter Nordstrom, Marcel Ballin, Anna Nordstrom

Summary: This study examined the safety and effectiveness of COVID-19 vaccination in adolescents and identified risk factors for COVID-19 hospitalisation. The results showed that COVID-19 vaccination did not increase the risk of hospitalisation in adolescents, and receiving 2 doses of the vaccine was associated with a lower risk of COVID-19 hospitalisation, particularly in high-risk groups. However, the risk of severe COVID-19 in the general adolescent population was extremely low, indicating that additional vaccine doses may not be necessary at this stage of the pandemic.

PLOS MEDICINE (2023)

Review Health Care Sciences & Services

Older Adults' Experiences With Using Wearable Devices: Qualitative Systematic Review and Meta-synthesis

Kevin Moore, Emma O'Shea, Lorna Kenny, John Barton, Salvatore Tedesco, Marco Sica, Colum Crowe, Antti Alamaki, Joan Condell, Anna Nordstrom, Suzanne Timmons

Summary: The motivation behind older adults' use of wearable devices is crucial for long-term use, with the useful purpose and user experience of the device significantly impacting acceptance and use. Additionally, a support structure plays a key role in the long-term adoption of wearable devices.

JMIR MHEALTH AND UHEALTH (2021)

No Data Available