Article
Cardiac & Cardiovascular Systems
Ahmed Muhammed, Mohamed Abdelazeem, Mohamed Gamaleldin Elewa, Mohamed Sharief, Ahmed Ammar
Summary: Sudden cardiac death and significant ventricular arrhythmias in patients with dilated cardiomyopathy have been reduced over the past few decades due to advances in treatment. However, risk stratification and decision-making for primary prevention implantable cardioverter-defibrillator (ICD) in these patients remains challenging.
HEART FAILURE REVIEWS
(2023)
Article
Medicine, General & Internal
Mariusz Klopotowski, Krzysztof Kukula, Jacek Jamiolkowski, Artur Oreziak, Maciej Dabrowski, Zbigniew Chmielak, Adam Witkowski
Summary: Hello, the aim of this study was to investigate how the calculated SCD risk in HCM patients with an ICD implanted in the past changed over time. The results showed that SCD risk in HCM patients is usually stable or gets lower, suggesting the need for re-evaluating the risk profile when considering ICD re-implantation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Pietro Francia, Iacopo Olivotto, Pier D. Lambiase, Camillo Autore
Summary: Choosing the right ICD for patients with HCM is crucial, as overly complex devices may increase the risk of complications. Young patients stand to gain the most from ICD therapy but also face higher risks, necessitating careful consideration in device selection.
Review
Biology
Fabrizio Guarracini, Alberto Preda, Eleonora Bonvicini, Alessio Coser, Marta Martin, Silvia Quintarelli, Lorenzo Gigli, Matteo Baroni, Sara Vargiu, Marisa Varrenti, Giovanni Battista Forleo, Patrizio Mazzone, Roberto Bonmassari, Massimiliano Marini, Andrea Droghetti
Summary: The difference between subcutaneous implantable cardioverter defibrillators (S-ICDs) and transvenous ICDs (TV-ICDs) lies in the extra-thoracic implantation of S-ICDs, without endovascular components. S-ICDs have been rapidly adopted due to their improved safety profile, especially among younger patients. Although S-ICDs show comparable efficacy, reliability, and safety outcomes to TV-ICDs, technical issues limit their employment, making them an alternative rather than a mainstream option.
Article
Cardiac & Cardiovascular Systems
Federico Migliore, Raimondo Pittorru, Manuel De Lazzari, Alberto Cipriani, Barbara Bauce, Martina Perazzolo Marra, Enrico Giacomin, Pietro Bernardo Dall'Aglio, Stefano Accinelli, Sabino Iliceto, Domenico Corrado
Summary: This study evaluated the long-term outcome of patients with arrhyth-mogenic cardiomyopathy (ACM) who underwent third-generation subcutaneous implantable cardioverter defibrillator (S-ICD) implantation with the intermuscular (IM) two-incision technique. The findings showed that although the third-generation S-ICD with the IM two-incision technique appeared to have a low risk of complications and inappropriate shocks (IS) due to cardiac oversensing, the risk of IS due to myopotential mainly during effort should be considered.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Victor Nauffal, Peter Marstrand, Larry Han, Victoria N. Parikh, Adam S. Helms, Jodie Ingles, Daniel Jacoby, Neal K. Lakdawala, Sunil Kapur, Michelle Michels, Anjali T. Owens, Euan A. Ashley, Alexandre C. Pereira, Joseph W. Rossano, Sara Saberi, Christopher Semsarian, James S. Ware, Samuel G. Wittekind, Sharlene Day, Iacopo Olivotto, Carolyn Y. Ho
Summary: Primary prevention ICDs are implanted more frequently in US vs. non-US sites across the spectrum of SCD risk. There was a Lower rate of appropriate ICD therapy in US sites, consistent with a lower-risk population, and no significant difference in SCD in US vs. non-US patients who did not receive an ICD.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Hossein Salehi Omran, Farah Naghashzadeh, Rana Irilouzadian, Sina Dolatshahi, Mohammad Taghi Hedayati Goudarzi, Mohammad Taghi Salehi Omran
Summary: This study retrospectively analyzed data from patients with nonischemic dilated cardiomyopathy (DCM) treated at our hospital from January 2020 to November 2021. The study found that in addition to standard medical treatments, the insertion of an implantable cardioverter defibrillator (ICD) can significantly reduce the sudden cardiac death (SCD) rate in patients with nonischemic DCM.
CLINICAL CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Barry J. Maron, N. A. Mark Estes, Ethan J. Rowin, Martin S. Maron, Matthew R. Reynolds
Summary: Implantable cardioverter-defibrillators (ICDs) have been the most significant advancement in cardiovascular medicine in the past 50 years. The development of ICDs was a result of the determination and vision of pioneers, and they have now become the primary prevention tool for sudden death in countless patients worldwide. Clinical trials have shown that ICDs can reduce mortality rates and they have been successfully used in the treatment of coronary disease and inherited arrhythmia conditions.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sarah A. Goldstein, Kevin F. Kennedy, Daniel J. Friedman, Sana M. Al-Khatib, Andrew Wang
Summary: This study investigated the appropriate use of primary prevention implantable cardioverter-defibrillators (ICDs) among older patients with hypertrophic cardiomyopathy. The study found an increase in ICD utilization over time in all age groups and identified a history of nonsustained ventricular tachycardia and New York Heart Association class as important risk factors for hospitalization for ventricular arrhythmia/cardiac arrest following ICD implantation in patients aged 65 and older.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Gianluca Pontone, Andrea Igoren Guaricci, Laura Fusini, Andrea Baggiano, Marco Guglielmo, Giuseppe Muscogiuri, Alessandra Volpe, Raffaele Abete, Giovanni Aquaro, Andrea Barison, Jan Bogaert, Giovanni Camastra, Samuela Carigi, Nazario Carrabba, Grazia Casavecchia, Stefano Censi, Gloria Cicala, Carlo N. De Cecco, Manuel De Lazzari, Gabriella Di Giovine, Mauro Di Roma, Monica Dobrovie, Marta Focardi, Nicola Gaibazzi, Annalaura Gismondi, Matteo Gravina, Chiara Lanzillo, Massimo Lombardi, Valentina Lorenzoni, Jordi Lozano-Torres, Chiara Martini, Francesca Marzo, Ambra Masi, Riccardo Memeo, Claudio Moro, Alberto Nese, Alessandro Palumbo, Anna Giulia Pavon, Patrizia Pedrotti, Martina Perazzolo Marra, Silvia Pica, Silvia Pradella, Cristina Presicci, Mark G. Rabbat, Claudia Raineri, Jose F. Rodriguez-Palomares, Stefano Sbarbati, U. Joseph Schoepf, Angelo Squeri, Nicola Sverzellati, Rolf Symons, Emily Tat, Mauro Timpani, Giancarlo Todiere, Adele Valentini, Akos Varga-Szemes, Pier-Giorgio Masci, Juerg Schwitter
Summary: The DERIVATE-ICM registry demonstrates the added value of CMR in stratifying the risk for MAACE in patients with ICM compared to standard of care.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Giulia De Angelis, Marco Merlo, Giulia Barbati, Silvia Bertolo, Antonio De Luca, Federica Ramani, Luigi Adamo, Gianfranco Sinagra
Summary: In patients with dilated cardiomyopathy (DCM), stratifying the risk for major ventricular arrhythmic events or sudden cardiac death based on left ventricular ejection fraction (LVEF) <= 35% is effective after 2 years of guideline-directed medical therapy (GDMT), but not after 6 months. Waiting 24 months before primary prevention ICD implantation may be appropriate for selected DCM patients.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Article
Cardiac & Cardiovascular Systems
Arjan Sammani, Rutger R. van de Leur, Michiel T. H. M. Henkens, Mathias Meine, Peter Loh, Rutger J. Hassink, Daniel L. Oberski, Stephane R. B. Heymans, Pieter A. Doevendans, Folkert W. Asselbergs, Anneline S. J. M. te Riele, Rene van Es
Summary: Inherently explainable DNNs can detect patients at risk of LTVA, mainly driven by P-wave abnormalities.
Article
Cardiac & Cardiovascular Systems
Pier D. Lambiase, Dominic A. Theuns, Francis Murgatroyd, Craig Barr, Lars Eckardt, Petr Neuzil, Marcoen Scholten, Margaret Hood, Jurgen Kuschyk, Amy J. Brisben, Nathan Carter, Timothy M. Stivland, Reinoud Knops, Lucas V. A. Boersma
Summary: This study reports the 5-year outcomes of EFFORTLESS registry patients with early generation subcutaneous implantable cardioverter-defibrillator (S-ICD) devices. The study found that the spontaneous shock efficacy remained consistently high over the 5-year period and very few patients required replacement with a transvenous device. Additionally, early arrhythmic episodes did not predict later complications.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Tom E. Verstraelen, Freyja H. M. van Lint, Laurens P. Bosman, Remco de Brouwer, Virginnio M. Proost, Bob G. S. Abeln, Karim Taha, Aeilko H. Zwinderman, Cathelijne Dickhoff, Toon Oomen, Bas A. Schoonderwoerd, Gerardus P. Kimman, Arjan C. Houweling, Juan R. Gimeno-Blanes, Folkert W. Asselbergs, Paul A. van der Zwaag, Rudolf A. de Boer, Maarten P. van den Berg, J. Peter van Tintelen, Arthur A. M. Wilde
Summary: This study aimed to develop a new mutation-specific prediction model for malignant VA in PLN p.Arg14del mutation carriers to improve risk stratification for primary prevention ICD implantation. The model outperformed the existing PLN risk model, indicating that using mutation-specific phenotypic features for risk prediction can enhance accuracy.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Tom E. Verstraelen, Freyja H. M. van Lint, Laurens P. Bosman, Remco de Brouwer, Virginnio M. Proost, Bob G. S. Abeln, Karim Taha, Aeilko H. Zwinderman, Cathelijne Dickhoff, Toon Oomen, Bas A. Schoonderwoerd, Gerardus P. Kimman, Arjan C. Houweling, Juan R. Gimeno-Blanes, Folkert W. Asselbergs, Paul A. van der Zwaag, Rudolf A. de Boer, Maarten P. van den Berg, J. Peter van Tintelen, Arthur A. M. Wilde
Summary: This study aimed to develop a new mutation-specific prediction model for malignant ventricular arrhythmia (VA) in phospholamban (PLN) p.Arg14del mutation carriers, and compared it to an existing PLN risk model. The new model demonstrated superior accuracy in predicting individual VA risk compared to the existing model.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Vijayabharathy Kanthasamy, Nikolaos Papageorgiou, Tomi Bajomo, Christopher Monkhouse, Antonio Creta, Malcolm Finlay, Pier D. Lambiase, Phil Moore, Simon Sporton, Mark J. Earley, Richard J. Schilling, Carl Hayward, Rui Providencia, Ross J. Hunter, Anthony W. Chow, Amal Muthumala
Summary: This study aimed to assess the determinants of pacing induced left ventricular dysfunction (LVD) in patients with high burden of right ventricular pacing (RVP). The results showed that the presence of atrial fibrillation (AF), borderline low systolic function (BLSF), and male gender were independent predictors for RVP induced LVD. Age and BLSF were independent predictors of earlier development of LVD after implant.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Mafalda Carrington, Rui Providencia, C. Anwar A. Chahal, Flavio D'Ascenzi, Alberto Cipriani, Fabrizio Ricci, Mohammed Y. Khanji
Summary: Sudden cardiac arrest is rare in young athletes but poses an increased risk for those with clinically silent cardiac disease. The use of automated external defibrillators in public spaces is crucial for preventing these events, and smartphone apps can play a key role in enhancing emergency response.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Mihir M. Sanghvi, Daniel M. Jones, Jeremy Kalindjian, Christopher Monkhouse, Rui Providencia, Richard J. Schilling, Nikhil Ahluwalia, Mark J. Earley, Malcolm Finlay
Summary: This study examines the real-world performance of implantable loop recorders (ILRs) and finds that ILRs can alter management in a portion of patients. Age and baseline electrocardiogram are important factors influencing the treatment management changes resulting from ILR data. In younger patients, ILR diagnoses rarely lead to treatment changes, while in older patients, ILRs frequently provide new diagnoses and trigger important treatment changes.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2022)
Article
Clinical Neurology
Sheng-Chia Chung, Rui Providencia, Reecha Sofat, Mar Pujades-Rodriguez, Ana Torralbo, Ghazaleh Fatemifar, Natalie K. Fitzpatrick, Julie Taylor, Ken Li, Caroline Dale, Martin Rossor, Dionisio Acosta-Mena, John Whittaker, Spiros Denaxas
Summary: This study analyzed longitudinal cohort data of 4.3 million individuals in the UK to examine dementia incidence and mortality. The results showed that dementia incidence was higher in individuals living in high deprivation areas. Prior to dementia diagnosis, patients experienced repeated hospitalizations and multiple primary care visits. The findings highlight the importance of addressing the disparities in dementia for prevention and patient care.
ALZHEIMERS & DEMENTIA
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Maiwand Farouq, Rasmus Borgquist, Johan Brandt, David Mortsell, Lingwei Wang
Summary: We present a case of transient ischemic attacks after pacemaker implantation due to the malpositioned pacemaker lead in the left ventricle. The misplaced ventricular lead was identified during regular echocardiography and successfully percutaneously extracted after dabigatran treatment. No neurologic events were observed during a 4-year follow-up.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jonathan Berg, Julius Akesson, Robert Jablonowski, Kristian Solem, Einar Heiberg, Rasmus Borgquist, Hakan Arheden, Marcus Carlsson
Summary: This study found that low ventricular longitudinal function is associated with an increase in the number of cardiovascular events as well as longer in-hospital stays. Additionally, both AVPD and GLS have independent prognostic value for cardiovascular mortality and morbidity in HFrEF patients.
Article
Cardiac & Cardiovascular Systems
Sheng-Chia Chung, Alvina Lai, Gregory Y. H. Lip, Pier D. Lambiase, Rui Providencia
Summary: Using real-world data from the UK, this study aimed to investigate the effectiveness of anti-arrhythmic drugs and catheter ablation in improving the survival of atrial fibrillation patients. The study found that patients receiving rhythm control treatment had lower mortality rates, with pulmonary vein isolation showing the most pronounced survival benefit.
Article
Cardiac & Cardiovascular Systems
Lukasz Januszkiewicz, Sergio Barra, Eloi Marijon, Rui Providencia, Carlo de Asmundis, Julian K. R. Chun, Michal M. Farkowski, Giulio Conte, Serge Boveda
Summary: This study aims to evaluate the information transmission to patients prior to ICD implantation and its impact on their quality of life. The findings show that although 71.5% of patients felt optimally informed at the time of implantation, many were not provided with information about ICD-related complications, driving restrictions, and end-of-life ICD deactivation. Women were less involved in the decision-making process and reported to be less often optimally informed before ICD implantation compared to men.
Article
Cardiac & Cardiovascular Systems
Ana Carolina Schwab, Ante Anic, Michal M. Farkowski, Jose Guerra, Konstantinos E. Iliodromitis, Kristine Jubele, Rui Providencia, Julian K. R. Chun, Serge Boveda
Summary: This study conducted a survey to show how clinicians currently approach the knowledge gap in dealing with recurrences after a failed ablation for atrial fibrillation (AF). The majority of respondents perform routine monitoring for AF recurrences after ablation and prefer a long-term monitoring strategy. The combination of absence of symptoms and recorded AF is considered as the definition of success by most respondents.
Article
Cardiac & Cardiovascular Systems
Tove Olsson Brandtvig, Sofia Marinko, Maiwand Farouq, Johan Brandt, David Mortsell, Lingwei Wang, Uzma Chaudhry, Samir Saba, Rasmus Borgquist
Summary: The position of the left ventricular lead is an important factor for the success of cardiac resynchronization therapy. This study found that non-lateral lead positions were associated with worse clinical outcomes and less reduction in QRS duration, especially in patients with native left or right bundle branch block.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Lukasz Januszkiewicz, Sergio Barra, Rui Providencia, Julian K. R. Chun, Giulio Conte, Michal M. Farkowski, Jose M. Guerra, Eloi Marijon, Carlo de Asmundis, Serge Boveda
Summary: The aim of this study was to identify potential regional disparities in characteristics of ICD recipients, patient perceptions and perspectives after implantation and level of information provided to patients. The study found that patients in Western Europe reported higher satisfaction after ICD placement, while patients in Central/Eastern Europe felt more optimally informed at the time of device implantation. Therefore, novel strategies are needed to address regional differences in patients' quality of life and provision of information.
Review
Medicine, General & Internal
Kara G. Fields, Jie Ma, Tatjana Petrinic, Hassan Alhassan, Anthony Eze, Ankith Reddy, Mona Hedayat, Rui Providencia, Gregory Y. H. Lip, Jonathan P. Bedford, David A. Clifton, Oliver C. Redfern, Benjamin O'Brien, Peter J. Watkinson, Gary S. Collins, Jochen D. Muehlschlegel
Summary: This systematic review aims to critically appraise the methodology and risk of bias in the development and validation of multivariable prediction models for atrial fibrillation after cardiac surgery (AFACS). The findings will be disseminated to improve future studies and provide a clinically useful risk estimation tool.
Article
Cardiac & Cardiovascular Systems
Maiwand Farouq, Cecilia Rorsman, Sofia Marinko, David Mortsell, Uzma Chaudhry, Lingwei Wang, Pyotr G. Platonov, Rasmus Borgquist
Summary: This study aimed to compare the mortality rates and mode of death in patients with nonischemic cardiomyopathy who were treated with either primary preventive CRT-D or CRT-P. The results showed that CRT-D was associated with higher 5-year survival, especially in patients aged <60 years.
Article
Cardiac & Cardiovascular Systems
Cecilia Rorsman, Maiwand Farouq, Sofia Marinko, David Mortsell, Uzma Chaudhry, Lingwei Wang, Rasmus Borgquist
Summary: This study evaluated sex-based differences in patients with new-onset heart failure post right ventricular pacing. The results showed that women with pacemaker due to AV block were older but had fewer comorbidities than men. They were less likely to develop new-onset heart failure, but also less likely to receive a CRT upgrade if they did develop heart failure.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Rasmus Borgquist, Sofia Marinko, Pyotr G. Platonov, Lingwei Wang, Uzma Chaudhry, Johan Brandt, David Mortsell
Summary: This study aimed to evaluate the feasibility of optimizing cardiac resynchronization therapy (CRT) by maximizing QRS duration reduction and whether reduced QRS duration is associated with a better clinical outcome. The results showed that optimizing device parameters to maximize QRS duration reduction is feasible and associated with improved clinical outcomes.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)