Article
Immunology
Xiaoxue Bai, Yingjie Zhu, Jing Jie, Dan Li, Lei Song, Jingjing Luo
Summary: This study found that Maackiain, a natural compound from Sophora flavescens, protects against sepsis by reducing organ injury, inflammation, and oxidative stress. Maackiain activates the AMPK/Nrf2/HO-1 pathway, leading to its anti-inflammatory and antioxidant effects. Inhibition of this pathway abolishes the protective effects of Maackiain.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shan Hu, Beilei Liu, Manqi Yang, Shuai Mao, Hao Ju, Zheyu Liu, Min Huang, Gang Wu
Summary: A study found that carnosic acid (CA) can inhibit the oxidative damage, apoptosis, and pyroptosis induced by doxorubicin (DOX) in the heart, thereby protecting the heart. This study suggests that CA could be a potential therapeutic strategy in the prevention of DOX-associated cardiomyopathy.
Article
Medicine, Research & Experimental
Jiacong Xiao, Gangyu Zhang, Bohao Chen, Qi He, Jiale Mai, Weijian Chen, Zhaofeng Pan, Junzheng Yang, Jianliang Li, Yanhuai Ma, Ting Wang, Haibin Wang
Summary: The aim of this study was to investigate the therapeutic effects of quercetin (QUE) against iron overload-induced osteoporosis and its potential molecular mechanisms. The results showed that QUE can attenuate oxidative stress damage induced by iron overload by activating the Nrf2/HO-1 signaling pathway, thus protecting bone health.
Article
Plant Sciences
Yanfen Cheng, Xiaoping Wu, Xin Nie, Yihan Wu, Chen Zhang, Simon Ming-Yuen Lee, Kongpeng Lv, George Pak-Heng Leung, Chaomei Fu, Jinming Zhang, Jingjing Li
Summary: Glycyrrhetinic acid (GA) protects against doxorubicin-induced cardiotoxicity by suppressing oxidative stress, mitochondrial dysfunction, and apoptosis via upregulating the Nrf2/HO-1 signaling pathway.
Article
Biochemistry & Molecular Biology
Dezhao Lu, Yifei Le, Jiali Ding, Xiaobing Dou, Wei Mao, Ji Zhu
Summary: The study demonstrates that CLIC1 acts as a sensor of oxidative stress in endothelial cells, and its regulation of the Nrf2/HO-1 pathway can protect cells from oxidative damage. In addition, inhibition of CLIC1 activity can reduce oxidative stress injury and promote antioxidant effects.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Neurosciences
Li-Na Xuan, Zhen-Xin Hu, Zhen-Fu Jiang, Cong Zhang, Xiao-Wan Sun, Wen-Hua Ming, Hui-Tao Liu, Rong-Fang Qiao, Lin-Jie Shen, Shao-Bo Liu, Guan-Yu Wang, Lin Wen, Zhi-Lin Luan, Jian Yin
Summary: In this study, it was found that pregnane X receptor (PXR) is involved in the recovery of motor function after spinal cord injury (SCI) by regulating the NRF2/HO-1 pathway. Activation of PXR suppressed the NRF2/HO-1 pathway, while PXR deficiency activated this pathway and improved motor function in mice after SCI.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Zhong-Yan Zhou, Wen-Ting Shi, Jing Zhang, Wai-Rong Zhao, Ying Xiao, Kai-Yu Zhang, Jie Ma, Jing-Yi Tang, Yu Wang
Summary: Sodium tanshinone IIA sulfonate (STS) exhibits potent endothelial protective effect against Hcy-induced cell injury, which is related to the inhibition of oxidative stress and mitochondrial dysfunction, as well as activation of AKT/MAPKs, SIRT1/NRF2/HO-1, and NNMT/MNA signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Sen Guo, Bin-Bin Zhang, Lu Gao, Xiao-Yue Yu, Ji-Hong Shen, Fan Yang, Wen-Cai Zhang, Ya-Ge Jin, Gang Li, Yan-Ge Wang, Zhan-Ying Han, Yuan Liu
Summary: Heart failure severely impairs human health, and cardiac hypertrophy is one of the main causes. This study found that RNF13 plays a protective role in cardiac hypertrophy by activating the p62-NRF2 axis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Medicinal
Ran An, Dong Li, Yingying Dong, Qiuyun She, Ting Zhou, Xiaoqi Nie, Ronghua Pan, Yunhua Deng
Summary: The study found that MeCbl attenuated H2O2-induced oxidative stress in melanocytes by activating the Nrf2/HO-1 pathway, suggesting its potential efficacy as a treatment for vitiligo.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Immunology
Reem S. Alruhaimi, Emad H. M. Hassanein, Mostafa K. Abd El-Aziz, Maisa Siddiq Abduh, Albandari Bin-Ammar, Emadeldin M. Kamel, Ayman M. Mahmoud
Summary: In this study, it was found that the melatonin receptor agonist agomelatine can protect against acute pancreatitis induced by cadmium by preventing inflammation, oxidative stress, and apoptosis, and by modulating the Nrf2/HO-1 pathway. Agomelatine enhanced the antioxidant capacity through the activation of the Nrf2/HO-1 pathway, while reducing inflammation and cellular damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Surgery
Tianzhu Tao, Bo Ye, Yuhai Xu, Yi Wang, Ying Zhu, Ye Tian
Summary: In this study, the protective effects of beta-patchoulene (beta-PAE) on hepatic ischemia-reperfusion (I/R) injury were investigated. The results demonstrated that beta-PAE could alleviate tissue damage and inflammation induced by hepatic I/R injury, and it exerted its effects by modulating the balance between Nrf2/HO-1 and NF-kappa B pathways.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Akash Shivling Mali, Ondrej Honc, Lucie Hejnova, Jiri Novotny
Summary: Opioid receptor agonists have anti-inflammatory and antioxidant effects on microglia, as shown in this study. The selected agonists DAMGO, DADLE, and U-50488 were found to protect microglial cells from lipopolysaccharide-induced oxidative stress by affecting ROS production, NADPH synthesis, and glucose uptake. These beneficial effects were associated with the upregulation of the Nrf2/HO-1 pathway. The findings suggest that opioids can preserve mitochondrial function and eliminate ROS in microglia through a Nrf2/HO-1 signaling pathway-dependent mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Min-yan Yang, Zhen Fan, Zhao Zhang, Jin Fan
Summary: The study showed that MitoQ protects against HG-induced BMECs injury by activating the Nrf2/HO-1 pathway, improving mitochondrial membrane potential, reducing mitochondrial ROS production, and attenuating cell apoptosis.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Immunology
Zhijun Tan, Bin Zhang
Summary: In this study, the effect of Ech on osteoarthritis (OA) was investigated. Results showed that Ech enhanced the viability of rat chondrocytes, repressed inflammatory response and extracellular matrix degradation, and alleviated oxidative stress. Mechanically, Ech achieved these effects by activating the Nrf2/HO-1 signaling pathway. Additionally, Ech showed protective effects in vivo in a rat model of OA.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rui-xuan Wang, Xing Gu, Si-xue Zhang, Yan-jun Zhao, Hong-jun Zhang, Fei-yan Li
Summary: This study aimed to investigate the role of BACH1 in the pathophysiological process of acute lung injury (ALI) with a focus on ferroptosis. The results showed that BACH1 expression was increased upon exposure to LPS, and its deletion exerted anti-inflammatory effects and reduced oxidative stress damage and ferroptosis induced by LPS. Mechanistically, the beneficial effects of BACH1 inhibition were mediated through the Nrf2/HO-1 signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
