Article
Oncology
Cecelia MacFarling Meure, Belinda Steer, Judi Porter
Summary: The relationship between nutritional intake and clinical outcomes in hospitalised adult oncology patients remains unclear. This study found no significant relationship between nutritional intake and clinical outcomes. However, patients at risk of malnutrition had longer length of stay.
Article
Health Care Sciences & Services
Anupam Ashutosh Sule, Rachel Sarah Dada, Jafar Dada
Summary: The study showed that the MORIS strata can predict disease-specific mortality and readmission, but are not useful in predicting length of stay or discharge disposition. Managing resources effectively is crucial in ensuring high value in care.
AMERICAN JOURNAL OF MANAGED CARE
(2021)
Article
Cardiac & Cardiovascular Systems
Ayman Elbadawi, Kirolos Barssoum, Michael Megaly, Devesh Rai, Ahmed Elsherbeeny, Hend Mansoor, Mehdi H. Shishehbor, Ahmed Abdel-Latif, Martha Gulati, Islam Y. Elgendy
Summary: In a nationwide analysis of CLI hospitalizations, women were older and less likely to undergo revascularization. Women had higher in-hospital mortality and bleeding complications compared to men. Sex-specific interventions are needed to reduce these disparities in this high-risk population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Peripheral Vascular Disease
Alexandra Yannoutsos, Franck Lin, Olivier Billuart, Anne Buronfosse, Emmanuelle Sacco, Helene Beaussier, Jean-Jacques Mourad, Joseph Emmerich, Isabelle Lazareth, Pascal Priollet
Summary: This study revealed an inverse correlation between admission systolic blood pressure, mean blood pressure, and pulse pressure with 1-year mortality in patients undergoing revascularization for critical limb ischemia. These findings suggest that blood pressure may represent a modifiable therapeutic target to prevent poor outcomes in CLI patients.
JOURNAL OF HYPERTENSION
(2021)
Article
Surgery
Christopher A. Latz, Linda J. Wang, Laura Boitano, Charles DeCarlo, Anna A. Pendleton, Brandon Sumpio, Samuel Schwartz, Anahita Dua
Summary: This study compares the 30-day unplanned readmission rates of CLI patients who underwent LEB and IEI treatments, finding LEB to be independently associated with readmissions. Several independent predictors of readmission were identified in the study. Further research is needed to understand the economic impact of these readmissions.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Nutrition & Dietetics
Hongpeng Liu, Jing Jiao, Minglei Zhu, Xianxiu Wen, Jingfen Jin, Hui Wang, Dongmei Lv, Shengxiu Zhao, Xiang Sun, Xinjuan Wu, Tao Xu
Summary: This study found that nearly half of older inpatients in tertiary hospitals in China are at risk of malnutrition, which is associated with increased hospital length of stay, mortality, and 90-day readmission. The use of nutritional assessment tools combined with hemoglobin level may help identify high-risk patients. These findings have important implications for hospital service planning.
FRONTIERS IN NUTRITION
(2022)
Review
Cell & Tissue Engineering
Zeinab Shirbaghaee, Mohammad Hassani, Saeed Heidari Keshel, Masoud Soleimani
Summary: This article reviews the immunomodulatory features of mesenchymal stem cells (MSCs) and their potential applications as therapeutic agents in the treatment of critical limb ischemia (CLI). Despite advances in clinical research, MSC therapy is still considered experimental and not recommended for regular clinical use. The article provides recommendations to improve the efficacy of cell therapy for CLI patients.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Larissa Vainqueur, Nadine Simo-Tabue, Roxane Villeneuve, Dorice Dagonia, Bernard Bhakkan-Mambir, Ludwig Mounsamy, Vaynome Delacroix, Maturin Tabue-Teguo
Summary: The study aimed to investigate the relationship between frailty index and length of hospital stay, and death in a non-COVID population of patients aged 75 years old and above. The results showed a significant association between frailty index and mortality, but it was not significant in predicting length of stay.
FRONTIERS IN MEDICINE
(2022)
Article
Geriatrics & Gerontology
Caterina Trevisan, Marianna Noale, Giancarlo Zatti, Davide Liborio Vetrano, Stefania Maggi, Giuseppe Sergi
Summary: There is a gradual reduction in hospital length of stay (LOS) and an increase in 30-day readmission rates in older patients in Italy. This suggests that careful pre-discharge assessment is necessary for older people, and community healthcare services should be improved to reduce the risk of readmission.
Review
Engineering, Biomedical
Zheng Xing, Chen Zhao, Siwen Wu, Chunchen Zhang, Haifeng Liu, Yubo Fan
Summary: Therapeutic angiogenesis provides a potential solution for critical limb ischemia by manipulating blood vessel growth in vivo without the need for extra pharmaceutics and surgery. With the rise of interdisciplinary research, regenerative medicine strategies offer new possibilities for treating various clinical diseases.
Article
Cardiac & Cardiovascular Systems
Monil Majmundar, Kunal N. Patel, Rajkumar Doshi, Harsh Mehta, Mohinder R. Vindhyal, Kirk A. Hance, Adam Ali, Kamal Gupta
Summary: This study demonstrates that the hospital frailty risk score can identify frailty and predict clinical outcomes in patients undergoing revascularization for critical limb-threatening ischemia.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, Research & Experimental
Aamal G. El-Waseif, Manar A. Nader, Hatem A. Salem, Sally L. Elshaer
Summary: The study demonstrates that the ROCK inhibitor Fasudil provides vascular protection in an experimentally induced unilateral critical limb ischemia (CLI) model in mice, possibly by restoring antioxidant capacity and inhibiting inflammatory response.
Article
Peripheral Vascular Disease
Prakash Acharya, Prince Sethi, Sagar Ranka, Adam Alli, Kirk Hance, Anand Prasad, Zubair Shah, Kamal Gupta
Summary: This study found that surgical and hybrid procedures were associated with lower risk of unplanned critical limb ischemia-related readmission, but higher risk of non-critical limb ischemia-related readmission due to procedure-related/wound complications. Differences in discharge disposition based on revascularization strategy were also identified, suggesting opportunities for reducing readmissions by focusing on nonprocedural aspects such as wound-care, discharge planning, and placement.
Review
Biochemistry & Molecular Biology
Lucia Beltran-Camacho, Marta Rojas-Torres, Ma Carmen Duran-Ruiz
Summary: Critical limb ischemia is the most severe form of peripheral arterial disease, commonly caused by atherosclerosis leading to progressive blockage of arterial vessels. For patients not suitable for surgical intervention, angiogenic cell therapy has emerged as a promising alternative, showing potential for enhancing revascularization by promoting vessel formation and blood flow recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Matilde Zamboni, Massimo Pedriali, Luca Ferretto, Sabrina Scian, Francesca Ghirardini, Riccardo Bozza, Romeo Martini, Sandro Irsara
Summary: The development of chronic vascular wounds is a major issue, especially with the aging population and increasing incidence of underlying diseases. Local injection of peripheral blood mononuclear cells may be a promising cell treatment for wound healing, but more research is needed to establish its clinical efficacy.
