Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 15, Pages 5297-5300Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b01115
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Funding
- National Science Foundation [NSF-1566402]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1566402] Funding Source: National Science Foundation
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We report a general method for the synthesis of chiral thiosquaramides, a class of bifunctional catalysts not previously described in the literature. Thiosquaramides are found to be more acidic and significantly more soluble in nonpolar solvents than their oxosquaramide counterparts, and they are excellent catalysts for the unreported, enantioselective conjugate addition reaction of the barbituric acid pharmacaphore to nitroalkenes, delivering the chiral barbiturate derivatives in high yields and high enantioselectivities, even with catalyst loadings as low as 0.05 mol%.
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