Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 31, Pages 10875-10879Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b05850
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Funding
- Engineering and Physical Sciences Research Council [EP/H021620/12]
- ERC [339019]
- Royal Society for University Research Fellowships
- Engineering and Physical Sciences Research Council [EP/H021620/2, 1232301] Funding Source: researchfish
- EPSRC [EP/H021620/2] Funding Source: UKRI
- European Research Council (ERC) [339019] Funding Source: European Research Council (ERC)
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We report on the synthesis and operation of a three-barrier, rotaxane-based, artificial molecular machine capable of sequence-specific beta-homo (beta(3)) peptide synthesis. The machine utilizes nonproteinogenic beta(3)-amino acids, a class of amino acids not generally accepted by the ribosome, particularly consecutively. Successful operation of the machine via native chemical ligation (NCL) demonstrates that even challenging 15- and 19-membered ligation transition states are suitable for information translation using this artificial molecular machine. The peptide-bond-forming catalyst region can be removed from the transcribed peptide by peptidases, artificial and biomachines working in concert to generate a product that cannot be made by either machine alone.
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