Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 6, Pages 2196-2199Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b13042
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Funding
- Thousand Youth Talents Plan
- National Natural Sciences Foundation of China [21672235]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- Shanghai Rising-Star Plan [15QA1404600]
- CAS Key Laboratory of Synthetic Chemistry of Natural Substances and Shanghai Institute of Organic Chemistry
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A direct catalytic asymmetric vinylogous Mannich-type reaction has been disclosed in good yield, excellent regio-, diastereo- and enantioselectivity. The key to control the regioselectivity is the combination of a bulky N-acylpyrazole and a bulky bisphosphine ligand. The catalytic system was extended to a bisvinylogous Mannich-type reaction by changing the ligand. The synthetic utility of the vinylogous products was demonstrated by several transformations.
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