Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 139, Issue 18, Pages 6431-6436Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b02076
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Funding
- Fundamental Research Funds for the Central Universities in China [CQDXWL-2014-Z003]
- Scientific Research Foundation of China [21402016]
- Graduate Scientific Research and Innovation Foundation of Chongqing, China [CYB16032]
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Structural motifs containing contiguous halide bearing stereocenters are common in natural products as well as bioactive molecules. A few successful examples have been reported in the area of asymmetric vicinal dihalogenation of alkenes for accessing dihalogenated products; in this report, an alternative generation method of contiguous halide-bearing stereocenters alpha,beta,gamma,delta relative to carbonyl group in excellent enantioselectivity is proposed by utilizing a Song's oligoEG catalyst-catalyzed asymmetric beta-elimination. According to this methodology, a wide range of anti-syn-trihalides and anti-syn-anti-tetrahalides with high levels of enantioselectivity were synthesized. The synthetic utility of the contiguous halide-bearing stereocenters was demonstrated by several transformations. The results of high-resolution mass spectrometry indicated that the favorable interaction between catalyst and one of the enantiomers of racemic contiguously multihalogenated ketone contributed to the original enantioselectivity of dehydrohalogenation. A deuterium kinetic isotope effect experiment revealed that this beta-elimination reaction proceeds by the E2 mechanism. This strategy opens a new pathway for the asymmetric synthesis of contiguous halide bearing stereocenters of great complexity.
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