Article
Health Care Sciences & Services
Oriana Ciani, Maximilian Salcher-Konrad, Michela Meregaglia, Kathrine Smith, Sarah L. Gorst, Susanna Dodd, Paula R. Williamson, Giovanni Fattore
Summary: This study reviewed core outcome sets (COS) with patient-reported outcomes measures (PROMs) and found that while most instruments cover broad health-related constructs, there are issues of resource overlap within and across different disease areas.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2021)
Article
Obstetrics & Gynecology
Sarah Louise Killeen, Shauna L. Callaghan, Sharleen L. O'Reilly, Fionnuala M. McAuliffe
Summary: The objective of this study was to develop a core outcome set for pregnancy nutrition. Candidate outcomes were identified from a systematic review and additional data were collected through interviews with women with pregnancy experience. A modified Delphi survey and consensus meeting were conducted to finalize the core outcome set. The set includes critical outcomes for both pregnant women and newborns, providing important guidance for researchers and healthcare professionals.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Rheumatology
Anna Antony, Richard Holland, Maria-Antonietta D'Agostino, Walter P. Maksymowych, Heidi Bertheussen, Lori Schick, Niti Goel, Alexis Ogdie, Ana-Maria Orbai, P. Hojgaard, Laura C. Coates, Vibeke Strand, Dafna D. Gladman, Robin Christensen, Ying Ying Leung, Philip Mease, William Tillett
Summary: This systematic review focused on the measurement properties of radiographic outcome instruments for structural damage in Psoriatic Arthritis, identifying significant knowledge gaps in the responsiveness of peripheral radiographic instruments and the need for further validation of axial instruments. The peripheral instruments Ratingen and modified Sharp van der Heijde scores showed some evidence of reliability and validity while the evidence for axial instruments was limited.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Medicine, Research & Experimental
Lara S. Chapman, Anthony C. Redmond, Caroline A. Flurey, Pamela Richards, Toby O. Smith, John B. Arnold, Dorcas Beaton, Philip G. Conaghan, Yvonne M. Golightly, Marian T. Hannan, Catherine Hofstetter, Lara J. Maxwell, Hylton B. Menz, Beverley Shea, Peter Tugwell, Philip Helliwell, Heidi J. Siddle
Summary: This study aims to develop a core outcome set (COS) for interventions in foot and ankle disorders in RMDs. Through literature reviews, qualitative interviews, and focus groups, important outcome domains will be identified and prioritized using an online consensus study and subsequent meeting. The findings will be disseminated widely to enhance uptake.
Review
Rheumatology
Krystel Aouad, Georgia Moysidou, Antsa Rakotozafiarison, Bruno Fautrel, Laure Gossec
Summary: PsA outcome measures are diverse, but data collection shows significant heterogeneity. There is a need for international consensus on outcome measures.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Dermatology
Yael A. Leshem, Eric L. Simpson, Christian Apfelbacher, Phyllis Spuls, Kim S. Thomas, Jochen Schmitt, Laura Howells, Louise A. A. Gerbens, Michael E. Jacobson, Norito Katoh, Hywel C. Williams
Summary: This article provides a practical guide for implementing Core Outcome Sets (COS) in clinical trials to improve the consistency of outcome measurement and reporting. The implementation roadmap offered in this study can enhance the quality and applicability of research.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Critical Care Medicine
T. W. Davies, R. J. J. van Gassel, M. van de Poll, J. Gunst, M. P. Casaer, K. B. Christopher, J. C. Preiser, A. Hill, K. Gundogan, A. Reintam-Blaser, A. F. Rousseau, C. Hodgson, D. M. Needham, M. Castro, S. Schaller, T. McClelland, J. J. Pilkington, C. M. Sevin, P. E. Wischmeyer, Z. Y. Lee, D. Govil, A. Li, L. Chapple, L. Denehy, J. C. Montejo-Gonzalez, B. Taylor, D. E. Bear, R. Pearse, A. McNelly, J. Prowle, Z. A. Puthucheary
Summary: This study identified a core outcome set for nutritional and metabolic clinical research in critically ill adults, reaching consensus on essential domains and measurement instruments for use at 30 and 90 days post-randomisation. The CONCISE core outcome set provides internationally agreed minimum outcomes to guide future research.
Article
Rheumatology
Philip J. Mease, Mei Liu, Sabrina Rebello, Robert R. McLean, Blessing Dube, Meghan Glynn, Peter Hur, Alexis Ogdie
Summary: Patients with PsA who have nail psoriasis demonstrated worse disease activity, quality of life, and work productivity compared to those without nail involvement, highlighting the importance of identifying and managing nail disease in PsA patients.
JOURNAL OF RHEUMATOLOGY
(2021)
Review
Health Care Sciences & Services
Meera R. Agar, Najma Siddiqi, Annmarie Hosie, Jason W. Boland, Miriam J. Johnson, Imogen Featherstone, Peter G. Lawlor, Shirley H. Bush, Valerie Page, Ingrid Amgarth-Duff, Maja Garcia, Domenica Disalvo, Louise Rose
Summary: This study analyzed the outcomes of published palliative care studies on delirium prevention or treatment interventions and found heterogeneity in outcomes, definitions, and measurements, highlighting the need for a uniform approach in delirium interventions in palliative care research.
PALLIATIVE MEDICINE
(2021)
Review
Medicine, Research & Experimental
Olalekan Lee Aiyegbusi, Lavinia Ferrante di Ruffano, Ameeta Retzer, Philip N. Newsome, Christopher D. Buckley, Melanie J. Calvert
Summary: This review aims to identify and map core outcome sets (COS) for tissue-agnostic drug therapies in immune-mediated inflammatory diseases (IMIDs). The study found that outcomes such as disease activity, pain, fatigue, and quality of life were recommended across most conditions. Similarities and differences were also observed in the recommendations of the US FDA and European Medicines Agency (EMA). The findings emphasize the need for collaboration between regulators and COS developers to enhance outcome selection in innovative trials.
Article
Endocrinology & Metabolism
Jiao Jiao, Lingmin Chen, Yong Peng, Qingyi Jia, Ying He, Yonggang Zhang, Nian Li
Summary: This paper introduces the methodological framework for developing a core outcome set (COS) in cardiovascular diabetology. The framework includes steps such as establishing stakeholder groups, conducting systematic reviews, and using Delphi survey to select potential core outcomes. The study aims to provide evidence for the future development of COS in cardiovascular diabetology.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Rheumatology
Laura C. Coates, Joseph F. Merola, Philip J. Mease, Alexis Ogdie, Dafna D. Gladman, Vibeke Strand, Leonieke J. J. van Mens, Lyrica Liu, Priscilla K. Yen, David H. Collier, Gregory Kricorian, James B. Chung, Philip S. Helliwell
Summary: In PsA patients, etanercept was found to be more effective in achieving ACR 20 and MDA, while PASDAS showed relatively greater changes in the continuous composite measures and may better quantify the change in PsA disease burden.
Article
Rheumatology
Ying Ying Leung, Ana-Maria Orbai, Maarten de Wit, Andra Balanescu, Emmanuelle Dernis, Martin Soubrier, Lihi Eder, Josef S. Smolen, Laura C. Coates, Laure Gossec
Summary: HAQ DI, SF-12 PCS, and PsAID-FC are valid measures of physical function for PsA, with PsAID-FC being potentially a more sensitive option to measure PsA-specific physical function.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Surgery
Nusrat Iqbal, Astrid J. H. M. Machielsen, Merel L. Kimman, Gillian Kane, Rebecca Woodcock, Ugo Grossi, Phil J. Tozer, Stephanie O. Breukink
Summary: The objective of this study was to develop a core outcome set for cryptoglandular anal fistula treatment. In order to achieve consistency in fistula research and identify the best treatment, candidate outcomes were generated through systematic review and patient interviews, and then prioritized by key stakeholders in an online Delphi consensus process. The final core outcome set includes clinical and radiological healing, recurrence, development of additional fistulas, fistula symptoms, incontinence, psychological impact of treatment, complications and reinterventions, patient satisfaction, and quality of life.
Review
Biochemistry & Molecular Biology
Robert Gurke, Annika Bendes, John Bowes, Michaela Koehm, Richard M. Twyman, Anne Barton, Dirk Elewaut, Carl Goodyear, Lisa Hahnefeld, Rainer Hillenbrand, Ewan Hunter, Mark Ibberson, Vassilios Ioannidis, Sabine Kugler, Rik J. Lories, Eduard Resch, Stefan Rueping, Klaus Scholich, Jochen M. Schwenk, James C. Waddington, Phil Whitfield, Gerd Geisslinger, Oliver FitzGerald, Frank Behrens, Stephen R. Pennington
Summary: The definitive diagnosis and early treatment of immune-mediated inflammatory diseases (IMIDs) are challenging due to variable clinical manifestations. Psoriatic arthritis (PsA) is an example of such a disease. The detection of molecular biomarkers offers hope for the early diagnosis and treatment of PsA, but specific biomarkers are not yet available. By analyzing multi-omics data and integrating them with clinical assessment, it is possible to develop molecular profiles that improve the diagnosis and treatment outcomes of PsA patients.
Article
Rheumatology
Philip J. Mease, Akihiko Asahina, Dafna D. Gladman, Yoshiya Tanaka, William Tillett, Barbara Ink, Deepak Assudani, Christine de la Loge, Jason Coarse, Jason Eells, Laure Gossec
Summary: This study evaluated the effects of long-term bimekizumab treatment on symptoms and impact of PsA on patients. The results showed sustained improvements in pain and fatigue, reducing the overall impact of PsA on patients. Physical function and quality of life also improved up to 3 years.
Article
Rheumatology
Kristine M. Latocha, Katrine B. Loppenthin, Mikkel Ostergaard, Poul J. Jennum, Merete L. Hetland, Henrik Rogind, Tine Lundbak, Julie Midtgaard, Robin Christensen, Bente A. Esbensen
Summary: The objective of the study was to compare the effects of cognitive behavioural therapy for insomnia (CBT-I) to usual care on sleep efficiency. The study found that CBT-I did not significantly improve sleep efficiency measured by polysomnography (PSG). However, CBT-I showed significant improvement in patient-reported sleep and RA-related outcomes.
Article
Orthopedics
M. Henriksen, S. M. Nielsen, R. Christensen, L. E. Kristensen, H. Bliddal, C. Bartholdy, M. Boesen, K. Ellegaard, D. J. Hunter, R. Altman, E. Bandak
Summary: This study aimed to identify contextual factors that modify the treatment effect of the GLAD exercise and education programme compared to open-label placebo on knee pain in individuals with knee OA. The results suggest that patients who take analgesics or report constant knee pain seem to benefit more from the GLAD programme compared to OLP in terms of knee pain.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Rheumatology
Dafne Capelusnik, Diego Benavent, Desiree van der Heijde, Robert Landewe, Denis Poddubnyy, Astrid van Tubergen, Louise Falzon, Victoria Navarro-Compan, Sofia Ramiro
Summary: This study conducted a systematic literature review to summarize the relationship between early treatment and treatment clinical response in patients with SpA. It found that early treatment was associated with better outcomes in patients with non-radiographic axSpA and symptom duration of less than 5 years, but no differences in response to treatment were found in radiographic axSpA or in patients with longer symptom duration.
Article
Rheumatology
Casper Webers, Uta Kiltz, Juergen Braun, Desiree van der Heijde, Annelies Boonen
Summary: Treating active SpA improves depressive symptoms, especially with TNF inhibitors (TNFis) which have a stronger effect mainly due to their impact on disease activity.
Editorial Material
Rheumatology
Pei-En Kao, Yung-Heng Lee, Kevin Sheng-Kai Ma, Amy Ker, Ying-Ying Leung
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Immunology
Margaret Ma, Amelia Santosa, Warren Fong, Li-Ching Chew, Andrea H. L. Low, Annie Law, Yih Jia Poh, Siaw Ing Yeo, Ying Ying Leung, Victoria W. W. Ng, Joshua Z. E. Koh, Sen Hee Tay, Anselm Mak, Gim Gee Teng, Chuanhui Xu, Johnston G. X. Tang, Kok Ooi Kong, Stanley Angkodjojo, Wei-Rui Goh, Tyng Yu Chuah, Nur Emillia Roslan, Thaschawee Arkachaisri, Kai Liang Teh, Melonie Sriranganathan, Teck Choon Tan, Kee Fong Phang, Qai Ven Yap, Yiong Huak Chan, Peter P. M. Cheung, Manjari Lahiri
Summary: A national retrospective cohort study found a moderately high rate of flares of autoimmune inflammatory rheumatic diseases (AIIRD) after COVID-19 mRNA vaccination, but also improvement in several patients. Severe flares and hospitalization were rare. Thus, vaccination remains safe and highly recommended.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Rheumatology
Abel Davtyan, Jennifer J. Y. Lee, Lihi Eder, Gillian A. Hawker, Jin Luo, Claire E. H. Barber, J. Carter Thorne, Jessica Widdifield
Summary: A study found that continuity of rheumatology care influences rates of emergency department visits and hospitalizations in patients with rheumatoid arthritis (RA). Patients who received continuous rheumatology care during the first 5 years after diagnosis had lower rates of ED visits and hospitalizations compared to those who did not receive continuous care. This study provides evidence supporting the value of early and continuous rheumatology care for reducing hospitalizations and ED visits.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
L. Uhrenholt, R. Christensen, L. Dreyer, E-M Hauge, A. Schlemmer, A. G. Loft, M. N. B. Rasch, H. C. Horn, K. H. Gade, R. D. Ostgard, P. C. Taylor, K. Duch, S. Kristensen
Summary: This study aimed to evaluate whether disease activity-guided tapering of biologics enables a significant dose reduction while maintaining equivalent disease activity. The results showed that disease activity-guided tapering of biologics allowed one-third of the patients to achieve a reduction of 50% or more, while disease activity remained equivalent between the tapering and control groups. Although flare rates were higher in the tapering group, they could be managed with rescue therapy.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
P. R. Lage-Hansen, S. Chrysidis, K. Amris, S. Fredslund-Andersen, R. Christensen, T. Ellingsen
Summary: This study evaluated the prevalence of survey-based fibromyalgia (FM) criteria among newly referred patients in a rheumatic outpatient clinic, and compared the use of healthcare services between survey-based FM and non-FM cases. The study found that FM cases were more likely to be women and received more medications and public economic support. FM cases also had a higher number of hospital courses and had undergone more invasive procedures compared to non-FM cases. Consultations with various specialists were also more frequent for FM cases.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Marlene Sousa, Ennio Lubrano, Josef S. Smolen, Clemence Gorlier, Maarten de Wit, Laura C. Coates, Umut Kalyoncu, Adeline Ruyssen-Witrand, Ying-Ying Leung, Rossana Scrivo, Juan D. Canete, Penelope Palominos, Sandra Meisalu, Andra Balanescu, Uta Kiltz, Sibel Zehra Aydin, Inna Gaydukova, Emmanuelle Dernis, Bruno Fautrel, Ana-Maria Orbai, Laure Gossec
Summary: This study aimed to explore patient-defined flares in psoriatic arthritis (PsA) and compare them to an increase in disease activity in psoriatic arthritis (DAPSA). The validity of a patient-reported flare question was also analyzed. The results showed that patient-reported flares were associated with disease activity and symptoms, and there was moderate agreement between patient and physician definitions of worsening.
Review
Rheumatology
Wendy Zhu, Sally Ayoub, Eric Morand, William Tillett, Anna Antony
Summary: This study conducted a systematic review of participants recruited for phase III RCTs of b/tsDMARDs in peripheral PsA and found that despite the increase in countries involved, the proportion of white participants did not significantly change and non-white participants continue to be underrepresented. Improving diversity in patient representation is crucial for advancing our understanding and treatment of psoriatic disease.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Rheumatology
Lihi Eder, Ker-Ai Lee, Vinod Chandran, Jessica Widdifield, Aaron M. Drucker, Christopher Ritchlin, Cheryl F. Rosen, Richard J. Cook, Dafna D. Gladman
Summary: The study aimed to develop a risk prediction model for psoriasis patients to predict their risk of developing psoriatic arthritis (PsA) and evaluate its performance. The results showed that using readily available clinical variables, the development of PsA within clinically meaningful time frames can be predicted with reasonable accuracy for psoriasis patients.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
E. Gremese, Francesco Ciccia, Carlo Selmi, Giovanna Cuomo, Rosario Foti, Marco Matucci-Cerinic, Fabrizio Conti, Enrico Fusaro, Giuliana Guggino, Florenzo Iannone, Andrea Delle Sedie, Roberto Perricone, Luca Idolazzi, Paolo Moscato, Elke Theander, Wim Noel, Paul Bergmans, Silvia Marelli, Laure Gossec, Josef S. Smolen
Summary: This study compared the real-world persistence, effectiveness, and tolerability of ustekinumab and TNFi in PsA patients. The results showed that ustekinumab had better persistence than TNFi, overall and in specific subgroups. After one year of treatment, both ustekinumab and TNFi showed similar effectiveness.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Rheumatology
D. Guellec, G. Carvajal-Alegria, C. Daien, L. Gossec, F. Guillemin, F. Berenbaum, A. Constantin, P. Dieude, M. Dougados, R. M. Flipo, P. Goupille, X. Mariette, C. Richez, O. Vittecoq, B. Combe, A. Saraux
Summary: In patients with recent-onset arthritis, a self-reported familial occurrence of rheumatoid arthritis (RA) is associated with a higher prevalence of extra articular manifestations (EAMs), a higher likelihood of severe EAMs, and a higher probability of initiating targeted DMARD treatment over time.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)