Journal
JOURNAL OF REPRODUCTION AND DEVELOPMENT
Volume 63, Issue 1, Pages 9-11Publisher
SOCIETY REPRODUCTION & DEVELOPMENT-SRD
DOI: 10.1262/jrd.2016-133
Keywords
1-Cell embryos; Gene expression; Transcription; Zygote
Funding
- Grants-in-Aid for Scientific Research [16H01215, 25252054] Funding Source: KAKEN
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After fertilization, the genome of zygotes is transcriptionally silent. The timing of the initiation of transcription is species-specific and occurs at the mid-1-cell stage in mice. Recent analyses using high-throughput sequencing (HTS) have identified thousands of genes transcribed at the 1-cell stage, and the pattern of expression among these genes appears to be unique. In this article, we show the result of an additional analysis using HTS data from a previous study, and present the hypothesis that an extremely loose chromatin structure causes promiscuous gene expression in 1-cell embryos.
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