Article
Ophthalmology
Elsie Chan, Elaine W. Chong, Gareth Lingham, Louis J. Stevenson, Paul G. Sanfilippo, Alex W. Hewitt, David A. Mackey, Seyhan Yazar
Summary: This study in Perth, Western Australia, examined the prevalence and systemic associations of keratoconus in young adults, finding a prevalence of 1.2% with significant differences in visual acuity and other refractive measures, as well as an association with regular cigarette smoking.
Article
Multidisciplinary Sciences
Sonia Kakkar, Phulen Sarma, Inusha Panigrahi, S. P. Mandal, Pankaj Shrivastava, R. K. Kumawat
Summary: Kinship analysis in forensics relies on kinship indices, which can be challenging to calculate when large-scale disasters occur. The AMCOS method developed in this study offers an alternative approach based on allele sharing, allowing for kinship determination without relying on allele frequency data. The method has shown promising results in various analyses, but further validation is needed.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Bernardo T. Lopes, Prema Padmanabhan, Ashkan Eliasy, Haixia Zhang, Ahmed Abass, Ahmed Elsheikh
Summary: The regional deterioration in biomechanical stiffness was observed inside the area of pathology, while only mild non-significant alterations were observed outside the area of pathology.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Maia Banige, Dulanjalee Kariyawasam, Valerie Gauthereau, Dominique Luton, Michel Polak
Summary: This study evaluated the feasibility of using the thyroid-stimulating hormone value in dried blood collected on the third postnatal day for screening neonatal hyperthyroidism. The results showed that this screening test can effectively detect severe NH.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Ophthalmology
Yan Liu, Yu Zhang, Yueguo Chen
Summary: The combination of a Scheimpflug-based biomechanical analyser and tomography could increase the accuracy in detecting subclinical keratoconus in Chinese patients. The tomographic and biomechanical index (TBI) was the most valuable index for detecting subclinical keratoconus, with a high sensitivity and specificity. Evaluation of corneal biomechanical properties in refractive surgery candidates could be helpful for recognizing potential keratoconic eyes and increasing surgical safety.
Article
Biotechnology & Applied Microbiology
Xuan Chen, Huazheng Cao, Yan Huo, Jiaxin Song, Haohan Zou, Jing Li, Jie Hou, Yan Wang
Summary: This study analyzed and compared sensitive in vivo characteristics for screening early keratoconus using a multicenter, case-control design. The results showed significant differences in corneal biomechanical indices between early keratoconus and normal corneas, with A1 dArc length showing high discriminatory ability. The clinical application of corneal biomechanics, combined with corneal tomography, should be emphasized for the timely and accurate detection of early keratoconus.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Ophthalmology
Renato Ambrosio, Aydano P. Machado, Edileuza Leao, Joao Marcelo G. Lyra, Marcella Q. Salomao, Louise G. Pellegrino Esporcatte, Joaob. R. Da Fonseca Filho, Erica Ferreira-Meneses, Nelson B. Sena, Jorge S. Haddad, Alexandre Costa Neto, Gildasio Castelo De Almeida, Cynthia J. Roberts, Ahmed Elsheikh, Riccardo Vinciguerra, Paolo Vinciguerra, Jens Buhren, Thomas Kohnen, Guy M. Kezirian, Farhad Hafezi, Nikki L. Hafezi, Emilio A. Torres-Netto, Nanji Lu, David Sung Yong Kang, Omid Kermani, Shizuka Koh, Prema Padmanabhan, Suphi Taneri, William Trattler, Luca Gualdi, Jose Salgado-Borges, Fernando Faria-Correia, Elias Flockerzi, Berthold Seitz, Vishal Jhanji, Tommy C. Y. Chan, Pedro Manuel Baptista, Dan Z. Reinstein, Timothy J. Archer, Karolinne M. Rocha, George O. Waring, Ronald R. Krueger, William J. Dupps, Ramin Khoramnia, Hassan Hashemi, Soheila Asgari, Hamed Momeni-Moghaddam, Siamak Zarei-Ghanavati, Rohit Shetty, Pooja Khamar, Michael W. Belin, Bernardo T. Lopes
Summary: This study aims to enhance ectasia detection by optimizing artificial intelligence algorithms to integrate Scheimpflug-based corneal tomography and biomechanics.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Clinical Neurology
Brandon A. Sherrod, Trevor Schwehr, Daniel Waldram, Andrew Adams, Sterling Averett, Jeewon Ha, Simon Kahle, Derek Mitchell, Seth Polevoi, Andrew T. Dailey, Andrew S. Merryweather, Marcus D. Mazur
Summary: This study demonstrates that robotic cervical traction can apply closed cervical traction as effectively as manual weight-and-pulley traction.
Article
Biotechnology & Applied Microbiology
Yuxin Li, Lei Tian, Li-Li Guo, Yiran Hao, Ying Jie
Summary: This study evaluated the repeatability and reproducibility of 36 DCR parameters and bIOP parameters derived from Corvis ST in healthy eyes, and investigated their relationship with demographic and ocular characteristics.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Obstetrics & Gynecology
Emily Eisner, Shon Lewis, Charlotte Stockton-Powdrell, Ria Agass, Pauline Whelan, Clare Tower
Summary: This study developed a smartphone app to improve access to postnatal depression (PND) treatment. The app was found to be feasible, acceptable, valid, and safe, and it also overcomes some of the limitations of conventional health visitor-delivered screening.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Chemistry, Multidisciplinary
Ran Liu, Yuansheng Hu, Ying He, Tian Lan, Jingjing Zhang
Summary: Home testing is an emerging strategy to combat the COVID-19 pandemic and prevent healthcare resource overload. Current diagnostic technologies for SARS-CoV-2 have drawbacks in terms of sensitivity, usability, and costs, making the tests unaffordable for most users at home. To address these limitations, a target-responsive CRISPR-PGM system has been proposed for translating SARS-CoV-2 detection into a glucose test, offering a potential single-device solution for monitoring multiple COVID-19 biomarkers at home.
Article
Hematology
Maxime Fieux, Renaud Rovera, Evelyne Colomb, Nathalie Enjolras, Emilie Bequignon, Claire Monge, Sandra Le Quellec
Summary: This study demonstrated that intranasal delivery of rFIX and rFIX-Fc is a promising alternative to intravenous infusion for the treatment of hemophilia B, as both forms of the drug were effectively transported to the blood compartment through a passive mechanism across the mucosal barrier, regardless of the mouse strain studied.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Ophthalmology
Prema Padmanabhan, Bernardo T. Lopes, Ashkan Eliasy, Ahmed Abass, Ahmed Elsheikh
Summary: This study assessed the biomechanical deterioration caused by keratoconus progression and found significant changes in corneal biomechanical parameters during the progression.
CURRENT EYE RESEARCH
(2022)
Article
Multidisciplinary Sciences
C. Russo, L. Wyld, M. Da Costa Aubreu, C. S. Bury, C. Heaton, L. M. Cole, S. Francese
Summary: Breast cancer is a major global health issue, affecting millions of women and causing a significant number of deaths each year. The current gold standard for screening and diagnosis, mammography, has limitations and may be culturally unacceptable for some women. A proof-of-concept study using proteomics and MALDI MS detection suggests the potential for a non-invasive technique using fingertip smears for early detection of breast cancer. Statistical analyses and machine learning approaches achieved high accuracy in categorizing MALDI MS spectra as either benign, early, or metastatic cancer classes. Further research into the use of sweat deposits for non-invasive breast cancer screening is warranted.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Jean-Philippe Deneuville, Maksym Yushchenko, Tanguy Vendeuvre, Arnaud Germaneau, Maxime Billot, Manuel Roulaud, Mathieu Sarracanie, Najat Salameh, Philippe Rigoard
Summary: The study aims to analyze morphological and biomechanical changes of the intervertebral disc structure and stress distribution using a quantitative MRI protocol combined with ex vivo sagittal loading, potentially offering new opportunities for non-invasive disc exploration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)