Article
Neurosciences
Amir Englund, Dominic Oliver, Edward Chesney, Lucy Chester, Jack Wilson, Simina Sovi, Andrea De Micheli, John Hodsoll, Paolo Fusar-Poli, John Strang, Robin M. Murray, Tom P. Freeman, Philip McGuire
Summary: As countries adopt more permissive cannabis policies, it is increasingly important to identify strategies that can reduce the harmful effects of cannabis use. This study aimed to determine if increasing the CBD content of cannabis can reduce its harmful effects. The results showed that increasing the CBD content did not reduce the harmful effects of cannabis on memory and psychotic symptoms. Therefore, CBD may not protect against the acute adverse effects of cannabis.
NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Morteza Abyadeh, Vivek Gupta, Joao A. Paulo, Veer Gupta, Nitin Chitranshi, Angela Godinez, Danit Saks, Mafruha Hasan, Ardeshir Amirkhani, Matthew McKay, Ghasem H. Salekdeh, Paul A. Haynes, Stuart L. Graham, Mehdi Mirzaei
Summary: This review discusses the therapeutic properties of cannabinoids found in cannabis for various diseases and the need for more research to understand the molecular and biochemical effects of cannabis at a cellular level. Proteomics technology is highlighted as an efficient tool to study the mechanistic effects of cannabis on the human body, drawing conclusions about its toxicity, therapeutic benefits, safety, and efficacy profiles.
Article
Pharmacology & Pharmacy
Samridhi Lal, Anusmita Shekher, Puneet, Acharan S. Narula, Heidi Abrahamse, Subash C. Gupta
Summary: Cannabis and its constituents have shown potential anticancer effects against various types of cancers, by modulating pathways such as PKB, AMPK, CAMKK-beta, mTOR, PDHK, HIF-l alpha, and PPAR-gamma. They can inhibit cell growth, progression of cell cycle, and induce apoptosis selectively in tumor cells, while also enhancing the efficacy of cancer therapeutics.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Plant Sciences
Ae Lim Kim, Young Jae Yun, Hyong Woo Choi, Chang-Hee Hong, Hyun Joo Shim, Jeong Hwan Lee, Young-Cheon Kim
Summary: In this study, the levels of various cannabinoids in different Cannabis cultivars were detected using different analytical methods, and a correlation between cannabinoid accumulation and gene expression levels was observed.
Article
Pharmacology & Pharmacy
Sarah S. Stith, Xiaoxue Li, Franco Brockelman, Keenan Keeling, Branden Hall, Jacob M. Vigil
Summary: This study measured the associations between feeling high and treatment outcomes during cannabis consumption. The results showed that feeling high was associated with symptom relief but increased negative side effects. Factors such as plant phenotype, consumption mode, THC and CBD potencies, and dose influenced the intensity of feeling high for individual patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Food Science & Technology
Aurash J. Soroosh, Robin Henderson, Lori Dodson, Clifford S. Mitchell, Jed W. Fahey
Summary: Edible cannabis products (ECPs) made with food ingredients are vulnerable to contamination and pose potential health risks to consumers. Preventing accidental ingestion of ECPs is a major concern for public health professionals, who can benefit from adopting best practices and safety measures from the regulatory landscape in the United States to safeguard public health.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Plant Sciences
Kenneth J. Olejar, Sang-Hyuck Park
Summary: Cross-pollination in the cannabis industry has been a topic of concern, with fears that low THC hemp may become high in THC if pollinated by high THC cannabis. However, the article highlights that there are multiple factors that contribute to THC levels, debunking the misconception that cross-pollination alone leads to increased THC in hemp crops.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Medicine, General & Internal
Francesco Bartoli, Ilaria Riboldi, Bianca Bachi, Angela Calabrese, Federico Moretti, Cristina Crocamo, Giuseppe Carra
Summary: CBD may attenuate psychotic-like symptoms induced by THC in healthy volunteers and positive symptoms in individuals with schizophrenia. Preliminary data on the efficacy of CBD for cannabis use disorders show mixed findings. Evidence from ongoing clinical studies will provide insight into the possible role of CBD for treating psychotic and cannabis use disorders.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Behavioral Sciences
Claire Wang, Simon Erridge, Carl Holvey, Ross Coomber, Azfer Usmani, Mohammed Sajad, Rahul Guru, Wendy Holden, James J. Rucker, Michael W. Platt, Mikael H. Sodergren
Summary: This study analyzed the changes in health-related quality of life and adverse events in patients with fibromyalgia treated with cannabis-based medicinal products (CBMPs). The results showed that CBMP treatment improved fibromyalgia-specific symptoms, sleep, anxiety, and overall quality of life, with good tolerability.
BRAIN AND BEHAVIOR
(2023)
Article
Plant Sciences
Michihito Deguchi, Seema Dhir, Shobha Potlakayala, Sarwan Dhir, Wayne R. Curtis, Sairam Rudrabhatla
Summary: This study successfully altered the composition of cannabinoids in hemp by utilizing the vacuum agroinfiltration method. Overexpressing CBDAS gene and silencing THCAS gene led to a significant increase in total CBD content and a reduction in total THC content. This provides strong evidence for metabolic engineering of cannabinoids in hemp.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Albert Garcia-Romeu, Joshua Elmore, Rhiannon E. Mayhugh, Nicolas J. Schlienz, Erin L. Martin, Justin C. Strickland, Marcel Bonn-Miller, Heather Jackson, Ryan Vandrey
Summary: Medicinal cannabis users perceive benefits from cannabis use for various conditions where traditional treatments are ineffective or unacceptable. However, concerns about cannabis side effects, legality, lack of information, and cost exist. More research and education on the safety and efficacy of medicinal cannabis/cannabinoid use are warranted.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychiatry
Erin L. Martin, Justin C. Strickland, Nicolas J. Schlienz, Joel Munson, Heather Jackson, Marcel O. Bonn-Miller, Ryan Vandrey
Summary: This study found that medicinal cannabis use was associated with lower depression symptoms, but not anxiety. Medicinal cannabis users reported better sleep, quality of life, and less pain on average. Initiating medicinal cannabis during the follow-up period was linked to significantly decreased anxiety and depressive symptoms.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Gastroenterology & Hepatology
Sarah S. Stith, Xiaoxue Li, Joaquin Orozco, Victoria Lopez, Franco Brockelman, Keenan Keeling, Branden Hall, Jacob M. Vigil
Summary: By studying 2220 cannabis self-administration sessions completed by 886 individuals, it was found that the majority of patients can experience relief from nausea within a short period of time, but the characteristics of cannabis products consumed can affect the level of antiemetic effect. Future research should focus on long-term symptom relief, risks of medical cannabis consumption, and potential interactions with other medications and substances.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Review
Agriculture, Dairy & Animal Science
Nancy De Briyne, Danny Holmes, Ian Sandler, Enid Stiles, Dharati Szymanski, Sarah Moody, Stephan Neumann, Arturo Anadon
Summary: The increasing availability of cannabis-derived products has led to more cases of toxicosis in pets seen by veterinarians, with a growing interest among animal owners for using these products for their pets. This review examines the situation in Europe and North America, different types of cannabis and its derivatives used historically in animals, the regulatory framework for human and animal use as medicines or supplements, clinical indications, toxicosis, and recommendations and warnings surrounding medical cannabis use.
Article
Food Science & Technology
Wiwit Suttithumsatid, Muhammad Ajmal Shah, Shabana Bibi, Pharkphoom Panichayupakaranant
Summary: This study found that standardized cannabinoid extracts have greater potential than CBD and THC in inhibiting alpha-glucosidase, with good pharmacokinetic profiles and low toxicity.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)