Article
Environmental Sciences
Leny Mathew, Nathaniel W. Snyder, Kristen Lyall, Brian K. Lee, Leslie A. McClure, Amy J. Elliott, Craig J. Newschaffer
Summary: The study measured phthalate metabolites in urine and meconium samples from a population at high risk for neurodevelopmental disorders, finding that most metabolites were present in both samples but with low correlation. The distribution of metabolites in urine was similar between T2 and T3, and correlations between the same metabolites in urine and meconium varied by trimester.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Obstetrics & Gynecology
Marcela C. Smid, Amanda A. Allshouse, Gwendolyn A. McMillin, Kendyl Nunez, Tyler Cavin, Joseph Worden, Karen Buchi, Bhanu Muniyappa, Michael W. Varner, Gerald Cochran, Torri D. Metz
Summary: This study estimated the statewide prenatal substance exposure based on umbilical cord sampling and compared the prevalence of exposure across different regions. The results showed that nearly 10% of births statewide had prenatal substance exposure, with opioids being the most common, followed by cannabinoids, amphetamines, benzodiazepines, alcohol, and cocaine. The prevalence of exposure did not differ significantly by region or substance type.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Biology
Pilar Jarque, Antonia Roca, Isabel Gomila, Emilia Marchei, Roberta Tittarelli, Miguel Angel Elorza, Pilar Sanchis, Bernardino Barcelo
Summary: Through studying 372 mothers, it was found that maternal characteristics such as age < 24 years, lack of pregnancy care, single-mother families, and active tobacco smoking were major indicators of maternal substance use during pregnancy. These profiles can help in identifying newborns exposed to psychoactive drugs.
Article
Chemistry, Analytical
Emilia Marchei, Maria Concetta Rotolo, Giulio Mannocchi, Angelica Capomassi, Larissa-Maria Gomez-Ruiz, Aracely Acosta-Lopez, Ruth-Yesica Ramos-Gutierrez, Mary-Buhya Varela-Busaka, Simona Pichini, Oscar Garcia-Algar
Summary: Substance use in pregnancy is a global public health problem, and hair analysis can objectively assess maternal consumption of substances, which is important for assessing the risk of fetal exposure to toxic substances.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Review
Biochemistry & Molecular Biology
Aniela Golub, Michal Ordak, Tadeusz Nasierowski, Magdalena Bujalska-Zadrozny
Summary: The effectiveness of pharmacotherapy in patients abusing new psychoactive substances (NPSs) is enhanced by proper liver function. However, current articles on NPS hepatotoxicity only focus on non-specific liver parameters. This study reviews three advanced markers of hepatotoxicity, osteopontin (OPN), high-mobility group box 1 protein (HMGB1), and glutathione dehydrogenase (GDH/ GLDH), to identify recommendations for future studies on NPS abusers. Determining the hepatotoxic effects of NPSs and distinguishing them from other factors such as additional substances and hepatitis C virus (HCV) infection is crucial, particularly due to the heightened risk of HCV infection in NPS abusers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Zorimar Rivera-Nunez, Carolyn W. Kinkade, Leena Khoury, Jessica Brunner, Hannah Murphy, Christina Wang, Kurunthachalam Kannan, Richard K. Miller, Thomas G. O'Connor, Emily S. Barrett
Summary: The study found that maternal serum levels of poly- and perfluoroalkyl substances (PFAS) are associated with sex steroid hormone levels during pregnancy. Specifically, PFHxS is associated with increased testosterone levels in male fetuses, while PFNA and PFDA are associated with increased free testosterone levels in male fetuses. For female fetuses, PFHxS is associated with increased levels of estradiol and estriol. No associations were found for PFOS and PFOA.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Zorimar Rivera-Nunez, Megan Hansel, Camila Capurro, Danielle Kozlosky, Christina Wang, Cathleen L. Doherty, Brian Buckley, Pamela Ohman-Strickland, Richard K. Miller, Thomas G. O'Connor, Lauren M. Aleksunes, Emily S. Barrett
Summary: This study found that cadmium exposure during pregnancy may lead to lower testosterone levels in pregnant women, while estrogen levels remain unchanged. This effect may be stronger in pregnancies carrying female fetuses. Further research is needed to understand how alterations in gestational testosterone activity may impact pregnancy and child health.
Article
Environmental Sciences
Stephanie M. Eick, Dana E. Goin, Jessica Trowbridge, Lara Cushing, Sabrina Crispo Smith, June-Soo Park, Erin DeMicco, Amy M. Padula, Tracey J. Woodruff, Rachel Morello-Frosch
Summary: This study suggests that consumption of animal products during pregnancy may contribute to elevated prenatal PFAS levels.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Michelle Z. L. Kee, Ai Ling Teh, Andrew Clappison, Irina Pokhvisneva, Julie L. MacIssac, David T. S. Lin, Katia E. Ramadori, Birit F. P. Broekman, Helen Chen, Mary Lourdes Daniel, Neerja Karnani, Michael S. Kobor, Peter D. Gluckman, Yap Seng Chong, Jonathan Y. Huang, Michael J. Meaney
Summary: This study found an association between prenatal maternal depressive symptoms and inter-individual genome-wide DNA methylation, specifically in mothers carrying female fetuses. It also revealed sex-dependent associations with depression-related genes and signaling pathways, suggesting the potential role of maternal-fetal interactions in intergenerational transmission.
Article
Multidisciplinary Sciences
Kaitlin R. Taibl, Anne L. Dunlop, Dana Boyd Barr, Yuan-Yuan Li, Stephanie M. Eick, Kurunthachalam Kannan, P. Barry Ryan, Madison Schroder, Blake Rushing, Timothy Fennell, Che-Jung Chang, Youran Tan, Carmen J. Marsit, Dean P. Jones, Donghai Liang
Summary: This study investigated the impact of PFAS exposure on birth outcomes in an African American population in Atlanta. The findings suggest that higher concentrations of certain PFAS chemicals increase the risk of early birth and identified specific metabolic pathways and metabolites associated with reduced gestational age. These findings provide insights into the mechanisms linking PFAS exposure to adverse birth outcomes.
NATURE COMMUNICATIONS
(2023)
Article
Environmental Sciences
Yuhan Zhou, Qiang Li, Pengpeng Wang, Jinhong Li, Wenxuan Zhao, Liyi Zhang, Hang Wang, Yukai Cheng, Huijing Shi, Jiufeng Li, Yunhui Zhang
Summary: This study found that maternal exposure to PFAS during pregnancy can negatively affect infant neurodevelopment trajectories. The study also found that PFOS is the main PFAS associated with communication development in children, and gender differences exist in these associations.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Jennifer Ames, Mohamad A. Burjak, Lyndsay M. Avalos, Joseph M. Braun, Catherine A. Bulka, Lisa L. Croen, Anne Dunlop, Assiamira C. Ferrara, Rebecca M. Fry, Monique R. Hedderson, Margaret Karagas, Donghai Liang, Pi-I D. Lin, Kristen Lyall, Brianna Moore, Rachel G. Morello-Frosch, Thomas O'Connor, Jiwon M. Oh, Amy J. Padula, Tracey Woodruff, Yeyi B. Zhu, Ghassan Hamra
Summary: This study investigated the association between prenatal blood concentrations of per- and polyfluoroalkyl substances (PFAS) and autism-related outcomes in children. The majority of PFAS in maternal blood were not associated with child autism-related traits, except for perfluorononanoic acid (PFNA) which showed a modest increase in autism-related traits. These findings suggest the need for further research on the relationship between exposure to PFAS and autism-related outcomes in children.
Article
Environmental Sciences
Janina Maschke, Jakob Roetner, Sophia Boesl, Anne-Christine Plank, Nicolas Rohleder, Tamme W. Goecke, Peter A. Fasching, Matthias W. Beckmann, Oliver Kratz, Gunther H. Moll, Bernd Lenz, Johannes Kornhuber, Anna Eichler
Summary: Adolescents with prenatal alcohol exposure are at risk for low-grade systemic inflammation, with the EtG biomarker potentially being more accurate than self-reports. Prenatal maternal depression does not seem to evoke low-grade systemic inflammation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Atakan Hernandez, Valerie Lacroze, Natalia Doudka, Jenny Becam, Carole Pourriere-Fabiani, Bruno Lacarelle, Caroline Solas, Nicolas Fabresse
Summary: The aim of this study was to develop and validate a toxicological untargeted screening method using LC-HRMS to detect drugs of abuse in meconium. The method was applied to real samples and showed good performance and accuracy.
Article
Environmental Sciences
Teresa Durham, Jia Guo, Whitney Cowell, Kylie W. Riley, Shuang Wang, Deliang Tang, Frederica Perera, Julie B. Herbstman
Summary: This study analyzed the association between prenatal PM2.5 exposure and relative leukocyte telomere length (TL) in mothers and newborns. The results showed a negative relationship between prenatal PM2.5 exposure and TL in both mothers and newborns, particularly in the second trimester.
Article
Clinical Neurology
Sandrine Lamy, Estelle Houivet, Jacques Benichou, Stephane Marret, Florence Thibaut
Summary: The study found a relationship between caffeine intake during pregnancy and reduced birth length, but this effect was no longer significant after adjusting for potential confounding variables.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Benedicte Sudrie-Arnaud, Sarah Snanoudj, Ivana Dabaj, Helene Dranguet, Lenaig Abily-Donval, Axel Lebas, Myriam Vezain, Benedicte Heron, Isabelle Marie, Marc Duval-Arnould, Stephane Marret, Abdellah Tebani, Soumeya Bekri
Summary: Diagnosis of lysosomal disorders can be challenging due to their clinical heterogeneity and overlapping phenotypes. A newly developed capture-based NGS panel allows for efficient detection of genetic variations associated with LDs, potentially improving diagnostic speed and accuracy. This advanced sequencing approach, combined with bioinformatics analyses, offers a cost-effective method for identifying causative variants in lysosomal disorders.
Article
Biology
Ivana Dabaj, Benedicte Sudrie-Arnaud, Francois Lecoquierre, Kimiyo Raymond, Franklin Ducatez, Anne-Marie Guerrot, Sarah Snanoudj, Sophie Coutant, Pascale Saugier-Veber, Stephane Marret, Gael Nicolas, Abdellah Tebani, Soumeya Bekri
Summary: NGLY1 deficiency is an autosomal recessive disorder characterized by developmental delay, acquired microcephaly, hypotonia and other clinical features. Diagnosis is often made through genetic testing and biochemical analysis.
Article
Biochemistry & Molecular Biology
Berenice Le Dieu-Lugon, Nicolas Dupre, Celine Derambure, Francois Janin, Bruno J. Gonzalez, Stephane Marret, Arnaud Arabo, Philippe Leroux
Summary: MgSO4 is widely used in preventing neurological disabilities in preterm infants, mainly by suppressing synaptogenesis and axonal development to reduce inflammation and innate immune responses. Additionally, MgSO4 affects neural development by inhibiting RNA polymerase II transcription and regulating mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Veronique Pierrat, Laetitia Marchand-Martin, Stephane Marret, Catherine Arnaud, Valerie Benhammou, Gilles Cambonie, Thierry Debillon, Marie-Noelle Dufourg, Catherine Gire, Francois Goffinet, Monique Kaminski, Alexandre Lapillonne, Andrei Scott Morgan, Jean-Christophe Roze, Sabrina Twilhaar, Marie-Aline Charles, Pierre-Wes Ancel
Summary: This study aimed to describe neurodevelopment at age 5 among children born preterm. The results showed that rates of neurodevelopment disabilities increased as gestational age decreased and were higher in families with low socioeconomic status. The findings indicate that early interventions and support are crucial for preterm children to optimize their development outcomes.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Biochemical Research Methods
Thomas Gicquel, Romain Pelletier, Camille Richeval, Alexandr Gish, Florian Hakim, Pierre-Jean Ferron, Vadim Mesli, Delphine Allorge, Isabelle Morel, Jean-michel Gaulier
Summary: This study investigated the metabolites of 2-fluoro-deschloroketamine (2F-DCK) using in vitro experimental approaches and molecular networking to compare results. Thirteen metabolites were produced in vitro with additional seven metabolites found in post-mortem samples. The HLMs and HepaRG cell models were complementary in identifying specific 2F-DCK metabolites, with nor-2F-DCK and a hydrogenated metabolite proposed as reliable markers for detection in HRMS libraries.
DRUG TESTING AND ANALYSIS
(2022)
Article
Pharmacology & Pharmacy
Alexandr Gish, Veronique Dumestre-Toulet, Camille Richeval, Jean-Francois Wiart, Florian Hakim, Delphine Allorge, Jean-Michel Gaulier
Summary: This study reports the pharmaceutical design of new psychoactive substances (NPS) detected in oral fluid from drivers during a music festival in 2019. The results show an increase in the proportion of synthetic cannabinoids and cathinone derivatives, and a decrease in cyclohexanones.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Pharmacology & Pharmacy
Sixtine Gilliot, Anne-Sophie Ducloy-Bouthors, Florence Loingeville, Benjamin Hennart, Delphine Allorge, Gilles Lebuffe, Pascal Odou
Summary: The aim of this study was to evaluate the population pharmacokinetics of tranexamic acid (TXA) in parturients undergoing active hemorrhagic cesarean delivery. The study found a correlation between estimated creatinine clearance and TXA pharmacokinetics and successfully developed a pharmacokinetic model for TXA in active hemorrhagic cesarean delivery.
Review
Medicine, General & Internal
Ivana Dabaj, Adnan Hassani, Lydie Burglen, Leila Qebibo, Anne-Marie Guerrot, Stephane Marret, Abdellah Tebani, Soumeya Bekri
Summary: Pontocerebellar hypoplasia (PCH) is a neurodegenerative disorder that leads to severe neurodevelopmental disabilities. This study reports a case of PCH1D in an infant with two variants in the EXOSC9 gene and highlights the crucial role of the exosome in cellular homeostasis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Sanaa M. Aly, Ahmed Omran, Jean-Michel Gaulier, Delphine Allorge
Summary: Research on adolescent substance use is crucial for designing effective prevention programs. A study conducted in France found that illicit substances, alcohol, and prescription substances were commonly used among adolescents, and nearly one-third of deaths were attributed to substance use.
Article
Biochemistry & Molecular Biology
Lou Legouez, Berenice Le Dieu-Lugon, Sherine Feillet, Gaetan Riou, Melissa Yeddou, Thibault Plouchart, Nathalie Dourmap, Marie-Anne Le Ray, Stephane Marret, Bruno J. Gonzalez, Carine Cleren
Summary: Cerebral palsy is a permanent disorder of movement and posture, with prematurity and hypoxia-ischemia being risk factors and boys being more vulnerable. The combination of magnesium sulfate and 4-phenylbutyrate can extend the neuroprotective effects and improve motor and cognitive deficits caused by hypoxia-ischemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Catherine Gire, Ninon Fournier, Johanna Pirrello, Stephane Marret, Hugues Patural, Cyril Flamant, Veronique Pierrat, Monique Kaminski, Pierre-Yves Ancel, Barthelemy Tosello, Julie Berbis
Summary: This study examined the relationship between hemoglobin levels in very preterm infants within the first 24 hours of birth and the neurodevelopment outcomes at 24 months of corrected age. The results showed that early low hemoglobin levels were associated with major neonatal morbidities but not with neurodevelopment outcomes at two years of age, except in male infants born at gestational age of more than 26 weeks.
Article
Behavioral Sciences
Joaquin Fuentes, Mara Parellada, Christina Georgoula, Guiomar Oliveira, Stephane Marret, Veronique Crutel, Cristina Albarran, Estelle Lambert, Pierre-Francois Penelaud, Denis Ravel, Yehezkel Ben Ari
Summary: The efficacy and safety of bumetanide oral solution for the treatment of autism spectrum disorder (ASD) in children and adolescents was evaluated in two international, multi-center, randomized, double-blind, placebo-controlled phase III trials. The results showed that bumetanide did not demonstrate a significant benefit compared to placebo in the overall studied populations. The sponsor has discontinued the development of bumetanide for the treatment of pediatric ASD.
Article
Medicine, Legal
Sanaa M. Aly, Alexandr Gish, Florian Hakim, Douniazad Guelmi, Vadim Mesli, Valery Hedouin, Delphine Allorge, Jean-michel Gaulier
Summary: This study aims to demonstrate the potential of entomological samples as complementary matrices for toxicological analysis in cases of advanced putrefaction. Two cases were presented to highlight the usefulness of analyzing pupae and flies in identifying substances and determining possible causes of death. The results from these analyses complemented the findings from other biological samples.
Article
Biochemical Research Methods
Jennifer Lagoutte-Renosi, Camille Richeval, Melodie Phanithavong, Jean-Francois Wiart, Eugenie Castex, Xavier Vanhoy, Florian Hakim, Sylvie Deheul, Juliana Tournebize, Delphine Allorge, Jean-Michel Gaulier
DRUG TESTING AND ANALYSIS
(2021)
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)