Article
Polymer Science
Jixiang Ni, Matteo Lanzi, David H. Lamparelli, Arjan W. Kleij
Summary: A series of bicyclic carbonates with different functionalities have been prepared through various chemical reactions, which can be polymerized to obtain polycarbonates with diverse properties. This method provides an effective approach to synthesize functional polymer materials.
Review
Chemistry, Physical
Claire A. L. Lidston, Sarah M. Severson, Brooks A. Abel, Geoffrey W. Coates
Summary: The ring-opening copolymerization (ROCOP) of epoxides with CO2 or cyclic anhydrides using multifunctional catalysts has been explored as a versatile route for synthesizing a wide range of polycarbonate and polyester copolymers. Covalently tethering the Lewis acid catalyst and cocatalyst together has been shown to increase both catalyst activity and selectivity in epoxide ROCOP. This review examines the development of multifunctional catalysts for copolymerization of epoxides with CO2, cyclic anhydrides, carbonyl sulfide (COS), and cyclic thioanhydrides, and evaluates how the mechanisms of these catalysts lead to improved activity and selectivity in ROCOP.
Review
Chemistry, Multidisciplinary
Alex J. Plajer, Charlotte K. Williams
Summary: Heteroatom-containing polymers have potential as sustainable replacements for petrochemicals, offering a wide range of properties for various applications. Catalysed ring-opening copolymerisation (ROCOP) provides a route to create precise new polymer structures, leading to a renaissance in research and commercial products.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Polymer Science
Jin Huang, Peter Diner, Vincent Nieboer, Peter Olsen, Karin Odelius
Summary: A combined experimental and theoretical investigation reveals mechanistic differences in the ring-opening polymerization behavior of macrocyclic carbonates. Factors such as ring size, thermodynamic stability of conformer, and stability of transition state affect the polymerization rate.
Article
Chemistry, Multidisciplinary
David K. Tran, Ashley N. Braaksma, Autumn M. Andras, Senthil K. Boopathi, Donald J. Darensbourg, Karen L. Wooley
Summary: This study aims to utilize copolymerizations of carbohydrates with C1 feedstocks to produce polymers. The incorporation of sulfur atoms through the establishment of monothiocarbonates allows for modulating the backbone composition and resulting in unique effects on the properties of the polymer. These findings contribute to the advancement of sustainable polymer production.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Polymer Science
Ilya Nifant'ev, Andrey Shlyakhtin, Vladimir Bagrov, Evgeny Shaputkin, Alexander Tavtorkin, Pavel Ivchenko
Summary: The study found that the acyl chlorides derived from NHS and MI can efficiently terminate the living ring-opening polymerization of aliphatic polyesters, producing NHS- and MI-functionalized polymers with high yields. These polymers exhibit high reactivity towards amine- and thiol-containing model substrates in both organic and aqueous media.
Article
Polymer Science
KaitlinR. Albanese, Yoichi Okayama, Parker T. Morris, Matthias Gerst, Rohini Gupta, Joshua C. Speros, Craig J. Hawker, Chungryong Choi, Javier Read de Alaniz, Christopher M. Bates
Summary: We report a strategy to create degradable poly(acrylate) pressure-sensitive adhesives (PSAs) using 1,2-dithiolanes as drop-in replacements for traditional acrylate comonomers. The resulting PSA materials have comparable thermal and viscoelastic properties to nondegradable analogues, but can undergo reversible transformation between high and low molecular weights through oxidative repolymerization and reductive degradation. This simple and versatile chemistry could play a pivotal role in improving the sustainability of contemporary adhesives.
Article
Polymer Science
Grazyna Adamus, Adrian Dominski, Marek Kowalczuk, Piotr Kurcok, Iza Radecka
Summary: This study presents the feasibility of synthesizing functionalized poly(3-hydroxybutanoic acid) analogues and its copolymers via ring-opening polymerization of beta-butyrolactone mediated by activated anionic initiators. Polyesters with defined chemical structures of end groups, block, graft, and random copolymers were obtained and characterized using modern instrumental techniques, with a focus on ESI-MS. The relationship between the structure and properties of the prepared polymeric materials was also discussed.
Review
Chemistry, Multidisciplinary
Xiaoqian Wang, Ziyu Huo, Xiaoyu Xie, Narasimhamurthy Shanaiah, Rong Tong
Summary: The demand to replace unsustainable polyolefins drives the transformation of renewable resources into functional and degradable polymers. However, the properties of many degradable homopolymers are inferior to commodity polyolefins, limiting their utility. One-pot synthesis of sequence-defined copolymers from cyclic monomer mixtures is attractive in terms of concept and economics, as it maximizes materials usage and improves polymer performance. Recent advances in one-pot, sequence-controlled polymerizations of cyclic monomer mixtures using a single catalytic system that combines multiple catalytic cycles are highlighted, including the scopes of cyclic monomers, catalysts, and polymerization mechanisms.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Polymer Science
Raita Goseki, Shogo Miyai, Satoshi Uchida, Takashi Ishizone
Summary: The study evaluated the polymerizability of novel exomethylene monomers based on an adamantyl skeleton under anionic, cationic, and radical conditions. It was found that 2-methyleneadamantane (MAd) formed dimeric compounds predominantly due to beta-hydrogen elimination, while 2-allylideneadamantane (AAd) polymerized successfully under all conditions, with anionic polymerization producing high-quality polymer with a specific microstructure.
Article
Polymer Science
Jieni Hu, Chuanhao Sun, Siqi Li, Yuan Yuan, Yan Zhang
Summary: A facile one-step ring-closure methodology was established to obtain a novel macrocyclic tellurocarbonate series, which was further used to develop well-defined poly(telluride-carbonate)s through one-pot organocatalytic ring-opening polymerization. This work provides a strategy for utilizing heterotellurium macrocarbonates as feedstocks in polymer synthesis of degradable tellurium-containing materials.
Article
Chemistry, Multidisciplinary
Taeyang An, Hanseul Ryu, Tae-Lim Choi
Summary: This study presents a versatile approach to improve the alternation and degradability of 2,3-dihydrofuran (DHF) copolymers by carefully controlling the reactivity of both the Ru initiators and the monomers. The DHF copolymers showed outstanding A, B-alternation and could be broken down to a single repeat unit level under acidic conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Xue Liang, Fei Tan, Yunqing Zhu
Summary: The biomedical applications of polyesters and polycarbonates hold great potential but face challenges, with ring-opening copolymerization offering new possibilities to overcome these challenges, while advancements in catalyst development and post-polymerization modification methods have also been made in this field.
FRONTIERS IN CHEMISTRY
(2021)
Review
Polymer Science
Jianqun Wang, Youhua Tao
Summary: The review highlights the use of various catalysts, especially metal-based catalysts, for controlled ROP of OCAs. It also summarizes recent progress on the organocatalytic ROP of OCAs and discusses the future development of this method for sustainable polyester synthesis.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Molin Wang, Enhao Wang, Han Cao, Shunjie Liu, Xianhong Wang, Fosong Wang
Summary: By immortal copolymerization of CO2 and oligoethylene glycol monomethyl ether-functionalized epoxides, a fluorescence signal self-reporting biodegradable thermoresponsive polycarbonates was developed. The temperature-dependent fluorescence intensity study revealed the details of its thermal-induced phase transition.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Engineering, Biomedical
Krzysztof Pietryga, Katarzyna Reczynska-Kolman, Janne E. Reseland, Havard Haugen, Veronique Larreta-Garde, Elzbieta Pamula
Summary: Biphasic monolithic materials were produced from polysaccharide hydrogel by enzymatic mineralization. The distribution of calcium phosphate mineral phase was achieved by limiting the availability of calcium glycerophosphate to specific parts of the hydrogel sample. The formation of CaP was confirmed by spectroscopy and mapping techniques.
BIOCYBERNETICS AND BIOMEDICAL ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Gaelle Desante, Iwona Pudelko, Malgorzata Krok-Borkowicz, Elzbieta Pamula, Philipp Jacobs, Alicja Kazek-Kesik, Jonas Niessen, Rainer Telle, Jesus Gonzalez-Julian, Karolina Schickle
Summary: This study proposes a novel biomimetic calcium phosphate (CaP) coating decorated with antibiotic-loaded nanoparticles on inert ceramic implants to enhance bioactivity and provide antibacterial effect. The coprecipitation method was found to achieve a favorable and homogenous distribution of nanoparticles within the CaP coating. The coating, consisting of hydroxyapatite and octacalcium phosphate, showed controlled release of antibiotics and inhibited the growth of bacteria.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Anna Smola-Dmochowska, Kamila Lewicka, Alicja Macyk, Piotr Rychter, Elzbieta Pamula, Piotr Dobrzynski
Summary: Antibiotic resistance is a major global health and food security threat. The development of new antimicrobial therapeutics and antibacterial packaging materials is crucial for preventing and treating infectious diseases. This review highlights the significant research activities conducted in recent years in the field of polymeric materials and polymer composites with antibacterial properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Iwona Pudelko, Anna Moskwik, Konrad Kwiecien, Sven Kriegseis, Malgorzata Krok-Borkowicz, Karolina Schickle, Dorota Ochonska, Piotr Dobrzynski, Monika Brzychczy-Wloch, Jesus Gonzalez-Julian, Elzbieta Pamula
Summary: Implant-related infections are a global challenge, and new solutions are being investigated to overcome conventional therapy failures. In this study, porous zirconia scaffolds were manufactured and coated with antibiotic-loaded polymer nanoparticles to enhance bioactivity and achieve antibacterial effects. The scaffolds exhibited high encapsulation efficiency and drug loading, and showed excellent cytocompatibility and antimicrobial properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Natalia Smigiel-Gac, Anna Smola-Dmochowska, Henryk Janeczek, Piotr Dobrzynski
Summary: The article presents the synthesis and characteristics of amphiphilic block terpolymers consisting of a hydrophilic polyesteramine block and hydrophobic blocks made of lactidyl and glycolidyl units. These terpolymers were obtained through copolymerization of L-lactide with glycolide using macroinitiators with protected amine and hydroxyl groups. The terpolymers were designed to have biodegradability, biocompatibility, antibacterial properties, and high surface wettability by water. The properties of the terpolymers, such as molecular mass, contact angle, crystallinity, and melting behavior, were evaluated using various tests.
Article
Chemistry, Applied
Agnieszka Kumorkiewicz-Jamro, Renata Gorska, Malgorzata Krok-Borkowicz, Katarzyna Reczynska-Kolman, Przemyslaw Mielczarek, Lukasz Popenda, Aneta Sporna-Kucab, Anna Tekieli, Elzbieta Pamula, Slawomir Wybraniec
Summary: Atriplex hortensis var. rubra L. extracts from different parts of the plant were analyzed for betalainic profiles and showed strong antioxidant activity. Celosianin and amaranthin were identified as the most potent compounds. The chemical structure of celosianin was elucidated for the first time. Furthermore, the extracts and purified pigments did not induce cytotoxicity and effectively protected cells from oxidative stress-induced cell death and apoptosis.
Article
Biochemistry & Molecular Biology
Marcin Magacz, Sergio Alatorre-Santamaria, Karolina Kedziora, Kacper Klasa, Pawel Mamica, Wiktoria Pepasinska, Magdalena Lebiecka, Dorota Koscielniak, Elzbieta Pamula, Wirginia Krzysciak
Summary: The LPO system has potential in preventing dental caries by exhibiting antimicrobial properties. Modifying the enzymatic system using different substrates showed varying effects on biofilm growth and lactate synthesis. The LPO-iodide system had the strongest inhibitory effect on biofilm growth, while the LPO-selenocyanate system showed a moderate inhibitory effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Biomaterials
Karolina Knap, Katarzyna Reczynska-Kolman, Konrad Kwiecien, Daria Niewolik, Joanna Plonka, Dorota Ochonska, Piotr Jelen, Przemyslaw Mielczarek, Alicja Kazek-Kesik, Katarzyna Jaszcz, Monika Brzychczy-Wloch, Elzbieta Pamula
Summary: This article presents the development of degradable poly(sebacic acid) (PSA) microparticles loaded with azithromycin (AZ) as a potential powder formulation for localized delivery to the lungs in patients with cystic fibrosis and chronic obstructive pulmonary disease. The microparticles demonstrate appropriate physicochemical properties, controlled degradation and drug release, cytocompatibility, and antibacterial behavior, making them promising for the local treatment of lung infections.
BIOMATERIALS ADVANCES
(2023)
Article
Materials Science, Coatings & Films
Alicja Kazek-Kesik, Weronika Maciak, Joanna Kosczielny, Malgorzata Krok-Borkowicz, Katarzyna Reczy, Sebastian Student, Monika Smiga-Matuszowicz, Elzbieta Pamu, Wojciech Simka
Summary: Titanium dental implants were anodized and covered with a poly(sebacic anhydride) (PSBA) layer containing amoxicillin to achieve a porous and bioactive surface. The released concentration of amoxicillin was sufficient to inhibit bacterial growth and reduce bacteria adhesion to the implant surface.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Konrad Kwiecien, Monika Brzychczy-Wloch, Elzbieta Pamula
Summary: Resistance to antibiotics is a major threat to humanity. Various targeted drug delivery systems, such as biopolymeric micro- or nanoparticles, electrospun nanofibers, or self-emulsifying drug delivery systems, are being explored to reduce antibiotic usage. One approach is to modify the chemical character of hydrophilic antibiotics using ion pairing with cationic or ionic surfactants, enhancing encapsulation efficiency and providing sustainable release. However, the presence of surfactants may increase toxicity, and the mechanisms behind improved antibacterial properties are not fully understood.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2023)
Meeting Abstract
Cell & Tissue Engineering
Agata Flis, Konrad Kwiecien, Izabela Misiolek, Filip Koper, Tomasz Swiergosz, Wiktor Kasprzyk, Elzbieta Pamula
TISSUE ENGINEERING PART A
(2023)
Article
Polymer Science
Klaudia Ordon, Piotr Szatkowski, Wojciech Piekarczyk, Elzbieta Pamula, Kinga Pielichowska
Summary: Novel polyurethane-based materials were synthesized using a two-step process with poly(epsilon-caprolactone) diol (PCL) and 1,3-propanediol/starch (PDO/ST) systems as chain extenders/cross-linkers. Poly(ethylene glycol)/starch (PEG/ST) system as a phase change material (PCM) decreased the maximum setting temperature, and hydroxyapatite (HAp) was used as a bioactive nanofiller. The synthesized polyurethanes showed good energy storage effect and potential application for bone cements.
Article
Polymer Science
Martyna Gawel, Patrycja Domalik-Pyzik, Timothy E. L. Douglas, Katarzyna Reczynska-Kolman, Elzbieta Pamula, Kinga Pielichowska
Summary: This study proposes and investigates new scaffolds based on whey protein isolate (WPI) and chitosan (CS) for osteochondral tissue repair. The optimal WPI/CS hydrogels were chosen based on various evaluation criteria, and it was found that the hydrogels with CS incorporated in powder form exhibited superior mechanical properties and those with CS incorporated after dissolution showed enhanced wettability. The introduction of CS powder promoted apatite formation and the CS powder modified WPI hydrogels showed good cytocompatibility, indicating their potential for osteochondral tissue repair.