Article
Biochemistry & Molecular Biology
Maria Knyrim, Sindy Rabe, Claudia Grossmann, Michael Gekle, Barbara Schreier
Summary: miR-221/222 in cardiomyocytes play a role in beta-adrenergic regulation of LTCC function, calcium handling, and beating frequency, leading to slower depolarization-dependent Ca2+ entry and increased proportion of non-responding cells. This study expands our knowledge about the role of these miRs in cardiac ion channel regulation.
CELL AND BIOSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Yingqiu Cui, Mario Kassmann, Sophie Nickel, Chenglin Zhang, Natalia Alenina, Yoland Marie Anistan, Johanna Schleifenbaum, Michael Bader, Donald G. Welsh, Yu Huang, Maik Gollasch
Summary: This study demonstrates that myogenic arterial constriction requires G(q/11)-dependent signaling pathways of mechanoactivated AT1R but not G protein-independent, noncanonical pathways in smooth muscle cells.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Neurosciences
Xianwei Zhang, Charlotte E. R. Smith, Stefano Morotti, Andrew G. Edwards, Daisuke Sato, William E. Louch, Haibo Ni, Eleonora Grandi
Summary: This study investigates the independent and interactive effects of TATS and Ca2+-handling protein remodelling on Ca2+-handling abnormality driven membrane instabilities. The results show that the impact of protein remodelling on Ca2+-driven proarrhythmic behaviour varies depending on TATS density.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Cardiac & Cardiovascular Systems
Drew Theobald, Anand R. Nair, Srinivas Sriramula, Joseph Francis
Summary: Toll-like receptor 4 (TLR4) plays a crucial role in the innate immune response and cardiovascular diseases. This study found that cardiomyocyte-specific deletion of TLR4 provides protection against hypertension, cardiac hypertrophy, and remodeling. The results showed that in mice with cardiomyocyte-specific TLR4 knockdown, angiotensin II-induced hypertension and cardiac hypertrophy were attenuated, myocardial fibrosis was reduced, and cardiac function was improved.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Xiangxiang Wei, Jiayu Jin, Jian Wu, Yunquan He, Jieyu Guo, Zhaohua Yang, Liang Chen, Kui Hu, Liliang Li, Mengping Jia, Qinhan Li, Xiaoyu Lv, Fei Ge, Siyu Ma, Huijie Wu, Xiuling Zhi, Xinhong Wang, Lindi Jiang, Elena Osto, Jianyi Zhang, Dan Meng
Summary: This research investigates the function and mechanisms of BACH1 in the regulation of cardiac hypertrophy. The study found that cardiac-specific knockout of BACH1 protected against cardiac hypertrophy induced by Ang II or TAC, while cardiac-specific overexpression of BACH1 exaggerated cardiac hypertrophy and fibrosis. Mechanistically, BACH1 regulated the AT1R expression and the Ca2+/CaMKII pathway to mediate cardiac hypertrophy.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Leonid Tyan, Daniel Turner, Karlie R. Komp, Roman Y. Medvedev, Evi Lim, Alexey Glukhov
Summary: This study reveals the association of Angiotensin II receptor 1 with caveolae and caveolar scaffolding protein caveolin-3 in mouse atrial myocytes, which is essential for the regulation of I-to by Angiotensin II. Downregulation of caveolae/caveolin-3 disrupts this regulation and may be implicated in pathophysiological atrial remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cell Biology
Huanhuan Wang, Ge Yang, Yuan Tian, Jinjie Li, Lingbin Meng, Xin Jiang, Ying Xin
Summary: Sulforaphane (SFN) prevents angiotensin II-induced cardiomyocyte apoptosis by activating Nrf2 and inhibiting HDACs, leading to increased histone H3 acetylation levels.
Article
Immunology
Jie Liao, Shaoshao Zhang, Shuaitao Yang, Yang Lu, Kai Lu, Yuwei Wu, Qiongfeng Wu, Ning Zhao, Qian Dong, Lei Chen, Yimei Du
Summary: IL-6 neutralization improved atrial inflammation and fibrosis, as well as atrial fibrillation susceptibility in ST rats, which is associated with Ca2+ handling abnormalities and RyR2 dysfunction.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura Amores-Bonet, Ralf Kleene, Thomas Theis, Melitta Schachner
Summary: The interaction between NCAM and TRPC1, -4, and -5 is important for the NCAM-stimulated and PSA-dependent Ca2+ entry into neurons, influencing essential neural functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Laura Kate Gadanec, Kristen Renee McSweeney, Peter Kubatka, Martin Caprnda, Ludovit Gaspar, Robert Prosecky, Jozef Dragasek, Peter Kruzliak, Vasso Apostolopoulos, Anthony Zulli
Summary: Abdominal aortic aneurysms (AAA) are caused by abnormal remodeling of the vascular wall and have different vasoactive responses to Angiotensin II (AngII). This study found that mouse arteries have different responses to AngII, with iliac arteries showing significantly higher vasoconstriction responses, which may play a role in AAA development.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Xujie Liu, Suya Wang, Xiaoling Guo, Yifei Li, Roza Ogurlu, Fujian Lu, Maksymilian Prondzynski, Sofia de la Serna Buzon, Qing Ma, Donghui Zhang, Gang Wang, Justin Cotton, Yuxuan Guo, Ling Xiao, David J. Milan, Yang Xu, Michael Schlame, Vassilios J. Bezzerides, William T. Pu
Summary: The study identified a molecular pathway linking TAZ mutation with abnormal Ca2+ handling and decreased cardiomyocyte contractility, offering potential therapeutic opportunities for treating Barth syndrome and other diseases with elevated mitochondrial reactive oxygen species production.
Article
Pharmacology & Pharmacy
Miyuki Kobara, Hiroe Toba, Tetsuo Nakata
Summary: Autophagy induced by angiotensin II helps to remove ROS-producing mitochondria, benefiting against myocyte apoptosis in the early phase but with limited benefit in the late phase of angiotensin II stimulation.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hawa Nordin Siti, Juriyati Jalil, Ahmad Yusof Asmadi, Yusof Kamisah
Summary: The study found that Parkia speciosa empty pod extract can protect against angiotensin II-induced cardiomyocyte hypertrophy by modulating the Ang II/reactive oxygen species/nitric oxide axis and mitogen-activated protein kinase signaling pathway, potentially through a mechanism distinct from valsartan.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Tlili Barhoumi, Fatmah A. Mansour, Maroua Jalouli, Hassan S. Alamri, Rizwan Ali, Abdel Halim Harrath, Maha Aljumaa, Mohamed Boudjelal
Summary: Angiotensin II (Ang II) is a key component of the renin-angiotensin-aldosterone system and is associated with cardiopathology. High levels of Ang II have been linked to inflammatory conditions such as coronary heart disease, obesity, and type 2 diabetes. This study evaluated the cellular effects of Ang II on THP-1-derived macrophages, showing that it stimulates differentiation markers and proinflammatory markers while decreasing an M2 marker. Ang II also induces calcium overload, increases reactive oxygen species, and arrests cells in the G1 phase, primarily through the angiotensin II type 1 receptor (AT1R).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Tassia S. R. da Costa, Ursula Urias, Marcelo Negrao, Camila P. Jordao, Clevia S. Passos, Igor L. Gomes-Santos, Vera Maria C. Salemi, Anamaria A. Camargo, Patricia C. Brum, Edilamar M. Oliveira, Ludhmila A. Hajjar, Roger Chammas, Roberto K. Filho, Carlos E. Negrao
Summary: Breast cancer patients have alterations in cardiac function and cardiomyocyte Ca2+-handling protein expression, leading to decreased exercise capacity and subclinical left ventricular dysfunction. Exercise training does not prevent or reverse these changes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Biochemistry & Molecular Biology
Yun Liu, Mengxue Wang, Yin Liang, Chen Wang, Keiji Naruse, Ken Takahashi
Summary: This article discusses the regulation of oxidative stress in coronary heart disease and the potential of exosomes as targeted carriers for endogenous ROS modulation. Exosomes have potential advantages and can serve as a new direction in the treatment of cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Multidisciplinary Sciences
Ken Takahashi, Hideyuki Takahashi, Takuya Furuichi, Masatsugu Toyota, Makoto Furutani-Seiki, Takeshi Kobayashi, Haruko Watanabe-Takano, Masahiro Shinohara, Takuro Numaga-Tomita, Asako Sakaue-Sawano, Atsushi Miyawaki, Keiji Naruse
Summary: Gravity determines the shape and functions of body tissues in plants and animals, and cellular response to gravity is an active process of mechanotransduction. Despite sharing common mechanisms, each species has its own way of sensing and responding to gravity. Understanding cellular responses to gravity is important not only for life on Earth, but also for laying the foundation for living in space in the age of Mars exploration.
Review
Biochemistry & Molecular Biology
Yin Liang, Mengxue Wang, Chen Wang, Yun Liu, Keiji Naruse, Ken Takahashi
Summary: Lifestyle changes can increase the risk of prediabetes, and the pathophysiology of atherosclerosis may progress even before the onset of diabetic symptoms. Changes in platelets and leukocytes, damage to vascular endothelial cells, as well as involvement of extracellular vesicles and microRNAs have been found to play a role in the progression of prediabetes atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Naoya Hirata, Shigeru Yamada, Shota Yanagida, Atsushi Ono, Yukuto Yasuhiko, Motohiro Nishida, Yasunari Kanda
Summary: This study identified the highly expressed LPA receptor 3 in ALDH-positive TNBC cells and elucidated the regulatory role of the LPA-TRPC3 signaling axis in BCSCs. The findings provide important insights into potential therapeutic targets for TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ryota Murata, Hiroshi Watanabe, Hiroto Nosaki, Kento Nishida, Hitoshi Maeda, Motohiro Nishida, Toru Maruyama
Summary: In this study, a long-acting Thioredoxin (Trx) was prepared by fusing human Trx with human serum albumin (HSA) and its efficacy in treating drug-induced heart failure was evaluated. The results showed that HSA-Trx administration suppressed the adverse effects of drug-induced cardiomyopathy, including heart weight decrease, myocardial fibrosis increase, and markers for myocardial damage. HSA-Trx also inhibited oxidative stress and inflammation, as well as the expression of myocardial atrophy factors. The findings suggest that HSA-Trx can improve the pathological condition associated with doxorubicin-induced cardiomyopathy.
Article
Biophysics
Yohei Yamaguchi, Masayoshi Nishiyama, Hiroaki Kai, Toshiyuki Kaneko, Keiko Kaihara, Gentaro Iribe, Akira Takai, Keiji Naruse, Masatoshi Morimatsu
Summary: This study used a high-pressure microscope to investigate the mechanism behind slow contractions in cardiomyocytes caused by pressure stimulation. The results suggest that these contractions are driven by the activation of actomyosin interactions without an acute transient increase in intracellular Ca2+ concentration.
BIOPHYSICAL JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Yuri Kato, Kazuhiro Nishiyama, Akiyuki Nishimura, Takamasa Noda, Kaori Okabe, Takahiro Kusakabe, Yasunari Kanda, Motohiro Nishida
Summary: This article discusses the global research efforts and outcomes of drug repurposing for the treatment of COVID-19, and introduces a new protein-protein interaction that is common to COVID-19 aggravation and heart failure.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Tsukasa Shimauchi, Takuro Numaga-Tomita, Yuri Kato, Hiroyuki Morimoto, Kosuke Sakata, Ryosuke Matsukane, Akiyuki Nishimura, Kazuhiro Nishiyama, Atsushi Shibuta, Yutoku Horiuchi, Hitoshi Kurose, Sang Geon Kim, Yasuteru Urano, Takashi Ohshima, Motohiro Nishida
Summary: Inhibition of TRPC6 channel activity in vascular smooth muscle cells promotes blood flow recovery in peripheral artery disease. The drug 1-BP can inhibit this channel activity, leading to improved peripheral circulation and skeletal muscle mass. Additionally, 1-BP can increase vascular nitric oxide bioavailability and enhance blood flow recovery in patients with endothelial dysfunction.
Article
Multidisciplinary Sciences
Sayaka Oda, Kazuhiro Nishiyama, Yuka Furumoto, Yohei Yamaguchi, Akiyuki Nishimura, Xiaokang Tang, Yuri Kato, Takuro Numaga-Tomita, Toshiyuki Kaneko, Supachoke Mangmool, Takuya Kuroda, Reishin Okubo, Makoto Sanbo, Masumi Hirabayashi, Yoji Sato, Yasuaki Nakagawa, Koichiro Kuwahara, Ryu Nagata, Gentaro Iribe, Yasuo Mori, Motohiro Nishida
Summary: This study demonstrates that TRPC6-mediated Zn2+ influx enhances baroreflex-induced positive inotropy, potentially offering a new therapeutic strategy for chronic heart failure.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Kazuhiro Nishiyama, Kohei Ariyoshi, Akiyuki Nishimura, Yuri Kato, Xinya Mi, Hitoshi Kurose, Sang Geon Kim, Motohiro Nishida
Summary: Nonalcoholic steatohepatitis (NASH) is a disease characterized by inflammation and fibrosis that progresses from nonalcoholic fatty liver (NAFL). The study reveals that the P2Y(6) receptor (P2Y(6)R) is upregulated in NASH liver and positively correlates with the expression of CCL2 and Coll1a1. However, the functional deficiency of P2Y(6)R does not seem to affect the progression of liver injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Keiko Kaihara, Hiroaki Kai, Yumiko Chiba, Keiji Naruse, Gentaro Iribe
Summary: Myocardial stretch activates NADPH oxidase 2 (NOX2) to produce reactive oxygen species (ROS). The role of stretch-induced ROS in the intact myocardium was investigated using isolated cardiomyocytes. The lack of stretch-induced ROS in NOX2(-/-) mice delayed the rise of calcium transients and reduced contractility. The faster rise in calcium transients in the presence of stretch-induced ROS contributes to increased contractility.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Biology
Akiko Ogawa, Seiya Ohira, Yuri Kato, Tatsuya Ikuta, Shota Yanagida, Xinya Mi, Yukina Ishii, Yasunari Kanda, Motohiro Nishida, Asuka Inoue, Fan-Yan Wei
Summary: The antiviral drug remdesivir used for COVID-19 treatment has been found to have cardiovascular side effects, but the underlying mechanism was unclear. Through screening and modeling, researchers discovered that remdesivir acts as a selective, partial agonist for the UTS2R receptor, leading to cardiac malfunctions. Antagonizing UTS2R signaling was found to effectively attenuate the cardiac effects of remdesivir.
COMMUNICATIONS BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Nalinrat Petpiroon, Woranan Netkueakul, Kanokwan Sukrak, Chen Wang, Yin Liang, Mengxue Wang, Yun Liu, Qiang Li, Rumaisa Kamran, Keiji Naruse, Sasitorn Aueviriyavit, Ken Takahashi
Summary: The lungs are vital organs that are important for studying lung diseases and the effects of inhaled toxins. Due to ethical concerns, researchers are working on developing alternative models using human cells to replace animal testing. However, there is currently no accepted lung tissue model, making the development of a relevant model crucial.
Meeting Abstract
Cardiac & Cardiovascular Systems
K. Takahashi, Y. Liu, M. Wang, Y. Liang, K. Naruse
EUROPEAN HEART JOURNAL
(2022)
