Article
Immunology
Lucy Kundura, Renaud Cezar, Manuela Pastore, Christelle Reynes, Jeremy Deverdun, Emmanuelle Le Bars, Albert Sotto, Jacques Reynes, Alain Makinson, Pierre Corbeau
Summary: HIV infection is associated with immune activation markers that correlate with neurocognitive impairment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Takahiro Manabe, Heamin Park, Takashi Minami
Summary: Wound healing is a complex process involving multiple cell types and signaling pathways, which can be easily impaired or dysregulated by the microenvironment, leading to the occurrence of various diseases. The calcium signaling pathway plays an important regulatory role in wound healing, affecting the progress of various healing steps.
INFLAMMATION AND REGENERATION
(2021)
Article
Multidisciplinary Sciences
Judith Grau-Exposito, Nerea Sanchez-Gaona, Nuria Massana, Marina Suppi, Antonio Astorga-Gamaza, David Perea, Joel Rosado, Anna Falco, Cristina Kirkegaard, Ariadna Torrella, Bibiana Planas, Jordi Navarro, Paula Suanzes, Daniel Alvarez-Sierra, Alfonso Ayora, Irene Sansano, Juliana Esperalba, Cristina Andres, Andres Anton, Santiago Ramon y Cajal, Benito Almirante, Ricardo Pujol-Borrell, Vicenc Falco, Joaquin Burgos, Maria J. Buzon, Meritxell Genesca
Summary: The study suggests that lung resident memory T cells play a crucial role in limiting the spread of SARS-CoV-2 and COVID-19. Different clinical outcomes are associated with distinct virus-specific T cell responses, and the persistence of antiviral lung T-RM cells in convalescent patients may help limit reinfection.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Xiao-Peng Dai, Feng-Ying Wu, Cheng Cui, Xue-Jiao Liao, Yan-Mei Jiao, Chao Zhang, Jin-Wen Song, Xing Fan, Ji-Yuan Zhang, Qing He, Fu-Sheng Wang
Summary: Platelet-T cell aggregates play a critical role in maintaining inflammation in chronic HIV-1 infection. The formation of platelet-CD4(+) T cell aggregates was increased in treatment-naive HIV-1-infected individuals compared to healthy controls. Higher levels of these aggregates were associated with HIV-1 permissiveness and immune activation during HIV-1 infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mina Yang, Haojie Jiang, Chen Ding, Lin Zhang, Nan Ding, Guoming Li, Fei Zhang, Jing Wang, Liufu Deng, Junling Liu, Yanyan Xu
Summary: Sepsis is a dysregulated inflammatory response caused by systemic infection, leading to excessive platelet activation and coagulation dysfunction. Through the use of a sepsis mouse model, researchers observed thrombosis and NETosis in the vasculature, triggered by STING activation in platelets. Platelet-specific STING deficiency reduced platelet activation and granule secretion, resulting in reduced thrombosis in septic mice. Mechanistically, sepsis-derived cGAMP promoted STING binding to STXBP2, leading to granule secretion and subsequent thrombosis, which may rely on STING palmitoylation. The peptide C-ST5, designed to block STING binding to STXBP2, showed promise in reducing thrombosis in septic mice. In conclusion, targeting platelet activation through STING activation provides a potential strategy for mitigating sepsis-induced coagulopathy.
Review
Biochemistry & Molecular Biology
Silvia M. G. Trivigno, Gianni Francesco Guidetti, Silvia Stella Barbieri, Marta Zara
Summary: Platelets play a crucial role in hemostasis and thrombosis, but they are also involved in various physiological and pathological processes, including infection. They are among the first responders recruited to sites of inflammation and infection, actively cooperating with the immune system to exert their antimicrobial response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Debora Mondatore, Francesca Bai, Matteo Augello, Marco Giovenzana, Andrea Pisani Ceretti, Valeria Bono, Enrico Opocher, Antonella d'Arminio Monforte, Giulia Carla Marchetti, Camilla Tincati
Summary: People with HIV infection are at higher risk of HPV-related disease progression. This study found that CD8+ CD38+ T cells were associated with dysplasia, while the CD4:CD8 T-cell ratio was not.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Immunology
Wouter A. van der Heijden, Rosanne C. van Deuren, Lisa van de Wijer, Inge C. L. van den Munckhof, Marloes Steehouwer, Niels P. Riksen, Mihai G. Netea, Quirijn de Mast, Linos Vandekerckhove, Richarda M. de Voer, Andre J. van der Ven, Alexander Hoischen
Summary: The prevalence of clonal hematopoiesis is higher in individuals with HIV, and these mutations are associated with low CD4 nadir, increased residual HIV-1 transcriptional activity, and coagulation factors.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Anais Mariscal, Carlos Zamora, Cesar Diaz-Torne, Ma Angels Ortiz, Juan Jose de Agustin, Delia Reina, Paula Estrada, Patricia Moya, Hector Corominas, Silvia Vidal
Summary: The binding of platelets to monocytes is increased in rheumatoid arthritis, and this interaction is modulated by IL-6 blockage. After treatment, the percentage of CD14+PLT+ increases in patients who achieve remission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Rachel A. Bender Ignacio, Sayan Dasgupta, Rogelio Valdez, Urvashi Pandey, Siavash Pasalar, Ricardo Alfaro, Florian Hladik, German Gornalusse, Javier R. Lama, Ann Duerr
Summary: Previous studies on linking immune activation biomarkers with HIV risk often relied on cross-sectional samples, but this study showed that dynamic changes in certain biomarkers, in addition to traditional risk factors, could jointly predict HIV risk and modify the association between sociobehavioral risk factors and HIV acquisition.
Article
Cardiac & Cardiovascular Systems
Laura C. Burzynski, Alejandra Morales-Maldonado, Amanda Rodgers, Lauren A. Kitt, Melanie Humphry, Nichola Figg, Martin R. Bennett, Murray C. H. Clarke
Summary: Atherosclerosis is driven by multiple processes involving the immune and coagulation systems. Thrombin can activate interleukin-1α, which contributes to atherogenesis. Inhibition of thrombin can reduce atherosclerotic plaque formation, but also results in a more unstable plaque phenotype.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biology
Sara Svensson Akusjarvi, Shuba Krishnan, Bianca B. Jutte, Anoop T. Ambikan, Soham Gupta, Jimmy Esneider Rodriguez, Akos Vegvari, Maike Sperk, Piotr Nowak, Jan Vesterbacka, J. Peter Svensson, Anders Sonnerborg, Ujjwal Neogi
Summary: The study reveals that individuals who naturally control the virus HIV-1 exhibit a unique chemokine receptor profile and lower levels of apoptosis and p53 signaling proteins, indicating a heightened sensitivity to cell death mechanisms. This data sheds light on the mechanisms of natural control of HIV-1 infection in comparison to individuals on suppressive antiretroviral therapy and HIV-negative controls.
COMMUNICATIONS BIOLOGY
(2022)
Review
Oncology
D. G. Menter
Summary: Platelets play a crucial role in both coagulation and immune responses, with their small size and lack of a nucleus making them difficult to track but also enabling them to effectively deal with pathogens. Their sheer number in circulation, along with active biological responses, allows them to contribute to wound repair and immune function.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Cell Biology
Elisa D'Alessandro, Billy Scaf, Chantal Munts, Arne van Hunnik, Christopher J. Trevelyan, Sander Verheule, Henri M. H. Spronk, Neil A. Turner, Hugo ten Cate, Ulrich Schotten, Frans A. van Nieuwenhoven
Summary: The study demonstrates that FXa induces overexpression of proinflammatory genes in human cardiac fibroblasts through PAR-1, which is the most abundant PAR isoform in this cell type.
Article
Immunology
Ziang Zhu, Tong Li, Jinya Chen, Jai Kumar, Princy Kumar, Jing Qin, Colleen Hadigan, Irini Sereti, Jason V. Baker, Marta Catalfamo
Summary: This study examines the impact of HIV infection on endothelial inflammation and repair by evaluating cell phenotypes and subsets in the blood of HIV-infected individuals. The researchers found that infection-induced phenotypic changes were associated with inflammatory biomarkers, suggesting that HIV infection may affect endothelial inflammation and repair.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Brad T. Sherman, Xiaojun Hu, Kanal Singh, Lillian Haine, Adam W. Rupert, James D. Neaton, Jens D. Lundgren, Tomozumi Imamichi, Weizhong Chang, H. Clifford Lane
Summary: The study identified 11 loci associated with three biomarker levels in PLWH, including six known in the general population and five novel loci. These findings support the hypothesis that host genetics may partly contribute to chronic inflammation in PLWH.
Article
Immunology
Hongyan Sui, Qian Chen, Tomozumi Imamichi
Summary: Human Ku70 protein functions as a cytosolic DNA sensor, translocating from the nucleus to the cytoplasm upon DNA transfection or infection with DNA virus. This translocation predominantly induces interferon lambda1 (IFN-lambda 1) through a STING-dependent signalling pathway. The cytoplasmic translocation of Ku70 is an essential and early event for its cytosolic DNA sensing, with its acetylation status influencing DNA-mediated IFN-lambda 1 induction.
Article
Biochemistry & Molecular Biology
Tomozumi Imamichi, Suranjana Goswami, Xiaojun Hu, Sylvain Laverdure, Jun Yang, Ju Qiu, Qian Chen, Brad T. Sherman, Weizhong Chang
Summary: IL-27 treatment led to the discovery of 38 novel miRNAs in differentiated macrophages, with 16 of them being differentially regulated. Overexpression of miRAB40 showed potent HIV-inhibiting and autophagy-inducing properties, partially mediated via IFN-dependent and -independent pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Suranjana Goswami, Xiaojun Hu, Qian Chen, Ju Qiu, Jun Yang, Deepak Poudyal, Brad T. Sherman, Weizhong Chang, Tomozumi Imamichi
Summary: IL-27 pretreatment promotes CD4(+) T cells into HIV-1-resistant cells by inhibiting an uncoating step, and also leads to the discovery of 15 novel microRNAs. Among them, miRTC14 shows potent anti-HIV effects in macrophages through induction of IFN-α and IFN-λ 1 production, suggesting it may serve as a potential therapeutic target for HIV and other viral infections.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2021)
Article
Biochemistry & Molecular Biology
Xiaojun Hu, Suranjana Goswami, Ju Qiu, Qian Chen, Sylvain Laverdure, Brad T. Sherman, Tomozumi Imamichi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Virology
Tomozumi Imamichi, John G. Bernbaum, Sylvain Laverdure, Jun Yang, Qian Chen, Helene Highbarger, Ming Hao, Hongyan Sui, Robin Dewar, Weizhong Chang, H. Clifford Lane
Summary: A genome-wide association study identified 14 naturally occurring SNPs in HIV associated with virus load, with a variant containing a Met-to-Ile change in integrase found to be impaired in replication. The study also showed that GagPol assembly, virus release, and autoprocessing are regulated not only by integrase but also by RNase H.
JOURNAL OF VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Sylvain Laverdure, Ziqiu Wang, Jun Yang, Takuya Yamamoto, Tima Thomas, Toyotaka Sato, Kunio Nagashima, Tomozumi Imamichi
Summary: IL-27 has been shown to induce autophagy in macrophages, particularly when combined with huAB. The induction of autophagy by IL-27 was found to be independent of the dephosphorylation of mTOR or lipidation of LC3, suggesting a novel non-canonical pathway. Additionally, this study demonstrated that IL-27 induces autophagy during monocyte-to-macrophage differentiation in a subtype-dependent manner.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Raphael M. Oguariri, Terrence W. Brann, Joseph W. Adelsberger, Qian Chen, Suranjana Goswami, Anthony R. Mele, Tomozumi Imamichi
Summary: S100A8 and S100A9 proteins play important roles in inflammation and infection, and they have been identified as novel biomarkers for SARS-CoV-2 infection. However, their role in HIV replication is still unclear. This study found that these proteins inhibit HIV in macrophages but have no impact on T cells.
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2022)
Article
Medicine, General & Internal
J. D. Lundgren, R. L. Gottlieb, U. Sandkovsky, S. M. Brown, J. Baker, A. A. Ginde, C. C. Chang, A. L. Goodman, E. S. Higgs, D. D. Murray, T. A. Murray, R. Paredes, A. N. Phillips, H. Cao, A. G. Babiker, V. J. Davey, A. C. Gelijns, V. L. Kan, M. N. Polizzotto, B. T. Thompson, H. C. Lane, J. D. Neaton
Summary: The study aimed to evaluate the efficacy and safety of bamlanivimab in COVID-19 patients, with results indicating potential benefits in patients without neutralizing antibodies at baseline. However, due to the limited sample size, further research is needed to assess the effects of other types of passive immune therapies in the same patient setting.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Virology
Jun Yang, Ming Hao, Muhammad A. Khan, Muhammad T. Rehman, Helene C. Highbarger, Qian Chen, Suranjana Goswami, Brad T. Sherman, Catherine A. Rehm, Robin L. Dewar, Weizhong Chang, Tomozumi Imamichi
Summary: The study found that a recombinant HIV-1NL4.3 with IN:M50I mutation exhibits suppression of virus release and replication incompetence. Coexisting mutations at codon 17 of IN or codon 79 of RNaseH compensate for the defective phenotype. A combination of IN:M50I and IN:V151I mutations, but not IN:M50I alone, results in a defective virus.
Review
Immunology
Hongyan Sui, Ming Hao, Weizhong Chang, Tomozumi Imamichi
Summary: Ku70, known for its role in DNA repair, has been identified as a multifunctional protein involved in various cellular processes. This review focuses on its role as a cytosolic DNA sensor, inducing interferons and proinflammatory cytokines, and discusses the unique structure of Ku70 binding with DNA and its involvement in the innate immune response pathway. Strategies to modulate Ku70-mediated innate immune response are also discussed, along with potential physiological insights based on its role in innate immunity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Brad T. Sherman, Ming Hao, Ju Qiu, Xiaoli Jiao, Michael W. Baseler, H. Clifford Lane, Tomozumi Imamichi, Weizhong Chang
Summary: DAVID, a popular bioinformatics resource system, has undergone updates in 2021, including the rebuilding of the DAVID Gene system, increasing the number of gene-term records for annotation types, adding new annotations, assigning specific subgroups, and adding a species parameter for improved user experience.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Virology
Weizhong Chang, Xiaoli Jiao, Hongyan Sui, Suranjana Goswami, Brad T. Sherman, Caroline Fromont, Juan Manuel Caravaca, Bao Tran, Tomozumi Imamichi
Summary: This study assembled and annotated the complete genome of HSV-2 strain G using PacBio long sequencing reads. It analyzed the 'alpha' sequence and identified packaging signals homologous to HSV-1, as well as determined the termini and cleavage site of the linear genome. The study also visualized four HSV-2 genome isomers using Oxford Nanopore Technology sequencing reads. Additionally, the coding sequences of strain G were compared with other HSV-2 strains and a phylogenetic analysis was conducted.
Article
Multidisciplinary Sciences
Hongyan Sui, Qian Chen, Jun Yang, Selena Srirattanapirom, Tomozumi Imamichi
Summary: Study found that manganese enhances DNA-mediated interferon production and boosts antiviral immunity, potentially offering a new approach for nucleic-acid-based treatment of infectious diseases.
Article
Virology
Tomozumi Imamichi, Qian Chen, Ming Hao, Weizhong Chang, Jun Yang
Summary: The defect in HIV(IN:M50I/V151I) virus release and autoprocessing initiation is regulated by the C-terminal domains of RNase H and integrase. Specifically, aspartic acid at codon 109 of RNase H C-terminal domain and aspartic acid at the C terminus of integrase induce the defect.