Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 121, Issue 51, Pages 11465-11471Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcb.7b11151
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Funding
- NSF [CBET-1403208]
- ARC DP [DP150100936, DP160100973]
- NHMRC Development grant [APP1113262]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1403208] Funding Source: National Science Foundation
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An artificial Ca2+-regulated PQQ glucose dehydrogenase (PQQ-GDH) enzyme was electrically connected to conducting electrodes and semiconductor interfaces. Direct electron transfer from the enzyme to the conducting electrode support was stimulated by the addition of Ca2+ cations resulting in reversible enzyme activation. A signal-switchable biofuel cell and biomolecular release have been realized using the Ca2+-activated enzyme immobilized on conducting electrodes. Interfacing the signal-switchable enzyme with a semiconductor chip allowed electronic read out of the enzyme ON-OFF states. The developed approach based on the signal-regulated PQQ-GDH enables numerous bioelectrochemical/bioelectronic applications of the developed systems in signal-activated biosensors and biofuel cells, as well as in biomolecular computing/logic systems.
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