Journal
JOURNAL OF PHOTOPOLYMER SCIENCE AND TECHNOLOGY
Volume 30, Issue 1, Pages 33-40Publisher
TECHNICAL ASSOC PHOTOPOLYMERS,JAPAN
DOI: 10.2494/photopolymer.30.33
Keywords
Hydrogel; Chitosan; Water-solubility; Photopolymerization; Tissue engineering
Categories
Funding
- Project of Wuhan Science and Technology Bureau [2015070404010210]
- Educational Commission of Hubei Province of China [D20151605]
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Photocrosslinkable water-soluble maleilated chitosan was synthesized by mixing high molecular weight of chitosan with maleic anhydride under mild and heterogeneous reaction conditions using dimethyl sulfoxine as a solvent. And then, maleilated chitosan (MCS)/ poly(ethylene glycol) diacrylate (PEGDA) hydrogels were prepared under UV radiation. Series of properties of the hydrogels including rheological property, swelling behavior, morphology and mechanical test were investigated. The results showed that, the MCS/PEGDA hydrogels had faster gel-fowling rate, higher compressive strength than MCS hydrogel. The swelling behavior and mechanical properties of the hydrogels were also tunable via the control of weight ratio of MCS to PEGDA. The indirect cytotoxicity assessments of the hydrogels were studied. The result showed the photocrosslinked hydrogels was compatible to L929 cells at low dosages. Cell culture assay also demonstrated that the hydrogels were good in promoting the L929 cells attachment, showing their potential as tissue engineering scaffolds.
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