Review
Chemistry, Multidisciplinary
Subin Son, Jungryun Kim, Jaewon Kim, Byungkook Kim, Jieun Lee, Yuri Kim, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Light-based phototherapy has limitations in cancer treatment due to its limited penetration depth. To overcome these limitations, various energy sources such as ultrasound, chemiluminescence, radiation, microwave, electricity, and magnetic field have been developed. Combining these energy sources with other strategies or therapies can improve the effectiveness of cancer treatment.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Medicinal
Thabang Calvin Lebepe, Sundararajan Parani, Vuyelwa Ncapayi, Rodney Maluleke, Grace It Mwad Mbaz, Olufunto Tolulope Fanoro, Jose Rajendran Varghese, Atsuki Komiya, Tetsuya Kodama, Oluwatobi Samuel Oluwafemi
Summary: The study proposed a novel synergistic phototherapeutic agent combining photothermal and photodynamic therapy, showing promising dual therapeutic effects for cancer treatment. The water-soluble cationic porphyrin and gold nanorods anchored on graphene-oxide were synthesized to form a stable nanocomposite with high biocompatibility and efficiency.
Article
Biochemistry & Molecular Biology
Marcin Wierzchowski, Daniel Ziental, Dawid Lazewski, Artur Korzanski, Agnieszka Gielara-Korzanska, Ewa Tykarska, Jolanta Dlugaszewska, Lukasz Sobotta
Summary: Newly developed tetra- and octasubstituted methimazole-phthalocyanine conjugates have been characterized and found to have strong fluorescence and excellent singlet oxygen generation capabilities. Liposomal formulations were prepared to improve solubility in water. One of the conjugates showed high antibacterial activity against S. aureus when activated with red light.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Jinyuan Liu, Lin Kang, Ishara Ratnayake, Phil Ahrenkiel, Steve Smith, Congzhou Wang
Summary: Targeting CD146 with low-dose gold nanorods and mild hyperthermia can effectively stop cancer cell migration by disrupting the actin cytoskeleton. This approach alters cell morphology and inhibits cell migration by depleting membrane CD146 and interfering with ezrin-radixin-moesin phosphorylation. The findings suggest a versatile and safe strategy for preventing cancer metastasis.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Thabang Calvin Lebepe, Rodney Maluleke, Nande Mgedle, Oluwatobi Samuel Oluwafemi
Summary: This study reports the conjugation of graphene oxide-coated gold nanorods with a water-soluble porphyrin to enhance their re-dispersibility and phototherapeutic properties. The freeze-dried conjugate showed similar optical properties to the unfreeze-dried conjugate, indicating the potential of the freeze-dried conjugate as a dual photodynamic and photothermal agent. Porphyrin demonstrated cryoprotectant properties for the freeze-dried conjugate.
Article
Chemistry, Multidisciplinary
Faeza Alkorbi, Alejandro Diaz-Moscoso, Jacob Gretton, Isabelle Chambrier, Graham J. Tizzard, Simon J. Coles, David L. Hughes, Andrew N. Cammidge
Summary: This study demonstrates a strategy for straightforward, controlled access to differentially substituted meso-aryl-tetrabenzotriazaporphyrins, allowing selective preparation of functionalized hybrids.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Radmila Razlog, Cherie Ann Kruger, Heidi Abrahamse
Summary: Cervical cancer is the most prevalent gynecological malignancy worldwide and the leading cause of cancer deaths in women in South Africa. Photodynamic therapy (PDT) and cannabidiol (CBD) have been investigated for their anti-cancer effects. This study examined the cytotoxic combinative effect of PDT and CBD on cervical cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sergey Tikhonov, Natalia Morozova, Anna Plutinskaya, Ekaterina Plotnikova, Andrey Pankratov, Olga Abramova, Ekaterina Diachkova, Yuriy Vasil'ev, Mikhail Grin
Summary: Photodynamic therapy (PDT) is a promising method for treating oncological diseases, but it has limitations such as tumor hypoxia, limited light penetration, and low accumulation sensitivity. This study successfully combined PDT with chemotherapy by obtaining agents that contain a photodynamic subunit and implement the chemotherapy effect. In vitro and in vivo studies demonstrated high photoinduced activity and enhanced antitumor activity of the obtained compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Marina Lazaro, Pablo Lupianez, Jose L. Arias, Maria P. Carrasco-Jimenez, Angel Delgado, Guillermo R. Iglesias
Summary: This study investigates the synthesis and applications of magnetite nanorods (MNRs) in magnetic hyperthermia, photothermia, and drug release. The results show that the MNRs exhibit high monodispersity and consistent shape, and their photothermia response can be improved by controlling the parameters of external fields. By coating the MNRs with a layer of gold and polyethyleneimine (PEI), the efficiency of MNRs in magnetic hyperthermia and photothermia treatments can be enhanced. Furthermore, the study confirms the non-cytotoxicity of MNRs to human cells and demonstrates their ability to release drugs at a faster rate.
Article
Biotechnology & Applied Microbiology
Leticia B. Silva, Kelly A. D. F. Castro, Caroline E. A. Botteon, Cristiano L. P. Oliveira, Roberto S. da Silva, Priscyla D. Marcato
Summary: By developing hybrid nanostructures to immobilize third-generation PS P, high phototoxicity was demonstrated in bladder cancer cells, showing potential for application in oncological diseases for PDT.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Ravindra R. Cheruku, Joseph Cacaccio, Farukh A. Durrani, Walter A. Tabaczynski, Ramona Watson, Kevin Siters, Joseph R. Missert, Erin C. Tracy, Mykhaylo Dukh, Khurshid Guru, Richard C. Koya, Pawel Kalinski, Heinz Baumann, Ravindra K. Pandey
Summary: Among the modified erlotinib conjugates investigated, PS 10 was identified as the most effective candidate for achieving tumor cell-specific accumulation and yielding improved long-term tumor control.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Materials Science, Biomaterials
Xiaokang Jin, Chengfeng Xu, Jinhua Hu, Shuting Yao, Zhiwen Hu, Bing Wang
Summary: The study introduced a versatile nanoplatform using antimonene nanosheets coated with biodegradable chitosan, loaded with small molecule photosensitizer IR820 and gold nanoparticles. This system demonstrated excellent photothermal and photodynamic properties, satisfactory degradability, photoacoustic imaging ability, good biocompatibility, and effective intracellular synergistic treatment triggered by near infrared light.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Applied
Nuno M. M. Moura, Kelly A. D. F. Castro, Juliana C. Biazzotto, Juliana A. Prandini, Carlos Lodeiro, Maria A. F. Faustino, Mario M. Q. Simoes, Roberto S. da Silva, Maria G. P. M. S. Neves
Summary: This paper reports the synthesis, characterization, and efficacy of porphyrin derivatives bearing ruthenium or iridium terpyridine units as photosensitizers against resistant melanoma cells. The combination of porphyrin derivatives with ruthenium or iridium ions improves the PDT effect, leading to a decrease in cell viability due to their high singlet oxygen production and cellular uptake. The fluorescent properties of the iridium derivative were observed to be uniformly dispersed in the cells.
Article
Chemistry, Physical
Lin Li, Fenglian Qi, Jiong Guo, Jing Fan, Wenxiang Zheng, Murtaza Ghulam, Weizhi Wang, Zihui Meng, Lili Qiu
Summary: In this study, Fe2O3@Au hexagonal nanodisks with tunable near-infrared (NIR) absorptions were successfully prepared. The localized surface plasmon resonance (LSPR) peaks of Au nanodisks were accurately tuned in the NIR therapeutic window. The Fe2O3@Au nanodisks showed low cytotoxicity and high photothermal therapy (PTT) performance.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Biochemistry & Molecular Biology
O. Casanova-Carvajal, M. Zeinoun, A. L. Urbano-Bojorge, F. Bacha, J. Solera Livi, E. Agudo, G. Vargas, M. Ramos, R. Martinez-Murillo, J. J. Serrano-Olmedo
Summary: This article explores the role of silica microparticles in combination with conventional nanoparticles to reduce the high concentrations of particles and intense laser beams in optical hyperthermia, aiming to improve the overall biocompatibility of the procedure. Experimental results confirm the hypothesis, indicating potential improvement in cell survival efficiency with reduced concentrations of conventional nanoparticles. Further studies are needed to explore the application of this technique in 3D tissue structures for potentially higher optical density and improved outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Afshin Taheriazam, Ghazaleh Gholamiyan Yousef Abad, Shima Hajimazdarany, Mohammad Hassan Imani, Setayesh Ziaolhagh, Mohammad Arad Zandieh, Seyedeh Delaram Bayanzadeh, Sepideh Mirzaei, Michael R. Hamblin, Maliheh Entezari, Amir Reza Aref, Ali Zarrabi, Yavuz Nuri Ertas, Jun Ren, Romina Rajabi, Mahshid Deldar Abad Paskeh, Mehrdad Hashemi, Kiavash Hushmandi
Summary: Nanotechnology offers great potential in the field of nanomedicine for the treatment of various diseases, especially cancer. Graphene oxide nanoparticles have emerged as promising carbon-based nanocarriers for drug and gene delivery, photothermal therapy, overcoming chemotherapy resistance, and imaging. This review focuses on the biological functions of graphene oxide nanoparticles as regulators of apoptosis and autophagy, and their potential toxicity in major body organs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Psychiatry
Masoumeh Beheshti, Nikta Rabiei, Mohammad Taghizadieh, Pariya Eskandari, Samaneh Mollazadeh, Ehsan Dadgostar, Michael R. Hamblin, Arash Salmaninejad, Raziye Emadi, Amir Hossein Mohammadi, Hamed Mirazei
Summary: Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder characterized by intrusive thoughts and repetitive or ritualized actions. It is believed to have a genetic component, but the specific genetic factors involved are still unknown. This review summarizes the single nucleotide polymorphisms associated with OCD symptoms, early onset disease, neuroimaging results, and response to therapy. This information can help to understand the genetic basis of OCD, characterize individual patients, predict prognosis, and develop personalized treatment approaches.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Spectroscopy
Faezeh Fallahi, Atarodalsadat Mostafavinia, Zahranadia Sharifi, Leila Mohaghegh Shalmani, Abdollah Amini, Houssein Ahmadi, Hamidreza Omidi, Masoumeh Hajihosseintehrani, Sahar Bayat, Michael R. Hamblin, Sufan Chien, Mohammad Bayat
Summary: This study reports the effects of photobiomodulation (PBM) on diabetic adipose-derived stem cells (ADSCs) in vitro. The results showed that PBM significantly increased ATP levels and mitochondrial membrane potential (MMP), while decreasing reactive oxygen species (ROS) levels and the expression of PINK1 and PARKIN genes in diabetic-ADSCs. These findings suggest that PBM has the potential to improve the function and quality of mitochondrial diabetic-ADSCs, making it a promising approach for treating diabetic foot ulcers in diabetic patients.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Multidisciplinary Sciences
Erivelto Luis Chacon, Mirella Romanelli Vicente Bertolo, Ana Maria de Guzzi Plepis, Virginia da Conceicao Amaro Martins, Geovane Ribeiro dos Santos, Clovis Antonio Lopes Pinto, Andre Antonio Pelegrine, Marcelo Lucchesi Teixeira, Daniela Vieira Buchaim, Fabricio Montenegro Nazari, Rogerio Leone Buchaim, Gustavo Tenorio Sugano, Marcelo Rodrigues da Cunha
Summary: Lesions with bone loss may require autologous grafts or biomaterials for bone neoformation support. In this study, collagen/chitosan/hydroxyapatite scaffolds were used to investigate the osteoregenerative capacity in rats with hormone deficiency caused by ovariectomy. The results showed that the scaffolds stimulated bone growth, but the abnormal conditions of bone fragility caused by gonadal hormone deficiency may have delayed the bone repair process.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, Research & Experimental
Seyed Mohammad Reza Hashemian, Amirhossein Sheida, Mohammad Taghizadieh, Mohammad Yousef Memar, Michael R. Hamblin, Hossein Bannazadeh Baghi, Javid Sadri Nahand, Zatollah Asemi, Hamed Mirzaei
Summary: Due to the lack of effective therapies for COVID-19, patients have to rely on supportive and nonspecific treatments. Certain proteins of SARS-CoV-2, such as 3 C-like protease (3CLpro) and major protease (Mpro), have been identified as potential targets for antiviral drugs. Nirmatrelvir, combined with ritonavir, has shown potent antiviral activity against SARS-CoV-2 variants, but there are still uncertainties regarding their efficacy, safety, and side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biotechnology & Applied Microbiology
Ali Arash Anoushirvani, Arezoo Jafarian Yazdi, Sanaz Amirabadi, Sahar Ahmadi Asouri, Rana Shafabakhsh, Amirhossein Sheida, Maryam Sadat Hosseini Khabr, Ameneh Jafari, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Leila Kalantari, Sayyed Alireza Talaei Zavareh, Hamed Mirzaei
Summary: Neuroblastoma is the most common extracranial malignancy in childhood and is derived from neural crest. Non-coding RNAs (ncRNAs) have been found to play important roles in various cancers, including glioma and gastrointestinal cancers, by regulating cancer gene networks. Recent studies have shown that ncRNA genes are deregulated in human cancers through various mechanisms, and disturbances in their expression can act as either oncogenes or tumor suppressor genes, leading to the development of cancer. Moreover, ncRNAs can be secreted from tumor cells in exosomes and transferred to other cells, exerting their functions. However, further research is needed to fully understand the roles of ncRNAs in neuroblastoma.
CANCER GENE THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Nasim Ebrahimi, Elmira Fardi, Hajarossadat Ghaderi, Sahar Palizdar, Roya Khorram, Reza Vafadar, Masoud Ghanaatian, Fatemeh Rezaei-Tazangi, Payam Baziyar, Amirhossein Ahmadi, Michael R. Hamblin, Amir Reza Aref
Summary: Targeted therapy is a new approach in cancer treatment, using drugs that specifically target proteins in cancer cells. Inhibiting these proteins can impede cancer progression. Understanding the structures, activation mechanisms, and functions of receptor tyrosine kinases (RTKs) has led to the development of targeted drug therapies, including RTK inhibitors (RTKIs), some of which have been used in clinical settings. This article discusses RTKs and their role in cancer treatment, as well as the potential effects of combination drug therapy for drug resistant cancers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Irina Pereira, Carina Monteiro, Miguel Pereira-Silva, Diana Peixoto, Claudia Nunes, Salette Reis, Francisco Veiga, Michael R. Hamblin, Ana Claudia Paiva-Santos
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Review
Chemistry, Physical
Houra Nekounam, Javad Malakootikhah, Donya Shaterabadi, Babak Negahdari, Mohammad Reza Kandi, Michael R. Hamblin
Summary: This article summarizes the advances in the preparation, optimization, and applications of silica nanoparticles in biomedical nanotechnology, as well as the inevitable human, environmental, and industrial contacts with these particles. Understanding the physicochemical properties of silica nanoparticles and their interactions with biological systems at the cellular level is crucial for the rational design of these particles. Control of toxicity risk can guide the design of silica nanoparticles for drug delivery and bioimaging systems.
Review
Microbiology
Weitao Zhu, Michael R. Hamblin, Xiang Wen
Summary: Rosacea is a chronic inflammatory skin disorder affecting the centrofacial region. Its etiology and treatment methods are still unclear. This review examines common bacterial species found in the skin and gut microbiota of rosacea patients and their role in pathogenesis. Additionally, it summarizes the impact of factors such as temperature and age on rosacea and reviews commonly used clinical treatment methods, including antibiotics and probiotics, along with their mechanisms and precautions.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Microbiology
Hanane Joudaki, Negar Aria, Roya Moravej, Mohamadreza Rezaei Yazdi, Zarrindokht Emami-Karvani, Michael R. Hamblin
Summary: Microbial phytases are enzymes that can break down phytic acid, providing several benefits in the food industry such as improved nutrient utilization, enhanced mineral bioavailability, and improved taste and functionality of food products. Factors like enzyme production and engineering techniques play a crucial role in effectively using microbial phytases.
CURRENT MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Renato de Moraes, Ana Maria de Guzzi Plepis, Virginia da Conceicao Amaro Martins, Claudio Fernandes Garcia, Ewerton Alexandre Galdeano, Fernanda Latorre Melgaco Maia, Eduardo Gomes Machado, Marcelo de Azevedo e Souza Munhoz, Daniela Vieira Buchaim, Victor Augusto Ramos Fernandes, Rodrigo Alves Beraldo, Rogerio Leone Buchaim, Marcelo Rodrigues da Cunha
Summary: Bone lesions have the ability to regenerate under normal bone metabolism conditions, but scaffolds are needed to assist in the bone regeneration process due to increasing incidence of major traumas and diseases like osteoporosis. This study evaluated the osteoregenerative potential of mineralized collagen and nanohydroxyapatite (nHA) scaffolds combined with elastin in the tibiae of healthy and ovariectomized rats. The results showed that these scaffolds had superior osteogenic potential and promoted new bone formation in rats with normal bone metabolism and with gonadal deficiency, compared to control groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Chemical
Marilia M. Horn, Virginia C. Amaro Martins, Ana Maria de Guzzi Plepis
Summary: Polysaccharide films made from modified rice starch were evaluated for their properties and interactions. The study found that the interaction between chitosan and oxidized starch was stronger, while the plasticizers had a lower effect on the rheological behavior. The number of OH groups in the polyols played an essential role in the associations between chitosan and gelatinized starch. The films showed improved properties with the addition of polyols, such as enhanced elongation at break.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Engineering, Biomedical
Fahimeh Ghasemi Moravej, Abdollah Amini, Reza Masteri Farahani, Samira Mohammadi-Yeganeh, Atarodalsadat Mostafavinia, Houssein Ahmadi, Hamidreza Omidi, Fatemehalsadat Rezaei, Latif Gachkar, Michael R. Hamblin, Sufan Chien, Mohammad Bayat
Summary: Diabetic wounds lead to chronic inflammation and the development of diabetic foot ulcers, which can cause amputation and death. This study examined the effect of photobiomodulation (PBM) plus allogeneic diabetic adipose tissue-derived stem cells (ad-ADS) on wound healing in type I diabetic rats. The results showed that the ad-ADS plus PBM treatment group had significantly better histological results compared to the other experimental groups.
LASERS IN MEDICAL SCIENCE
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Talison Alvarenga dos Santos, Anderson Orzari Ribeiro, Franciane Freitas Silveira
Summary: Despite the known advantages of digital transformation, many chemical industries have encountered difficulties in advancing digital maturity, particularly in the implementation process of digital technologies. This article proposes a process framework comprising three phases to support the implementation of digital projects and enhance their effectiveness.
PROCEEDINGS OF THE 7TH BRAZILIAN TECHNOLOGY SYMPOSIUM (BTSYM 21): EMERGING TRENDS IN HUMAN SMART AND SUSTAINABLE FUTURE OF CITIES, VOL 1
(2023)
Article
Biochemistry & Molecular Biology
Girgis Obaid, Menitte Eroy, Jie Zhao, Shazia Bano, Mari Mino-Kenudson, Tayyaba Hasan
Summary: The presence of desmoplasia in pancreatic ductal adenocarcinoma (PDAC) is associated with poor treatment outcomes and reduced drug delivery. By analyzing collagen subtypes in PDAC tumors following different treatment regimens, immunofluorescence profiling can predict long-term survival and tumor growth inhibition. This information can aid in personalized treatment and improve patient survival.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Fatemeh Malekpour, Rashin Bahrami, Mahshid Hodjat, Neda Hakimiha, Behnam Bolhari, Aidin Sooratgar, Soheil Niavarzi
Summary: This study investigated the effect of photobiomodulation (PBM) therapy using an 808 nm diode laser on cellular modulation mechanisms in regenerative endodontic procedures (REPs). The results showed that PBM treatment significantly increased cell viability and migration, and enhanced the release of TGF-131 from dentin.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Pranathi Tata, Ramakrishnan Ganesan, Jayati Ray Dutta
Summary: Thin film coatings with potent antibacterial properties are widely used in medical devices, frequently touched surfaces, and food packaging. However, achieving antibacterial performance under both light and dark conditions remains a challenge. In this study, we successfully prepared AgBr-coated ZnO nanorod thin film architecture using a unique surfactant-mediated solution-phase spin-coating approach. The resulting structures showed dual functionality as antimicrobial agents and photosensitizers, effectively enhancing the visible-light photodisinfection efficacy of ZnO nanorods. The concentration of the surfactant-based precursor solution could be modulated to control the AgBr content. Additionally, components like urea and lactic acid were found to enhance the photocatalytic efficiency of the structures.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)