Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Volume 334, Issue -, Pages 101-106Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotochem.2016.10.037
Keywords
Photodynamic therapy; Tyrosine; Zn(II) phthalocyanine; Fluorescence; Singlet oxygen; Photostability
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Funding
- TUBITAK [2216]
- Program for career development of young scientist, Bulgarian Academy of Sciences [150]
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Biologically active photosensitizers with long absorption wavelength are among the new generation drugs for potential application in photodynamic therapy (PDT). This study presents a new phthalocyanine photosensitizer functionalized with amino acid for application in PDT. This photosensitizer, tetra-(4-tyrosylamido) phenoxy substituted zinc(II) phthalocyanine (ZnPcTyr), was synthesized and chemically characterized. The properties of electronic absorption, fluorescence, photostability, and singlet oxygen generation were studied. The obtained photophysicochemical characteristics suggested that this newly synthesized tyrosine conjugated zinc(II) phthalocyanine has promising potential as photosensitizer for photodynamic therapy. (C) 2016 Elsevier B.V. All rights reserved.
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