Drug repurposing may generate novel approaches to treating depression

Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation

(2017) Carmine M. Pariante   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in antidepressant-like effect

(2017) Karolina Pytka et al.   Pharmacological Reports

Repurposing of Anti-Diabetic Agents for the Treatment of Cognitive Impairment and Mood Disorders

(2016) D.S. Cha et al.   CURRENT MOLECULAR MEDICINE

Inflammation in Depression and the Potential for Anti-Inflammatory Treatment

(2016) Ole Kohler et al.   Current Neuropharmacology

Drug combination therapy increases successful drug repositioning

(2016) Wei Sun et al.   DRUG DISCOVERY TODAY

Peripheral Inflammatory Parameters in Late-Life Depression: A Systematic Review

(2016) Mónica Martínez-Cengotitabengoa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Efficacy of High-Dose Supplementation With Oral Vitamin D3 on Depressive Symptoms in Dialysis Patients With Vitamin D3 Insufficiency

(2016) Ying Wang et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Genetic Contributions of Inflammation to Depression

(2016) Jacob Barnes et al.   NEUROPSYCHOPHARMACOLOGY

The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect

(2016) Karolina Pytka et al.   Pharmacological Reports

The role of glutamatergic, GABA-ergic, and cholinergic receptors in depression and antidepressant-like effect

(2016) Karolina Pytka et al.   Pharmacological Reports

Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders

(2016) Linda Nguyen et al.   PHARMACOLOGY & THERAPEUTICS

PPAR-γ Agonists for the Treatment of Major Depression: A Review

(2016) R. Colle et al.   PHARMACOPSYCHIATRY

Glucocorticoid resistance in chronic diseases

(2016) Juan M. Rodriguez et al.   STEROIDS

In silico methods for drug repurposing and pharmacology

(2016) Rachel A. Hodos et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Involvement of AMPA receptors in the antidepressant-like effects of dextromethorphan in mice

(2015) Linda Nguyen et al.   BEHAVIOURAL BRAIN RESEARCH

Metformin: Repurposing Opportunities for Cognitive and Mood Dysfunction

(2015) Melissa Ying et al.   CNS & Neurological Disorders-Drug Targets

The Involvement of TNF-α in Cognitive Dysfunction Associated with Major Depressive Disorder: An Opportunity for Domain Specific Treatments

(2015) Beatrice Bortolato et al.   Current Neuropharmacology

Simvastatin as an adjuvant therapy to fluoxetine in patients with moderate to severe major depression: A double-blind placebo-controlled trial

(2015) Amirhossein Gougol et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Vortioxetine, a novel antidepressant with multimodal activity: Review of preclinical and clinical data

(2015) Connie Sanchez et al.   PHARMACOLOGY & THERAPEUTICS

N-acetylcysteine prevents stress-induced anxiety behavior in zebrafish

(2015) Ricieri Mocelin et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Valproate augmentation in a subgroup of patients with treatment-resistant unipolar depression

(2015) Maykel F. Ghabrash et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Two Phase III randomised double-blind studies of fixed-dose TC-5214 (dexmecamylamine) adjunct to ongoing antidepressant therapy in patients with major depressive disorder and an inadequate response to prior antidepressant therapy

(2015) Hans-Jürgen Möller et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Dysregulated Hypothalamic–Pituitary–Adrenal Axis Function Contributes to Altered Endocrine and Neurobehavioral Responses to Acute Stress

(2015) Scott A. Kinlein et al.   Frontiers in Psychiatry

Topical and Peripheral Ketamine as an Analgesic

(2014) Jana Sawynok   ANESTHESIA AND ANALGESIA

Agomelatine in the Treatment of Major Depressive Disorder: An Assessment of Benefits and Risks

(2014) Maximilian Gahr   Current Neuropharmacology

Ketamine: repurposing and redefining a multifaceted drug

(2014) David E. Potter et al.   DRUG DISCOVERY TODAY

The utility of the combination of dextromethorphan and quinidine in the treatment of bipolar II and bipolar NOS

(2014) Tammas Frederick Kelly et al.   JOURNAL OF AFFECTIVE DISORDERS

The Efficacy of AdjunctiveN-Acetylcysteine in Major Depressive Disorder

(2014) Michael Berk et al.   JOURNAL OF CLINICAL PSYCHIATRY

In a randomized, double-blind clinical trial, adjuvant atorvastatin improved symptoms of depression and blood lipid values in patients suffering from severe major depressive disorder

(2014) Mohammad Haghighi et al.   JOURNAL OF PSYCHIATRIC RESEARCH

N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action

(2014) Olivia Dean et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Cognitive decline and depressive symptoms in late-life are associated with statin use: evidence from a population-based study of Sardinian old people living in their own home

(2014) Antonella Mandas et al.   NEUROLOGICAL RESEARCH

The Antidepressant 5-HT2A Receptor Antagonists Pizotifen and Cyproheptadine Inhibit Serotonin-Enhanced Platelet Function

(2014) Olivia A. Lin et al.   PLoS One

Depressive-Like Behaviors in a Rat Model of Chronic Cerebral Hypoperfusion

(2014) Sang Rim Lee et al.   Translational Stroke Research

Effect of Anti-inflammatory Treatment on Depression, Depressive Symptoms, and Adverse Effects

(2014) Ole Köhler et al.   JAMA Psychiatry

Ketamine as a Fast Acting Antidepressant: Current Knowledge and Open Questions

(2013) Giacomo Salvadore et al.   CNS Neuroscience & Therapeutics

AUGMENTATION OF FLUOXETINE WITH LOVASTATIN FOR TREATING MAJOR DEPRESSIVE DISORDER, A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED-CLINICAL TRIAL

(2013) Ahmad Ghanizadeh et al.   DEPRESSION AND ANXIETY

Efficacy and tolerability of flexibly-dosed adjunct TC-5214 (dexmecamylamine) in patients with major depressive disorder and inadequate response to prior antidepressant

(2013) Eduard Vieta et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

microRNAs as novel antidepressant targets: converging effects of ketamine and electroconvulsive shock therapy in the rat hippocampus

(2013) Richard M. O'Connor et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The vascular depression hypothesis: mechanisms linking vascular disease with depression

(2013) W D Taylor et al.   MOLECULAR PSYCHIATRY

Depression in Cognitive Impairment

(2013) Laurel D. Pellegrino et al.   Current Psychiatry Reports

Relationship of endothelial function and atherosclerosis to treatment response in late-life depression

(2012) R. Paranthaman et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: Randomized double-blind placebo-controlled study

(2012) Seyed-Hesameddin Abbasi et al.   JOURNAL OF AFFECTIVE DISORDERS

Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice

(2012) Xiaoying Bi et al.   JOURNAL OF NEUROCHEMISTRY

Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) and Neurodegenerative Disorders

(2012) Yu-Chang Chen et al.   MOLECULAR NEUROBIOLOGY

Minocycline as adjunctive therapy for patients with unipolar psychotic depression: An open-label study

(2012) Tsuyoshi Miyaoka et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Inflammatory biomarkers predict depressive, but not anxiety symptoms during aging: The prospective Sydney Memory and Aging Study

(2012) B.T. Baune et al.   PSYCHONEUROENDOCRINOLOGY

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

(2012) Charles L. Raison et al.   JAMA Psychiatry

Use of insulin sensitizers for the treatment of major depressive disorder: A pilot study of pioglitazone for major depression accompanied by abdominal obesity

(2011) David E. Kemp et al.   JOURNAL OF AFFECTIVE DISORDERS

Macrophages-mediated neurotoxic effects of intra-nigral manganese administration are attenuated by minocycline

(2011) Silvia Ponzoni   NEUROSCIENCE LETTERS

Therapeutic interventions for vascular depression: a systematic review

(2011) Andre Russowsky Brunoni et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Replication of Scopolamine's Antidepressant Efficacy in Major Depressive Disorder: A Randomized, Placebo-Controlled Clinical Trial

(2010) Wayne C. Drevets et al.   BIOLOGICAL PSYCHIATRY

Deconstructing the Drug Development Process: The New Face of Innovation

(2010) K I Kaitin   CLINICAL PHARMACOLOGY & THERAPEUTICS

P.2.a.002 The potential of the nicotinic channel blocker tc-5214 as augmentation treatment in patients with major depression

(2010) G. Dunbar et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A study of orthostatic hypotension, heart rate variability and baroreflex sensitivity in late-life depression

(2010) Akshya Vasudev et al.   JOURNAL OF AFFECTIVE DISORDERS

Ustekinumab significantly improves symptoms of anxiety, depression, and skin-related quality of life in patients with moderate-to-severe psoriasis: Results from a randomized, double-blind, placebo-controlled phase III trial

(2010) Richard G. Langley et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The effect of adalimumab on reducing depression symptoms in patients with moderate to severe psoriasis: A randomized clinical trial

(2010) Alan Menter et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

How an Age of Anxiety Became an Age of Depression

(2010) ALLAN V. HORWITZ   MILBANK QUARTERLY

Sigma receptors: Potential targets for a new class of antidepressant drug

(2010) James A. Fishback et al.   PHARMACOLOGY & THERAPEUTICS

Brain-derived neurotrophic factor: role in depression and suicide

(2010) Yogesh Dwivedi   Neuropsychiatric Disease and Treatment

Dextromethorphan

(2009) Joseph A. Banken et al.   Annals of the New York Academy of Sciences

Pharmacological Aspects and Potential New Clinical Applications of Ketamine: Reevaluation of an Old Drug

(2009) Filippia Aroni et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

Further evidence for an antidepressant potential of the selective σ1 agonist SA 4503: electrophysiological, morphological and behavioural studies

(2008) Guillaume Lucas et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Nicotinic Antagonist Augmentation of Selective Serotonin Reuptake Inhibitor-Refractory Major Depressive Disorder

(2008) Tony P. George et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Inflammatory markers in late-life depression: Results from a population-based study

(2007) M.A. Bremmer et al.   JOURNAL OF AFFECTIVE DISORDERS