Integrated TK–TD modeling for drug-induced concurrent tachycardia and QT changes in beagle dogs

Early Drug Discovery Prediction of Proarrhythmia Potential and Its Covariates

(2015) Sebastian Polak et al.   AAPS Journal

The Biopharmaceutics Classification System: Subclasses for in vivo predictive dissolution (IPD) methodology and IVIVC

(2014) Yasuhiro Tsume et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

Age and gender dependent heart rate circadian model development and performance verification on the proarrhythmic drug case study

(2013) Kamil Fijorek et al.   Theoretical Biology and Medical Modelling

Preclinical QT safety assessment: Cross-species comparisons and human translation from an industry consortium

(2013) Henry Holzgrefe et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The thorough QT/QTc study 4 years after the implementation of the ICH E14 guidance

(2009) B Darpo   BRITISH JOURNAL OF PHARMACOLOGY