A High-Throughput Bioluminescent Assay to Monitor the Deamidation of Asparagine and Isomerization of Aspartate Residues in Therapeutic Proteins and Antibodies

Title
A High-Throughput Bioluminescent Assay to Monitor the Deamidation of Asparagine and Isomerization of Aspartate Residues in Therapeutic Proteins and Antibodies
Authors
Keywords
deamidation, high-throughput technologies, HPLC, mAb, enzymes, chemical stability, biopharmaceuticals characterization, LC-MS, protein formulation, proteins
Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 106, Issue 6, Pages 1528-1537
Publisher
Elsevier BV
Online
2017-03-03
DOI
10.1016/j.xphs.2017.02.022

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