Article
Chemistry, Multidisciplinary
Mingxin Wang, Somia Yassin Hussain Abdalkarim, Ruixin Gong, Haibin Ji, Zhiming Chen, Yunfei Shen, Ying Zhou, Jiayuan Shen, Hou-Yong Yu
Summary: Polymer composite microspheres with excellent biodegradable and controlled long-term release characteristics have gained significant attention. However, producing polymer microspheres with controlled properties and customizable drug release is still a major challenge. In this study, dual-responsive cellulose nanocrystals were engineered and incorporated into polylactide composite microspheres to achieve controlled and sustained drug release behavior. The results demonstrated a temperature and pH dual-responsive controlled drug release capability of the composite microspheres, highlighting their potential as multifunctional drug delivery systems for medical applications.
Article
Chemistry, Multidisciplinary
Ankur Jain, David King, Giuseppe Pontrelli, Sean McGinty
Summary: The dissolution of drugs from solid form to dissolved form is important in the design and optimization of drug delivery devices. However, the interplay between dissolution and diffusion in drug delivery is not well understood. In this study, a mathematical model is presented to describe controlled release from a drug-loaded device surrounded by a porous layer. The model accurately predicts the drug release curve based on experimental data from a cylindrical drug-loaded orthopedic fixation pin. The model provides valuable insights into the factors influencing drug dissolution and release profile.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Physical
Soledad Stagnoli, Cintia Garro, Ozlem Ertekin, Susanne Heid, Stefan Seyferth, Gaston Soria, N. Mariano Correa, Aldo Leal-Egana, Aldo R. Boccaccini
Summary: This study developed a system for delivering water-insoluble drugs, which can efficiently load drugs and increase the likelihood of drug uptake by cancer cells instead of healthy cells. The system also demonstrates high efficiency and stability during topical application, and it is less invasive compared to alternative methods.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Inorganic & Nuclear
Atefeh Kamali Dolatabadi, Javad Mokhtari, Nasrin Talebian
Summary: Sol gel method was used to investigate the release of Montelukast drug in silica matrix. Encapsulation of montelukast was examined under different parameters, and the best condition for drug release was found to be the presence of montelukast sodium salt at room temperature. The releasing data were analyzed using mathematical kinetic models, and the suitable models were determined for Montelukast sodium and imidazolium. Various analyses were employed to characterize the sol-gel process and drug encapsulation. The mechanism of drug release was a combination of dissolution and diffusion processes.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Beatriz D. Cardoso, Vanessa F. Cardoso, Senetxu Lanceros-Mendez, Elisabete M. S. Castanheira
Summary: Stimuli-responsive liposomes, particularly solid magnetoliposomes (SMLs), have been designed as lipid-based nanosystems for controlled release of doxorubicin (DOX) in response to thermal, magnetic, and pH stimuli. The combination of lipids and PEGylation plays a crucial role in determining the stability and release kinetics of SMLs. Integrated assessment and characterization of SMLs enable the optimization of lipid formulations for specific controlled release profiles, offering a multi-functional approach to cancer targeting and therapy.
Review
Pharmacology & Pharmacy
Lu Han, Ke Peng, Li-Ying Qiu, Meng Li, Jing-Hua Ruan, Li-Li He, Zhi-Xiang Yuan
Summary: Cancer vaccines show promise in fighting cancer, but their clinical efficacy is limited by delivery issues and the need for multiple injections. Controlled-release drug delivery systems can address these challenges, improving vaccine safety and effectiveness.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Max L. Wang, Christian F. Chamberlayne, Haixia Xu, Mohammad Mofidfar, Spyridon Baltsavias, Justin P. Annes, Richard N. Zare, Amin Arbabian
Summary: On-demand drug delivery systems combined with wireless implants can control drug release, reducing dosage and side effects. Researchers designed a release system based on a modified electroresponsive polypyrrole nanoparticulate film for negatively charged compounds. They also developed an ultrasonically powered mm-sized implant to electronically control the on-demand drug delivery system in vivo. The feasibility of wireless, controllable drug release was demonstrated through in vitro and in vivo characterization using fluorescein as a model drug.
Review
Chemistry, Inorganic & Nuclear
Seoyoon Song, Deborah Lee, Lucia C. Dalle Ore, Sungjun Kwak, Lifeng Kang, Hyung Kyo Kim, Noah Malmstadt, Sun Min Kim, Tae-Joon Jeon
Summary: This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.
COORDINATION CHEMISTRY REVIEWS
(2024)
Article
Engineering, Biomedical
Jichuan Qiu, Jianchang Xu, Younan Xia
Summary: Nanobottles are colloidal particles with a hollow interior and a single opening, making them ideal for loading, encapsulation, release, and delivery of therapeutic agents in biomedical applications. Control of release can be achieved by varying the opening size and integrating stimuli-responsive materials. Future directions for nanomaterials include manufacturing, functionalization, and application advancements.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Polymer Science
Sagar Pardeshi, Fouad Damiri, Mehrukh Zehravi, Rohit Joshi, Harshad Kapare, Mahendra Kumar Prajapati, Neha Munot, Mohammed Berrada, Prabhanjan S. Giram, Satish Rojekar, Faraat Ali, Md. Habibur Rahman, Hasi Rani Barai
Summary: Temperature-induced changes in the viscosity and formation of 3-D structure make thermosensitive hydrogels ideal for cell scaffolds or drug reservoirs. This review presents a comprehensive overview of the synthesis, mechanism, and biomedical applications of thermosensitive hydrogels, and discusses their commercial potential.
Review
Biochemistry & Molecular Biology
Wei Shi, Yern Chee Ching, Cheng Hock Chuah
Summary: This review focuses on the preparation and application of spherical aerogels for drug delivery, with a specific emphasis on their potential as drug carriers. Various innovative approaches and future prospects are proposed to inspire readers in creating novel drug release systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biotechnology & Applied Microbiology
Yanghui Xing, Buhui Zeng, Wang Yang
Summary: Light responsive hydrogels are an important drug delivery system that can accurately control drug release by incorporating photosensitive moieties into their structures. Advances in photosensitizers have enabled the use of different light sources, and hydrogels with photosensitizers have improved therapeutic effects. Existing light responsive drug delivery systems have been applied in chemotherapy, immunotherapy, photodynamic therapy, gene therapy, and other fields.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Environmental
Ting-Ting Li, Li Sun, Ying Zhang, Bing-Chiuan Shiu, Hai-Tao Ren, Hao-Kai Peng, Jia-Horng Lin, Ching-Wen Lou
Summary: A multifunctional Janus composite membrane was prepared using electrostatic spinning and electrostatic spraying techniques, which exhibited antibacterial and antioxidant properties, unidirectional fluid delivery, and monitoring of wound healing. The composite membrane showed excellent drug retardation and antibacterial activity, as well as the ability to act as a pH indicator in the wound healing process.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Avelino Corma, Pablo Botella, Eva Rivero-Buceta
Summary: This article introduces silica-based nanomedicines and their significant role in cancer treatment. Silica nanoparticles have been proposed as safe and effective vehicles for delivering antitumor drugs due to their stability, high surface area, and easy functionalization. These silica nanomedicines have specific mechanisms for intracellular drug release, allowing for precise control of drug discharge. By responding to endogenous and exogenous stimuli, these nanomedicines can achieve selective delivery to cancer cells.
Article
Crystallography
Petr Zamostny, Michal Drahozal, Ondrej Svehla, Simona Römerova, Nikita Marinko
Summary: The impregnation of a poorly water-soluble drug onto a suitable pharmaceutical excipient as a hydrophilic carrier can improve dissolution properties by separating drug crystal particles on the carrier surface. In this study, a method based on impregnation of a hydrophilic matrix with a solution of the hydrophobic poorly water-soluble drug Meloxicam (MX) in a volatile organic solvent was used. The results show that the amount and concentration of the impregnating solution influenced the size of MX crystals and the dissolution rate. Optimum preparation methods were used to produce impregnated granules, and their dissolution performance was evaluated.
Article
Pharmacology & Pharmacy
Wenhua Wang, Beibei Yang, Zhengwei Huang, Ying Huang, Ping Hu, Xin Pan, Chuanbin Wu
Summary: The study revealed a positive correlation between particle size of solid lipid nanoparticles (SLN) and cellular uptake behaviors, laying a solid foundation for understanding the effect of particle size on nanoparticle delivery systems and promoting the development of novel pulmonary drug delivery systems.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2022)
Article
Chemistry, Multidisciplinary
Wenhao Wang, Huihui Liu, Zhengwei Huang, Fangqin Fu, Wenhua Wang, Linjing Wu, Ying Huang, Chuanbin Wu, Xin Pan
Summary: Nanoscale metal organic frameworks (NMOFs) have unique porous structures and tunable multifunctionality, making them widely used in the biomedical field. However, the formation of protein corona on the surface of NMOFs affects their biodistribution, pharmacokinetics, and drug release. This study investigates the impact of organic ligand modification on the protein corona formation process of NMOFs and provides insights into the design and applications of NMOFs.
CHINESE CHEMICAL LETTERS
(2022)
Article
Engineering, Environmental
Wenhua Wang, Wenhao Wang, Shiwei Jin, Fangqin Fu, Zhengwei Huang, Ying Huang, Chuanbin Wu, Xin Pan
Summary: Cisplatin (DDP)-based ferroptosis-apoptosis synergetic therapy is a novel strategy for lung cancer treatment. A combination of a ROS generator and a GSH scavenger can overcome the strong antioxidant system in tumor cells. Pulmonary delivery with targeted nanoparticles can improve drug accumulation in lung lesions.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Chemical
Linjing Wu, Fangqin Fu, Wenhao Wang, Wenhua Wang, Zhengwei Huang, Ying Huang, Xin Pan, Chuanbin Wu
Summary: Protein corona refers to the biomolecules adsorbed on the surface of nanomaterials. Understanding the interaction between protein and nanoparticles is crucial for nanodrug delivery. This study investigated the interaction between C60 nanocomplex and various plasma proteins and found that protein binding did not alter protein charge properties but induced aggregation of the nanocomplex. The study provides insights for the research and development of C60 nanocomplex and carbon-based nanocomplex as nanoparticulate drug delivery systems.
Article
Chemistry, Multidisciplinary
Fangqin Fu, Wenhao Wang, Linjing Wu, Wenhua Wang, Zhengwei Huang, Ying Huang, Chuanbin Wu, Xin Pan
Summary: Lung cancer is a major threat to human health. Ferroptosis therapy, which boosts reactive species production and lipid peroxidation, has shown promise in treating lung cancer. However, the low levels of reactive species and inadequate drug accumulation in lung cancer lesions limit the efficacy of this therapy. Therefore, a new inhalable biomineralized liposome was developed, which effectively delivered drugs to lung lesions and enhanced the process of ferroptosis therapy by inducing calcium-mediated endoplasmic reticulum stress. The liposome showed promising results in a murine lung tumor model. This study highlights the potential of the liposome for nebulization-based pulmonary delivery and its application in enhanced ferroptosis therapy for lung cancer.
Article
Engineering, Environmental
Jiawei Hu, Wen Li, Ling Zhang, Chuan-Yu Wu
Summary: In this study, a microscopic model considering the microstructural evolution of individual particles is developed and validated by using discrete element method (DEM). The model is compared with macroscopic and phenomenological swelling models, and it is found that the microscopic model can better describe the swelling behaviors of single particles and particle beds. Additionally, the microscopic model is capable of reproducing volume expansion phenomena and predicting the microstructural evolution of particles. It is demonstrated that DEM with the microscopic swelling model is a useful tool for modeling swellable granular materials in various industrial processes.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Chemical
Francisco Kisuka, Colin Hare, Chuan-Yu Wu
Summary: This study investigates the heat generation and contact temperatures during particle interactions. Both theoretical models and a finite element method (FEM) model are employed, and they agree well with each other. The study also identifies the dependence of temperature profiles on heat generation and material properties, and proposes simple theoretical solutions for further research on heat generation in granular flows.
Article
Instruments & Instrumentation
Wenhao Wang, Jingxuan Zeng, Peili Luo, Jiayi Fang, Qingao Pei, Jinwu Yan, Chune Zhu, Wei Chen, Yanyun Liu, Zhengwei Huang, Ying Huang, Chuanbin Wu, Xin Pan
Summary: This study presents a lipid liquid crystalline nanoparticle NLP@Z, modified with a surface zwitterion material HB and encapsulated with NAC, to achieve the combination strategy of mucus-inert surface and mucus degradation. This combination strategy significantly enhances mucus penetration and epithelial cell uptake, and the NLP@Z also exhibits desired nebulization property, making it a potential pulmonary delivery nanoplatform.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Lei Shu, Wenhua Wang, Chon-iong Ng, Xuejuan Zhang, Ying Huang, Chuanbin Wu, Xin Pan, Zhengwei Huang
Summary: This study explores the industrialization potential of solid lipid nanoparticle (SLN)-based MDIs by utilizing SLNs as a model inhalable nanoparticle system. Three types of SLN-based MDIs with functions of stabilization, cellular uptake enhancement, and targetability were successfully fabricated. The results demonstrate the feasibility and stability of these SLN-based MDIs, providing a pilot study for the scale-up of SLN-based MDIs and contributing to the future development of inhalable nanoparticles.
Article
Multidisciplinary Sciences
Rafael L. Rangel, Francisco Kisuka, Colin Hare, Vincenzino Vivacqua, Alessandro Franci, Eugenio Onate, Chuan-Yu Wu
Summary: This paper provides experimental data on the temperature rise during granular flows in a small-scale rotating drum due to heat generation. Different material types of particles, multiple rotation speeds, and variable particle amounts were considered. Thermal cameras were used to monitor the temperature of the granular materials inside the drum. The data can be used as a reference for setting operating conditions of rotating drums and validating computer simulations.
Article
Biotechnology & Applied Microbiology
Mengqin Guo, Tingting Peng, Chuanbin Wu, Xin Pan, Zhengwei Huang
Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia. Ferroptosis inhibitors have been proven to be able to slow down the occurrence of IPF. This perspective proposes the use of inhalable nanomedicines carrying ferroptosis inhibitors as a promising strategy for the treatment of IPF.
BIOENGINEERING-BASEL
(2023)
Article
Pharmacology & Pharmacy
Ziyao Chang, Wenhao Wang, Zhengwei Huang, Ying Huang, Chuanbin Wu, Xin Pan
Summary: Protein drugs in pressurized metered dose inhalers (pMDIs) have potential for research and applications, but the stability of carrier particles is a major obstacle. This study proposes using lecithin to construct a reverse micelle system, aiming to improve the stability of carrier particles in pMDIs and protect protein drugs from degradation.
ADVANCED THERAPEUTICS
(2023)
Review
Polymer Science
Peili Luo, Lei Shu, Zhengwei Huang, Ying Huang, Chuanbin Wu, Xin Pan, Ping Hu
Summary: Management of chronic wounds is a global health problem that requires suitable healing environment and sustained delivery of growth factors. Researchers have been exploring new approaches, such as modifying hydrogels and using materials like lyotropic liquid crystalline, to overcome the limitations of current methods and improve the therapy and management of chronic wounds.
Article
Engineering, Chemical
Chao Zheng, Edward Yost, Ariel R. Muliadi, Nicolin Govender, Ling Zhang, Chuan-Yu Wu
Summary: This paper analyzes the die filling process using a discrete element method, and evaluates the influence of different stirrer designs on the filling performance. The results show that the helical-ribbon stirrer design exhibits the highest filling ratio and is the most robust design. Furthermore, the stirrer speed and filling speed have an impact on the filling performance.
Article
Materials Science, Multidisciplinary
Meihong Zhang, Yixian Zhou, Biyuan Wu, Chao Lu, Guilan Quan, Zhengwei Huang, Chuanbin Wu, Xin Pan
Summary: Photodynamic therapy selectively kills tumor cells using reactive oxygen species (ROS), but traditional methods lack sufficient ROS. Metal organic frameworks (MOFs) can convert hydrogen peroxide in tumor tissues into ROS and improve efficiency through their unique pores. Furthermore, MOFs can co-deliver photosensitizers and chemotherapeutic drugs for synergistic tumor cell killing.
MATERIALS ADVANCES
(2023)
