Review
Gastroenterology & Hepatology
Raquel Rozner, Savanah Gisriel, John Damianos, Alyssa A. A. Grimshaw, Rabia Rizwan, Ahmad Nawaz, Kevin Chan, David Wan, Haddon Pantel, Abdul O. Q. Bhutta, Marc Fenster, Lawrence J. J. Brandt, Andrea Barbieri, Marie E. E. Robert, Paul Feuerstadt, Darrick K. K. Li
Summary: In this study, clinical, radiologic, and endoscopic findings in 124 patients with idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) were examined in order to provide clinicians with a framework for pre-surgical identification of this rare disease.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Hui Li, Hong Shu, Hong Zhang, Mingming Cui, Yuying Gao, Feng Tian
Summary: Idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) is a rare and poorly understood disease characterized by non-thrombotic and non-inflammatory occlusion of the mesenteric veins. Its etiology is unknown and it presents with symptoms such as abdominal pain, bloody diarrhea, and weight loss. IMHMV is often misdiagnosed as inflammatory bowel disease, highlighting the need for increased awareness among clinicians.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Huanhuan Xie, Xiaopei Xu
Summary: IMHMV is a rare cause of ischemic bowel disease, characterized by proliferation of smooth muscles in mesenteric veins. Pre-operative CT with specific imaging features such as continuous concentric thickening of the colonic wall, poor enhancement, and enlarged tortuous pericolic arteries can facilitate rapid diagnosis of IMHMV.
Article
Surgery
W. Kelly Wu, Claudio R. Tombazzi, Catherine F. Howe, Melissa A. Kendall, Douglas B. Walton, Mary K. Washington, Molly M. Ford, Michael B. Hopkins, Timothy M. Geiger, Alexander T. Hawkins, Roberta L. Muldoon
Summary: Idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) is a rare cause of chronic colonic ischemia characterized by smooth muscle proliferation and narrowing of the mesenteric veins. It mainly affects the rectosigmoid colon in middle-aged males. Diagnosis and treatment require surgery, but misdiagnosis is common, leading to prolonged clinical course. We present a case of IMHMV presenting as left hemicolitis in a 53-year-old male, with endoscopic, histopathologic, and radiographic findings confirming the diagnosis.
Article
Surgery
Ali Al Ansari, Shehab Ahmed, Eyad Mansour, Maher A. Abass
Summary: IMHMV is a rare disease caused by proliferation of smooth muscle cells in mesenteric veins, leading to venous ischemia. This report describes a case of colonic ischemia in a 63-year-old man due to IMHMV.
JOURNAL OF SURGICAL CASE REPORTS
(2021)
Article
Surgery
Himani Bhatt, Roger K. Moreira, Sherief F. Shawki, Kristen K. Rumer
Summary: Idiopathic myointimal hyperplasia of mesenteric veins (IMHMV) is a rare type of chronic colonic ischemia. It often mimics inflammatory bowel disease and surgical resection is the curative treatment.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2023)
Review
Surgery
Ahmed Almumtin, Eman Al Sulais, Mohammed Atif Elhag
Summary: In this case report, a male patient with idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) and a presumed history of ulcerative colitis was described. The incorrect diagnosis of ulcerative colitis based on radiological findings led to unnecessary treatment with immuno-modulators and poor treatment response. Physicians should consider the possibility of IMHMV in cases with suspected inflammatory bowel disease or non-occlusive ischemia of the distal colorectum to prevent misdiagnosis and inappropriate treatment.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2021)
Article
Surgery
Eddy P. Lincango, Ju Yong Cheong, Christopher Prien, Tara M. Connelly, Oscar Hernandez Dominguez, Naz Tursun, David Liska, Jeremy Lipman, Amy Lightner, Hermann Kessler, Michael A. Valente, Tracy Hull, Scott R. Steele, Stefan D. Holubar
Summary: This study aimed to systematically evaluate the surgical procedures and outcomes for patients with idiopathic myointimal hyperplasia of the mesenteric veins. The majority of patients achieved remission with surgical intervention, with surgical resection being the most commonly performed procedure. Surgical decision-making should consider the extent of the disease.
Article
Surgery
Ga-Ram Han, Anchit P. Mehrotra, Adam J. Gomez, Eric Romanucci, Vivienne J. Halpern
Summary: Idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) is a rare etiology often misdiagnosed as inflammatory bowel disease. There is no effective medical treatment available, and surgical resection is the curative approach.
JOURNAL OF VASCULAR SURGERY CASES INNOVATIONS AND TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Michael G. Noujaim, Helen Tang, Kevin Kalisz, Natasha Iranzad, Daniel Wild
Summary: Idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) is a rare and poorly understood noninflammatory ischemic colitis. It is frequently misdiagnosed as an inflammatory bowel disease and is characterized by chronic abdominal pain, weight loss, and diarrhea. The pathophysiology involves the proliferation of the intimal smooth muscle in mesenteric veins, leading to bowel ischemia. Surgical resection is typically required for diagnosis as there are no effective medical therapies.
ACG CASE REPORTS JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Michael G. Noujaim, Helen Tang, Kevin Kalisz, Natasha Iranzad, Daniel Wild
Summary: Idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) is a rare noninflammatory ischemic colitis that is often misdiagnosed as an inflammatory bowel disease. It is characterized by chronic abdominal pain, weight loss, and diarrhea. The pathophysiology involves the proliferation of intimal smooth muscle in mesenteric veins, leading to bowel ischemia. Surgical resection is commonly required for diagnosis.
ACG CASE REPORTS JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Michelle Temby, Theresa L. Boye, Jacqueline Hoang, Ole H. Nielsen, John Gubatan
Summary: This article reviews the role of kinase signaling pathways in colitis-associated colon cancer, including MAPK, CDK, autophagy-activated kinases, JAK-STAT, and other kinases. It also discusses the involvement of JAK-STAT signaling in the pathogenesis of inflammatory bowel disease (IBD) and the potential use of JAK inhibitors for treating IBD.
Review
Gastroenterology & Hepatology
Anusha Shirwaikar Thomas, Stephen Hanauer, Yinghong Wang
Summary: Immune checkpoint inhibitors have revolutionized the management of advanced malignancies, but their use is often complicated by immune related adverse events, with immune checkpoint inhibitor enterocolitis being the most common toxicity. This review highlights the similarities and differences in the pathophysiology, clinical presentation, evaluation, and management of immune checkpoint inhibitor enterocolitis and idiopathic inflammatory bowel disorders.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Anusha Shirwaikar Thomas, Stephen Hanauer, Yinghong Wang
Summary: Immune checkpoint inhibitors have greatly advanced cancer treatment, but their use often leads to immune related adverse events (irAEs), with immune checkpoint inhibitor enterocolitis (IMEC) being the most common toxicity. IMEC is a distinct form of bowel inflammation that resembles idiopathic inflammatory bowel disorders. This review compares the pathophysiology, clinical presentation, evaluation, and management of IMEC and inflammatory bowel disorders. IMEC is an immune-related adverse event similar to inflammatory bowel disease, but little is known about its long-term outcomes.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Writaja Halder, Faidon-Marios Laskaratos, Hanan El-Mileik, Sergio Coda, Stevan Fox, Saswata Banerjee, Owen Epstein
Summary: The COVID-19 pandemic has heavily impacted healthcare services for patients with chronic diseases. This review explores the use of colon capsule endoscopy as a method for assessing and treating inflammatory bowel disease. Despite its limitations, there is increasing evidence to support the use of the second-generation colon capsule.
Correction
Oncology
Kenji Fujiyoshi, Tomoya Sudo, Fumihiko Fujita, Akiko Chino, Kiwamu Akagi, Akinari Takao, Masayoshi Yamada, Kohji Tanakaya, Hideyuki Ishida, Koji Komori, Soichiro Ishihara, Masashi Miguchi, Keiji Hirata, Yasuyuki Miyakura, Toshiaki Ishikawa, Tatsuro Yamaguchi, Naohiro Tomita, Yoichi Ajioka, Kenichi Sugihara
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Kenji Fujiyoshi, Tomoya Sudo, Fumihiko Fujita, Akiko Chino, Kiwamu Akagi, Akinari Takao, Masayoshi Yamada, Kohji Tanakaya, Hideyuki Ishida, Koji Komori, Soichiro Ishihara, Masashi Miguchi, Keiji Hirata, Yasuyuki Miyakura, Toshiaki Ishikawa, Tatsuro Yamaguchi, Naohiro Tomita, Yoichi Ajioka, Kenichi Sugihara
Summary: This study found an association between alcohol consumption and earlier onset of the first colorectal cancer (CRC) in a Japanese Lynch syndrome (LS) cohort. This association was stronger in men, carriers of pathogenic MLH1 and MSH2 gene mutations, and tumors located in the proximal colon.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Letter
Pathology
Rin Yamada, Risa Shimokawa, Toshimi Sato, Yoshiki Mikami
PATHOLOGY INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Takaaki Matsubara, Naohito Beppu, Masataka Ikeda, Hideyuki Ishida, Yoji Takeuchi, Toshiya Nagasaki, Akinari Takao, Kazuhito Sasaki, Kiwamu Akagi, Tomoya Sudo, Hideki Ueno, Tatsuro Yamaguchi, Naohiro Tomita, Yoichi Ajioka
Summary: This study analyzed the clinical practice in Japanese patients with familial adenomatous polyposis (FAP) and found that over one-third of non-dense FAP patients did not undergo colectomy after the age of 30, showing acceptable survival with early diagnosis of colorectal cancer and a low rate of desmoid tumor development.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2022)
Article
Gastroenterology & Hepatology
Yozo Suzuki, Fumio Ishida, Hideyuki Ishida, Hideki Ueno, Hirotoshi Kobayashi, Tatsuro Yamaguchi, Tsuyoshi Konishi, Yukihide Kanemitsu, Takao Hinoi, Yasuhiro Inoue, Naohiro Tomita, Kenichi Sugihara
Summary: This study aimed to clarify the morphological characteristics of colorectal cancer (CRC) in Japanese familial adenomatous polyposis (FAP) patients. Depressed superficial CRC lesions rarely developed but were detected in our study group, and ulcerated non-superficial CRC lesions were also present with similar ratios. Clinicians should pay attention to depressed superficial lesions during endoscopic surveillance of FAP patients.
JOURNAL OF THE ANUS RECTUM AND COLON
(2022)
Article
Gastroenterology & Hepatology
Katsunori Sakamoto, Toru Beppu, Goro Honda, Kenjiro Kotake, Masakazu Yamamoto, Keiichi Takahashi, Itaru Endo, Kiyoshi Hasegawa, Michio Itabashi, Yojiro Hashiguchi, Yoshihito Kotera, Shin Kobayashi, Tatsuro Yamaguchi, Soichiro Natsume, Ken Tabuchi, Hirotoshi Kobayashi, Kensei Yamaguchi, Kimitaka Tani, Satoshi Morita, Masaru Miyazaki, Kenichi Sugihara
Summary: The aim of this study was to evaluate the changes in characteristics and treatment strategies of patients with colorectal liver metastasis (CRLM) and analyze prognostic factors using large-scale data. The study summarized data of patients diagnosed between 2015 and 2017, and presented prognostic data of patients diagnosed in 2013 and 2014. The results showed changes in patient and oncological characteristics, a transition in treatment strategy, and different independent prognosticators compared to previous reports.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Toru Beppu, Kensuke Yamamura, Katsunori Sakamoto, Goro Honda, Shin Kobayashi, Itaru Endo, Kiyoshi Hasegawa, Kenjiro Kotake, Michio Itabashi, Yojiro Hashiguchi, Yoshihito Kotera, Tatsuro Yamaguchi, Soichiro Natsume, Ken Tabuchi, Hirotoshi Kobayashi, Kensei Yamaguchi, Satoshi Morita, Ken Kikuchi, Masaru Miyazaki, Kenichi Sugihara, Masakazu Yamamoto, Keiichi Takahashi
Summary: This study investigated the utility of the JSHBPS nomogram in patients with colorectal liver metastases. The results showed that the nomogram was beneficial for patients undergoing upfront hepatectomy, but less effective for patients undergoing hepatectomy after chemotherapy. Adjuvant chemotherapy should be recommended for high-risk patients.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Letter
Clinical Neurology
Rin Yamada, Hirotaka Inoue, Jun-ichiro Kuroda, Takuya Furuta, Mayuko Moritsubo, Naoki Shinojima, Akitake Mukasa, Yoshiki Mikami
Article
Oncology
Taichi Tamura, Masachika Ikegami, Yusuke Kanemasa, Makiko Yomota, Akiko Furusawa, Ryohei Otani, Chiaki Saita, Ichiro Yonese, Tomoko Onishi, Hiroshi Kobayashi, Toru Akiyama, Tatsu Shimoyama, Tomoyuki Aruga, Tatsuro Yamaguchi
Summary: In Japan, patients with advanced cancer only undergo comprehensive genomic profiling after treatment options have been exhausted. However, length bias may affect the accuracy of survival analysis, and no appropriate methods for adjusting this bias have been developed. This study established a simulation-based model for length bias adjustment and found that patients who underwent profiling tests early had a worse prognosis. Adjusting for length bias allowed for the analysis of prognostic relevance of oncogenic mutations and treatments.
Article
Immunology
Hiroaki Matsuzaki, Yoshihiro Komohara, Hiromu Yano, Yukio Fujiwara, Keitaro Kai, Rin Yamada, Daiki Yoshii, Ken Uekawa, Naoki Shinojima, Yoshiki Mikami, Akitake Mukasa
Summary: This study investigated the role of tumor-associated macrophages (TAMs) in recurrent pituitary neuroendocrine tumors (PitNETs). The study found that the density of TAMs increased in recurrent PitNETs and that cell-to-cell communication between TAMs and tumor cells promoted tumor growth.
MICROBIOLOGY AND IMMUNOLOGY
(2023)
Article
Oncology
Kensuke Yamamura, Toru Beppu, Koichi Kinoshita, Kazuki Matsumura, Eri Oda, Yasunori Nagayama, Toshihiko Motohara, Hideaki Miyamoto, Fujio Matsumura, Rin Yamada, Yoshihiko Komohara, Hirohisa Okabe, Tatsunori Miyata, Takatoshi Isiko
Summary: A rare case of peritoneal dissemination from distal cholangiocarcinoma after pancreaticoduodenectomy mimicking liver metastasis is reported. Laparoscopic surgery successfully diagnosed and treated the tumors, with no recurrence observed three months after the second operation.
ANTICANCER RESEARCH
(2023)
Article
Immunology
Rin Yamada, Koji Ohnishi, Cheng Pan, Hiromu Yano, Yukio Fujiwara, Takuya Shiota, Yoshiki Mikami, Yoshihiro Komohara
Summary: The specific molecules expressed in human sinus macrophages (SMs) have not been well studied. This research identified certain dendritic cell- or macrophage-related molecules in SMs in human lymph nodes (LNs). The study found that CD209, known as a DC-related molecule, was expressed in human SMs, while the expression of CXCL10 mRNA was not observed.
MICROBIOLOGY AND IMMUNOLOGY
(2023)
Letter
Pathology
Rin Yamada, Osamu Nakahara, Hiroshi Takamori, Yoshihiro Komohara, Minako Fujiwara
PATHOLOGY INTERNATIONAL
(2023)
Article
Oncology
Yoshikazu Kananazawa, Takeshi Yamada, Tatsuro Yamaguchi, Yoshinobu Saito, Daisuke Kakinuma, Yuka Masuda, Fumihiko Ando, Ryuji Ohashi, Hidetaka Eguchi, Yasushi Okazaki, Hideyuki Ishida, Hiroshi Yoshida
Summary: Juvenile polyposis syndrome (JPS) is an inherited disorder caused by genetic variants in SMAD4 or BMPR1A genes. Some JPS patients also develop hereditary hemorrhagic telangiectasia (HHT). In this study, a novel pathogenic variant in the SMAD4 gene was identified in a Japanese family with JPS and HHT. This variant has not been previously reported and is predicted to cause significant changes in the structure of the SMAD4 protein.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yasuyuki Miyakura, Akiko Chino, Kohji Tanakaya, Alan Kawarai Lefor, Kiwamu Akagi, Akinari Takao, Masayoshi Yamada, Hideyuki Ishida, Koji Komori, Kazuhito Sasaki, Masashi Miguchi, Keiji Hirata, Tomoya Sudo, Toshiaki Ishikawa, Tatsuro Yamaguchi, Naohiro Tomita, Yoichi Ajioka
Summary: Colonoscopy surveillance in patients with Lynch syndrome can reduce the incidence of colorectal cancer. This study reviewed the quality and safety of colonoscopy surveillance in patients with Lynch syndrome nationwide in Japan and found that high-volume experienced endoscopists and appropriate surveillance intervals may minimize the risk of developing colorectal cancers.