Article
Dentistry, Oral Surgery & Medicine
Sebastian-Edgar Baumeister, Birte Holtfreter, Stefan Lars Reckelkamm, Thomas Kocher, Zoheir Alayash, Benjamin Ehmke, Hansjorg Baurecht, Michael Nolde
Summary: Genetically proxied inhibition of NCP1L1 and PCSK9 was associated with lower odds of periodontitis, while genetically proxied HMGCR inhibition was not associated with periodontitis.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zhen Zhou, Joanne Ryan, Michael E. Ernst, Sophia Zoungas, Andrew M. Tonkin, Robyn L. Woods, John J. McNeil, Christopher M. Reid, Andrea J. Curtis, Rory Wolfe, Jo Wrigglesworth, Raj C. Shah, Elsdon Storey, Anne Murray, Suzanne G. Orchard, Mark R. Nelson
Summary: The study found that statin therapy in adults aged 65 and older was not associated with incident dementia, MCI, or declines in individual cognition domains. The impact of statin lipophilicity and baseline neurocognitive ability on these associations was also explored. Further confirmation from ongoing randomized trials is needed.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Charles M. Cobb, John S. Sottosanti
Summary: This commentary highlights the importance of subgingival calculus in the progression and treatment of periodontitis, emphasizing the critical role of SRP in removing calculus and biofilm deposits to reduce inflammatory burden. It also mentions that inflammation associated with periodontal infections affects both the oral environment and the patient's systemic health.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
An-Yi Wang, Guan-Ling Lin, Joseph Jordan Keller, Li-Hsuan Wang
Summary: The study found that in patients with hyperlipidemia, the combination of statins and fibrates can reduce the risk of chronic periodontitis, and long-term use of these drugs can also lower the risk of developing the disease.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Clinical Neurology
Jong S. Kim
Summary: Hyperlipidemia is an important risk factor for ischemic stroke, and statins have been shown to benefit stroke patients. Guidelines now emphasize high-intensity statins and low LDL-C target strategies for stroke patients, but the benefits of lipid-lowering therapy vary among patients with different levels of cerebral arterial diseases.
Article
Health Care Sciences & Services
Tak Kyu Oh, In-Ae Song, Young-Tae Jeon
Summary: Statin therapy may have potential benefits for the prevention of COVID-19 in South Korea, but it does not affect the hospital mortality of patients diagnosed with COVID-19.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hongye Lu, Lu He, Dongsiqi Jin, Yunxuan Zhu, Huanxin Meng
Summary: Periodontitis treatment with SRP and adjunctive antibiotics led to significant clinical improvement and reduced microbial diversity within 6 months. The use of antibiotics also showed potential benefits for systemic inflammation and glucose levels.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Bom Lee, Sung-Jin Hong, Seung-Woon Rha, Jung Ho Heo, Seung-Ho Hur, Hyun Hee Choi, Kyung-Jin Kim, Ju Han Kim, Hyun Kuk Kim, Ung Kim, Yu Jeong Choi, Yong-Joon Lee, Seung-Jun Lee, Chul-Min Ahn, Young-Guk Ko, Byeong-Keuk Kim, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: The combination therapy of moderate-intensity statin plus ezetimibe showed consistent effectiveness in reducing cardiovascular outcomes for patients with atherosclerotic cardiovascular disease (ASCVD), regardless of their baseline low-density lipoprotein cholesterol (LDL-C) levels.
Review
Pharmacology & Pharmacy
Ayala Hirsch, Natali Ternovsky, Donna R. R. Zwas, Reut Rotem, Offer Amir, Bruria Hirsh Raccah
Summary: This study assessed the effect of statin exposure during pregnancy on congenital anomalies and spontaneous abortions. The results showed that overall, treatment with statins during pregnancy was not associated with an increased risk of congenital anomalies. There was also no significant association between lipophilic statins and the rate of congenital anomalies. However, pregnant women receiving statins did have a slight elevation in the risks of cardiac malformation and spontaneous abortions.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Peripheral Vascular Disease
Mitra Nekouei Shahraki, Soroush Mohammadi Jouabadi, Daniel Bos, Bruno H. Stricker, Fariba Ahmadizar
Summary: This review aimed to determine the association between statin use and coronary artery calcification (CAC) in the general population. The analysis of previously published observational studies and randomized controlled trials revealed differences in the effects of statins on CAC depending on the study design.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Review
Peripheral Vascular Disease
Mitra Nekouei Shahraki, Soroush Mohammadi Jouabadi, Daniel Bos, Bruno H. Stricker, Fariba Ahmadizar
Summary: This review aimed to determine the association between statin use and coronary artery calcification (CAC). Observational studies found an association between statin use and higher CAC scores and presence, while randomized controlled trials did not show statistically significant results and varied depending on the quantification method.
CURRENT ATHEROSCLEROSIS REPORTS
(2023)
Article
Medicine, General & Internal
Karina Cardenas-Jaen, Alicia Vaillo-Rocamora, Angel Gracia, Pramoud K. Garg, Pedro Zapater, Georgios I. Papachristou, Vikesh K. Singh, Bechien U. Wu, Enrique de-Madaria
Summary: The SIMBA trial aims to determine whether simvastatin, a safe, widely used, and inexpensive drug, can alter the natural course of recurrent pancreatitis.
FRONTIERS IN MEDICINE
(2021)
Article
Urology & Nephrology
Sunjae Bae, JiYoon B. Ahn, Corey Joseph, Ryan Whisler, Mark A. Schnitzler, Krista L. Lentine, Bernard S. Kadosh, Dorry L. Segev, Mara A. McAdams-DeMarco
Summary: Statins appear to be well tolerated in kidney transplant recipients, but their use may be associated with a slightly higher risk of post-transplant diabetes mellitus, cataract, and rhabdomyolysis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Seon-Rye Kim, Minkook Son, Yu-Rin Kim
Summary: This study investigated the association between statin medication compliance and stroke risk in older adults with chronic periodontitis. The results suggest that increased compliance to statin medication may reduce the risk of stroke, particularly in female patients, individuals aged 85 or older, and patients with comorbidities.
EPIDEMIOLOGY AND HEALTH
(2022)
Article
Neurosciences
Guangshuo Li, Shang Wang, Yunyun Xiong, Hongqiu Gu, Kaixuan Yang, Xin Yang, Chunjuan Wang, Chuanying Wang, Zixiao Li, Xingquan Zhao
Summary: This study aimed to compare in-hospital mortality and evacuation rates of intracranial hematoma in patients with primary intracerebral hemorrhage who were prior statin users and nonusers. The results showed that prior statin use was not associated with in-hospital mortality but reduced the proportion of patients undergoing evacuation of intracranial hematoma.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
A. R. Pradeep, Vibhuti Garg, Dharmendra Kanoriya, Sandeep Singhal
JOURNAL OF PERIODONTOLOGY
(2016)
Article
Dentistry, Oral Surgery & Medicine
A. R. Pradeep, Deepak Kumar Suke, Santosh S. Martande, Sonender Pal Singh, Kanika Nagpal, Savitha B. Naik
JOURNAL OF PERIODONTOLOGY
(2016)
Article
Dentistry, Oral Surgery & Medicine
Dharmendra Kanoriya, A. R. Pradeep, Sandeep Singhal, Vibhuti Garg, C. N. Guruprasad
JOURNAL OF PERIODONTOLOGY
(2016)
Article
Dentistry, Oral Surgery & Medicine
A. R. Pradeep, Vibhuti Garg, Dharmendra Kanoriya, Sandeep Singhal
JOURNAL OF PERIODONTOLOGY
(2016)
Article
Dentistry, Oral Surgery & Medicine
Santosh S. Martande, Minal Kumari, A. R. Pradeep, Sonender Pal Singh, Deepak Kumar Suke, C. N. Guruprasad
JOURNAL OF PERIODONTOLOGY
(2016)
Article
Dentistry, Oral Surgery & Medicine
A. R. Pradeep, Shruti Karvekar, Kanika Nagpal, Kaushik Patnaik, Arjun Raju, Priyanka Singh
JOURNAL OF PERIODONTOLOGY
(2016)
Article
Dentistry, Oral Surgery & Medicine
Minal Kumari, Santosh S. Martande, A. R. Pradeep, Savitha B. Naik
JOURNAL OF PERIODONTOLOGY
(2016)
Article
Dentistry, Oral Surgery & Medicine
A. R. Pradeep, Vibhuti Garg, Arjun Raju, Priyanka Singh
JOURNAL OF PERIODONTOLOGY
(2016)
Article
Dentistry, Oral Surgery & Medicine
Sandeep Singhal, Avani R. Pradeep, Dharmendra Kanoriya, Vibhuti Garg
JOURNAL OF ORAL SCIENCE
(2016)
Article
Dentistry, Oral Surgery & Medicine
N. Priyanka, A. Abhilash, Shahab Saquib, Nikhil Malgaonkar, Nitin Kudyar, Aashima Gupta, Nitish Kalra, R. Pradeep
INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Anuj Sharma, Achala Raman, Avaru Raju Pradeep
JOURNAL OF APPLIED ORAL SCIENCE
(2017)
Article
Dentistry, Oral Surgery & Medicine
Dharmendra Kanoriya, A. R. Pradeep, Vibhuti Garg, Sandeep Singhal
JOURNAL OF PERIODONTOLOGY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Minal Kumari, Santosh S. Martande, Avani R. Pradeep
JOURNAL OF INVESTIGATIVE AND CLINICAL DENTISTRY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Kaushik Patnaik, A. R. Pradeep, Kanika Nagpal, Shruti Karvekar, Priyanka Singh, Arjun Raju
JOURNAL OF INVESTIGATIVE AND CLINICAL DENTISTRY
(2017)