Review
Dentistry, Oral Surgery & Medicine
Akihiro Yoshida, Amal Bouziane, Samir Erraji, Leila Lakhdar, Meryem Rhissassi, Hideo Miyazaki, Toshihiro Ansai, Masanori Iwasaki, Oumkeltoum Ennibi
Summary: Aggressive periodontitis (AgP) is a form of periodontitis that primarily affects adolescents and has a higher prevalence in individuals of African descent. It shows familial aggregation and genetic predisposition. Specific bacterial strains, like A. actinomycetemcomitans, and increased prevalence of Atopobium and Prevotella genera are associated with AgP. Additionally, IL-1a and IL-1b genetic polymorphisms, as well as elevated levels of IL-17, may play a role in the severity of AgP.
JAPANESE DENTAL SCIENCE REVIEW
(2021)
Article
Health Care Sciences & Services
Charity Masilela, Brendon Pearce, Joven Jebio Ongole, Oladele Vincent Adeniyi, Mongi Benjeddou
Summary: This study examined the association of specific gene polymorphisms with the glycaemic response to metformin and sulphonylureas in South African adults with type 2 diabetes. Certain genotypes were found to be significantly associated with uncontrolled diabetes, while others were associated with controlled diabetes. An interaction between two gene polymorphisms was observed, indicating a potential influence on treatment response.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Cell Biology
Farbod Bahreini, Elham Rayzan, Nima Rezaei
Summary: Breast cancer, a multifactorial disease, may have an increased risk due to alterations in microRNA sequences. miR-SNPs are potential biomarkers for early detection of breast cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Genetics & Heredity
Charity Masilela, Oladele Vincent Adeniyi, Mongi Benjeddou
Summary: This study describes the SNPs in amlodipine-associated genes and their correlation with blood pressure control among South African adults with hypertension. The study discovered five SNPs in amlodipine genes among the Xhosa-speaking tribe of South Africa, and one SNP was associated with blood pressure control.
Article
Genetics & Heredity
Muhammad Ahmad Yahaya, Hussein Shimelis, Baloua Nebie, Chris Ochieng Ojiewo, Abhishek Rathore, Roma Das
Summary: This study assessed the genetic diversity and population structure of 200 sorghum accessions using diversity arrays technology (DArT)-derived single nucleotide polymorphism (SNP) markers. The results showed a high level of genetic diversity among the accessions, which will be useful for enhancing sorghum breeding programs in West Africa by developing new gene pools and novel genotypes. Several distantly related sorghum accessions were identified, indicating the wide genetic diversity within the crop.
Article
Microbiology
Yiping Wei, Meng Shi, Yong Nie, Cui Wang, Fei Sun, Wenting Jiang, Wenjie Hu, Xiaolei Wu
Summary: This study identified significant differences in the salivary microbial community and metabolite composition between patients with periodontitis and healthy controls, as well as between different types of periodontitis. Specific microbial genera and metabolic pathways play important roles in the occurrence and development of periodontitis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Cell Biology
Concetta Scimone, Luigi Donato, Simona Alibrandi, Concetta Alafaci, Angela D'Ascola, Sergio Vinci, Rosalia D'Angelo, Antonina Sidoti
Summary: This study reveals the importance of epitranscriptomic modifications in gene expression regulation and suggests the involvement of altered epitranscriptome profile in the development of CCM. These findings provide new insights for further investigation into the pathogenesis of CCM.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Laura Massarenti, Christian Enevold, Dres Damgaard, Peter Riis Hansen, Morten Frisch, Niels Odum, Soren Jacobsen, Claus Henrik Nielsen
Summary: Epidemiological studies have shown an association between periodontitis and rheumatoid arthritis (RA). This study investigated whether this association is influenced by genetic polymorphisms. The study found that carrying specific alleles of certain genes increased the risk of RA in individuals with periodontitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria Radanova, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, Ivan Donev
Summary: There is a growing interest in studying single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, as they may be associated with susceptibility, prognosis, and treatment response in colorectal cancer (CRC). These miRNA-SNPs could serve as non-invasive biomarkers for early detection of CRC. However, contradictory findings have been reported when different research groups investigated the same SNP in a gene for a specific miRNA, highlighting the need for more case-control studies involving participants from different ethnic backgrounds. According to our review, three miRNA-SNPs - miR-146a rs2910164, miR-27a rs895819, and miR-608 rs4919510 - appear to be promising prognostic, diagnostic, and predictive biomarkers for CRC.
Article
Dentistry, Oral Surgery & Medicine
Alicia de Coo, Raquel Cruz, Ines Quintela, David Herrera, Mariano Sanz, Pedro Diz, Segundo Rodriguez Grandio, Nuria Vallcorba, Isabel Ramos, Alfonso Oteo, Cristina Serrano, Alejandro Esmatges, Francisco Enrile, Leopoldo Mateos, Roberto Garcia, Pablo Alvarez-Novoa, Blas Noguerol, Ion Zabalegui, Jose Blanco-Moreno, Angel Alonso, Ramon Lorenzo, Angel Carracedo, Juan Blanco
Summary: Through a genome-wide association study, no significantly associated SNPs were found with stages III/IV, grade C periodontitis (PIII/IV-C). However, 8 SNPs of 8 loci showed suggestive evidence of association with PIII/IV-C, with other interesting signals identified at different gene loci. Pathway analysis revealed significant enrichment of pathways related to cAMP, IL-2, CD28, VDR/RXR and PI3K/Akt.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Aniela Brodzikowska, Bartlomiej Gorski
Summary: Genetic factors play a significant role in the variability of periodontitis traits in humans. Different allelic variants can affect tissue structure, antibody responses, and inflammatory mediators, acting as protective or risk factors for periodontal diseases. Identifying genes associated with periodontitis can be used for risk assessment.
Article
Medicine, General & Internal
Charity Masilela, Brendon Pearce, Joven Jebio Ongole, Oladele Vincent Adeniyi, Rabia Johnson, Mongi Benjeddou
Summary: This study investigated the association of 5 single nucleotide polymorphisms (SNPs) in selected genes with blood pressure (BP) response to enalapril treatment among South African adults with hypertension. The study found that certain variants in ADRB2 and BDKRB2 genes were independently associated with controlled hypertension, while there was a significant interaction observed between VEGFA, ABO, and NOS3 genes in blood pressure response to enalapril. The findings suggest that SNPs can be predictive markers for enalapril response in South African adults with hypertension.
Review
Engineering, Environmental
Seyed Samad Hosseini, Asiyeh Jebelli, Somayeh Vandghanooni, Ali Jahanban-Esfahlan, Behzad Baradaran, Mohammad Amini, Negar Bidar, Miguel de la Guardia, Ahad Mokhtarzadeh, Morteza Eskandani
Summary: Single nucleotide polymorphisms (SNPs) are the main cause of individual variability and are associated with various diseases. The healthcare industry requires more advanced technologies to detect SNPs. This review focuses on novel SNP biosensors based on electrochemical, optical, and piezoelectric analysis, and explores future trends in sensing.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Medicine, General & Internal
Maha Daghestani, Nashwa Othman, Mohammed A. Omair, Fahidah Alenzi, Maha A. Omair, Eman Alqurtas, Shireen Amin, Arjumand Warsy
Summary: This study conducted an investigation on the Saudi population and found that 6 single nucleotide polymorphisms (SNPs) were significantly associated with rheumatoid arthritis (RA), with 4 of them having a protective effect. Two SNPs showed significantly higher heterozygote frequencies in the control group compared to the patients. This indicates considerable heterogeneity in the genetics of RA in different populations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Analytical
Salvatore Petralia, Antonella Vigilanza, Emanuele Sciuto, Michele Maffia, Antonella Romanini, Sabrina Conoci
Summary: The study investigated single nucleotide polymorphisms in the MC1R gene using a miniaturized silicon-based microarray-chip, showing good sensitivity and high confidence level, paving the way for future development of portable genetic assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)