Review
Medicine, General & Internal
Sylwia Slawek-Szmyt, Katarzyna Kawka-Paciorkowska, Aleksandra Cieplucha, Maciej Lesiak, Mariola Ropacka-Lesiak
Summary: Cardiovascular diseases (CVDs) are the top cause of death in women worldwide. Traditional risk factors and pregnancy-related complications both impact a woman's future CVD risk. Some pregnancy complications and CVDs may share common pathophysiological pathways.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Katherine M. Nelson, N'Dea Irvin-Choy, Matthew K. Hoffman, Jason P. Gleghorn, Emily S. Day
Summary: Maternal mortality rates in the United States have been steadily increasing, with most deaths attributed to underlying conditions and pregnancy-related diseases. The challenges of treating diseases in pregnant women are further complicated by potential harm to the developing fetus. Engineered nanomedicines offer potential solutions to improve outcomes for pregnant women and their offspring.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Medicine, General & Internal
Daniel Boron, Jakub Kornacki, Ewa Wender-Ozegowska
Summary: Intima-media thickness (IMT) measurement is a non-invasive method to assess arterial wall, and it is associated with atherosclerosis and endothelial dysfunction. Pre-existing conditions like diabetes, chronic hypertension, and obesity may impair the adaptation to pregnancy and influence fetal IMT. Increased fetal abdominal aorta IMT (aIMT) has been correlated with placental dysfunctions, which may lead to gestational hypertension, preeclampsia, and fetal growth restriction. Understanding the underlying pathomechanism is crucial for developing targeted therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Jamie Morgan, Samuel Bauer, Amy Whitsel, C. Andrew Combs
Summary: Due to increasing risks and disparities in postpartum care, a shift towards comprehensive and continuous care is necessary. Checklists have been developed to ensure that physical and mental well-being, follow-up appointments, and future health risks are appropriately addressed.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Nutrition & Dietetics
Qianqian Zhang, Chen Zhang, Yi Wang, Jiuru Zhao, Haiyuan Li, Qianwen Shen, Xiaoli Wang, Meng Ni, Fengxiu Ouyang, Angela Vinturache, Hao Chen, Zhiwei Liu
Summary: The study revealed that first trimester insufficient or deficient vitamin D levels and being overweight or obese significantly increased the risk of early fetal growth restriction. Furthermore, a combination of low Vitamin D concentrations and overweight or obesity had a significant effect on early fetal growth.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Multidisciplinary Sciences
Jezid Miranda, Cristina Paules, Guillaume Noell, Lina Youssef, Angel Paternina-Caicedo, Francesca Crovetto, Nicolau Canellas, Maria L. Garcia-Martin, Nuria Amigo, Elisenda Eixarch, Rosa Faner, Francesc Figueras, Rui Simos, Fatima Crispi, Eduard Gratacos
Summary: This study used machine learning to conduct cluster analysis of FGR, confirming the existence of two distinct subtypes with different molecular and clinical features. The clusters generated by machine learning outperformed single data subtype analysis in predicting adverse maternal and neonatal outcomes, supporting the current clinical classification.
Article
Medicine, General & Internal
Emmanuel Bujold, Alexandre Fillion, Florence Roux-Dalvai, Marie Pier Scott-Boyer, Yves Giguere, Jean-Claude Forest, Clarisse Gotti, Genevieve Laforest, Paul Guerby, Arnaud Droit
Summary: This study demonstrated that maternal urine proteomic profiling can differentiate women with and without preeclampsia. Specific proteins like ceruloplasmin and serpin A7 were upregulated in maternal urine before the diagnosis of preeclampsia and fetal growth restriction, suggesting their potential role as biomarkers for early detection.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Maria L. Boutet, Lina Youssef, Lena Erlandsson, Eva Hansson, Dolors Manau, Fatima Crispi, Gemma Casals, Stefan R. Hansson
Summary: This study examined the concentrations of scavenger proteins in the plasma of pregnant women and fetuses with and without corpus luteum in preeclampsia. The results showed that maternal haemopexin levels were higher in IVF pregnancies with corpus luteum and lower in IVF pregnancies without corpus luteum compared to naturally conceived pregnancies. Maternal alpha(1)-microglobulin levels were higher in severe cases of preeclampsia without corpus luteum compared to naturally conceived pregnancies and IVF pregnancies with corpus luteum. In cord blood, haemopexin levels were higher in IVF pregnancies with corpus luteum compared to naturally conceived pregnancies in preeclampsia and alpha(1)-microglobulin levels were higher in IVF pregnancies without corpus luteum compared to IVF pregnancies with corpus luteum in the normotensive population.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Engineering, Environmental
Zahra Aghaei, John G. Sled, John C. Kingdom, Ahmet A. Baschat, Paul A. Helm, Karl J. Jobst, Lindsay S. Cahill
Summary: This study investigated the effects of maternal exposure to microplastics and nanoplastics on fetal and placental growth using experimental mice. The results showed that fetuses from dams exposed to plastics exhibited growth restriction in late gestation, with a 12% decrease in fetal weight at the highest exposure concentration.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu'uhevaha J. Kaitu'u-Lino, Susan P. Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Lisa Hui, Natalie J. Hannan
Summary: Elevated levels of OLAH in the placenta may be associated with placental dysfunction in pregnancies complicated by preterm preeclampsia and fetal growth restriction. Further research is required to understand the role of OLAH in the placenta, and whether these changes are a maternal adaptation or consequence of disease.
Article
Peripheral Vascular Disease
Eva G. Mulder, Chahinda Ghossein-Doha, Ella Cauffman, Veronica A. Lopes van Balen, Veronique M. M. M. Schiffer, Robert-Jan Alers, Jolien Oben, Luc Smits, Sander M. J. van Kuijk, Marc E. A. Spaanderman
Summary: Tailored circulatory normalization of nonphysiological hemodynamic changes during pregnancy can reduce the risk of recurrent preeclampsia in high-risk populations. This simple and innovative treatment strategy shows no adverse effects on offspring outcomes.
Article
Biochemistry & Molecular Biology
Natalie K. K. Binder, Sally Beard, Natasha de Alwis, Bianca R. R. Fato, Tuong-Vi Nguyen, Tu'uhevaha J. Kaitu'u-Lino, Natalie J. J. Hannan
Summary: Preeclampsia is associated with increased risk of cardiovascular disease, possibly due to systemic organ and vascular damage or shared cardiovascular pathophysiology. Dysregulation of corin and ANP is common to both conditions. ANP, converted from pro-ANP by corin, is involved in blood pressure regulation. Although corin is mainly a cardiac enzyme, corin and pro-ANP are upregulated in the gravid uterus and dysregulated in preeclampsia. Limited information is available on the function of ANP in endothelial cells during preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Minori Kasuya, Naoya Akiba, Takayuki Iriyama, Seisuke Sayama, Kaori Kubota, Masatake Toshimitsu, Takahiro Seyama, Kenbun Sone, Keiichi Kumasawa, Takeshi Nagamatsu, Tomoyuki Fujii, Yutaka Osuga
Summary: This study aimed to compare the impact of fetal growth restriction (FGR) and maternal organ dysfunction on the severity of maternal preeclamptic features. The results showed that PE cases preceded by FGR had earlier diagnosis and delivery, but there were no significant differences in maternal morbidities compared to cases without FGR. For early-onset PE, the results were comparable between two groups.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Giorgia Sebastiani, Elisabet Navarro-Tapia, Laura Almeida-Toledano, Mariona Serra-Delgado, Anna Lucia Paltrinieri, Oscar Garcia-Algar, Vicente Andreu-Fernandez
Summary: Hypoxia and oxidative stress are crucial for fetal development during pregnancy, but an imbalance in oxidative molecules can lead to complications. Antioxidants may be a promising tool for treating these complications.
Article
Acoustics
T. Van Mieghem, L. Lewi, F. Slaghekke, E. Lopriore, Y. Yinon, L. Raio, D. Baud, P. Dekoninck, N. Melamed, E. Huszti, L. Sun, S. Shinar
Summary: This study aimed to identify predictors of fetal death in monochorionic diamniotic twin pregnancies complicated by Type-III selective fetal growth restriction (sFGR). The results showed that earlier diagnosis, oligohydramnios in the smaller twin, deterioration in umbilical artery Doppler flow, and larger fetal weight discordance were associated with an increased risk of fetal death. The CART model identified three risk groups. These findings are of importance for improving pregnancy outcomes in this high-risk population.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Giovanna Irene Battistoni, Giovanni Delli Carpini, Massimo Colaneri, Ramona Montironi, Giulia Gelzoni, Luca Giannella, Stefano Raffaele Giannubilo, Marco Pozzi, Andrea Ciavattini
Summary: This study aimed to validate the Thymic-Thoracic Ratio as a sonographic marker for conotruncal defects and investigate its correlation with the severity of these defects. The results showed that the T-T ratio had good diagnostic performance in identifying conotruncal defects and was negatively correlated with the Aristotle score.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Luca Giannella, Giovanni Delli Carpini, Jacopo Di Giuseppe, Barbara Gardella, Giorgio Bogani, Ermelinda Monti, Carlo Antonio Liverani, Elena Roncella, Francesco Raspagliesi, Arsenio Spinillo, Paolo Vercellini, Andrea Ciavattini
Summary: This study aimed to evaluate the independent variables associated with positive endocervical margin (EM) in women with high-grade cervical intraepithelial neoplasia (CIN) and fully visible transformation zone (TZ). The study found that TZ type and lesion extension were positively associated with positive EM, while cone depth was inversely related to positive EM. In women with TZ type 2 and lesion extension ≥2 cervical quadrants, an 8-mm cone depth provided a good cutoff value.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Sherif A. A. Shazly, Pluvio J. J. Coronado, Ercan Yilmaz, Rauf Melekoglu, Hanifi Sahin, Luca Giannella, Andrea Ciavattini, Giovanni Delli Carpini, Jacopo Di Giuseppe, Angel Yordanov, Konstantina Karakadieva, Nevena Milenova Nedelcheva, Mariela Vasileva-Slaveva, Juan Luis Alcazar, Enrique Chacon, Nabil Manzour, Julio Vara, Erbil Karaman, Onur Karaaslan, Latif Hacioglu, Duygu Korkmaz, Cem Onal, Jure Knez, Federico Ferrari, Esraa M. M. Hosni, Mohamed E. E. Mahmoud, Gena M. M. Elassall, Mohamed S. S. Abdo, Yasmin I. I. Mohamed, Amr S. S. Abdelbadie
Summary: The objective of this study was to establish a prognostic model for endometrial cancer that individualizes a risk and management plan based on patient and disease characteristics. Machine learning algorithms were applied to analyze patient and disease characteristics, and three models were developed to predict cancer-specific survival and disease-free survival. The Endometrial Cancer Individualized Scoring System (ECISS) developed in this study showed high accuracy in assessing patient-specific survival probability.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Biochemistry & Molecular Biology
Christian Giommi, Marta Lombo, Nina Montik, Michela Paolucci, Valentina Notarstefano, Giovanni Delli Carpini, Andrea Ciavattini, Antonio Ragusa, Francesca Maradonna, Elisabetta Giorgini, Oliana Carnevali
Summary: Gestational diabetes mellitus (GDM) and small-for-gestational-age (SGA) are metabolic-related diseases that can occur during pregnancy. This study investigated the changes in the placental chorionic villi (CVs) of GDM and SGA patients. The results showed higher levels of SOD-1 and CAT in GDM placentae, which may be related to the hyperglycemic environment. Lipid composition and structure of the placenta were altered in both pathologies, with SGA inducing lipid peroxidation and reducing collagen deposition in the CVs. The cannabinoid system does not seem to be involved in these two pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Luca Giannella, Jacopo Di Giuseppe, Giovanni Delli Carpini, Camilla Grelloni, Mariasole Fichera, Gianmarco Sartini, Serena Caimmi, Leonardo Natalini, Andrea Ciavattini
Summary: Cervical cancer is a major cause of death in women, particularly in developing countries. Cervical adenocarcinoma, a subtype of the disease, often presents at an advanced stage and has a poorer prognosis compared to squamous lesions. Treatment options and the impact of HPV vaccination and screening in managing these lesions require further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Alice Di Paolo, Arianna Vignini, Sonila Alia, Valentina Membrino, Giovanni Delli Carpini, Luca Giannella, Andrea Ciavattini
Summary: Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid involved in various biological processes and diseases. Dysregulation of S1P signaling and metabolism is implicated in gynecologic disorders, indicating its potential as a therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Stefano R. Giannubilo, Alessia Fiorelli, Daniela Marzioni, Giovanni Tossetta, Giulia Capogrosso, Andrea Ciavattini
Summary: The frequency of inherited thrombophilia is higher in monochorionic twin pregnancies with TTTS, with an increased risk for Factor I and Factor V Leiden allele polymorphism. Maternal inherited thrombophilia may result in impaired development of placental vascular architecture.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Giorgio Bogani, Alessandro Ghelardi, Francesco Sopracordevole, Marco Annoni, Andrea Ciavattini, Luca Giannella, Rosa De Vincenzo, Paolo Cattani, Maggiorino Barbero, Paolo Vercellini, Francesco Raspagliesi, Paolo Bonanni, Giovanni Scambia
Summary: Human papillomavirus (HPV) is a common sexually transmitted infection that can cause various diseases, including cervical cancer. Prophylactic HPV vaccines have been developed to prevent the spread of HPV and reduce the prevalence of HPV-related diseases. Despite their high efficacy, HPV vaccines are underutilized in Italy, with decreasing coverage rates. Action is needed to improve HPV awareness and education to promote widespread adoption of HPV vaccination.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Editorial Material
Medicine, General & Internal
Stefano R. Giannubilo, Andrea Ciavattini
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Luca Giannella, Camilla Grelloni, Dayana Quintili, Alessia Fiorelli, Ramona Montironi, Sonila Alia, Giovanni Delli Carpini, Jacopo Di Giuseppe, Arianna Vignini, Andrea Ciavattini
Summary: The human microbiota consists of microorganisms, such as bacteria, fungi, and viruses, that live on and inside our bodies. Recent research has shown the important role of microbiota changes in health and disease, particularly during pregnancy. This literature review focuses on the significant changes in the microbiota associated with four common obstetric diseases: hypertensive disorders, gestational diabetes mellitus, preterm birth, and recurrent miscarriage. The review also discusses potential advancements in developing personalized therapies for disease prevention and tailored treatments by modulating the microbiota.
Article
Oncology
Giovanni Delli Carpini, Paolo Giorgi Rossi, Luca Giannella, Jacopo Di Giuseppe, Nicolo Clemente, Francesco Sopracordevole, Maggiorino Barbero, Giorgio Bogani, Rosa De Vincenzo, Massimo Origoni, Francesco Cantatore, Barbara Gardella, Mattia Dominoni, Ermelinda Monti, Carlo Antonio Liverani, Anna Viscardi, Alessio Pagan, Andrea Amadori, Chiara Alessi, Matteo Andolfatto, Paolo Cattani, Annalisa Pieralli, Guido Stevenazzi, Andrea Ciavattini
Summary: This study evaluates the impact of healthcare reorganization during the COVID-19 pandemic on Italian colposcopy clinic activities, specifically focusing on cervical excision procedures, follow-ups for conservative management of low-grade lesions, and follow-ups post cervical excision. The results show a reduction in the number of cervical excisions by 8.8% during the pandemic period compared to pre-pandemic. There were also significant reductions in the follow-ups for low-grade lesion management and follow-up appointments after cervical excision.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Nicolo Clemente, Andrea Ciavattini, Gaetano Valenti, Federica Zannier, Jacopo Di Giuseppe, Giovanni Delli Carpini, Mariasole Fichera, Anna Del Fabro, Giorgio Giorda, Gaia Goteri, Vincenzo Canzonieri, Francesco Sopracordevole
Summary: Extramammary Paget's disease of the vulva (EMPDV) is a rare disease, but it is often associated with other premalignant/malignant vulvar lesions. This study aimed to evaluate the incidence of concomitant vulvar cancers or premalignant lesions in women surgically treated for EMPDV. The medical records of 69 women with EMPDV were analyzed, and 31.9% of them had concomitant vulvar lesions, including VIN and LS. One patient had synchronous vulvar SCC. Women with EMPDV and concomitant premalignant/malignant vulvar lesions had a higher rate of invasive EMPDV and wider lesions. The significance of this association remains unclear, highlighting the importance of specialized healthcare providers.
Article
Obstetrics & Gynecology
Stefano Raffaele Giannubilo, Mirco Amici, Simone Pizzi, Alessandro Simonini, Andrea Ciavattini
Summary: This study aimed to analyze the mechanisms involved in fetal heart rate abnormalities after epidural analgesia in labor. The study found that the maternal hemodynamic status at the onset of labor may affect the fetal response to analgesia.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Meeting Abstract
Oncology
Giuseppe Capalbo, Violante Di Donato, Francesco Sopracordevole, Andrea Ciavattini, Benito Chiofalo, Enrico Vizza, Paolo Vercellini, Fabio Ghezzi, Giovanni Scambia, Francesco Raspagliesi, Innocenza Palaia, Pierluigi Benedetti Panici, Ludovico Muzii, Giorgio Bogani
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Medicine, General & Internal
Francesco Sopracordevole, Nicolo Clemente, Maria Papiccio, Anna Del Fabro, Matteo Serri, Mariasole Fichera, Monica Buttignol, Giorgio Giorda, Giovanni Delli Carpini, Andrea Ciavattini
Summary: The histopathological findings in postmenopausal women who underwent hysterectomy for postsurgical cervical stenosis were analyzed to evaluate the incidental findings of preinvasive or invasive uterine and cervical disease.