GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice

Liraglutide: A Review of Its Use in the Management of Obesity

(2015) Lesley J. Scott   DRUGS

Effects of secretin on neuronal activity and feeding behavior in central amygdala of rats

(2015) Ya-Yan Pang et al.   PEPTIDES

A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents

(2015) Louise S. Dalbøge et al.   PLoS One

Effects of PYY3–36 and GLP-1 on energy intake, energy expenditure, and appetite in overweight men

(2014) Julie Berg Schmidt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The potential risks of pancreatitis and pancreatic cancer with GLP-1-based therapies are far outweighed by the proven and potential (cardiovascular) benefits

(2014) R. E. J. Ryder   DIABETIC MEDICINE

Secretin receptor-knockout mice are resistant to high-fat diet-induced obesity and exhibit impaired intestinal lipid absorption

(2014) Revathi Sekar et al.   FASEB JOURNAL

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

(2014) Brian Finan et al.   NATURE MEDICINE

A Meta-Analysis of Short-Term Outcomes of Patients with Type 2 Diabetes Mellitus and BMI ≤35 kg/m2 Undergoing Roux-en-Y Gastric Bypass

(2014) Wen-Sheng Rao et al.   WORLD JOURNAL OF SURGERY

Update for BayesApp: a web site for analysis of small-angle scattering data

(2014) Steen Hansen   JOURNAL OF APPLIED CRYSTALLOGRAPHY

A PEGylated analog of the gut hormone oxyntomodulin with long-lasting antihyperglycemic, insulinotropic and anorexigenic activity

(2013) Elisabetta Bianchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent progress and future options in the development of GLP-1 receptor agonists for the treatment of diabesity

(2013) Martin Lorenz et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Critical Analysis of the Clinical Use of Incretin-Based Therapies: Are the GLP-1 therapies safe?

(2013) P. C. Butler et al.   DIABETES CARE

A Novel Glucagon-like Peptide-1 (GLP-1)/Glucagon Hybrid Peptide with Triple-acting Agonist Activity at Glucose-dependent Insulinotropic Polypeptide, GLP-1, and Glucagon Receptors and Therapeutic Potential in High Fat-fed Mice

(2013) Victor A. Gault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypertrophy Dependent Doubling of L-Cells in Roux-en-Y Gastric Bypass Operated Rats

(2013) Carl Frederik Hansen et al.   PLoS One

Characterisation of Age-Dependent Beta Cell Dynamics in the Male db/db Mice

(2013) Louise S. Dalbøge et al.   PLoS One

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

(2013) B. Finan et al.   Science Translational Medicine

The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis

(2012) Niels Vrang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents

(2012) Jonathan W. Day et al.   BIOPOLYMERS

Outstanding Scientific Achievement Award Lecture 2011: Defeating Diabesity: The Case for Personalized Combinatorial Therapies

(2012) M. H. Tschop et al.   DIABETES

Chronic GLP-1 Receptor Activation by Exendin-4 Induces Expansion of Pancreatic Duct Glands in Rats and Accelerates Formation of Dysplastic Lesions and Chronic Pancreatitis in the KrasG12DMouse Model

(2012) Belinda Gier et al.   DIABETES

BayesApp: a web site for indirect transformation of small-angle scattering data

(2012) Steen Hansen   JOURNAL OF APPLIED CRYSTALLOGRAPHY

GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus

(2012) Juris J. Meier   Nature Reviews Endocrinology

Importance of Each Residue within Secretin for Receptor Binding and Biological Activity

(2011) Maoqing Dong et al.   BIOCHEMISTRY

Pancreatitis, Pancreatic, and Thyroid Cancer With Glucagon-Like Peptide-1–Based Therapies

(2011) Michael Elashoff et al.   GASTROENTEROLOGY

Health and economic burden of the projected obesity trends in the USA and the UK

(2011) Y Claire Wang et al.   LANCET

Discovery and characterization of taspoglutide, a novel analogue of human glucagon-like peptide-1, engineered for sustained therapeutic activity in type 2 diabetes

(2010) J. Z. Dong et al.   DIABETES OBESITY & METABOLISM

Taspoglutide, an Analog of Human Glucagon-Like Peptide-1 with Enhanced Stability andin VivoPotency

(2010) Elena Sebokova et al.   ENDOCRINOLOGY

Tesofensine, a Novel Triple Monoamine Reuptake Inhibitor, Induces Appetite Suppression by Indirect Stimulation of α1 Adrenoceptor and Dopamine D1 Receptor Pathways in the Diet-Induced Obese Rat

(2010) Anne Marie D Axel et al.   NEUROPSYCHOPHARMACOLOGY

Central and Peripheral Administration of Secretin Inhibits Food Intake in Mice through the Activation of the Melanocortin System

(2010) Carrie Yuen Yee Cheng et al.   NEUROPSYCHOPHARMACOLOGY

Weight and Type 2 Diabetes after Bariatric Surgery: Systematic Review and Meta-analysis

(2009) Henry Buchwald et al.   AMERICAN JOURNAL OF MEDICINE

Improvement in Glucose Metabolism After Bariatric Surgery: Comparison of Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy

(2009) Ralph Peterli et al.   ANNALS OF SURGERY

Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice

(2009) A. Pocai et al.   DIABETES

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

(2009) Jonathan W Day et al.   Nature Chemical Biology

Effect of Weight Loss by Gastric Bypass SurgeryVersusHypocaloric Diet on Glucose and Incretin Levels in Patients with Type 2 Diabetes

(2008) Blandine Laferrère et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM