Article
Biotechnology & Applied Microbiology
Pablo Manuel Bianculli, Lucile Bellier, Ignacio Olivera Mangado, Carlos Grau Perez, Gustavo Mieres, Luis Lazarov, Audrey Petitjean, Hugo Dibarboure, Juan Guillermo Lopez
Summary: This study evaluated the cost-utility of replacing trivalent influenza vaccine with quadrivalent influenza vaccine in Uruguay. The results showed that using quadrivalent influenza vaccine could avoid a considerable number of influenza cases and healthcare consultations, and save workdays. It is cost-effective, especially for the target populations in Uruguay, particularly for older adults.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Constantina Boikos, Lauren Fischer, Dan O'Brien, Joe Vasey, Gregg C. Sylvester, James A. Mansi
Summary: The study compared the effectiveness of different vaccines in preventing influenza-related medical encounters in adults aged 65 and older. Results showed that aIIV3 demonstrated greater reduction in influenza-related medical encounters compared to IIV4 and HD-IIV3 in both 2017-2018 and 2018-2019 US influenza seasons.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Manjusha Gaglani, Anupama Vasudevan, Chandni Raiyani, Kempapura Murthy, Wencong Chen, Michael Reis, Edward A. Belongia, Huong Q. McLean, Michael L. Jackson, Lisa A. Jackson, Richard K. Zimmerman, Mary Patricia Nowalk, Arnold S. Monto, Emily T. Martin, Jessie R. Chung, Sarah Spencer, Alicia M. Fry, Brendan Flannery
Summary: The study compared the vaccine effectiveness of quadrivalent and trivalent influenza vaccines against illness due to influenza B during the transition in the United States. Results showed that quadrivalent vaccines were more effective against influenza B cases, especially for the B lineage not included in the trivalent vaccines.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Mark Loeb, Margaret L. Russell, Caralyn Kelly-Stradiotto, Nola Fuller, Kevin Fonseca, David J. D. Earn, Khami Chokani, Lorne Babiuk, Binod Neupane, Pardeep Singh, Eleanor Pullenayegum
Summary: The study found that vaccinating children with MF59 adjuvanted trivalent influenza vaccine did not significantly reduce influenza infection rates in children and family members compared to inactivated quadrivalent vaccine, but it did result in significant protection against influenza A in children.
Article
Immunology
Constantina Boikos, Lauren Fischer, Dan O'Brien, Joe Vasey, Gregg C. Sylvester, James A. Mansi
Summary: This study estimated the relative vaccine effectiveness (rVE) of cell-propagated inactivated quadrivalent influenza vaccine (ccIIV4) versus egg-derived inactivated quadrivalent influenza vaccine (eIIV4) in preventing influenza-related medical encounters in the 2018-2019 US season. The results showed a statistically significantly greater reduction in influenza-related medical encounters in individuals vaccinated with ccIIV4 compared to eIIV4, supporting ccIIV4 as a potentially more effective public health measure against influenza.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Diana Tavares, Helena Mourino, Cristina Anton Rodriguez, Carlos Martin Saborido
Summary: This study evaluates the cost effectiveness of switching from trivalent inactivated vaccine (TIV) to quadrivalent inactivated vaccine (QIV) in the Portuguese elderly population from the perspective of the National Health Service. The findings indicate that QIV is not cost effective due to its high cost.
Article
Immunology
Yaping Chen, Yanhui Xiao, Ying Ye, Feng Jiang, Hanqing He, Linyun Luo, Haiping Chen, Lubin Shi, Qiuyue Mu, Wei Chen, Xue Guo, Min Zhang, Jun Li, Qinghu Guan, Zhiping Chen, Xiaoming Yang
Summary: This study demonstrates that in infants, coadministration of an inactivated enterovirus 71 vaccine (EV71 vaccine) with trivalent split-virion inactivated influenza vaccine (IIV3) is safe and does not interfere with immunogenicity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Lucile Bellier, Audrey Petitjean, Tatiana Sarazu, Julio Tresierra, Juan Guillermo Lopez
Summary: The study evaluated the cost-effectiveness of switching from trivalent to quadrivalent influenza vaccines in Peru, showing that introducing QIV instead of TIV is expected to be a cost-effective strategy, especially for younger children and the elderly. The benefits of QIV would be even greater if the coverage targeted by the Ministry of Health is reached, leading to significant health and economic impact in preventing influenza infections.
Review
Immunology
Constantina Boikos, Ian McGovern, Justin R. Ortiz, Joan Puig-Barbera, Eve Versage, Mendel Haag
Summary: This study summarizes the relative vaccine effectiveness of aIIV3 vs. HD-IIV3 and aIIV3 vs. standard, egg-based quadrivalent influenza vaccines in the elderly population, showing consistent benefits for aIIV3 in the overall and at-risk populations.
Article
Economics
Florian Zeevat, Pascal Crepey, F. Christiaan K. Dolk, Arjan J. Postma, Vidya N. A. Breeveld-Dwarkasing, Maarten J. Postma
Summary: Using quadrivalent influenza vaccine (QIV) instead of trivalent influenza vaccine (TIV) during the influenza seasons 2010 to 2018 in the Netherlands would have been cost-effective, potentially preventing an average of 9500 symptomatic influenza cases, 2130 outpatient visits, 84 hospitalizations, and 38 deaths per year. Retrospectively, this decision could have led to additional 385 QALYs and 398 life-years gained annually, with significant cost savings.
Review
Immunology
Amit Bansal, Mai-Chi Trieu, Kristin G. I. Mohn, Rebecca Jane Cox
Summary: Research shows that inactivated influenza vaccines (IIVs) are generally well tolerated in pregnant women and young children, generating good antibody responses and providing moderate to high protection rates against different influenza types. The efficacy/effectiveness of IIVs is around 50%-70% in pregnant women and 20%-90% in young children against lab-confirmed influenza, but depends on various factors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mbayame Nd Niang, Jonathan D. Sugimoto, Aldiouma Diallo, Bou Diarra, Justin R. Ortiz, Kristen D. C. Lewis, Kathryn E. Lafond, M. Elizabeth Halloran, Marc-Alain Widdowson, Kathleen M. Neuzil, John C. Victor
Summary: This study in Senegal found variable effectiveness of the trivalent inactivated influenza vaccine against influenza illness in children, with total and indirect vaccine effectiveness present when all circulating strains matched the vaccine formulation.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biotechnology & Applied Microbiology
Xiaoqiang Liu, Juliana Park, Shengli Xia, Bin Liang, Shuangmin Yang, Yanxia Wang, Olga Syrkina, Nathalie Lavis, Shuzhen Liu, Chenyan Zhao, Jian Ding, Jieqiong Hu, Sandrine Samson, Iris A. de Bruijn
Summary: The safety and immunogenicity of the quadrivalent, split-virion influenza vaccine (Shz QIV) developed in China were assessed. The vaccine showed good tolerability and induced immune responses in different age groups, demonstrating non-inferiority against various strains of influenza virus.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Huakun Lv, Xuejiao Pan, Hui Liang, Ying Wang, Yu Hu
Summary: Reports to the national adverse event following immunization surveillance system (NAEFISS) following inactivated quadrivalent influenza vaccine (QIV) in Zhejiang province from 2018 to 2020 did not reveal any new or unexpected safety concerns. Continual monitoring of the safety of QIV is recommended.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Antonio Arbo, Celia Martinez-Cellular, Cynthia Vazquez, Lucile Bellier, Cecilia Adorno, Hugo Dibarboure, Juan Guillermo Lopez, Audrey Petitjean, Pablo Bianculli
Summary: This study investigates the public health and economic benefits of using a quadrivalent influenza vaccine (QIV) instead of a trivalent influenza vaccine (TIV) in past seasons in Paraguay. The findings suggest that switching from TIV to QIV could have prevented influenza cases, hospitalizations, and deaths, potentially generating savings for the health system and society. The impact is influenced by vaccine prices and coverage rate.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Oncology
Deena R. Levine, Erik Liederbach, Liza-Marie Johnson, Erica C. Kaye, Holly Spraker-Perlman, Belinda Mandrell, Michele Pritchard, April Sykes, Zhaohua Lu, Dave Wendler, Justin N. Baker
Article
Oncology
Liza-Marie Johnson, April D. Sykes, Zhaohua Lu, Jessica M. Valdez, Jami Gattuso, Elsie Gerhardt, Kayla Hamilton, Lynn W. Harrison, Stacy J. Hines-Dowell, Niki Jurbergs, Rose B. McGee, Regina Nuccio, Annastasia A. Ouma, Michele Pritchard, Emily A. Quinn, Justin N. Baker, Belinda N. Mandrell, Kim E. Nichols
Article
Oncology
Wayne L. Furman, Sara M. Federico, Mary Beth McCarville, Barry L. Shulkin, Andrew M. Davidoff, Matthew J. Krasin, Natasha Sahr, April Sykes, Jianrong Wu, Rachel C. Brennan, Michael William Bishop, Sara Helmig, Elizabeth Stewart, Fariba Navid, Brandon Triplett, Victor M. Santana, Armita Bahrami, Gwendolyn Anthony, Alice L. Yu, Jacquelyn Hank, Stephen D. Gillies, Paul M. Sondel, Wing H. Leung, Alberto S. Pappo
CLINICAL CANCER RESEARCH
(2019)
Article
Clinical Neurology
Valerie McLaughlin Crabtree, Kimberly Lauren Klages, April Sykes, Merrill S. Wise, Zhaohua Lu, Daniel Indelicato, Thomas E. Merchant, Yvonne Avent, Belinda N. Mandrell
JOURNAL OF CLINICAL SLEEP MEDICINE
(2019)
Article
Oncology
Victor M. Santana, Natasha Sahr, Ruth G. Tatevossian, Sujuan Jia, Olivia Campagne, April Sykes, Clinton F. Stewart, Wayne L. Furman, Lisa M. McGregor
Article
Oncology
Hadeel Halalsheh, Sue C. Kaste, Matthew J. Krasin, April Sykes, Natasha Sahr, Sheri L. Spunt, Sara M. Federico, Michael W. Bishop
PEDIATRIC BLOOD & CANCER
(2020)
Article
Oncology
Belinda N. Mandrell, Kayla LaRosa, Donna Hancock, Mary Caples, April Sykes, Zhaohua Lu, Merrill S. Wise, Raja B. Khan, Thomas E. Merchant, Valerie McLaughlin-Crabtree
JOURNAL OF NEURO-ONCOLOGY
(2020)
Article
Oncology
Rosa Nguyen, Natasha Sahr, April Sykes, Mary Beth McCarville, Sara M. Federico, Amanda Sooter, David Cullins, Barbara Rooney, William E. Janssen, Aimee C. Talleur, Brandon M. Triplett, Gwendolyn Anthony, Michael A. Dyer, Alberto S. Pappo, Wing H. Leung, Wayne L. Furman
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Oncology
Sara M. Federico, Alberto S. Pappo, Natasha Sahr, April Sykes, Olivia Campagne, Clinton F. Stewart, Michael R. Clay, Armita Bahrami, Mary B. McCarville, Sue C. Kaste, Victor M. Santana, Sara Helmig, Jessica Gartrell, Anang Shelat, Rachel C. Brennan, Dana Hawkins, Kimberly Godwin, Michael W. Bishop, Wayne L. Furman, Elizabeth Stewart
EUROPEAN JOURNAL OF CANCER
(2020)
Article
Medicine, Research & Experimental
Janice M. Riberdy, Sheng Zhou, Fei Zheng, Young-In Kim, Jennifer Moore, Abishek Vaidya, Robert E. Throm, April Sykes, Natasha Sahr, Challice L. Bonifant, Byoung Ryu, Stephen Gottschalk, Mireya Paulina Velasquez
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2020)
Article
Anesthesiology
Eric I. Ly, Rachel C. Brennan, Matthew W. Wilson, Natasha Sahr, April Sykes, Kyle J. Morgan
PEDIATRIC ANESTHESIA
(2021)
Article
Oncology
Benjamin A. King, Natasha Sahr, April Sykes, Matthew W. Wilson, Rachel C. Brennan
Summary: The study evaluated the efficacy of neoadjuvant intravenous chemotherapy with two cycles of vincristine and topotecan (VT) in reducing retinoblastoma tumor volumes. Results showed a significant decrease in tumor dimensions, with most tumors demonstrating over 50% reduction in volume. Tumor location, distance from the optic nerve, and age at diagnosis were identified as important predictors of treatment response.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Jessica Gartrell, Marcia Mellado-Largarde, Michael R. Clay, Armita Bahrami, Natasha A. Sahr, April Sykes, Kaley Blankenship, Lauren Hoffmann, Jia Xie, Hyekyung P. Cho, Nathaniel Twarog, Michele Connelly, Koon-Kiu Yan, Jiyang Yu, Shaina N. Porter, Shondra M. Pruett-Miller, Geoffrey Neale, Christopher L. Tinkle, Sara M. Federico, Elizabeth A. Stewart, Anang A. Shelat
Summary: SLFN11 expression in pediatric sarcomas correlates strongly with sensitivity to PARP inhibitors and topoisomerase I inhibitors, but high SLFN11 expression may not be favorable for resistance to DDA-induced replicative stress.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Biology
Eric T. Hall, Miriam E. Dillard, Daniel P. Stewart, Yan Zhang, Ben Wagner, Rachel M. Levine, Shondra M. Pruett-Miller, April Sykes, Jamshid Temirov, Richard E. Cheney, Motomi Mori, Camenzind G. Robinson, Stacey K. Ogden
Summary: Morphogens act in concentration-dependent ways to guide cell fate during tissue patterning, with cytoneme transport model suggesting the extension of specialized filopodia between sending and responding cells to ensure proper signaling thresholds. The actin motor Myosin 10 facilitates vesicular transport of Sonic Hedgehog (SHH) morphogen in mouse cell cytonemes, and cytoneme-mediated deposition of SHH onto receiving cells induces a rapid, receptor-dependent signal response. The activity is dependent on a novel Dispatched (DISP)-BOC/CDON co-receptor complex in ligand-producing cells to promote cytoneme occurrence and facilitate signal activation.
Article
Oncology
Courtney E. Sullivan, Amber-Rose King, Joni Holdiness, Judith Durrell, Kristin K. Roberts, Christopher Spencer, Joshua Roberts, Susan W. Ogg, Meredith W. Moreland, Emily K. Browne, Carla Cartwright, Valerie McLaughlin Crabtree, Justin N. Baker, Mark Brown, April Sykes, Belinda N. Mandrell
ONCOLOGY NURSING FORUM
(2019)
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)