Review
Biotechnology & Applied Microbiology
Yuan Zhang, Xiaorong Chen, Yajuan Cao, Zongguo Yang
Summary: APOBEC3 (A3) cytidine deaminases play important roles in inhibiting HBV infection, but their deaminated deoxycytidine activity can also cause cellular genetic mutations, affecting genomic stability and cancer development.
Review
Biochemistry & Molecular Biology
Caroline Lefeuvre, Helene Le Guillou-Guillemette, Alexandra Ducancelle
Summary: Chronic HBV infection is a common factor associated with HCC, with studies showing that the HBc protein plays a significant role in affecting pathways involved in HCC development, such as migration, proliferation, apoptosis, metabolism, and immune responses. HBc can also promote HCC metastasis by modulating host gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Wenbin Liu, Shiliang Cai, Rui Pu, Zixiong Li, Donghong Liu, Xinyu Zhou, Jianhua Yin, Xi Chen, Liping Chen, Jianfeng Wu, Xiaojie Tan, Xin Wang, Guangwen Cao
Summary: Mutations in the preS region of hepatitis B virus (HBV) are associated with an increased risk of hepatocellular carcinoma (HCC). In this study, several specific preS mutations were found to significantly increase the risk of HCC by promoting inflammation and altering gene expression in inflammation- and metabolism-related pathways. These findings highlight the importance of monitoring these mutations for HCC prevention.
Article
Virology
Hao Liao, He Zhang, Jinman Shao, Xiaoyong Li, Wei V. Zheng, Le Li, Guangxin Yu, Lanlan Si, Tao Zhou, Zengtao Yao, Jiuzeng Dai, Dongping Xu, Guanxun Cheng, Jiuxin Qu, Yan Liu, Junhui Chen, Fengmin Lu
Summary: This study aimed to investigate the dynamic changes of serum hepatitis B virus (HBV) RNA levels and the quasispecies of HBV RNA virus-like particles in nucleos(t)ide analogues (NAs)-experienced chronic hepatitis B patients with NAs-resistant mutations and their effects on NAs resistance. The results showed that serum HBV RNA can reflect virological breakthrough and rebound earlier than HBV DNA in some patients. However, there are limitations in the detection of serum HBV RNA levels and drug-resistant mutations compared to serum HBV DNA.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Pharmacology & Pharmacy
Yan Liu, Rongjuan Chen, Wenhui Liu, Lanlan Si, Le Li, Xiaodong Li, Zengtao Yao, Hao Liao, Jun Wang, Yuanhua Li, Jun Zhao, Dongping Xu
Summary: MDR HBV, with mutations resistant to both LAM/LdT/ETV and ADV, can be difficult to treat. The study identified a variety of MDR mutation patterns, with different responses to therapies, and found that TDF/TDF+ETV showed higher inhibitory rates on MDR HBV compared to ADV + ETV, especially for ETVr + ADVr strains. This has important clinical implications for resistance management.
ANTIVIRAL RESEARCH
(2021)
Article
Infectious Diseases
Farzaneh Salarnia, Emad Behboudi, Iraj Shahramian, Abdolvahab Moradi
Summary: This study revealed a higher frequency of mutations in the X gene, enhancer II, and basal core promoter in cirrhotic patients with HBV genotype D. Novel mutations causing amino acid substitutions were detected, but their clinical impact remains to be clarified.
INFECTION GENETICS AND EVOLUTION
(2022)
Article
Immunology
Eveline Hofmann, Bernard Surial, Noemie Boillat-Blanco, Huldrych F. Guenthard, Marcel Stoeckle, Enos Bernasconi, Patrick Schmid, Alexandra Calmy, Franziska Suter-Riniker, Andri Rauch, Gilles Wandeler, Charles Beguelin
Summary: In the Swiss HIV Cohort Study, researchers found that 27% of HIV-suppressed individuals with chronic hepatitis B virus (HBV) infection had HBV replication after two years on tenofovir. However, 77% of them were able to achieve suppression thereafter. Self-reported adherence to therapy and HBV viral load at tenofovir initiation were identified as predictors of persistent replication.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Zhanqing Zhang, Wei Lu, Dong Zeng, Dan Huang, Weijia Lin, Li Yan, Yanling Feng
Summary: Quantitative HBsAg is more valuable than HBV DNA in predicting significant hepatitis activity of HBeAg-positive chronic HBV infection, with higher sensitivity and specificity levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Percy A. Knolle, Li-Rung Huang, Anna Kosinska, Dirk Wohlleber, Ulrike Protzer
Summary: Chronic hepatitis B affects over 250 million individuals worldwide, with prophylactic vaccination only establishing protective immunity but not eliminating HBV infections in patients. Current research focuses on therapeutic vaccination strategies and additional immune stimulation measures to improve efficacy in treating chronic hepatitis B.
Article
Biochemistry & Molecular Biology
Keiji Ueda, Yadarat Suwanmanee
Summary: The precise mechanism of HBV entry into cells is still largely unknown. However, researchers have identified ATP5B as an essential factor for HBV entry, which is believed to bind with myristoylated preS1 2-47. Knockdown of ATP5B in NTCP-expressing HepG2 cells reduced HBV infectivity, indicating that ATP5B is involved in the HBV entry process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Danli Yang, Jun Zou, Guiwen Guan, Xiaoyu Feng, Ting Zhang, Guixin Li, Hui Liu, Huiling Zheng, Jingyuan Xi, Guangxin Yu, Lizhong Dai, Fengmin Lu, Xiangmei Chen
Summary: This study systematically investigated the effect of A1762T/G1764A mutations on HBV replication and its underlying mechanisms. The results showed that these mutations enhance the replication ability of HBV and affect the expression levels of related RNA and proteins. In vitro and in vivo experiments confirmed that these mutations promote HBV replication and revealed their regulatory role in RNA transcription.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Yandi Xie, Hui Ma, Bo Feng, Guangjun Song
Summary: By analyzing the follow-up data of chronic hepatitis B patients, this study found that changes in serum HBsAg and HBcrAg levels, as well as specific gene mutations, were associated with spontaneous HBeAg seroconversion.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Microbiology
Shahrzad Shoraka, Seyed Mahdi Hosseinian, Ayda Hasibi, Amir Ghaemi, Seyed Reza Mohebbi
Summary: Hepatocellular carcinoma (HCC) is a significant global health issue, with most cases being due to long-term infection with Hepatitis B virus (HBV). Understanding the relationship between HBV genome variations and host signaling pathway alteration is crucial for better understanding the molecular pathogenesis of HBV-related HCC. Investigating commonly dysregulated pathways in HBV-related HCC is necessary for the discovery of specific therapeutic targets and the development of more effective strategies for HCC treatment.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Ya Fu, Fengling Fang, Hongyan Guo, Xialin Xiao, Yuhai Hu, Yongbin Zeng, Tianbin Chen, Songhang Wu, Ni Lin, Jinlan Huang, Ling Jiang, Qishui Ou, Can Liu
Summary: This study investigates the evolutionary characteristics of HBV X gene in the hepatocellular carcinoma microenvironment, and finds lower heterogeneity in tumor tissues and a location bias in X gene mutations. Additionally, the study reveals that HBx harboring mutation T81P/S101P/L123S promotes cell proliferation and increases genomic instability.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Microbiology
Mi So Seong, Hyeon Jeong Hwang, Eun Ah Jang, Jeong Ah Jang, Wah Wah Aung, Yi Yi Kyaw, JaeHun Cheong
Summary: Hepatitis B virus (HBV) infection is a major risk factor for liver cirrhosis and hepatocellular carcinoma (HCC). The clinical manifestation of HBV infection is influenced by viral genotype, host genetic factors, transmission mode, adaptive mutations, and environmental factors. Mutations in the core promoter region of HBV have been linked to HCC development.
JOURNAL OF MICROBIOLOGY
(2022)