Article
Medicine, General & Internal
Christina M. Regan, Alvin W. Su, Anthony A. Stans, Todd A. Milbrandt, A. Noelle Larson, William J. Shaughnessy, Emmanouil Grigoriou
Summary: Surgical treatment for Legg-Calve-Perthes disease (LCPD) is recommended for older children with moderate to severe disease. This study aimed to determine if double osteotomies improve radiologic outcomes compared to non-operative treatment. The results showed that double osteotomy did not provide better outcomes than previous non-operative cohorts in the treatment of LCPD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Kuei-Yu Liu, Kuan-Wen Wu, Chia-Che Lee, Sheng-Chieh Lin, Ken N. Kuo, Jia-Feng Chang, Ting-Ming Wang
Summary: This study investigated the effect of proximal femoral varus osteotomy (PFVO) on angular deformities in the knees and ankles. The results showed that in patients with Legg-Calve-Perthes disease (LCPD), the femoral neck-shaft angle (FNSA) significantly improved after the procedure, while in patients with developmental dysplasia of the hip (DDH), there was no significant change. Additionally, there were no significant differences in tibiotalar angle (TTA), mechanical lateral distal femoral angle (mLDFA), mechanical axis deviation (MAD), and leg length discrepancy between the operative and non-operative limbs after a 5-year follow-up. This study suggests that PFVO can narrow the gap of angular growth in the knees and ankles between the operative and non-operative limbs in LCPD or DDH patients.
FRONTIERS IN PEDIATRICS
(2022)
Review
Pediatrics
Alessia Caldaci, Gianluca Testa, Eleonora Dell'Agli, Marco Sapienza, Andrea Vescio, Ludovico Lucenti, Vito Pavone
Summary: This comprehensive review investigates the mid- and long-term outcome of surgical treatment for Legg-Calve-Perthes disease (LCPD). The age at onset and degree of initial disease severity were found to be the main prognostic factors for surgical outcome. Surgical treatment for patients older than 6 years showed excellent results in Herring B and B/C hips, while Herring C hips had poorer outcomes.
Article
Orthopedics
Sungmin Kim, Ho-Seok Oh, Minsu Lee, Sung Taek Jung
Summary: In this study, the relationship between postoperative neck shaft angle (NSA) and Stulberg outcome at skeletal maturity in patients with Legg-Calve-Perthes disease (LCPD) who underwent proximal femoral varus osteotomy (PFVO) was examined. The study found that patients with a postoperative NSA between 105 and 125 degrees were more likely to have a spherical femoral head.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2022)
Article
Pediatrics
Hao Li, Zhiqiang Zhang, Changyou Li, Zhenpeng Liang, Zhu Liu, Hai Li, Ziming Zhang
Summary: This study conducted a quantitative dynamic analysis of hip morphology using a computer-assisted design (CAD) model, aiming to evaluate the effectiveness of combined pelvic and femoral osteotomies in the treatment of Legg-Calve-Perthes disease (LCPD). The results showed that the surgery could effectively improve the superior and superior-posterior area of acetabular containment and increase femoral head volume.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pharmacology & Pharmacy
M. Albayrak, F. Ugur
Summary: This study investigated the effectiveness of only acetabular-side surgeries for treating hips affected by Legg-Calve-Perthes disease. Twelve patients who underwent different acetabular osteotomies were evaluated. The results showed significant improvements in both clinical and radiological evaluations. Pembersal osteotomy corrected the lateral center edge angle better than triple osteotomy, but no significant difference was observed between the two methods.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Orthopedics
A. R. Armstrong, F. Toth, C. S. Carlson, H. K. W. Kim, C. P. Johnson
Summary: This study investigated the effects of acute femoral head ischemia on the proximal femoral growth plate and metaphysis in a piglet model of Legg-Calve-Perthes disease. The results showed that by 2 days post-ischemia, there was significant thinning of the proliferative and hypertrophic zones, which persisted at 7 days post-ischemia. The primary spongiosa was also thinned to absent in all ischemic samples at 7 days post-ischemia.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
Sungmin Kim, Ho-Seok Oh, Jun-Hyuk Lim, Seunghyeon Cho, Sung Taek Jung
Summary: This study assessed the long-term radiographic outcomes of Legg-Calve-Perthes disease patients undergoing early proximal femoral osteotomy, finding that 40.5% of patients bypassed the fragmentation stage. Patients who bypassed fragmentation experienced less severe lateral pillar collapse and had a more spherical femoral head.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2021)
Article
Orthopedics
Tomoyuki Nakamura, Akifusa Wada, Ryosuke Yamaguchi, Miho Iwamoto, Kazuyuki Takamura, Haruhisa Yanagida, Toru Yamaguchi, Chinatsu Ishikawa
Summary: This study found that flexion varus osteotomy (FVO) may increase the possibility of obtaining good radiographic results compared with brace treatment for patients with late-onset Legg-Calve-Perthes disease (LCPD). However, additional surgical interventions may be indicated after the first and second implant removal procedures.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Review
Pediatrics
Aijing Wang, Thomas Nixon, Howard Martin, Allan Richards, Annie McNinch, Philip Alexander, Rathin Pujari, Peter Bale, Nicholas Shenker, Philip Bearcroft, Senjah Brown, Adrian Blackwell, Arabella Poulson, Martin Snead
Summary: Legg-Calve-Perthes' disease (LCP) is a condition with avascular necrosis of the femoral head in children. Stickler syndromes, on the other hand, are a group of disorders associated with hip dysplasia, retinal detachment, deafness, and cleft palate. This paper compares the two conditions and presents a case series of 19 patients with genetically confirmed Stickler syndrome initially diagnosed as LCP. It highlights the potential for preventable blindness in children with undiagnosed Stickler syndrome presenting as LCP.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Pediatrics
Shangyu Wang, Haobo Zhong, Renhao Ze, Pan Hong, Jin Li, Xin Tang
Summary: This study investigated the expression profiles and potential regulatory roles of lncRNAs in the development of Legg-Calve-Perthes disease (LCPD). The analysis revealed differentially expressed lncRNAs and mRNAs in LCPD tissues, and the construction of an mRNA-lncRNA interacting network identified novel potential targets for further investigation. These findings may provide new insights into the molecular mechanisms of LCPD.
FRONTIERS IN PEDIATRICS
(2022)
Article
Orthopedics
Angel Palazon-Quevedo, Maria Galan-Olleros, Rosa M. Egea-Gamez
Summary: Customized surgical treatment for residual hip deformity secondary to Perthes disease in a 15-year-old male resulted in substantial improvement in pain and function, with satisfactory radiographic studies post-operatively. Additional procedures to address adaptive acetabular dysplasia may enhance outcomes of conservative hip surgery in the sequelae of Leg-Calve-Perthes disease.
JOURNAL OF HIP PRESERVATION SURGERY
(2021)
Editorial Material
Medicine, General & Internal
Ting-Han Tai, Chin-Chean Wong
Summary: This paragraph describes a clinical case of a 4-year-old boy with right hip pain and limping, and a radiograph showing a focal area of collapse in the right femoral head.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Anna Matuszewska, Oliwer Sygacz, Lukasz Matuszewski, Szymon Stec, Andrzej Grzegorzewski, Jacek Gagala
Summary: This study investigated the relationship between genetic mutations associated with coagulation and vascular disorders and the occurrence of LCPD in Polish patients. The analysis revealed that the genotype and allele frequencies of eNOS4 were significantly higher in patients with LCPD, suggesting a potential association between the eNOS gene polymorphism and an increased risk of developing LCPD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Andrej Stancak, Jakub Kautzner, Petr Chladek, Ondrej Adamec, Vojtech Havlas, Tomas Trc
Summary: This retrospective study aimed to evaluate factors affecting radiographically assessed treatment outcomes in patients with Legg-Calve-Perthes disease (LCPD). The results showed that older age and severity of LCPD were the strongest predictors of treatment outcomes, while the type of treatment (conservative or surgical) did not have a significant impact. Furthermore, conservative and surgical treatments appeared to yield similar outcomes regardless of the age of the patients.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Orthopedics
Seung-Ju Kim, Ashok K. Ramanathan, Young-Sik Jeon, Hae-Ryong Song
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2017)
Article
Orthopedics
Rujuta Mehta, Bipin Arun Ghanghurde, Ishani Pinakin Shah, Mukund Thatte
Summary: This study aims to investigate the long-term outcomes of radial club hand treatment using a two-stage treatment protocol. The results showed consistent improvement in radial angulation, volar subluxation, and ulna growth after the treatment. However, some patients may require revision surgery.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2023)
Article
Surgery
Ishani P. Shah, Amit Yadav, Rujuta Mehta, Mukund Thatte
INDIAN JOURNAL OF PLASTIC SURGERY
(2014)