Article
Biochemistry & Molecular Biology
Agata Twardowska, Adam Makaro, Agata Binienda, Jakub Fichna, Maciej Salaga
Summary: Leaky gut syndrome is a medical condition characterized by intestinal hyperpermeability. Changes in bacterial composition, decreased expression levels of tight junction proteins, and increased concentration of pro-inflammatory cytokines can lead to intestinal hyperpermeability and the development of various diseases. Translocation of microorganisms and their toxic metabolites beyond the gastrointestinal tract can cause chronic inflammation and progression of disorders. Dietary intervention has shown potential in improving barrier function and restricting bacterial invasion, but there are no medical guidelines for the treatment or prevention of bacterial translocation in patients with leaky gut syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Andrew Foey, Neama Habil, Alex Strachan, Jane Beal
Summary: This study found that the probiotic Lacticaseibacillus casei strain Shirota (LcS) selectively modulates epithelial barrier integrity, pathogen sensing, and inflammatory cytokine profile. The specific effects depend on the subset of macrophages and their activation status.
Article
Microbiology
Wimonrat Panpetch, Chitrasak Kullapanich, Cong Phi Dang, Peerapat Visitchanakun, Wilasinee Saisorn, Jutamas Wongphoom, Dhammika Leshan Wannigama, Arthid Thim-uam, Kanitha Patarakul, Naraporn Somboonna, Somying Tumwasorn, Asada Leelahavanichkul
Summary: The impact of gut fungi and (1 -> 3)-beta-D-glucan (BG) on uremia was explored by orally administering Candida albicans in mice with bilateral nephrectomy. The study found that Candida worsened intestinal injury and altered gut microbiota in the mice, resulting in the presence of bacteria, endotoxin, and glucan in the bloodstream.
Article
Gastroenterology & Hepatology
Shihao Xie, Jiaxin Li, Fengyuan Lyu, Qingming Xiong, Peng Gu, Yuqi Chen, Meiling Chen, Jingna Bao, Xianglong Zhang, Rongjuan Wei, Youpeng Deng, Hongzheng Wang, Zhenhua Zeng, Zhongqing Chen, Yongqiang Deng, Zhuoshi Lian, Jie Zhao, Wei Gong, Ye Chen, Ke-Xuan Liu, Yi Duan, Yong Jiang, Hong-Wei Zhou, Peng Chen
Summary: In this study, it was found that the relative abundance of gut microbial AKK was significantly reduced in septic patients. Supplementation of live AKK or its culture supernatant reduced sepsis-induced mortality in mice. The novel tripeptide, RKH, derived from live AKK, demonstrated protective effects against sepsis-induced death and organ damage by directly binding to TLR4 and blocking its signal transduction in immune cells.
Review
Pharmacology & Pharmacy
Renata Mendonca Moraes, Ulrich Schlagenhauf, Ana Lia Anbinder
Summary: Periodontitis is a common condition that can lead to tooth loss, and its treatment usually involves scaling and root planing. However, recent studies have shown that probiotics and postbiotics may have potential therapeutic benefits in managing periodontitis. More research is needed to fully understand the impact and limitations of these treatments.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Food Science & Technology
Yung-Tsung Chen, Shiou-Yun Chiou, Ai-Hua Hsu, Yu-Chun Lin, Jin-Seng Lin
Summary: The study found that LRH05 significantly reduces body weight gain and WAT weight in mice, as well as improving hepatic steatosis and glucose intolerance. LRH05 can ameliorate the pro-inflammatory process by regulating gene expression and reducing inflammatory macrophage infiltration.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Nutrition & Dietetics
Luis Fontana, Julio Plaza-Diaz, Paula Robles-Bolivar, Hector Valente-Godinez, Maria Jose Saez-Lara, Francisco Abadia-Molina, Carolina Gomez-Llorente, Angel Gil, Ana I. Alvarez-Mercado
Summary: This study found that Bifidobacterium breve, Lactobacillus paracasei, and Lactobacillus rhamnosus can modulate macrophage polarization in the liver and decrease circulating levels of inflammation-related mediators. Lactobacillus paracasei also increased the ratio of P-Akt/Akt and NF-kB protein levels.
Review
Medicine, General & Internal
Barbara Skrzydlo-Radomanska, Bozena Cukrowska
Summary: Small Intestinal Bacterial Overgrowth (SIBO) is a form of dysbiosis that involves excessive bacterial colonization in the small intestine, with some bacteria more typical of the colon microbiota. The prevalence of SIBO has been estimated to range from 2.5% to 22%, increasing with age and comorbidities. The availability of noninvasive breath tests has led to an increase in diagnosed SIBO cases. This review provides an overview of the pathophysiology, manifestations, diagnostics, and recommended management of SIBO.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Pei-Chi Chen, Miao-Hsi Hsieh, Wen-Shuo Kuo, Lawrence Shih-Hsin Wu, Hui-Fang Kao, Li-Fan Liu, Zhi-Gang Liu, Wen-Yih Jeng, Jiu-Yao Wang
Summary: This study reveals the immunomodulatory effect of LGp40, a moonlighting protein from Lactobacillus gasseri, on allergic asthma through glycolytic activity. The findings provide a new strategy for the application of probiotics in alleviating allergic asthma.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Wan-Ru Zhuang, Yunfeng Wang, Weidong Nie, Yao Lei, Chao Liang, Jiaqi He, Liping Zuo, Li-Li Huang, Hai-Yan Xie
Summary: A nanosystem has been developed to enhance antitumor immunity by inhibiting MerTK-mediated efferocytosis and capturing tumor-associated agents.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Veronika Lang, Sebastian Ferencik, Bharath Ananthasubramaniam, Achim Kramer, Bert Maier
Summary: Local circadian clocks play a role in the body's immune response, with light affecting susceptibility to endotoxic shock. Conditional knockout mice showed rhythmic patterns of immune response even without a myeloid clock. This suggests that systemic time cues can orchestrate immune functions.
Article
Materials Science, Biomaterials
Yue Han, Jing Li, Lihua Zheng, Yunhua Chen, Yan Yang, Kai Liu, Yiyue Zhang, Meng Gao
Summary: Bacterial infections with emerging resistance to antibiotics require the development of new antibacterial agents. Researchers have reported a series of antibacterial agents based on positively charged organic groups that can selectively bind and destroy bacterial membranes. To achieve imaging-guided antibacterial therapy, these organic groups often need to be combined with imaging modalities. Researchers have successfully prepared positively charged and deep-red fluorescent supramolecular pyrrole radical cations, which can be used for selective imaging and killing of bacteria.
BIOMATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Ta-Chin Lin, I-Ling Hsu, Wan-Hua Tsai, Yi-Chih Chu, Lung-Ching Kuan, Min-Syuan Huang, Wen-Ling Yeh, Ya-Hui Chen, Shan-Ju Hsu, Wen-Wei Chang
Summary: The study found that VGA-1, a potential agent for bacterial vaginosis (BV) intervention, showed improvement effects in BV patients and reduced recurrent rates. Among the two lactobacillus formulas tested, VGA-1 demonstrated superior efficacy in improving symptoms and reducing recurrent rates in BV patients.
APPLIED SCIENCES-BASEL
(2021)
Review
Biotechnology & Applied Microbiology
Kangsan Kim, Minjeong Kang, Byung-Kwan Cho
Summary: In recent years, there has been increasing interest in gut commensal engineering for therapeutic applications. Recent advancements in synthetic biology and systems biology have enabled effective utilization of gut commensals for therapy and diagnosis, including the rational design of synthetic microbial consortia and the construction of synthetic cells that can detect specific signals in the intestine and deliver therapeutic drugs in real-time.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pediatrics
Gunilla Onning, Ragnhild Palm, Caroline Linninge, Niklas Larsson
Summary: The study investigated the tolerance of two probiotic lactobacilli in infants and found that the intake of probiotics increased the level of lactobacilli in the intestine. There were no significant differences observed in growth parameters and intestinal performance between the probiotic and placebo groups.
PEDIATRIC RESEARCH
(2022)