Journal
DIGESTIVE DISEASES AND SCIENCES
Volume 60, Issue 12, Pages 3513-3524Publisher
SPRINGER
DOI: 10.1007/s10620-015-3772-z
Keywords
Hepatitis B virus infection; Nonalcoholic fatty liver disease; Coincidence; Association
Categories
Funding
- National Natural Science Foundation of China [81371603, 31100701]
- Guangdong Science and Technology Plan Project [2013B051000051]
- National Training Programs of Innovation and Entrepreneurship [201412121039]
Ask authors/readers for more resources
Hepatitis B virus (HBV) infection is a major etiology of chronic liver disease worldwide. In the past decade, nonalcoholic fatty liver disease (NAFLD) has emerged as a common liver disorder in general population. Accordingly, the patient number of chronic hepatitis B (CHB) concomitant with NAFLD grows rapidly. The present article reviewed the recent studies aiming to explore the relationship between CHB and NAFLD from different aspects, including the relevant pathogenesis of CHB and NAFLD, the intracellular molecular mechanisms overlaying HBV infection and hepatic steatosis, and the observational studies with animal models and clinical cohorts for analyzing the coincidence of the two diseases. It is concluded that although numerous cross-links have been suggested between the molecular pathways in HBV infection and NAFLD pathogenesis, regarding whether HBV infection can substantially interfere with the occurrence of NAFLD or vice versa in the patients, there is still far from a conclusive agreement.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available