Article
Pharmacology & Pharmacy
Alireza Karimollah, Anahid Hemmatpur, Nafise Hosseini, Mahdi Dehghan Manshadi
Summary: Tropisetron modulates immune responses through targeting TLR2, TLR4, and JAK2/STAT3 signaling pathways, promoting the expression of anti-inflammatory cytokine IL-10 and suppressing pro-inflammatory cytokines levels.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Gastroenterology & Hepatology
Dominique Thabut, Masatoshi Kudo
Summary: Portal hypertension and hepatocellular carcinoma commonly coexist and their association affects the prognosis of cirrhosis patients. The interplay between these conditions has therapeutic significance in terms of treating HCC and managing PHT complications. The management recommendations for PHT have been revised, with new screening and prophylaxis indications. PHT may limit locoregional therapies and TIPS placement can be considered for HCC patients. New systemic HCC therapies can impact PHT levels and increase the risk of bleeding. Prevention and adequate treatment of PHT complications are important, particularly in advanced HCC cases. This expert opinion discusses specific aspects of managing both conditions, incorporating recent data in the HCC field.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Fanny Turon, Ellen G. Driever, Anna Baiges, Eira Cerda, Angeles Garcia-Criado, Rosa Gilabert, Concepcio Bru, Annalisa Berzigotti, Isabel Nunez, Lara Orts, Juan Carlos Reverter, Marta Magaz, Genis Camprecios, Pol Olivas, Fabian Betancourt-Sanchez, Valeria Perez-Campuzano, Annabel Blasi, Susana Seijo, Enric Reverter, Jaume Bosch, Roger Borras, Virginia Hernandez-Gea, Ton Lisman, Juan Carlos Garcia-Pagan
Summary: In patients with cirrhosis, the main predictive factors for portal vein thrombosis (PVT) development are related to the severity of portal hypertension. There is no significant relationship between PVT development and other clinical, biochemical, inflammatory, and acquired or hereditary hemostatic parameters.
JOURNAL OF HEPATOLOGY
(2021)
Article
Cell Biology
Cai-Lian Fan, Sui Liang, Meng-Nan Ye, Wan-Jun Cai, Miao Chen, Yun-Long Hou, Jun Guo, Yi Dai
Summary: This study found that periplocymarin (PM) can protect the cardiac structure and function by inhibiting the JAK2/STAT3 signaling pathway and alleviating pathological cardiac hypertrophy.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Hongqun Liu, Henry H. Nguyen, Sang Youn Hwang, Samuel S. Lee
Summary: Patients with portal hypertension may develop various complications, including cardiovascular abnormalities. Oxidative stress is believed to play a crucial role in the pathogenesis of these complications, and blocking oxidative stress could potentially alleviate the severity of cardiovascular diseases associated with portal hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Shinya Yokoyama, Yoji Ishizu, Takashi Honda, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Tomoyuki Tsuzuki, Masatoshi Ishigami
Summary: Portal vein thrombosis (PVT) in patients with liver cirrhosis may improve spontaneously when large collateral vessels are absent. In these cases, observation without anticoagulation therapy can be considered in expectation of spontaneous reduction of PVT.
HEPATOLOGY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Ming Zhang, Ming Xu, Kaijie Wang, Long Li, Jinping Zhao
Summary: The JAK2/STAT3 signaling pathway is confirmed to regulate the Th17/IL-17 axis in acute immune rejection of cardiac allografts, leading to decreased rejection ratings and expression of related factors after using the JAK2/STAT3 inhibitor AG490.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Review
Gastroenterology & Hepatology
Marco Senzolo, Guadalupe Garcia-Tsao, Juan Carlos Garcia-Pagan
Summary: Portal vein thrombosis (PVT) is a complication of cirrhosis with increasing incidence related to the severity of cirrhosis. Various risk factors contribute to PVT occurrence and progression. While the impact of complete PVT on liver transplant outcomes is clear, its effect on cirrhosis progression remains uncertain. Treatment options vary based on individual patient characteristics and thrombus features.
JOURNAL OF HEPATOLOGY
(2021)
Article
Endocrinology & Metabolism
Huilan Wang, Xiushan Feng, Tongfei Wang, Jianrong Pan, Zhiqun Zheng, Yanhua Su, Huixi Weng, Liping Zhang, Lin Chen, Ling Zhou, Luo Zheng
Summary: This study found that the p-JAK2/p-STAT3 signaling pathway is involved in follicular development in PCOS rats by upregulating LHCGR and CYP17a expression, and downregulating that of FSHR and CYP19. The treatment with AG490 has beneficial effects on PCOS rats, and LHCGR, FSHR, CYP17a, and CYP19 are candidate genes associated with follicular development in PCOS rats.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Narine Mesropyan, Alexander Isaak, Anton Faron, Michael Praktiknjo, Christian Jansen, Daniel Kuetting, Carsten Meyer, Claus C. Pieper, Alois M. Sprinkart, Johannes Chang, Burkhard Maedler, Daniel Thomas, Patrick Kupczyk, Ulrike Attenberger, Julian A. Luetkens
Summary: In patients with advanced liver disease, splenic ECV was found to be closely associated with portal pressure measurements, showing excellent diagnostic performance for clinically significant portal hypertension. Future studies should further investigate the diagnostic value of parametric mapping across a wider range of pressure values.
EUROPEAN RADIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Helene Larrue, Gennaro D'Amico, Pol Olivas, Yong Lv, Theresa Bucsics, Marika Rudler, Tilman Sauerbruch, Virginia Hernandez-Gea, Guohong Han, Thomas Reiberger, Dominique Thabut, Jean-Pierre Vinel, Jean-Marie Peron, Juan-Carlos Garcia-Pagan, Christophe Bureau
Summary: Through the analysis of patients with refractory ascites and prevention of variceal rebleeding, it was found that the use of transjugular intrahepatic portosystemic shunt (TIPS) compared to standard of care (SOC) has significant advantages in reducing the incidence of further decompensation events and improving patient survival.
JOURNAL OF HEPATOLOGY
(2023)
Article
Behavioral Sciences
Lichao Fan, Lichun Zhou
Summary: AG490 acts as a JAK antagonist showing both anti-apoptotic and neuroprotective effects in cerebral ischemia/reperfusion injury. It achieves the anti-apoptotic effect through regulating the JAK-STAT pathway and enhancing the expression of neurotrophins.
BRAIN AND BEHAVIOR
(2021)
Review
Medicine, General & Internal
Hitoshi Maruyama, Maki Tobari, Hiroaki Nagamatsu, Suichiro Shiina, Tadashi Yamaguchi
Summary: Portal hypertension is a common condition in patients with cirrhosis, and ultrasound, especially CEUS, is an effective and minimally invasive diagnostic tool for evaluating hepatic hemodynamics and lesions. Recent advancements in digital technology have further improved the resolution and expanded the applications of CEUS.
FRONTIERS IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiahui Li, Tejasav S. Sehrawat, Jingbiao Chen, Moira B. Hilscher, Kevin J. Glaser, Juan P. Arab, Thiago Milech De Assuncao, Douglas A. Simonetto, Taofic Mounajjed, Armando Manduca, Richard L. Ehman, Vijay H. Shah, Meng Yin
Summary: The bi-parametric dual-frequency hepatic MRE model showed improved diagnostic accuracy for predicting portal hypertension in mouse models, especially in cases of hepatic congestion and cholestatic liver injury. This technical advancement has the potential to monitor PHTN progression and treatment efficacy in the presence of varying fibrosis.
EUROPEAN RADIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Nicholas Brown, Heli Bhatt, Amrita Salunke, Srinath Chinnakotla, Athar M. Qureshi, Varun Aggarwal
Summary: Portal hypertension caused by liver cirrhosis is a significant cause of morbidity and mortality. Treatment options include liver transplant, endoscopic treatment for esophageal varices, and symptomatic management of ascites. The creation of a portosystemic shunt can be challenging in newborns and infants. This case report presents a successful palliative procedure using ductus venosus stenting in a newborn with severe portal hypertension.
LIVER INTERNATIONAL
(2022)