Review
Clinical Neurology
Mathias Moller Thygesen, Tim Damgaard Nielsen, Mads Rasmussen, Dariusz Orlowski, Michael Pedersen, Mikkel Mylius Rasmussen
Summary: Interventions on spinal cord perfusion pressure may have a positive correlation with neurological outcome in traumatic spinal cord injuries, but causality cannot be confirmed due to limited literature. Further well-designed studies are needed to address this issue.
EUROPEAN SPINE JOURNAL
(2021)
Article
Critical Care Medicine
Bizhan Aarabi, Noori Akhtar-Danesh, J. Marc Simard, Timothy Chryssikos, Kathirkamanathan Shanmuganathan, Joshua Olexa, Charles A. Sansur, Kenneth M. Crandall, Aaron P. Wessell, Gregory Cannarsa, Ashish Sharma, Cara D. Lomangino, Jason Boulter, Maureen Scarboro, Jeffrey Oliver, Abdul Kareem Ahmed, Nicole Wenger, Riccardo Serra, Phelan Shea, Gary T. Schwartzbauer
Summary: This retrospective study examined the impact of timing of decompression on the American Spinal Injury Association (ASIA) motor score following traumatic central cord syndrome (ATCCS) caused by spinal stenosis. The study found that the timing of decompression did not significantly affect the follow-up motor score, with only the admission motor score determining the outcome.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Tobias Pantel, Mona Lindschau, Andreas M. Luebke, Philip Kunkel, Marc Dreimann, Nicole Muschol, Sven O. Eicker
Summary: Spinal abnormalities are common in MPS patients, with SS being a serious complication. Timely detection and detailed neurological assessment play a crucial role in favorable outcomes. Surgical intervention often involves dorsal instrumentation with microsurgical decompression, with MPS type I patients showing the best neurological course.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Chengyue Ji, Yuluo Rong, Hongyu Jia, Ning Yan, Tiesheng Hou, Yao Li, Weihua Cai, Shunzhi Yu
Summary: Surgical decompression should be considered in patients with cervical SCI in the chronic stage and persistent spinal cord compression and/or gross cervical instability. Lower initial AMS, longer duration, injury above C4 level, higher age, and female gender are the five major relevant factors for functional recovery.
EUROPEAN SPINE JOURNAL
(2021)
Letter
Clinical Neurology
John Eraifej, Colin Nnadi, Mario Ganau
Summary: Recent evidence suggests that early decompressive spinal surgery can improve neurological outcomes in acute spinal cord injury patients, highlighting the need for hospital systems to swiftly restructure to meet the demand for early and possibly ultra-early spinal decompression in the future.
EUROPEAN SPINE JOURNAL
(2022)
Article
Physiology
Quan Zhou, Xiangyang Meng, Guoyang Huang, Hongjie Yi, Juan Zheng, Kun Zhang, Weigang Xu
Summary: The combination pretreatment of NBO and U0126 effectively alleviated DCS spinal cord injury in rats by upregulating HSP32, reducing the incidence of DCS, improving motor function, and attenuating oxidative stress, inflammatory response, and apoptosis. This approach could provide a more convenient method for DCS injury control, using non-pressurized NBO instead of HBO.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Clinical Neurology
Farzin Farahbakhsh, Sepehr Khosravi, Vali Baigi, Masoud Pourghahramani Koltapeh, Amirmahdi Khayyamfar, Zahra Eskandari, Zahra Ghodsi, James Harrop, Vafa Rahimi-Movaghar
Summary: This study aimed to determine the prevalence of asymptomatic cervical spinal cord compression (CSCC) in patients with lumbar spinal stenosis (LSS) through systematic review and meta-analysis. The findings revealed a relatively high prevalence of asymptomatic CSCC in LSS patients. Therefore, spine surgeons are strongly recommended to exercise caution during surgery for lumbar stenosis and closely monitor individuals with symptomatic LSS for potential signs of emerging myelopathy.
GLOBAL SPINE JOURNAL
(2023)
Article
Clinical Neurology
Tatsuya Yamamoto, Mitsuru Yagi, Satoshi Suzuki, Yohei Takahashi, Satoshi Nori, Osahiko Tsuji, Narihito Nagoshi, Jun Ogawa, Morio Matsumoto, Masaya Nakamura, Kota Watanabe
Summary: In this retrospective study, the outcomes of multilevel posterior decompression surgery for degenerative lumbar spinal stenosis were compared with single-level surgery. The study found that despite the longer surgical time and larger blood loss, multilevel surgery showed similar improvements in patient-reported outcomes and revision rates compared to single-level surgery.
Article
Clinical Neurology
Kunio Yokoyama, Naokado Ikeda, Hidekazu Tanaka, Yutaka Ito, Akira Sugie, Makoto Yamada, Masahiko Wanibuchi, Masahiro Kawanishi
Summary: This study aimed to investigate the long-term changes in spinal sagittal balance after micro-surgical decompression in lumbar canal stenosis. It was found that postoperative lumbar lordosis increased and sagittal balance tended to improve. However, after 5 years, adjacent intervertebral degeneration occurred more frequently and sagittal balance began to deteriorate in about one third of cases.
WORLD NEUROSURGERY
(2023)
Editorial Material
Clinical Neurology
Brendan F. Judy, Yike Jin, Daniel M. Sciubba
Summary: Spinal cord compression due to extramedullary hematopoiesis, a rare neurosurgical problem, requires urgent decompression for successful treatment. In this case report, a young man with hemoglobin Lepore disease and beta thalassemia was successfully treated with urgent thoracic laminectomies and fully recovered. The acute setting calls for decompression as a crucial modality in treating this pathology.
WORLD NEUROSURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guoliang Chen, Fuxin Wei, Liangyu Shi, Jiachun Li, Xianxiang Wang, Meng Wang, Huachuan Wu, Zuofeng Xu, Xizhe Liu, Shaoyu Liu
Summary: French-door laminoplasty with intraoperative ultrasound (IOUS) can confirm sufficient decompression for the treatment of DCM, leading to higher likelihood of neurological recovery; inadequate spinal cord expansion after sufficient decompression may predict less satisfactory neurological recovery in DCM patients.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jung-Hee Lee, Kyung-Chung Kang, Ki-Tack Kim, Yong-Chan Kim, Tae-Soo Chang
Summary: There is a moderate correlation between spinal canal dimension and canal-body ratio in both cervical and lumbar spine. Male patients tend to have smaller canal diameter and canal-body ratio, and patient age is negatively correlated with canal diameter and canal-body ratio. These findings may provide important evidence for patient explanation and treatment.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Megan L. Miller, Hillary L. Glandon, Michael S. Tift, D. Ann Pabst, Heather N. Koopman
Summary: Odontocetes, despite their highly derived diving adaptations, do not have specialized spinal cord microvasculature features to protect them from decompression sickness.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Chenghua Yuan, Jian Guan, Yueqi Du, Zeyu Fang, Xinyu Wang, Qingyu Yao, Can Zhang, Shanhang Jia, Zhenlei Liu, Kai Wang, Wanru Duan, Xingwen Wang, Zuowei Wang, Hao Wu, Zan Chen, Fengzeng Jian
Summary: The study found that PTS tends to progress faster than CCJ-related syringomyelia. Except for the red blood cell count, peripheral blood inflammation markers (PBIMs) showed no value in distinguishing the two forms of syringomyelia. Spinal cord injury associated with PTS was more severe than that associated with CCJ.
FRONTIERS IN NEUROLOGY
(2022)
Article
Mechanics
F. Moral-Pulido, J. I. Jimenez-Gonzalez, C. Gutierrez-Montes, W. Coenen, A. L. Sanchez, C. Martinez-Bazan
Summary: This paper presents experimental results on solute transport in a simplified model of the spinal canal, providing a deeper understanding of drug dispersion in intrathecal drug delivery procedures. The model consists of an annular channel with a rigid transparent tube representing the dura mater and a compliant insert representing the spinal cord. Laser induced fluorescence is used to characterize solute dispersion along the canal and into the cranial cavity. The study confirms the existence of a steady bulk flow that plays a key role in solute transport along the spinal canal.
Article
Clinical Neurology
Niccole Germscheid, Jason P. Y. Cheung, Marko H. Neva, F. Cumhur Oner, Brian K. Kwon, Marcelo Valacco, Waleed Awwad, Daniel M. Sciubba, Stephen J. Lewis, Laurence D. Rhines, S. Tim Yoon, Mauro Alini, Sibylle Grad, Charles G. Fisher, Dino Samartzis
Summary: A survey of AO Spine members was conducted to understand the research practices and needs of spine surgeons worldwide. The results showed heterogeneity among research practices and needs across regions, but there was global support for research registries and research training and education. To advance spine care, spine societies should establish guidelines, conduct pain management studies, and support predictive analytic modeling.
GLOBAL SPINE JOURNAL
(2023)
Review
Clinical Neurology
Mandy M. P. Kan, Stefano Negrini, Francesca Di Felice, Jason P. Y. Cheung, Sabrina Donzelli, Fabio Zaina, Dino Samartzis, Esther T. C. Cheung, Arnold Y. L. Wong
Summary: This study aimed to summarize the associations between lung function parameters and radiographic features in teenagers with adolescent idiopathic scoliosis (AIS). The findings revealed significant correlations between larger thoracic Cobb angles, greater apical vertebral rotation angles, or hypokyphosis and pulmonary impairments in patients with AIS.
EUROPEAN SPINE JOURNAL
(2023)
Article
Orthopedics
Sze-Hon Yu, Cheuk-Man Ng, Jason Pui-Yin Cheung, Graham Ka-Hon Shea
Summary: The aim of this study was to determine the progression of curves of 40 degrees to 50 degrees following skeletal maturity. The study found that although most of the patients showed progression, the rate of progression was slow, suggesting that yearly observation was a reasonable management approach. Apical wedging and coronal imbalance could potentially serve as indicators for closer monitoring and early spinal fusion in these patients.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Orthopedics
Pun Yuet Lam, Prudence Wing Hang Cheung, Sin Ting Lau, Jason Pui Yin Cheung
Summary: This study compared the effects of parathyroid hormone analogues, receptor activators of nuclear factor kappa-B ligand inhibitors, and bisphosphonates on the quality of life of postmenopausal women. The results showed that continuous one-year teriparatide treatment was most effective in improving the quality of life outcomes in postmenopausal osteoporotic women. Baseline visual analogue scale back pain was the only predictive factor for one-year back pain progression.
JOURNAL OF ORTHOPAEDICS TRAUMA AND REHABILITATION
(2023)
Article
Clinical Neurology
Prudence Wing Hang Cheung, Jason Pui Yin Cheung
Summary: The study aimed to determine whether the proximal humeral epiphyseal ossification system (PHOS) can be used to determine the timing of brace weaning in adolescent idiopathic scoliosis (AIS) by assessing the rate of curve progression after brace weaning. The results showed that patients with PHOS Stage 5 had no curve progression after brace weaning, regardless of whether the curve angle was less than or equal to 40 degrees. For curves greater than or equal to 40 degrees, PHOS Stage 5 and a radius grade of 10 were also effective in indicating the timing of weaning.
EUROPEAN SPINE JOURNAL
(2023)
Review
Clinical Neurology
Darren Li Liang Wong, Pak Tung Mong, Chun Yin Ng, Chun Kwan Ong, Zhekai Qian, Mang Hong Shao, Ling Kwan Ernest Sin, Bao Yi Wong, Chun Ming Wong, Jason Pui Yin Cheung, Michael To
Summary: This systematic review compares the impact of AVBT and PSF on ROM in treating AIS. The study found that AVBT outperforms PSF in maintaining ROM and achieving comparable Cobb angle correction. The comparison of QOL outcomes remains inconclusive. It should be noted that AVBT may cause over-correction and distal adding-on. Additionally, AIS patients treated with AVBT show better muscle strength and endurance when compared to those treated with PSF.
EUROPEAN SPINE JOURNAL
(2023)
Review
Clinical Neurology
Sandra Hiu-Tung Wan, Darren Li-Liang Wong, Samuel Ching-Hang To, Nan Meng, Teng Zhang, Jason Pui-Yin Cheung
Summary: The use of 3D parameters derived from reconstruction of biplanar radiographs can help evaluate the prognostic factors for surgical correction of scoliosis. Preoperative 3D thoracolumbar kyphosis (TK) should be used as a basis for rod contouring and selection of upper and lower instrumented vertebrae (UIV/LIV). For Lenke 1 patients with high-lying rotations, fusion to NV-1 is recommended while > 50% LIV rotation counterclockwise is recommended for Lenke 1C curves to achieve optimal correction.
EUROPEAN SPINE JOURNAL
(2023)
Review
Orthopedics
Kenney K. L. Lau, Karlen K. P. Law, Kenny Y. H. Kwan, Jason P. Y. Cheung, Kenneth M. C. Cheung
Summary: As idiopathic scoliosis is a multifactorial disorder, one of its possible causes is a proprioceptive defect. Genetic studies have identified several genes, including LBX1, PIEZO2, RUNX3, and NTF3, that are related to proprioception and may contribute to the development and pathology of idiopathic scoliosis. However, the relationship between these genes and the initiation, progression, and treatment outcomes of scoliosis is still unclear and requires further investigation.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Clinical Neurology
Sandra H. T. Wan, Ogulcan Guldeniz, Matthew H. Y. Yeung, Jason P. Y. Cheung, Kenny Y. H. Kwan, Kenneth M. C. Cheung
Summary: A retrospective review of AIS patients who underwent VBT showed that an increase in inter-screw angle of 5 degrees or more is not a reliable indicator for tether breakage, as breakage can occur without a loss of correction. Therefore, the use of the inter-screw index is proposed for diagnosing tether breakage radiographically.
Article
Clinical Neurology
Prudence Wing Hang Cheung, Hei Lung Wong, Damian S. L. Lau, Jason Pui Yin Cheung
Summary: This study investigated the difference in major curve Cobb angle and alignment between directed and nondirected positioning for adolescent idiopathic scoliosis (AIS) and evaluated its implications on treatment decision-making. The results showed that the major curve Cobb angle was smaller in nondirected positioning, and postural variation may lead to overestimation or underestimation of the curve size.
Article
Orthopedics
Wencan Ke, Teng Zhang, Bingjin Wang, Wenbin Hua, Kun Wang, Jason Pui Yin Cheung, Cao Yang
Summary: The study compared the biomechanical effects of different surgical approaches for the treatment of adjacent segment disease (ASD) after transforaminal lumbar interbody fusion (TLIF). The results showed that ALIF and LLIF surgeries had similar effects on adjacent segment range of motion (ROM) and intradiscal pressure (IDP), while TLIF surgery had greater effects on adjacent segment ROM and IDP. The stress in cages was highest in the TLIF revision model, indicating stress concentration due to direct extension of the surgical segment in the same direction.
ORTHOPAEDIC SURGERY
(2023)
Article
Medicine, General & Internal
Teng Zhang, Chuang Zhu, Yongkang Zhao, Moxin Zhao, Zhihao Wang, Ruoning Song, Nan Meng, Alisha Sial, Ashish Diwan, Jun Liu, Jason P. Y. Cheung
Summary: This diagnostic study evaluated the ability of an open platform application using a validated deep learning model to classify the severity and type of AIS, as well as identify progression. The results demonstrated that this deep learning app has the potential for radiation-free management of children with scoliosis, and performs comparably to experienced spine surgeons.
Article
Biotechnology & Applied Microbiology
Moxin Zhao, Nan Meng, Jason Pui Yin Cheung, Chenxi Yu, Pengyu Lu, Teng Zhang
Summary: SpineHRformer is a reliable learning-based approach that provides consistent and highly accurate measurements of Cobb angle (CA) from posteroanterior (PA) X-rays, surpassing the state-of-the-art method. It identifies anatomical landmarks and calculates CAs using the extracted features from an HRNet and transformer blocks. Experimental results show that SpineHRformer outperforms SpineHRNet+ in landmark detection, CA prediction, and severity grading, offering substantial potential for improving the efficiency and reliability of CA measurements in clinical settings.
BIOENGINEERING-BASEL
(2023)
Article
Health Care Sciences & Services
Fadi M. Al Zoubi, Arnold Y. L. Wong, Gladys L. Y. Cheing, Jason P. Y. Cheung, Siu Ngor Fu, Helen H. L. Tsang, Rainbow K. Y. Law, Billy Chun Lung So, Raymond Tsang, Sharon Tsang, Chunyi Wen, Michael Wong, Yim Ching Yau, Andre E. Bussieres
Summary: This study used the ADAPTE framework to adapt high-quality guideline recommendations for knee and hip osteoarthritis in Hong Kong. A total of 28 recommendations for knee osteoarthritis and 20 recommendations for hip osteoarthritis were adapted. The study recommends a multimodal treatment approach, including exercise therapy, patient education, and self-management.
Article
Clinical Neurology
Kenney Ki Lee Lau, Kenny Yat Hong Kwan, Jason Pui Yin Cheung, Janus Siu Him Wong, Graham Ka Hon Shea, Karlen Ka Pui Law, Kenneth Man Chee Cheung
Summary: This study longitudinally evaluated the incidence of back pain in adolescents with AIS. The results showed that the occurrence of back pain in scoliotic adolescents ranged from 14.7% to 19.0%, with most cases experiencing mild pain. Furthermore, subjects with new onset back pain exhibited poorer function, self-image, and mental health scores.