Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 82, Issue 23, Pages 12603-12612Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b02363
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Funding
- Chinese Academy of Sciences (Strategic Priority Research Program) [XDB20020200, QYZDJ-SSW-SLH029]
- National Natural Science Foundation of China [21621002]
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N,N'-Bis(furan-2-ylmethyl)oxalamide (BFMO), an inexpensive and conveniently available bidentate ligand, is very effective for promoting Cu-catalyzed N-arylation of anilines and cyclic secondary amines. The method enables coupling of a broad range of (hetero)aryl bromides with various (hetero)aryl amines and cyclic secondary amines at 0.5-5 mol % catalyst loadings at relatively low temperatures. For coupling with more sterically hindered acyclic secondary amines, using N,N'-bis(2,4,6-trimethoxyphenyl)oxalamide (BTMPO) as a ligand gives the better results. Additionally, high selectivity is achieved in CuI/BFMO-catalyzed direct monoarylation of piperazine with (hetero)aryl bromides to afford pharmaceutically important building blocks.
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