Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 82, Issue 19, Pages 10219-10225Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b01724
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Funding
- U.S. National Science Foundation [1300878]
- Northern Illinois University
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Michael addition has been achieved with a variety of amino acid esters and 2- or 4-vinylpyridine. Similar reactions were accomplished with an alkenyl-substituted pyrimidine, pyrazine, thiazole, quinoxaline, benzoxazole, and quinolone. In reactions at a prochiral center, modest diastereoselectivities were observed with the formation of the new stereogenic carbon. NMR experiments indicate that the addition reaction is reversible under acidic conditions.
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