Article
Dentistry, Oral Surgery & Medicine
Marco Mascitti, Lucrezia Togni, Vito Carlo Alberto Caponio, Khrystyna Zhurakivska, Lorenzo Lo Muzio, Corrado Rubini, Andrea Santarelli, Giuseppe Troiano
Summary: Tumor budding is found to be a reliable prognostic factor in oral tongue squamous cell carcinoma (OTSCC), but a standardized scoring system is lacking. This study aims to evaluate the prognostic role of tumor budding in 211 OTSCC patients. The results confirm the predictive value of tumor budding in disease-specific survival.
Article
Pathology
Kochli Channappa Niranjan, Monica Raj, Kaveri Hallikeri
Summary: Tumor budding and CD44 expression are of prognostic significance in OSCC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Ling Mao, Xiaoweng Wu, Zhengpeng Gong, Ming Yu, Zhi Huang
Summary: The study revealed that PDIA6 is upregulated in OSCC tissues and its overexpression promotes aerobic glycolysis and the progression of oral squamous cell carcinoma.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Steven He, Rajdeep Chakraborty, Shoba Ranganathan
Summary: Oral cancer is a common type of head and neck squamous cell carcinoma, with a high mortality rate. International research on the molecular pathways of oral cancer has implications for early diagnosis, prognosis, and the development of new drugs. This review focuses on the pathways of proliferation and apoptosis in OSCC progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Shaoqiu Zheng, Jing Luo, Shoucheng Xie, Shanming Lu, Qinghua Liu, Huanqin Xiao, Wenjuan Luo, Yanfang Huang, Kun Liu
Summary: Recent evidence suggests that cancer stem cells (CSCs) are the origin of cancers. This study investigated the relationship between tumor buds, which are hypothesized to represent epithelial-mesenchymal transition (EMT)-like CSCs, and EMT and CSC markers in cervical squamous cell carcinoma (CxSCC). The findings indicate that tumor buds in CxSCC may represent EMT-like CSCs in vivo.
Article
Pharmacology & Pharmacy
Danni Wang, Mei Tian, Yong Fu, Yawei Sun, Liang Ding, Xiaoxin Zhang, Yue Jing, Guowen Sun, Yanhong Ni, Yuxian Song
Summary: The study found that Halofuginone can inhibit the migration and invasion of oral squamous cell carcinoma (OSCC) by targeting cancer-associated fibroblasts (CAFs), and is involved in this process through inhibiting MMP2 secretion and the TGF-beta/Smad2/3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Leonardo de Oliveira da Rocha, Bruno Solano de Freitas Souza, Ricardo Della Coletta, Daniel W. Lambert, Clarissa A. Gurgel Rocha
Summary: Cell-in-cell (CIC) structures contribute to tumor aggressiveness and poor prognosis in oral squamous cell carcinoma (OSCC). In this study, spheroids obtained from OSCC and cancer-associated fibroblast (CAF) lines were used to investigate CIC structures. The spheroids showed the morphological aspects of the tumor microenvironment and CIC structures were found in both homotypic and heterotypic groups, predominantly in the proliferative zone of mixed spheroids. Complex cannibalism events were also observed. This model has the potential for further studies on CIC morphology, formation, and its relationship with tumor prognosis.
Article
Dentistry, Oral Surgery & Medicine
Hong Zhang, Zhenhua Wang, Zhongti Zhang
Summary: This study investigated the role and mechanism of a abnormally expressed circular RNA (hsa_circ_0009128) in oral squamous cell carcinoma (OSCC) progression. The results showed that hsa_circ_0009128 was upregulated in OSCC tissues and cell lines, and correlated with advanced TNM stage and lymph node metastasis. Knockdown of hsa_circ_0009128 inhibited cell proliferation and migration, and decreased EMT in OSCC cells. These findings suggest that hsa_circ_0009128 may play an important role in the malignant progression of OSCC by targeting MMP9 to activate EMT.
Article
Pathology
Lara Alessandrini, Elisabetta Zanoletti, Diego Cazzador, Marta Sbaraglia, Leonardo Franz, Giulia Tealdo, Anna Chiara Frigo, Stella Blandamura, Piero Nicolai, Antonio Mazzoni, Gino Marioni
Summary: This study highlights the significant role of tumor budding in the prognosis of TBSCC, showing associations with tumor invasion, lymph node metastasis, disease-free survival, and overall survival. Further research is needed to confirm these findings in larger prospective studies.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jun Liang, Jingang Liu, Zhaoming Deng, Zhigang Liu, Lizhong Liang
Summary: DLX6 is overexpressed in oral cancer tissues and is associated with advanced tumor stage and poor prognosis. DLX6 promotes proliferation and inhibits cell apoptosis in oral cancer cells. The EGFR-CCND1 pathway may be a potential mechanism involved in the regulatory axis.
Article
Chemistry, Medicinal
Guya Diletta Marconi, Ylenia Della Rocca, Luigia Fonticoli, Francesco Melfi, Thangavelu Soundara Rajan, Simone Carradori, Jacopo Pizzicannella, Oriana Trubiani, Francesca Diomede
Summary: The study aims to evaluate the role of c-Myc in the pathogenesis of oral squamous cell carcinoma (OSCC). The results show the vital role of c-Myc in tumor growth and cell survival/proliferation, along with the inhibitory effect of Doxorubicin (Doxo) on c-Myc signaling pathway.
Article
Otorhinolaryngology
Yeoun Eun Sung, Min-Sik Kim, Youn Soo Lee
Summary: This study evaluated risk factors in oral squamous cell carcinoma using image analysis, with significant differences in prognosis found between low-, intermediate-, and high-risk groups. The high-risk groups were associated with poor survival even within different tumor-node-metastasis stages, suggesting a possible descriptive model for prognosis prediction based on pathological and imaging findings regardless of TNM stage.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Yuri Noda, Mitsuaki Ishida, Yasuhiro Ueno, Takuo Fujisawa, Hiroshi Iwai, Koji Tsuta
Summary: Histological predictors of extranodal extension (ENE) in oral squamous cell carcinoma (OSCC) were determined through routine histopathological examination. The tumor microenvironment status, including desmoplastic reaction, tumor budding, and tumor-infiltrating lymphocytes, was significantly associated with ENE presence. These histological features can serve as useful predictors for ENE.
Review
Cell Biology
Yanhui Lu, Zhichao Zheng, Yunyi Yuan, Janak L. Pathak, Xuechao Yang, Lijing Wang, Zhitong Ye, William C. Cho, Mingtao Zeng, Lihong Wu
Summary: Oral cancer, primarily oral squamous cell carcinoma, remains a challenge to treat with high rates of metastasis. Exosomes play a crucial role in the tumorigenesis and progression of oral squamous cell carcinoma, and show potential for clinical application in treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Jiwei Sun, Qingming Tang, Shaoling Yu, Mengru Xie, Wenhao Zheng, Guangjin Chen, Ying Yin, Xiaofei Huang, Keqi Wo, Haoqi Lei, Junyuan Zhang, Qian Wan, Lili Chen
Summary: This study reveals that F. nucleatum, a tumor-resident bacterium, accumulates in invasive margins of OSCC tissues and promotes the formation of tumor-associated macrophages (TAMs). Mechanistically, F. nucleatum triggers the GalNAc-Autophagy-TBC1D5 signaling, leading to GLUT1 aggregation in the plasma membrane and the deposition of extracellular lactate. Targeting this process may provide a distinct clinical strategy for patients with advanced OSCC.
Article
Dentistry, Oral Surgery & Medicine
Bruno Augusto Benevenuto de Andrade, Jose Alcides Almeida de Arruda, Gerardo Gilligan, Eduardo Piemonte, Rene Panico, Ignacio Molina Avila, Juan Martin Pimentel Sola, Martha Cecilia Carmona Lorduy, Stella Pupo Marrugo, Angelica Sofia Sanchez Tatis, Laura Cecilia Werner, Aline Correa Abrahao, Michelle Agostini, Luisa Buoro, Monica Simoes Israel, Nathalia de Almeida Freire, Lucas Ambrosio Lima, Thamiris de Castro Abrantes, John Lennon Silva Cunha, Maria Eduarda Perez-de-Oliveira, Ana Luiza Oliveira Correa Roza, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Alan Roger Santos-Silva, Oslei Paes de Almeida, Flavia Sirotheau Correa Pontes, Helder Antonio Rebelo Pontes, Benjamin Martinez Rondanelli, Mariana Villarroel-Dorrego, Ronell Bologna-Molina, Nathalie Derderian, Celeste Sanchez-Romero, Lucas Guimaraes Abreu, Felipe Paiva Fonseca, Ricardo Alves Mesquita, Ricardo Santiago Gomez, Rene Martinez-Flores, Wilson Delgado-Azanero, Adriana Terezinha Neves Novellino Alves, Simone de Queiroz Chaves Lourenco, Carolina Coimbra, Giovanni Augusto Castanheira Polignano, Jose Narciso Rosa Assuncao Junior, Giovanna Ribeiro Souto, Paulo Eduardo Alencar Souza, Martinho Campolina Rebello Horta, Wilfredo Alejandro Gonzalez-Arriagada, Mario Jose Romanach
Summary: The study reported the clinicopathologic features of acquired oral syphilis cases in South American countries, finding that secondary syphilis was the most common stage, with lesions more commonly occurring in males and young adults. The most common clinical manifestations included mucous patches, papules, and ulcers, often accompanied by skin lesions, lymphadenopathy, and fever.
Article
Dentistry, Oral Surgery & Medicine
Fabio Fernandes Borem Bruzinga, Fernanda Carvalho Fulgencio Fernandes, Fernanda Ribeiro Dias, Marla Gabriela Lima, Paulo Eduardo Alencar de Souza, Maria Cassia Ferreira de Aguiar, Soraya de Mattos Camargo Grossmann
Summary: This study describes the frequency, clinical, and demographic features of minor salivary gland tumors, and identifies possible associated factors. The most common tumors were pleomorphic adenoma, mucoepidermoid carcinoma, and adenoid cystic carcinoma. The study provides valuable clinical and demographic data for further research in Brazil and other countries.
Article
Dentistry, Oral Surgery & Medicine
Alexandre Henrique dos Reis-Prado, Sabrina de Castro Oliveira, Juliana Goto, Gerluza Aparecida Borges Silva, Luciano Tavares Angelo Cintra, Ricardo Alves de Mesquita, Raphael Escorsim Szawka, Antonio Paulino Ribeiro-Sobrinho, Francine Benetti
Summary: EDTA irrigation was found to improve the formation of newly formed intracanal connective tissue after REP in immature rat molars. However, EDTA did not have an influence on cementum-like tissue formation, apical closure, inflammatory infiltrate, and maturation of collagen fibers.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Review
Dentistry, Oral Surgery & Medicine
Jose Alcides Almeida de Arruda, Fernanda Vieira Heimlich, Victor Zanetti Drumond, Lauren Frenzel Schuch, Manoela Domingues Martins, Lucas Guimaraes Abreu, Antonio Lucio Teixeira, Ricardo Alves Mesquita, Tarcilia Aparecida Silva
Summary: This systematic review examined the potential association between anxiety and depression and chemo/radiotherapy-induced oral mucositis. The results showed that there is a connection between anxiety and depression and the severity of oral mucositis in a significant number of participants. However, the limited number of cases and heterogeneity in the data hindered a conclusive conclusion about this association.
Letter
Dentistry, Oral Surgery & Medicine
Breno Amaral Rocha, Polianne Alves Mendes, Giovanna Ribeiro Souto, Paulo Eduardo Alencar Souza, Soraya de Mattos Camargo Grossmann, Martinho Campolina Rebello Horta
SPECIAL CARE IN DENTISTRY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Victor Zanetti Drumond, Thaynara Nascimento de Oliveira, Jose Alcides Almeida de Arruda, Ricardo Alves Mesquita, Lucas Guimaraes Abreu
Summary: This study aimed to assess whether children and adolescents with ADHD were more likely to have dental trauma compared to their healthy peers. Through the screening and meta-analysis of 239 studies, it was found that individuals with ADHD are more susceptible to dental trauma than their non-ADHD counterparts, but a causal relationship cannot be established due to limitations in study design.
SPECIAL CARE IN DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Elis Angela Batistella, Andressa Fernanda Paza Miguel, Nicole Lonni Nascimento, Martinho Campolina Rebello Horta, Daniella Serafin Couto Vieira, Elena Correa Riet Rivero
Summary: The role of blood and lymphatic microvascular density in the progression of oral squamous cell carcinoma (OSCC) was investigated in this study. It was found that the expression of anti-alpha-smooth muscle actin (a-SMA) and anti-endoglin (CD105) was associated with microvessel density (MVD), while anti-podoplanin (D2-40) was associated with lymphatic vessel density (LVD). Furthermore, high tumour budding (TB) and tumour thickness were identified as risk factors for OSCC progression and worse patient outcomes.
Article
Dentistry, Oral Surgery & Medicine
Gabriela Barros Lopes, Matheus Melo Pithon, Carolina Morsani Mordente, Lincoln Issamu Nojima, Martinho Campolina Rebello Horta, Dauro Douglas Oliveira, Rodrigo Vilamarim Soares
Summary: This study aimed to evaluate the mechanical properties of stainless steel mini-implants (MIs) and compare them with conventional titanium-aluminum-vanadium alloy MIs. Pull-out, insertion torque, fracture, and percussion tests were performed to measure the tensile strength, primary stability, and fracture strength of MIs. The results showed that stainless steel MIs had superior mechanical properties compared to titanium-aluminum-vanadium alloy MIs.
PESQUISA BRASILEIRA EM ODONTOPEDIATRIA E CLINICA INTEGRADA
(2023)
Article
Dentistry, Oral Surgery & Medicine
Diego Antonio Costa Arantes, Italo Cordeiro de Toledo, Jose Alcides Almeida de Arruda, Ricardo Alves Mesquita, Luciano Alberto de Castro, Aline Carvalho Batista, Rejane Faria Ribeiro-Rotta
Summary: A study found that there is a cross-talk between peripheral nerve fibers (NF) and neuropeptides secreted by mast cells in the etiopathogenesis of burning mouth syndrome (BMS). The density and integrity of peripheral NF in the tongue of symptomatic BMS patients were found to be similar to those of healthy individuals.
BRAZILIAN ORAL RESEARCH
(2023)
Article
Pathology
Emanuene Galdino Pires, Christany Rodrigues Ferreira, Roberta Barroso Cavalcante, Maria Cassia Ferreira de Aguiar, Ricardo Alves Mesquita, Pollianna Muniz Alves, Cassiano Francisco Weege Nonaka
Summary: This study investigated the immunoexpression of autophagy-related proteins in salivary gland tumors and found that autophagy may be involved in the development of these tumors. Upregulation of autophagy and reduced nuclear translocation of p62 may contribute to the aggressive biological behavior of salivary gland adenoid cystic carcinoma.
HEAD & NECK PATHOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Eliene Magda de Assis, Mayara Rodrigues, Jessica Campos Vieira, Maria Ines Mantuani Pascoaloti, Helvecio Marangon Junior, Giovanna Ribeiro Souto, Paulo Eduardo Alencar Souza, Martinho Campolina Rebello Horta
Summary: Oral squamous cell carcinoma (OSCC) is a prevalent and deadly head and neck tumor. Tumor budding, the presence of isolated neoplastic cells or small clusters of cells at the tumor's invasive front, is associated with a worse prognosis. This study aimed to evaluate the differences in microvascular density (MVD) between tumors with high-intensity tumor budding and tumors with low-intensity or no tumor budding in OSCC.
MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
(2023)
Article
Pathology
Eliene Magda de Assis, Mayara Rodrigues, Jessica Campos Vieira, Maria Ines Mantuani Pascoaloti, Helvecio Marangon Jr, Giovanna Ribeiro Souto, Paulo Eduardo Alencar Souza, Martinho Campolina Rebello Horta
Summary: Tumor budding in oral squamous cell carcinoma is associated with the progression and biological behavior of the cancer, as indicated by increased lymphatic vascular density and podoplanin expression in neoplastic cells.
HEAD & NECK PATHOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Daiana Cristina Pereira Santana, Larissa Abbehusen Couto, Johelle de Santana Passos-Soares, Flavia Calo de Aquino Xavier, Ricardo Alves Mesquita, Fernanda Aragao Felix, Tarcilia Aparecida da Silva, Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves, Christany Rodrigues Ferreira, Tatiana Nayara Liborio-Kimura, Lucileide Castro de Oliveira Moreira, Jeconias Camara, Caroline Alfaia Silva, Elismauro Francisco de Mendonca, Nadia do Lago Costa, Helder Antonio Rebelo Pontes, Lucas Lacerda de Souza, Jurema Freire de Castro Lisboa, Gustavo Pina Godoy, Lais Azevedo Lins de Holanda, Manoela Domingues Martins, Pantelis Varvaki Rados, Tuany Rafaeli Schmidt, Roseana de Almeida Freitas, Lelia Batista de Souza, Everton Freitas de Morais, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Gabriella Alves Quixabeira Oliveira, Jean Nunes dos Santos, aguida Cristina Gomes Henriques
Summary: This multicenter study aimed to evaluate cases of non-syndrome and syndromic odontogenic keratocysts. The study found that non-syndromic keratocysts were more common in the population. Clinicopathological features, age, and recurrence may differ between syndromic and non-syndromic cases. Additionally, there was an association between lesion size and clinical features, as well as between recurrence time interval and the syndromic spectrum.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Alyssa Sales dos Santos, Maria Aparecida Barbosa de Sa, Marco Antonio Hungaro Duarte, Martinho Campolina Rebello Horta, Frank Ferreira Silveira, Eduardo Nunes
Summary: This study aimed to evaluate the penetration of endodontic cement after the removal of calcium hydroxide dressing using XP-endo Finisher with different irrigating solutions. The results showed that the use of XP-endo Finisher was more effective than a needle and syringe during irrigation. Shaking with XP-endo Finisher and 17% EDTA increased the extent and perimeter of the penetration of the endodontic cement.
BRAZILIAN ORAL RESEARCH
(2022)