Journal
JOURNAL OF ORAL PATHOLOGY & MEDICINE
Volume 47, Issue 1, Pages 66-70Publisher
WILEY
DOI: 10.1111/jop.12646
Keywords
Denosumab; dental management; Oncology; osteonecrosis of the jaw; retrospective; side effect
Categories
Funding
- Cancer Institute of Lorraine (ICL)
- Dental Faculty of Nancy
Ask authors/readers for more resources
BackgroundOsteonecrosis of the jaw is a very delicate side effect of Denosumab. The aim of this retrospective study was to assess the occurrence rate of Denosumab-related osteonecrosis of the jaw (DRONJ) at the Cancer Institute of Lorraine (ICL) and to highlight necrosis risk factors. MethodsTo that purpose, we analyzed the medical records of 249 consecutive patients treated with Denosumab at the ICL during the past 5 years. Patients who received orofacial radiotherapy or a previous treatment with a bisphosphonate were excluded. The P-value was set at .005. ResultsA total of 141 patients treated at the ICL between January 2010 and December 2015 were included. All patients were treated with XGEVA((R)). Of the 141 patients included in the study, 10 developed DRONJ. The incidence of DRONJ increases with the duration of follow-up as follows: 3% at 1 year, 7% at 2 years, and 8% from 30 months on. No risk factor for necrosis could be identified except the realization of prior dental extraction (P = .025). ConclusionOur results raise important questions about the dental management of these patients, in particular, concerning the healing period between dental extractions and the initiation of Denosumab.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available