Article
Medicine, General & Internal
Xinyang Yu, Zhengfei Liu, Jie Fang, Hongbo Qi
Summary: miR-96-5p plays a significant role in diagnosing gestational diabetes mellitus (GDM), with decreased levels in both placenta and plasma samples of patients with GDM. It can serve as a diagnostic biomarker for GDM with high sensitivity and specificity, and may participate in the pathogenesis of GDM by affecting the viability of trophoblasts.
Review
Biochemistry & Molecular Biology
Sofie Dinesen, Alisar El-Faitarouni, Nanna Lond Skov Frisk, Anja Elaine Sorensen, Louise Torp Dalgaard
Summary: Gestational diabetes mellitus (GDM) is a severe complication during pregnancy, and identifying potential biomarkers for its early detection is crucial. This study conducted a systematic review and meta-analysis to investigate miRNAs associated with GDM. The findings suggest that certain miRNAs show altered expression in GDM, indicating their potential as biomarkers for early GDM detection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Masoumeh Karami, Seyyed Hossein Mousavi, Mohammad Rafiee, Reza Heidari, Seyedeh Zahra Shahrokhi
Summary: Gestational diabetes mellitus (GDM) is a common metabolic disorder during pregnancy with various short- and long-term complications. Its exact cause is not well understood, although it is believed to be influenced by genetic, epigenetic, and environmental factors. Screening time, diagnostic threshold, and treatment strategies for GDM are still debated. The identification of effective therapeutic strategies and accurate biomarkers for prognostic and diagnostic purposes will help reduce the incidence of GDM and improve its management. This review discusses current and future diagnostic approaches for GDM detection and evaluates lifestyle and pharmacological strategies for GDM prevention.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Review
Biochemistry & Molecular Biology
Hsiuying Wang
Summary: Parkinson's disease (PD) and Diabetes Mellitus (DM) have been shown to have a connection in recent studies. This link has been discussed in the literature in relation to different mechanisms. miRNAs play a crucial role in regulating insulin pathways, glucose absorption, and PD-related genes, making them a potential therapeutic target for both diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Wenqian Lu, Cheng Hu
Summary: This review summarizes recent studies on biomolecules associated with GDM and postpartum diabetes, focusing on their predictive value in screening and diagnosis.
CHINESE MEDICAL JOURNAL
(2022)
Article
Endocrinology & Metabolism
Qingwen He, Mengyuan Lin, Zhenhong Wu, Renqiang Yu
Summary: This study aimed to predict gestational diabetes mellitus (GDM) by detecting GPR120 expression levels in early pregnancy and constructing a model. Results from 250 pregnant women showed higher GPR120 levels in GDM patients during the first trimester. The nomogram incorporating GPR120 levels demonstrated good predictive ability for the onset of GDM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Zhu-Qiu Jin
Summary: Cardiac fibrosis, a main characteristic of diabetic cardiomyopathy, is influenced by multiple signaling pathways, with TGF-beta/Smad2/3 pathway playing a central role. miRNAs, stable molecules involved in gene silencing, are dysregulated in the diabetic heart, promoting or inhibiting cardiac fibrosis by targeting various pathways in different cardiac cells. Detection of miRNAs in plasma or serum could potentially serve as biomarkers for diabetes mellitus or heart failure diagnosis, providing insight into the pathogenesis of cardiac fibrosis.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cell Biology
Amarish Kumar Sharma, Sanjeev Singh, Himanshu Singh, Deviyani Mahajan, Prachetha Kolli, Gowtham Mandadapu, Bimlesh Kumar, Dharmendra Kumar, Sudarshan Kumar, Manoj Kumar Jena
Summary: This article focuses on the pathophysiology and potential biomarkers for early diagnosis of gestational diabetes mellitus (GDM), emphasizing the importance of early diagnosis and effective management of the disease during early pregnancy.
Article
Environmental Sciences
Zhigang Li, Rongrong Xu, Zhanshan Wang, Nianfeng Qian, Yan Qian, Jianhao Peng, Xiaojing Zhu, Chen Guo, Xiaoqian Li, Qiujin Xu, Yongjie Wei
Summary: This study found that ozone exposure, especially in the first month before pregnancy, is associated with an increased risk of gestational diabetes mellitus (GDM). The odds of GDM also increase with increasing ozone concentration. These findings highlight the importance of stricter air pollution controls to improve the health of pregnant women and their offspring.
Article
Endocrinology & Metabolism
Daryl J. Selen, Tanayott Thaweethai, Carolin C. M. Schulte, Sarah Hsu, Wei He, Kaitlyn James, Anjali Kaimal, James B. Meigs, Camille E. Powe
Summary: Gestational glucose intolerance (GGI), an abnormal initial gestational diabetes mellitus (GDM) screening test without a GDM diagnosis, is associated with an increased risk of future diabetes. Individuals with GGI have a higher risk of developing diabetes compared to those with normal glucose tolerance during pregnancy. Routine clinical data can be used to identify this unrecognized group who may benefit from enhanced diabetes screening and prevention.
Article
Public, Environmental & Occupational Health
Shih-Chun Pan, Ching-Chun Huang, Bing-Yu Chen, Wei-Shan Chin, Yue Leon Guo
Summary: This study aimed to determine whether air pollutants modify the effects of gestational diabetes mellitus (GDM) on the occurrence of diabetes mellitus (DM). The results showed that exposure to high levels of PM2.5 and O-3 increases the risk of DM, and GDM acts synergistically with PM2.5 exposure in DM development.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Endocrinology & Metabolism
Qian-Yi Wang, Liang-Hui You, Lan-Lan Xiang, Yi-Tian Zhu, Yu Zeng
Summary: GDM is a common metabolic disorder during pregnancy with unclear etiology and pathogenesis. Metabolomics can be utilized to discover diagnostic biomarkers, evaluate prognosis, guide treatment, and explore mechanisms in GDM research.
WORLD JOURNAL OF DIABETES
(2021)
Article
Biochemistry & Molecular Biology
Qiuhan Lu, Yue Li, Dewei Ye, Xiangtian Yu, Wenyu Huang, Shufei Zang, Guozhi Jiang
Summary: This study conducted a longitudinal untargeted metabolomic analysis to identify metabolomic profiles and biomarkers associated with the progression of gestational diabetes mellitus (GDM). The results revealed distinct patterns of metabolites throughout pregnancy and highlighted allantoic acid as a potential biomarker for early diagnosis of GDM.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Endocrinology & Metabolism
Yumeng Tian, Ping Li
Summary: This article reviews the research progress in the use of genetic risk score (GRS) in diabetes mellitus in recent years and discusses future prospects.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Julien Simon, Karine Goueslard, Sonia Bechraoui-Quantin, Patrick Arveux, Catherine Quantin
Summary: The association between gestational diabetes mellitus (GDM) and breast cancer (BC) risk remains controversial, with some studies suggesting an increased risk while others indicating a possible protective effect. Due to methodological shortcomings, caution should be taken when interpreting these conflicting results, and further research is needed to better understand the underlying mechanisms.