Article
Biochemistry & Molecular Biology
Qin Wang, Shuo Zhan, Yiqun Liu, Feng Han, Lili Shi, Chao Han, Weipeng Mu, Jizhong Cheng, Zhen-wu Huang
Summary: Selenium deficiency in rats had negative effects on growth and sperm quality, with reduced sperm motility and increased deformities. The expression levels of selenoproteins, particularly GPx4 and SEPP1, were significantly lower in the deficient group, suggesting a potential mechanism for the observed effects on sperm quality.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Jessica L. Nicholson, Pamela Toh, Naghum Alfulaij, Marla J. Berry, Daniel J. Torres
Summary: It has been 50 years since the discovery of the first selenoprotein, and our understanding of the importance of selenium has greatly increased. We now know that the brain relies on selenium for proper functioning, and a lack of certain selenoproteins can lead to neurodegeneration. Additionally, selenoprotein-mediated redox balance has been found to affect neuronal activity.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Medicine, Research & Experimental
Gunel Talibova, Zeynep Ozturk, Mesut Parlak, Alphan Kupesiz
Summary: This study measured SEPP concentrations in thalassemia patients for the first time, showing higher levels in TM patients compared to controls. Correlations between thyroid hormones and selenoproteins suggest that selenium may be necessary for thyroid function.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Maria Schwarz, Alina Loeser, Qing Cheng, Mareike Wichmann-Costaganna, Patrick Schaedel, Oliver Werz, Elias S. J. Arner, Anna P. Kipp
Summary: In humans, there are eight glutathione peroxidases (GPXs), and five of them are selenoproteins that play a crucial role in cellular redox homeostasis. Among the three main cytosolic GPXs, GPX1 and GPX2 reduce soluble hydroperoxides, while GPX4 reduces complex lipid hydroperoxides. The experiments show that GPX1 has the highest activity in reducing soluble and fatty-acid derived hydroperoxides among these isoforms.
Article
Biochemistry & Molecular Biology
Jiao Luo, Liqin Su, Xiaohong He, Yegang Du, Ning Xu, Rangpeng Wu, Yunfeng Zhu, Ting Wang, Ranqi Shao, Frederick W. Unverzagt, Ann M. Hake, Yinlong Jin, Sujuan Gao
Summary: This study found that higher blood selenium levels are associated with lower serum A beta 42 and A beta 40 levels, as well as a higher A beta 42/A beta 40 ratio. These results are specific to different selenoproteins.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Kamil Demircan, Qian Sun, Ylva Bengtsson, Petra Seemann, Johan Vallon-Christersson, Martin Malmberg, Lao H. Saal, Lisa Ryd, Waldemar B. Minich, Ake Borg, Jonas Manjer, Lutz Schomburg
Summary: The presence of SELENOP autoantibodies in breast cancer patients is associated with poor prognosis, particularly in patients with low selenium levels. These autoantibodies may disrupt the transport function of SELENOP, leading to an increased risk of recurrence and mortality.
Article
Biochemistry & Molecular Biology
Aiping Liu, Fengna Li, Ping Xu, Yanmei Chen, Xiongshun Liang, Shijie Zheng, Huicui Meng, Yumei Zhu, Junluan Mo, Chunmei Gong, Ji-Chang Zhou
Summary: The study investigated the mRNA expressions of testis-abundant selenogenes in response to different dietary selenium concentrations in rat models. The results showed that Gpx4, Selenov, and Txnrd3 were highly expressed in the testis, especially during reproductive ages, and were resistant to changes in dietary selenium levels.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Food Science & Technology
Frineth de la Luz Limon Aguilera, Sayra N. Serrano Sandoval, Mauricio Graciano-Palacios, Janet A. Gutierrez-Uribe, Anayansi Escalante-Aburto
Summary: Selenium in its organic form plays a crucial role in human metabolism, functioning as an antioxidant and reducing inflammatory biomarkers associated with overweight and obesity. Studies suggest that selenocompounds may have potential therapeutic effects for obesity. Various strategies have been developed worldwide to produce selenium-enriched foods and supplements, aiming to increase accessibility for consumers.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Erick Bahena Culhuac, Mona M. M. Y. Elghandour, Moyosore J. Adegbeye, Alberto Barbabosa-Pliego, Abdelfattah Z. M. Salem
Summary: This review analyzed the effect of dietary selenium on oxidative stress in horses by considering past and recent bibliographic sources. The findings suggest that selenium, as an important antioxidant, can regulate oxidative stress in horses when the body is under stress.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Fisheries
Aliakbar Ghaffarizadeh, Ebrahim Sotoudeh, Mansour Torfi Mozanzadeh, Ali Mohammad Sanati, Ahmad Ghasemi
Summary: This study examined the effects of dietary selenium nanoparticles (Se-N) on the performance of whiteleg shrimp juveniles. The results showed that supplementing the diet with Se-N improved the growth performance and feed conversion ratio of the shrimp. Increasing levels of Se-N in the diet also led to higher selenium levels in the shrimp's body. Additionally, Se-N supplementation increased the activities of certain enzymes and reduced oxidative stress in the shrimp.
AQUACULTURE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
David J. Hughes, Lutz Schomburg, Mazda Jenab, Carine Biessy, Catherine Meplan, Aurelie Moskal, Qian Sun, Kamil Demircan, Veronika Fedirko, Elisabete Weiderpass, Maryam Mukhtar, Anja Olsen, Anne Tjonneland, Kim Overvad, Matthias Schulze, Therese Haugdahl Nost, Guri Skeie, Karina Standahl Olsen, Fulvio Ricceri, Sara Grioni, Domenico Palli, Giovanna Masala, Rosario Tumino, Fabrizio Pasanisi, Pilar Amiano, Sandra M. Colorado Yohar, Antonio Agudo, Maria-Jose Sanchez, Eva Ardanaz, Malin Sund, Anne Andersson, Aurora Perez-Cornago, Ruth Travis, Alicia K. Heath, Laure Dossus
Summary: The study found no significant association between selenium status and breast cancer risk. However, higher activity of the selenoenzyme GPX3 was associated with a lower risk of premenopausal breast cancer. Several genetic variants were also found to be associated with breast cancer risk.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Stefanie Raschke, Franziska Ebert, Anna Patricia Kipp, Johannes Florian Kopp, Tanja Schwerdtle
Summary: Copper negatively affects selenium levels in brain cells and selenium can partially protect against copper-induced cell damage and neurodegeneration.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Laura G. Sherlock, William C. McCarthy, Maya R. Grayck, Mack Solar, Andres Hernandez, Lijun Zheng, Cassidy Delaney, Trent E. Tipple, Clyde J. Wright, Eva S. Nozik
Summary: Exposure to selenium deficiency during pregnancy and lactation can impair weight gain and lung growth in offspring. Selenium deficiency reduces the levels and activity of multiple selenoproteins in the neonatal lung, affecting oxidative stress and cell signaling.
Article
Biochemistry & Molecular Biology
Amra Jujic, John Molvin, Lutz Schomburg, Oliver Hartmann, Andreas Bergmann, Olle Melander, Martin Magnusson
Summary: A recent study found that high selenium levels are associated with reduced mortality and incidence of heart failure (HF), but only in non-smokers. This study aimed to investigate whether selenoprotein P (SELENOP) is associated with incident HF. The results showed that low SELENOP levels are associated with a higher risk of incident HF in the general population.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Qing Cheng, Antonella Roveri, Giorgio Cozza, Luciana Bordin, Isabelle Rohn, Tanja Schwerdtle, Anna Kipp, Fulvio Ursini, Matilde Maiorino, Giovanni Miotto, Elias S. J. Arner
Summary: This study discusses a new method for producing mammalian selenoproteins in E. coli, including GPX1, GPX2, and GPX4. Through various experiments and analyses, it reveals the characteristics of selenoproteins and a unique phenomenon of codon skipping in recombinant proteins.
Article
Agriculture, Dairy & Animal Science
Shanli Zhu, Mark Portman, Beth M. Cleveland, Andrew D. Magnuson, Kun Wu, Wendy Sealey, Xin Gen Lei
Summary: Replacing fish oil with DHA-rich microalgae in juvenile rainbow trout diets resulted in more negative metabolic responses compared to substituting synthetic astaxanthin with microalgal source. These substitutions had significant impacts on growth and nutrient utilization in rainbow trout.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kun Wu, Beth M. Cleveland, Mark Portman, Wendy M. Sealey, Xin Gen Lei
Summary: The substitution of fish oil with DHA-rich microalgae had a greater impact on the redox status and expression of antioxidant enzymes in rainbow trout tissues compared to the substitution of synthetic AST with microalgal AST.
Article
Biotechnology & Applied Microbiology
Madeleine Keefe, Xin Gen Lei
Summary: The black carpet beetle is a unique household pest with the ability to digest keratin-rich materials like feathers. Transcriptome analysis revealed a high proportion of proteases in the beetle, indicating a strong likelihood of keratinolytic function.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Entomology
Madeleine Keefe, Xin Gen Lei
Summary: The study showed that the black carpet beetle can effectively metabolize feather keratin, with a digestibility ranging from 68% to 89%. Gut enzyme analysis confirmed keratinolytic activity in the larval digestive tract, and larvae reared on a feather diet showed higher overall protein content compared to control-fed larvae. The black carpet beetle proves to be a promising biological fermenter for sustainably converting feather protein into insect protein.
JOURNAL OF APPLIED ENTOMOLOGY
(2022)
Review
Biochemical Research Methods
Sahil Kalia, Xin Gen Lei
Summary: This review provides an update on the effects of feeding different types and sources of microalgae to broiler chickens and laying hens. It discusses the impacts of these ingredients on the physical, chemical, and nutritional attributes of the resultant meat and eggs. However, the full potential and accurate mechanism of microalgae in producing health-promoting poultry foods are yet to be explored.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ruirui Yu, Zhoutian Wang, Miaomiao Ma, Ping Xu, Longjian Liu, Alexey A. Tinkov, Xin Gen Lei, Ji-Chang Zhou
Summary: This meta-analysis study reveals that patients with GLMDs have higher levels of SELENOP in their blood, and the levels of SELENOP are positively correlated with markers of GLMDs. Women with gestational diabetes have higher SELENOP concentrations, while individuals with metabolic syndrome have lower SELENOP concentrations. Additionally, SELENOP is positively correlated with low-density lipoprotein cholesterol.
Article
Biochemistry & Molecular Biology
Jia-Qiang Huang, Yun-Yun Jiang, Fa-Zheng Ren, Xin Gen Lei
Summary: This study demonstrates that the depletion of glutathione peroxidase 4 (GPX4) protein is a major contributor to the development of nutritional pancreatic atrophy (NPA), and this mechanism is related to the binding of GPX4 to prothymosin alpha (ProTalpha).
Review
Clinical Neurology
Miaomiao Ma, Yao Li, Shimiao Dai, Ming Chu, Litao Sun, Longjian Liu, Ji-Chang Zhou
Summary: Charcot-Marie-Tooth disease and related inherited peripheral neuropathies (CMT & RIPNs) cause significant suffering and burden to patients, but there is a lack of comprehensive understanding of their global prevalence rates. Further epidemiological studies with well-defined diagnostic criteria are needed to improve the assessment of prevalence and raise awareness for better healthcare support.
JOURNAL OF NEUROLOGY
(2023)
Article
Food Science & Technology
Rohil S. Bhatnagar, Xin-Gen Lei, Dennis D. Miller, Olga I. Padilla-Zakour
Summary: The study aimed to enhance the use of DGM in foods. Encapsulation of DGM and inulin in an oil-in-water emulsion was found to improve the utilization of DGM. The results showed that adding EC50 to wheat flour can effectively deliver highly bioavailable iron without any stability or sensory defects for at least 30 days of storage.
Article
Nutrition & Dietetics
Fengna Li, Zhan Shi, Minning Cheng, Zhongwei Zhou, Ming Chu, Litao Sun, Ji-Chang Zhou
Summary: SELENOI is an ethanolamine phosphotransferase involved in the synthesis of phosphatidylethanolamine. Defects in SELENOI can affect health through the functions of phosphatidylethanolamine. SELENOI incorporates selenium as selenocysteine and is important in the survival and evolution of organisms. Various factors regulate the expression of SELENOI, and it has multiple biochemical functions.
JOURNAL OF NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
Sahil Kalia, Andrew D. Magnuson, Tao Sun, Guanchen Liu, Woo Kyun Kim, Zackary Johnson, Xin Gen Lei
Summary: This study investigated the effects of high levels of DHA and calcidiol on the growth performance and metabolism of broiler chickens. It was found that feeding these substances can improve the growth performance, blood lipid concentration, and bone properties of broiler chickens.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marko Z. Vatamaniuk, Rong Huang, Zeping Zhao, Xin Gen Lei
Summary: Transition metals have essential roles in biological tissues, but some, like cadmium, can be highly toxic. Disturbances in metal balance caused by micronutrient deficiency, pollution or genetic factors can lead to malfunction and diseases. This study used synchrotron X-ray fluorescence microscopy and mice with altered antioxidant enzyme functions to demonstrate the potential of SXRF as a powerful tool for studying biologically relevant metal balance in the pancreas and liver of mice models with disturbed glucose homeostasis.
Article
Biochemistry & Molecular Biology
Hong Wang, Marko Z. Vatamaniuk, Zeping Zhao, Xin Gen Lei
Summary: Our study aimed to investigate the relationship between the expression and function of Reg family genes and antioxidant enzymes in pancreatic islets and human pancreatic cells. We found that altering the Gpx1 and Sod1 genes in mice affected the expression of most Reg genes in islets. In addition, REG2 protein inhibited islet proliferation in mice with Gpx1 or Sod1 alterations, and treating human pancreatic cells with murine REG2 protein affected gene expression, enzyme activities, and cell viability.
Review
Environmental Sciences
Alexey A. Tinkov, Michael Aschner, Abel Santamaria, Alfred R. Bogdanov, Yousef Tizabi, Miriam B. Virgolini, Ji-Chang Zhou, Anatoly V. Skalny
Summary: The objective of this study was to review existing epidemiological and laboratory findings supporting the role of toxic metal exposure in non-alcoholic fatty liver disease (NAFLD). The existing studies demonstrate a link between exposure to cadmium, lead, arsenic, and mercury and an increased risk of NAFLD, as well as altered liver injury markers. Laboratory studies also show that metal exposure leads to hepatic lipid accumulation and affects metabolic pathways and inflammatory response.
ENVIRONMENTAL RESEARCH
(2023)