Review
Endocrinology & Metabolism
Jie Jiang, Xiaoxia Tang, Yongzhu Pu, Yong Yang, Conghui Yang, Fake Yang, Yadong Tian, Jindan Li, Hua Sun, Sheng Zhao, Long Chen
Summary: This article reviews the progress of PET/CT research in biochemical recurrence of prostate cancer, aiming to introduce new technologies and provide more direction for future research.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Dajana Cuicchi, Margherita Mottola, Paolo Castellucci, Alessandro Bevilacqua, Arrigo Cattabriga, Maria Adriana Cocozza, Stefano Cardelli, Gerti Dajti, Susanna Mattoni, Rita Golfieri, Stefano Fanti, Alberta Cappelli, Francesca Coppola, Gilberto Poggioli
Summary: This study used radiomic analysis to improve the diagnosis accuracy of locally recurrent rectal cancer (LRRC). By characterizing tissue properties through quantitative features, it facilitated the accurate detection of LRRC through CT and PET/CT.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Sankarsh Jetty, James Ryan Loftus, Abhinav Patel, Akshya Gupta, Savita Puri, Vikram Dogra
Summary: The imaging of prostate cancer has advanced with the use of molecular imaging, particularly Positron Emission Tomography (PET), replacing traditional CT and MRI for detecting prostate cancer recurrence. PET imaging provides better localization and characterization of disease recurrence, and also plays a role in assessing treatment response and determining patient prognosis and survival. This article reviews the commonly used molecular imaging agents for prostate cancer, focusing on Fluorine-18 fluciclovine (Axumin) and PSMA-ligand agents, including their imaging protocols, interpretation, and potential pitfalls.
Article
Biotechnology & Applied Microbiology
Jiaying Zhang, Zefang Lin, Xiaojun Zhang, Rong Lin, Mengchao Cui, Weibing Miao, Shaobo Yao
Summary: The injection of Ga-68-DOTA-DiPSMA is safe and associated with low absorbed and effective doses. Ga-68-DOTA-DiPSMA demonstrates favorable kinetics and imaging characteristics, showing potential as an alternative for gallium-68-labeled PSMA clinical PET.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yazan Z. Alabed
Summary: This case demonstrates the significance of F-18-PSMA PET/CT for staging and follow-up of patients with ductal variant prostate cancer, particularly those with normal PSA levels. It highlights the diagnostic and monitoring value of this imaging modality in such patients.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Felix Dietlein, Carsten Kobe, Sergio Munoz Vazquez, Thomas Fischer, Heike Endepols, Melanie Hohberg, Manuel Reifegerst, Bernd Neumaier, Klaus Schomaecker, Alexander E. Drzezga, Markus Dietlein
Summary: The study found that Zr-89-PSMA-DFO can detect low-expressed PSMA prostate cancer lesions more sensitively and reliably than existing tracers in PET/CT scans. This research is of great significance in helping patients with undetectable lesions.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Beatrice Detti, Maria Grazia Carnevale, Sara Lucidi, Luca Burchini, Saverio Caini, Carolina Orsatti, Niccolo Bertini, Manuele Roghi, Vanessa di Cataldo, Simona Fondelli, Gianluca Ingrosso, Giulio Francolini, Daniele Scartoni, Angela Sardaro, Antonio Pisani, Silvia Scoccianti, Cynthia Aristei, Lorenzo Livi
Summary: Biochemical recurrence (BR) occurs in up to 40% of patients with prostate cancer (PCa) treated with primary radical prostatectomy (RP). Choline PET/CT may show the site of tumor recurrence earlier than traditional imaging methods, particularly at low prostate-specific antigen (PSA) levels, thus influencing subsequent treatment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Ioannis Tsechelidis, Alexis Vrachimis
Summary: PSMA PET, the latest nuclear medicine development, is regarded as the most promising tool for the diagnosis and treatment of prostate malignancy. However, there is still debate and ongoing research regarding its utility and position in guidelines, requiring further studies and trials for clarification.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
P. A. Glemser, L. T. Rotkopf, C. H. Ziener, B. Beuthien-Baumann, V Weru, A. Kopp-Schneider, H. P. Schlemmer, A. Dimitrakopoulou-Strauss, C. Sachpekidis
Summary: [Ga-68]PSMA-11 PET-CT and PET-MRI provide equally good detection rates for prostate cancer recurrence, both outperforming stand-alone MRI. PET-MRI is particularly efficient in detecting local recurrences in the prostate bed, while there were no significant differences in lesion detection rate between PET-CT and PET-MRI. The probability of a positive scan significantly increased with increasing PSA levels for all imaging modalities.
Review
Radiology, Nuclear Medicine & Medical Imaging
Feng-Yuan Liu, Ting-Wen Sheng, Jing-Ren Tseng, Kai-Jie Yu, Ke-Hong Tsui, Se-Tong Pang, Li-Jen Wang, Gigin Lin
Summary: This study compared the use of PET-CT and PET-MRI in patients with prostate cancer through a systematic literature search. The results showed that PET-MRI has better performance in the detection and staging of local tumors, as well as in the detection of recurrences, while PET-CT is more effective in detecting distant metastases.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ingrid L. Bakker, Alida C. Froberg, Martijn B. Busstra, J. Fred Verzijlbergen, Mark Konijnenberg, Geert J. L. H. van Leenders, Ivo G. Schoots, Erik de Blois, Wytske M. van Weerden, Simone U. Dalm, Theodosia Maina, Berthold A. Nock, Marion de Jong
Summary: The study demonstrated that the GRPr receptor overexpressed in prostate cancer cells is effective for early prostate cancer imaging, with 68Ga-SB3 PET/CT imaging showing tumor lesions and a significant correlation between GRPr expression and tracer uptake.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wolfgang P. Fendler, Matthias Eiber, Mohsen Beheshti, Jamshed Bomanji, Jeremie Calais, Francesco Ceci, Steve Y. Cho, Stefano Fanti, Frederik L. Giesel, Karolien Goffin, Uwe Haberkorn, Heather Jacene, Phillip J. Koo, Klaus Kopka, Bernd J. Krause, Liza Lindenberg, Charles Marcus, Felix M. Mottaghy, Daniela E. Oprea-Lager, Joseph R. Osborne, Morand Piert, Steven P. Rowe, Heiko Schoeder, Simon Wan, Hans-Jurgen Wester, Thomas A. Hope, Ken Herrmann
Summary: This article aims to provide updated guidance and standards for the use of PSMA PET/CT in imaging prostate cancer. It discusses procedures and characteristics of various PSMA small radioligands and different clinical scenarios for their use. The document is intended to support clinicians and technicians in implementing PSMA PET/CT imaging in both research and routine practice.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Oncology
Francesco Dondi, Alessandro Antonelli, Nazareno Suardi, Andrea Emanuele Guerini, Domenico Albano, Silvia Lucchini, Luca Camoni, Giorgio Treglia, Francesco Bertagna
Summary: Neuroendocrine prostate cancer is a rare and aggressive tumor, and the diagnostic approach is challenging due to the lack of specific features on conventional imaging or PET. This systematic review aimed to evaluate the role of imaging modalities in assessing this type of cancer. The data on the efficacy of PET/CT for neuroendocrine prostate cancer assessment are limited, and further research is needed to determine the best tracer and understand the tumor biology.
Article
Oncology
Xiaoxiang Rong, Jinyu Lv, Yantan Liu, Zhaojun Wang, Dongqiang Zeng, Yuedan Li, Shaowei Li, Jianhua Wu, Zheyu Shen, Min Shi, Wangjun Liao, Zhenzhen Wu, Chunlin Wang
Summary: The infiltration of immunosuppressive cells is associated with prognosis in GC patients. Ga-68-FAPI-04 PET/CT imaging is correlated with TMEscore and high uptake is associated with reduced therapeutic benefits from ICB therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, General & Internal
Jeremy McGale, Sakshi Khurana, Alice Huang, Tina Roa, Randy Yeh, Dorsa Shirini, Parth Doshi, Abanoub Nakhla, Maria Bebawy, David Khalil, Andrew Lotfalla, Hayley Higgins, Amit Gulati, Antoine Girard, Francois-Clement Bidard, Laurence Champion, Phuong Duong, Laurent Dercle, Romain-David Seban
Summary: HER2-positive breast cancer, characterized by amplification of the HER2 gene, is associated with aggressive tumor growth, increased metastatic risk, and poorer prognosis compared to other subtypes. HER2 expression is a crucial tumor feature for breast cancer diagnosis and treatment. Advancements in HER2 in vivo imaging techniques like PET and SPECT may enhance the role of HER2 status in guiding breast cancer management, enabling determination of tumor size, location, and evaluation of treatment effectiveness. This review explores the current and future role of HER2 imaging in personalized care for breast cancer patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Sophie Knipper, Mehrdad Mehdi Irai, Ricarda Simon, Daniel Koehler, Isabel Rauscher, Matthias Eiber, Fijs W. B. van Leeuwen, Pim van Leeuwen, Hilda de Barros, Henk van der Poel, Lars Budaeus, Thomas Steuber, Markus Graefen, Pierre Tennstedt, Matthias M. Heck, Thomas Horn, Tobias Maurer
Summary: This study evaluated the oncological outcomes of salvage PSMA-RGS in patients with recurrent oligometastatic prostate cancer and identified predictive preoperative factors for improved outcomes. The results showed that the 3-month and 2-year tumor survival rates were 32% and 58%, respectively. Preoperative PSA, number of PSMA-avid lesions, and localization of lesions were independent predictors of biochemical recurrence after PSMA-RGS.
Article
Cardiac & Cardiovascular Systems
Nabeel Mansour, Stephan G. Nekolla, Eliana Reyes, George Angelidis, Panagiotis Georgoulias, Constantinos Anagnostopoulos, Paco Bravo, Isabella Bruno, Albert Flotats, Francisco Fuentes-Ocampo, Roberto Sciagra, Felix Keng, Lukas Kessler, Maria Papathanasiou, Prem Soman, Christoph Rischpler
Summary: CZT-MPI has higher diagnostic sensitivity in detecting coronary artery disease compared to conventional Anger-MPI, but it has reduced specificity and diagnostic accuracy. Experienced readers show higher inter-rater agreement and special training is required for non-experienced readers.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Letter
Urology & Nephrology
Hilda A. de Barros, Matthias N. van Oosterom, Maarten L. Donswijk, Jeroen J. M. A. Hendrikx, Andre N. Vis, Tobias Maurer, Fijs W. B. van Leeuwen, Henk G. van der Poel, Pim J. van Leeuwen
Article
Cardiac & Cardiovascular Systems
Alberto Villagran Asiares, Teresa Vitadello, Borjana Bogdanovic, Esteban Lucas Solari, Lachlan McIntosh, Sylvia Schachoff, Tareq Ibrahim, Stephan G. Nekolla
Summary: This study investigated the impact of different cardiac gating methods on the assessment of cardiac function using FDG-PET. The results showed that the PET and MR-based cardiac function parameters were highly correlated, but the selected PET ECG gating method introduced variabilities and led to substantial disagreement in the assessment.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Urology & Nephrology
Mykyta Kachanov, Lars Budaeus, Dirk Beyersdorff, Pierre I. Karakiewicz, Zhe Tian, Fabian Falkenbach, Derya Tilki, Tobias Maurer, Guido Sauter, Markus Graefen, Sami-Ramzi Leyh-Bannurah
Summary: Combining targeted biopsy alone and combined with systematic biopsy, along with quantitative Gleason grading of biopsy specimen, accurately detects low levels of GP 4 and helps identify patients suitable for active surveillance.
EUROPEAN UROLOGY FOCUS
(2023)
Article
Oncology
Mohamed E. Elsesy, Su Jung Oh-Hohenhorst, Christoph Oing, Alicia Eckhardt, Susanne Burdak-Rothkamm, Malik Alawi, Christian Mueller, Ulrich Schueller, Tobias Maurer, Gunhild von Amsberg, Cordula Petersen, Kai Rothkamm, Wael Y. Mansour
Summary: This study provides preclinical models for castration-resistant prostate cancer (CRPC) that can predict homologous recombination repair (HRR) defects and the sensitivity to olaparib and cisplatin. These models recapitulate the features of primary tumors, enabling individualized drug screening for tailored therapy recommendations.
MOLECULAR ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Urs J. Muehlematter, Lilit Schweiger, Daniela A. Ferraro, Thomas Hermanns, Tobias Maurer, Matthias M. Heck, Niels J. Rupp, Matthias Eiber, Isabel Rauscher, Irene A. Burger
Summary: This study developed and evaluated a LNI prediction model using [Ga-68]Ga-PSMA-11 PET, showing improved prediction in intermediate to high-risk PCa patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Urology & Nephrology
Robert Seifert, Louise Emmett, Steven P. Rowe, Ken Herrmann, Boris Hadaschik, Jeremie Calais, Frederik L. Giesel, Robert Reiter, Tobias Maurer, Matthias Heck, Andrei Gafita, Michael J. Morris, Stefano Fanti, Wolfgang A. Weber, Thomas A. Hope, Michael S. Hofman, Wolfgang Peter Fendler, Matthias Eiber
Summary: This study proposes the PROMISE V2 framework for standardized interpretation and reporting of PSMA-PET findings, aiming to improve communication between imaging experts and uro-oncologists. The framework integrates an updated miTNM system, improved assessment of local disease, and a slightly modified PSMA-expression score for clinical routine and research.
Review
Radiology, Nuclear Medicine & Medical Imaging
Stephan G. Nekolla, Christoph Rischpler, Takahiro Higuchi
Summary: Noninvasive imaging techniques, such as SPECT, PET, CT, echocardiography, or MRI, have become essential in cardiovascular research and offer numerous advantages, such as high sensitivity and reliable quantification. Incorporating SPECT and PET imaging into a well-defined workflow similar to clinical imaging can effectively implement the concept of bench to bedside in cardiology translational research.
SEMINARS IN NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesca Ambrosini, Fabian Falkenbach, Lars Budaeus, Thomas Steuber, Markus Graefen, Daniel Koehler, Sophie Knipper, Tobias Maurer
Summary: This study compares the oncological and surgical outcomes of open and robot-assisted salvage prostate-specific membrane antigen-radioguided surgery (PSMA-RGS) in patients with recurrent prostate cancer. The results show comparable oncological outcomes between the two approaches.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Urology & Nephrology
Gisa Mehring, Derya Tilki, Hans Heinzer, Thomas Steuber, Randi M. Pose, Imke Thederan, Lars Budaeus, Georg Salomon, Alexander Haese, Uwe Michl, Tobias Maurer, Hartwig Huland, Markus Graefen, Hendrik Isbarn
Summary: Prostate cancer detection is usually achieved by PSA measurement and further diagnostics. However, some men might harbor significant PCa at a younger age. This study evaluated the histopathological results of men treated with RP in their 40s.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Elena Herms, Gregor Weirich, Tobias Maurer, Stefan Wagenpfeil, Stephanie Preuss, Andreas Sauter, Matthias Heck, Anita Gaertner, Katharina Hauner, Michael Autenrieth, Hubert P. Kubler, Konstantin Holzapfel, Ulrike Schwarz-Boeger, Uwe Heemann, Julia Slotta-Huspenina, Konrad Friedrich Stock
Summary: This study examines the benefits of using combined contrast-enhanced ultrasound (CEUS) and CT/MRI evaluation in diagnosing and monitoring renal cystic lesions. The results show that the CEUS-Bosniak classification is an essential tool in clinical practice for differentiating and monitoring renal cysts, and it enhances diagnostic work-up and patient care.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu Zhao, Chunmeng Tang, Bihao Cui, Arun Somasundaram, Johannes Raspe, Xiaobin Hu, Christina Holzapfel, Daniela Junker, Hans Hauner, Bjoern Menze, Mingming Wu, Dimitrios Karampinos
Summary: In this study, a multi-modal deep neural network-based method for the segmentation of supraclavicular brown adipose tissue (BAT) was proposed. The results showed that the proposed method outperformed the independent use of 2D or 3D networks, demonstrating the potential of deep learning-based segmentation methods for automated BAT segmentation.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Florian Kofler, Johannes Wahle, Ivan Ezhov, Sophia J. Wagner, Rami Al-Maskari, Emilia Gryska, Mihail Todorov, Christina Bukas, Felix Meissen, Tingying Peng, Ali Ertuerk, Daniel Rueckert, Rolf Heckemann, Jan Kirschke, Claus Zimmer, Benedikt Wiestler, Bjoern Menze, Marie Piraud
Summary: Machine learning models are often evaluated and trained based on their similarity with reference annotations. However, in the biomedical domain, subjective annotations and low reliability among raters can lead to sub-optimal predictions. The concept of Peak Ground Truth (PGT) is introduced to determine the point where increasing similarity with reference annotations no longer leads to better Real World Model Performance (RWMP). A quantitative technique is proposed to approximate PGT by assessing inter- and intra-rater reliability. Four categories of PGT-aware strategies to evaluate and improve model performance are discussed.
2023 IEEE 20TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING, ISBI
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Anjany Sekuboyina, Jannik Irmai, Suprosanna Shit, Jan Kirschke, Bjoern Andres, Bjoern Menze
Summary: This work proposes a simple pipeline for labelling vertebrae in a spine CT image, which combines a fully convolutional neural network and a conditional random field. The pipeline achieves high levels of automation in the labelling task.
2023 IEEE 20TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING, ISBI
(2023)