Article
Radiology, Nuclear Medicine & Medical Imaging
Ivan Ho Shon, Thomas Hennessy, Jennifer Guille, Michael P. Gotsbacher, Angelina J. Lay, Bruce McBride, Rachel Codd, Philip J. Hogg
Summary: This study evaluates the biodistribution, radiation dosimetry, safety, and tumor uptake of the novel radiopharmaceutical GA-68 ([GA-68] GA-CDI) for imaging multiple forms of cell death. The results demonstrate that GA-68 ([GA-68] GA-CDI) is safe, has low radiation dosimetry, and excellent biodistribution and imaging characteristics. It shows potential advantages over previous radiopharmaceuticals for imaging cell death and has progressed to a proof-of-concept trial.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Chemistry, Multidisciplinary
Ya-Qiong Yan, Hao Wang, Yuliang Zhao
Summary: Radionuclide imaging is a premier imaging method in clinical practice, utilizing PET and SPECT to detect anatomical abnormalities. Peptides as targeting vectors for contrast agents offer high specificity and low toxicity. Radiolabeled peptide probes have become essential tools for clinical radionuclide diagnosis.
CHINESE CHEMICAL LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Krystyna Pyrzynska, Krzysztof Kilian, Mateusz Pegier
Summary: This paper provides a brief overview of the application of porphyrin ligands in tumor diagnostics, including the chelation of metallic radioisotopes to form radiopharmaceuticals and the evaluation of metabolic changes in the human body through SPECT and PET. The chelation reactions are discussed in terms of the conditions, kinetics, and complex stability.
Article
Cardiac & Cardiovascular Systems
Ana Carolina do A. H. de Souza, Hendrik J. Harms, Laurel Martell, Courtney Bibbo, Meagan Harrington, Kyle Sullivan, Jon Hainer, Sharmila Dorbala, Ron Blankstein, Viviany R. Taqueti, Marie Foley Kijewski, Mi-Ae Park, Alejandro Meretta, Christopher Breault, Nathaniel Roth, Alexis Poitrasson-Riviere, Prem Soman, Grant T. Gullberg, Marcelo F. Di Carli
Summary: This study aimed to validate the accuracy of Tc-99m-sestamibi SPECT in quantifying MBF and MFR, as well as evaluate its reproducibility. The results showed that using splines in SPECT imaging improved the correlation with N-13-ammonia positron emission tomography and demonstrated good test/retest reproducibility.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Medicine, General & Internal
Mitchel R. Stacy
Summary: Peripheral arterial disease (PAD) is a non-coronary artery atherosclerotic disorder that affects the lower extremities and is associated with various health consequences. The diagnosis is typically made using non-invasive tests, but nuclear medicine techniques have recently emerged as a potential tool for assessing the functional consequences of PAD-related limb ischemia.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Ilker Ozsahin, Efe Precious Onakpojeruo, Berna Uzun, Dilber Uzun Ozsahin, Tracy A. A. Butler
Summary: The use of positron emission tomography (PET) imaging with tau-specific radiotracers allows for the detection and quantification of tau pathology in living subjects, which aids in the early diagnosis of Alzheimer's disease (AD) and monitoring disease progression and treatment effectiveness. This study analyzed, compared, and ranked currently available tau PET radiotracers using a multi-criteria decision-making (MCDM) tool called PROMETHEE. Based on weighted criteria such as specificity, target binding affinity, brain uptake, brain penetration, and rates of adverse reactions, the second-generation tau tracer [F-18]RO-948 was found to be the most favorable. This flexible method can be expanded and updated to assist researchers and clinicians in choosing the optimal tau PET tracer for specific purposes.
Article
Biochemistry & Molecular Biology
Mateusz Pegier, Krzysztof Kilian, Krystyna Pyrzynska
Summary: Searching for new compounds and synthetic routes for medical applications is a challenge in modern chemistry. Porphyrins can tightly bind metal ions and serve as complexing and delivering agents. Two methods, one using a reducing agent and another utilizing microwave-assisted synthesis, were developed to optimize the reaction of copper ions with water-soluble porphyrins. The proposed methods were successfully applied for radiolabeling of porphyrins with Cu-64.
Article
Pharmacology & Pharmacy
Ibolya Kalman-Szabo, Szilvia Bunda, Norbert Lihi, Zsofia Szaniszlo, Dezso Szikra, Judit Szabo Peline, Aniko Fekete, Barbara Gyuricza, Daniel Szucs, Gabor Papp, Gyorgy Trencsenyi, Ferenc K. Kalman
Summary: Malignant melanoma is a significant public health issue with high metastatic potential, and the early detection using imaging techniques is crucial for long-term survival. The radio-labelled alpha-MSH analog NAPamide has been found to be a suitable diagnostic tool for melanoma detection. In this study, a new radiotracer, [61Cu]Cu-KFTGNAPamide, has been synthesized to take advantage of the positron emitter 61Cu and the melanoma specificity of NAPamide. The [61Cu]Cu-KFTG-NAPamide demonstrated excellent diagnostic features for B16-F10 melanoma tumors through PET imaging.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemical Research Methods
Olga Ovdiichuk, Hemantha Mallapura, Florian Pineda, Virginie Hourtane, Bengt Langstrom, Christer Halldin, Sangram Nag, Fatiha Maskali, Gilles Karcher, Charlotte Collet
Summary: The iMiDEV(TM) microfluidic system is a new automated tool for small-scale production of radiopharmaceuticals, utilizing microfluidic cassettes for liquid phase reactions. The system allows for fully automated [F-18]NaF radiosynthesis with an intuitive user interface.
Review
Biochemistry & Molecular Biology
Nicolas Nicastro, Umberto Nencha, Pierre R. Burkhard, Valentina Garibotto
Summary: This study summarizes the current evidence on dopaminergic molecular imaging in the diagnostic evaluation of Parkinson's disease (PD), atypical parkinsonian syndromes, and dementia with Lewy bodies (DLB), as well as its potential to distinguish these conditions and estimate disease progression. Dopamine imaging has an outstanding potential for early detection of neurodegeneration.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Xiyi Qin, Han Jiang, Yu Liu, Hong Zhang, Mei Tian
Summary: Apoptosis is a natural, non-inflammatory form of programmed cell death that can be detected through characteristic biochemical changes. Imaging with radionuclide tracers allows for selective detection of apoptotic cell death in vivo, potentially serving as diagnostic markers, early-response indicators, and prognostic predictors.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Oncology
Jordan Eber, Cyrille Blondet, Clara Le Fevre, Isabelle Chambrelant, Fabrice Hubele, Olivier Morel, Delphine Antoni, Georges Noel
Summary: Radiotherapy can unintentionally expose the heart to radiation, leading to cardiac damage. Early detection and monitoring of radiation-induced heart disease are crucial, and nuclear medicine imaging techniques show promise in detecting subclinical effects.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Ikuya Miyamoto, Ryoichi Tanaka, Shintaro Kogi, Genki Yamaya, Tadashi Kawai, Yu Ohashi, Noriaki Takahashi, Mitsuru Izumisawa, Hiroyuki Yamada
Summary: Radiation therapy plays a significant role in managing head and neck malignancies. Osteoradionecrosis (ORN) can occur as a complication, characterized by bone marrow sclerosis and bone resorption, leading to chronic trismus and pathological fractures. Neurological symptoms may indicate tumor recurrence, but diagnostic imaging is challenging.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Nasim Vahidfar, Saeed Farzanefar, Hojjat Ahmadzadehfar, Eoin N. Molloy, Elisabeth Eppard
Summary: This literature review provides a brief overview of the role of nuclear medicine in the diagnosis of obstetric and gynecological cancers. Nuclear medicine has proven to be reliable in diagnostic imaging in nuclear medicine and cancer treatment. [F-18]FDG PET/CT imaging plays a crucial role in investigating gynecological cancer.
Review
Engineering, Biomedical
David Sarrut, Mateusz Bala, Manuel Bardies, Julien Bert, Maxime Chauvin, Konstantinos Chatzipapas, Mathieu Dupont, Ane Etxebeste, Louise M. Fanchon, Sebastien Jan, Gunjan Kayal, Assen S. Kirov, Pawel Kowalski, Wojciech Krzemien, Joey Labour, Mirjam Lenz, George Loudos, Brahim Mehadji, Laurent Menard, Christian Morel, Panagiotis Papadimitroulas, Magdalena Rafecas, Julien Salvadori, Daniel Seiter, Mariele Stockhoff, Etienne Testa, Carlotta Trigila, Uwe Pietrzyk, Stefaan Vandenberghe, Marc-Antoine Verdier, Dimitris Visvikis, Karl Ziemons, Milan Zvolsky, Emilie Roncali
Summary: GATE, built on top of Geant4 toolkit, is collaboratively developed for over 15 years to design Monte Carlo simulations of nuclear-based imaging systems. It is widely used by researchers and industrials to create innovative emission tomography systems and recent developments in simulating modern detectors have been reviewed. Methodological advancements such as Variance Reduction Techniques and Artificial Intelligence integration are discussed for improving detector modeling and computational efficiency.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Osamu Manabe, Masanao Naya
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shiro Miura, Osamu Manabe, Masanao Naya, Akira Ando, Atsushi Usami, Chihoko Miyazaki, Ohkusa Takanori, Takehiro Yamashita
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Article
Neurosciences
Kenji Tagai, Maiko Ono, Manabu Kubota, Naruhiko Sahara, Makoto Higuchi, Hitoshi Shimada, Soichiro Kitamura, Keisuke Takahata, Chie Seki, Yuhei Takado, Hitoshi Shinotoh, Yasunori Sano, Yasuharu Yamamoto, Kiwamu Matsuoka, Hiroyuki Takuwa, Masafumi Shimojo, Manami Takahashi, Kazunori Kawamura, Tatsuya Kikuchi, Maki Okada, Haruhiko Akiyama, Hisaomi Suzuki, Mitsumoto Onaya, Takahiro Takeda, Kimihito Arai, Nobutaka Arai, Nobuyuki Araki, Yuko Saito, John Q. Trojanowski, Virginia M. Y. Lee, Sushil K. Mishra, Yoshiki Yamaguchi, Yasuyuki Kimura, Masanori Ichise, Yutaka Tomita, Ming-Rong Zhang, Tetsuya Suhara, Masahiro Shigeta, Naruhiko Sahara, Makoto Higuchi, Hitoshi Shimada
Summary: A panel of radiochemicals for in vivo PET imaging of tau pathologies in AD has been developed, but sensitive detection of FTLD tau inclusions remains challenging. The imaging probe PM-PBB3 successfully captures diverse tau deposits in AD and FTLD, with increased binding observed in diseased patients in a subsequent clinical PET study. Visual inspection of F-18-PM-PBB3-PET images aids in individually based identification of diverse clinical phenotypes of FTLD on a neuropathological basis.
Article
Cardiac & Cardiovascular Systems
Rodolfo P. Lustosa, Steele C. Butcher, Pieter van der Bijl, Mohammed El Mahdiui, Jose M. Montero-Cabezas, Marina Kostyukevich, Andrea Rocha De Lorenzo, Juhani Knuuti, Nina Ajmone Marsan, Jeroen J. Bax, Victoria Delgado
Summary: The study found that global LV myocardial work efficiency (GLVMWE) calculated from blood pressure measurements is closely associated with long-term survival in patients with ST-segment-elevation myocardial infarction, with patients having GLVMWE below 86% showing higher all-cause mortality rates.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Manabu Kubota, Chie Seki, Yasuyuki Kimura, Keisuke Takahata, Hitoshi Shimada, Yuhei Takado, Kiwamu Matsuoka, Kenji Tagai, Yasunori Sano, Yasuharu Yamamoto, Maki Okada, Tatsuya Kikuchi, Masanori Ichise, Kazunori Kawamura, Ming-Rong Zhang, Makoto Higuchi
Summary: The study successfully visualized PDE7 in human brains using PET imaging with C-11-MTP38, demonstrating the potential of this novel ligand for quantitative investigation of central PDE7. The results showed high retentions in specific brain regions and the reversibility of C-11-MTP38 binding, with excellent agreements between different quantification methods, suggesting the practicality of MRTMO and SUVR for clinical use of C-11-MTP38-PET.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Mohammed El Mahdiui, Judit Simon, Jeff M. Smit, Jurrien H. Kuneman, Alexander R. van Rosendael, Ewout W. Steyerberg, Rob J. van der Geest, Lili Szaraz, Szilvia Herczeg, Nandor Szegedi, Laszlo Geller, Victoria Delgado, Bela Merkely, Jeroen J. Bax, Pal Maurovich-Horvat
Summary: The study found that the attenuation of posterior LA adipose tissue may serve as a promising predictor of AF recurrence following catheter ablation. Higher adipose tissue attenuation could indicate increased local inflammation and potentially be an imaging biomarker for increased risk of AF recurrence.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Tadao Aikawa, Tatsuro Ibe, Osamu Manabe, Noriko Oyama-Manabe
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Osamu Manabe, Nagara Tamaki
JOURNAL OF NUCLEAR CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Kenji Hirata, Osamu Manabe, Keiichi Magota, Sho Furuya, Tohru Shiga, Kohsuke Kudo
Summary: This study aimed to localize lesions using SUVmax and found that when larger and more precise SUVmax values were given, fewer voxels satisfied the criterion. The local maximum restriction was effective in improving identifying performance.
FRONTIERS IN MEDICINE
(2021)
News Item
Cardiac & Cardiovascular Systems
Junichi Tsuchiya, Shingo Moriyama, Osamu Manabe, Miki Amemiya, Kota Yokoyama, Koichiro Kimura, Yasuhisa Fujii, Ukihide Tateishi
JOURNAL OF NUCLEAR CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Masafumi Shimojo, Maiko Ono, Hiroyuki Takuwa, Koki Mimura, Yuji Nagai, Masayuki Fujinaga, Tatsuya Kikuchi, Maki Okada, Chie Seki, Masaki Tokunaga, Jun Maeda, Yuhei Takado, Manami Takahashi, Takeharu Minamihisamatsu, Ming-Rong Zhang, Yutaka Tomita, Norihiro Suzuki, Anton Maximov, Tetsuya Suhara, Takafumi Minamimoto, Naruhiko Sahara, Makoto Higuchi
Summary: This study utilized bacterial dihydrofolate reductase ecDHFR and its unique antagonist TMP to facilitate imaging in the brain, enabling PET and intravital microscopy of neuronal ecDHFR expression in mice. It showed the potential for PET studies of turnover and self-assembly of proteins tagged with ecDHFR mutants. The results establish new opportunities for previously unattainable PET analyses of mammalian brain circuits at the molecular level.
Article
Cardiac & Cardiovascular Systems
Jurrien H. Kuneman, Mohammed El Mahdiui, Alexander R. van Rosendael, Inge J. van den Hoogen, Manesh R. Patel, Bjarne Linde Norgaard, Timothy A. Fairbairn, Koen Nieman, Takashi Akasaka, Daniel S. Berman, Lynne M. Hurwitz Koweek, Gianluca Pontone, Tomohiro Kawasaki, Niels Peter Ronnow Sand, Jesper M. Jensen, Tetsuya Amano, Michael Poon, Kristian A. Ovrehus, Jeroen Sonck, Mark G. Rabbat, Bernard De Bruyne, Campbell Rogers, Hitoshi Matsuo, Jeroen J. Bax, Jonathon A. Leipsic, Juhani Knuuti
Summary: The V/M ratio is significantly lower in patients with diabetes compared to non-diabetics, even after correcting for obstructive coronary stenosis.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Noriko Oyama-Manabe, Tadao Aikawa, Satonori Tsuneta, Osamu Manabe
Summary: 4D flow MRI is a method for visualizing and quantifying aortic and intracardiac flow. It allows for comprehensive assessment of different vessels and is particularly beneficial for patients with complicated congenital heart disease.
MAGNETIC RESONANCE IN MEDICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Tatsuya Kikuchi, Masanao Ogawa, Toshimitsu Okamura, Antony D. Gee, Ming-Rong Zhang
Summary: This study reports a simple and efficient method for the production of [C-11]HCN that can be easily implemented in C-11 production facilities, eliminating the need for a dedicated infrastructure.
Review
Cardiac & Cardiovascular Systems
Noriko Oyama-Manabe, Osamu Manabe, Tadao Aikawa, Satonori Tsuneta
Summary: Although the etiology and progression of sarcoidosis are unknown, cardiac sarcoidosis (CS) is significantly associated with poor prognosis due to complications such as congestive heart failure and arrhythmias. Novel imaging modalities like FDG PET/CT and CMR play essential roles in diagnosing and monitoring patients with confirmed or suspected CS.
KOREAN CIRCULATION JOURNAL
(2021)
